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| 1 | Genetic correction of p-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice显示文摘 | Yixuan Wang Chen-Guang Zheng Yonghua Jiang Jiqin Zhang Jiayu Chen Chao Yao Qingguo Zhao Sheng Liu Ke Chen Juan Du Ze Yang Shaorong Gao | 2012 | Cell Research2012，22，4： | 27 |
| 2 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 3 | S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance显示文摘最近的研究证明 UHRF1 被指向 DNMT1 到 DNA 复制 foci 为 DNA methylation 维护要求,大概通过它的唯一的半甲醇化物有 DNMT1 的 DNA 有约束力的活动和相互作用。UHRF2, UHRF 家庭蛋白质的另一个成员,高度类似于在顺序和结构的 UHRF1,关于它在 DNA methylation 的角色的涨的问题。在这研究,我们证明 UHRF2 象 UHRF1 一样,也优先地绑在 methylated histone H3 离氨酸 9 (H3K9 ) 通过它的保存 tudor,通过 SET 和戒指的领域和半甲醇化物 DNA 联系了领域。象 UHRF1 一样, UHRF2 在 pericentric heterochromatin 被充实。heterochromatin 本地化取决于到大程度它的 methylated H3K9 有约束力的活动并且到它的 methylated 上的更少的程度 DNA 有约束力的活动。Coimmunoprecipitation 实验证明 UHRF1 和 UHRF2 与 DNMT1, DNMT3a, DNMT3b 和 G9a 交往。尽管有所有这些保存功能,我们发现 UHRF2 不能在 Uhrf1 空老鼠救 DNA methylation 缺点胚胎的干细胞。这个罐头在房间周期的 S 阶段期间为 UHRF2 被归因于无能到成员 DNMT1 到复制 foci。确实,我们发现当 UHRF1 在房间以一种 S 阶段依赖者方式与 DNMT1 交往时, UHRF2 不做。因此,我们的学习证明 UHRF2 和 UHRF1 不在 DNA methylation 维护是机能上地冗余的并且作为为 DNA methylation 指向 DNMT1 的关键规章的机制揭示在 UHRF1 和 DNMT1 之间的 cell-cycle-dependent 相互作用。 | Jiqin Zhang Qinqin Gao Pishun Li Xiaoli Liu Yuanhui Jia Weicheng Wu Jiwen Li Shuo Dong Haruhiko Koseki Jiemin Wong | 2011 | Cell Research2011，21，12： | 12 |
| 4 | Stem cell lineage in body layer specialization and vascular patterning of rice root and leaf显示文摘Since the first appearance of vascular plants during evolution, the plant body has become specialized for adaption to land conditions. Much of our knowledge of plant body specialization and the origins of tissues from stem cells have been obtained from studies on the dicot Arabidopsis thaliana. However, less is known about plant body specialization in monocots, another important branch of angiosperms. In this study, we analyzed stem cell lineage and differentiation during development of the root and leaf of the monocot model plant rice(Oryza sativa). Our results showed that three body layers of rice are established from stem cells accompanied by progressively reduced pluripotency. Layer 1(L1) is a single-cell layer of epidermis; L2 is the cortex/endodermis in the root and the mesophyll in the leaf; and L3 is the site of vascular initiation. At least two common steps in vascular development are shared between rice root and leaf. The preprocambium divides to form the procambium and root pericycle or leaf outer sheath. The procambium further differentiates into the xylem, phloem and circumambient cells. We found that the outer sheath of leaf vascular bundles originates not only from the preprocambium of L3,but also from the mesophyll precursor cells of L2. In addition, WUSCHEL-RELATED HOMEOBOX(WOX)genes are expressed in not only the stem cell niche but also metaxylem precursor in rice. This pattern differs from that of homologs in Arabidopsis, suggesting that WOX functions have been recruited in different stem cells in dicots and monocots. | Minhuan Zeng Bo Hu Jiqin Li Guifang Zhang Ying Ruan Hai Huang Hua Wang Lin Xu | 2016 | Science Bulletin2016，61，11： | 5 |
| 5 | Prehistoric damaging earthquake promoted the decline of'Heluo Ancient State'in Early China显示文摘The emergence of the'Ancient State'is considered an important stage in the discourse on human civilizations.Based on its complex and hierarchical social structure,the Shuanghuaishu site of Henan Province is regarded as an'Ancient state',specifically the'Heluo Ancient State'.The site is situated in the middle reaches of the Yellow River region and played a key role in prehistoric China.However,the reasons behind its decline are unclear.Here,we conducted an integrated investigation of the archaeological excavations and archaeoseismic analyses at the Shuanghuaishu site.We identified paleoseismic remains within paleo-artificial moats,which were formed owing to off-fault structures of soil liquefaction,hillslope landslides,and related ground fractures,along with shake-related wall disruption and building collapse in the residential zone.Charcoal dating was conducted to constrain the age for this earthquake event,which was determined to be approximately 5.0 cal kyr BP.Furthermore,based on the practical curve for earthquake-induced liquefaction,the preliminary estimate of the magnitude of this paleo seismic event is greater than M_(s)5.9-6.0.We propose that the Shuanghuaishu site experienced a recession after the earthquake event,which may have influenced the continuous development of the'Heluo Ancient State'as a regional center settlement. | Xiu HU Peng LU Youli LI Duowen MO Wanfa GU Qingri LIU Ailun GUO Panpan CHEN Hui WANG Yan TIAN Xu WANG Yayi HU Jiqin ZHANG Zhen WANG Quanxing LUO Junjie XU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 6 | Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://gffzzeb6f7f563f66445dhxvcwcu9bvfp96cuu.ffgz.tsg.suse.edu.cn/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2019 | Protein & Cell2019，10，9： | 0 |
| 7 | Intelligent tunable CAR-T cell therapy leads the new trend显示文摘Adoptive transfer of T cells engineered with chimeric antigen receptor(CAR)has been proved to have robust anti-tumor effects against hematological malignancies.However,problems about safety and efficacy,such as cytokine release syndrome(CRS),T cell exhaustion and antigen escape are still raised when patients are treated with CAR-T cells.Moreover,CAR-T therapy has limited applications in treating solid tumors,owing to inefficient infiltration and poor functional persistence of CAR-T cells and diverse immunosuppression in tumor microenvironment.In order to overcome these limitations and broad its applications,multiple controllable CAR-T technologies were exploited.In this article,we review the designs of intelligent controlled CAR-T technologies and the innovations that they bring about in recent years. | Jiayi Cheng Mingyao Liu Jiqin Zhang | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 8 | Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma显示文摘The important role of immunogenic cell death(ICD)in many tumors is increasingly being discovered.However,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(GBM)have not been well studied.We obtained GBM samples from the Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases,as well as the immunotherapy cohort from the IMvigor210 study.We used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different. | Sha Yang Mei Deng Yunbiao Xiong Bing Xiong Junwu Fu Jia Wang Jiqin Zhang Guoqiang Han Jian Liu Ying Tan | 2024 | Genes & Diseases2024，11，3： | 0 |
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