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| 1 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 2 | The visual word form area: evidence from an fMRI study of implicit processing of Chinese characters显示文摘 | Liu Chao Zhang Wutian Tang Yiyuan | 2008 | Neuroimage2008，40，3： | 1 |
| 3 | Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord显示文摘 | Wei Zhang Qing Yan Yuan-shan Zeng Xue-bao Zhang Yi Xiong Jun-mei Wang Shui-jun Chen Yan Li Iain C. Bruce Wutian Wu | 2010 | Brain Research2010，，： | 1 |
| 4 | Self-assembling peptide nanofibrous hydrogel as a promising strategy in nerve repair after traumatic injury in the nervous system显示文摘Following injury in central nervous system(CNS),there are pathological changes in the injured region,which include neuronal death,axonal damage and demyelination,inflammatory response and activation of glial cells.The proliferation of a large number of astrocytes results in the formation of glial scar。 | Na Zhang Liumin He Wutian Wu | 2016 | Neural Regeneration Research2016，11，5： | 1 |
| 5 | Deactivations during the numerical processing显示文摘Deactivation has been encountered frequently in functional brain imaging researches. However, the deactivations during the numerical processing have not been reported yet. In this study, the functional magnetic resonance imaging (fMRI) was employed to investigate the pattern of the deactivation in the brain of 15 healthy subjects during the numerical addition task. Analyses revealed significant deactivations in several brain regions, including the posterior cingulate, precuneus, anterior cingulate and prefrontal cortex. Especially, we found notable deactivation in bilateral insula. Accounting for the cognitive functions of these regions participating in a combinated way, we discuss their contributions in sustaining the brain activity during conscious resting state, and indicate that the insula is an important area of gathering auditory information from the external world. | FENG HongBo ZHANG Ye TANG YiYuan JIN Jing DONG Feng FENG ShiGang ZHANG WuTian | 2007 | Chinese Science Bulletin2007，52，13： | 1 |
| 6 | Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching显示文摘Cytoskeletal microtubule rearrangement and movement are crucial in the repair of spinal cord injury.Spastin plays an important role in the regulation of microtubule severing.Both spastin and collapsin response mediator proteins can regulate neurite growth and branching;however,whether spastin interacts with collapsin response mediator protein 3(CRMP3)during this process remains unclear,as is the mechanism by which CRMP3 participates in the repair of spinal cord injury.In this study,we used a proteomics approach to identify key proteins associated with spinal cord injury repair.We then employed liquid chromatography-mass spectrometry to identify proteins that were able to interact with glutathione S-transferase-spastin.Then,co-immunoprecipitation and staining approaches were used to evaluate potential interactions between spastin and CRMP3.Finally,we co-transfected primary hippocampal neurons with CRMP3 and spastin to evaluate their role in neurite outgrowth.Mass spectrometry identified the role of CRMP3 in the spinal cord injury repair process.Liquid chromatography-mass spectrometry pulldown assays identified three CRMP3 peptides that were able to interact with spastin.CRMP3 and spastin were co-expressed in the spinal cord and were able to interact with one another in vitro and in vivo.Lastly,CRMP3 overexpression was able to enhance the ability of spastin to promote neurite growth and branching.Therefore,our results confirm that spastin and CRMP3 play roles in spinal cord injury repair by regulating neurite growth and branching.These proteins may therefore be novel targets for spinal cord injury repair.The Institutional Animal Care and Use Committee of Jinan University,China approved this study(approval No.IACUS-20181008-03)on October 8,2018. | Zhi-Sheng Ji Jian-Ping Li Chao-Hua Fu Jian-Xian Luo Hua Yang Guo-Wei Zhang Wutian Wu Hong-Sheng Lin | 2021 | Neural Regeneration Research2021，16，12： | 0 |
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