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| 1 | Molecular basis for ligand activation of the human KCNQ2 channel显示文摘The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy,pain and several other diseases related to neuronal hyper-excitability.A list of synthetic compounds have been developed to directly activate KCNQ2,yet our knowledge of their activation mechanism is limited,due to lack of high-resolution structures.Here,we report cryo-electron microscopy(cryo-EM)structures of the human KCNQ2 determined in apo state and in complex with two activators,ztz240 or retigabine,which activate KCNQ2 through different mechanisms.The activator-bound structures,along with electrophysiology analysis,reveal that ztz240 binds at the voltage-sensing domain and directly stabilizes it at the activated state,whereas retigabine binds at the pore domain and activates the channel by an allosteric modulation.By accurately defining ligand-binding sites,these KCNQ2 structures not only reveal different ligand recognition and activation mechanisms,but also provide a structural basis for drug optimization and design. | Xiaoxiao Li Qiansen Zhangc Peipei Guo Jie Fu Lianghe Mei Dashuai Lv Jiangqin Wang Dongwu Lai Sheng Ye Huaiyu Yang Jiangtao Guo | 2021 | Cell Research2021，31，1： | 3 |
| 2 | Rank of loop, constraint degree of path, coupling degree of graph and their application显示文摘Some new concepts (rank of a loop, degree of freedom of a graph, path unit and ordered path arrangement, constraint degree of path, coupling degree of a graph, basic graph, etc.), formulas, and algorithms, are proposed in this paper. Based on these concepts, a new systematic theory and practical method for the design of topological structure, kinematics and dynamics of mechanical systems is established. Some conjectures and problems needed to be researched are also put forward. The concepts, formulae and algorithms presented in this paper will find wide potential applications. | YANGTingli LUOYufeng ZHANGCe YAOFanghua | 2005 | Progress in Natural Science:Materials International2005，15，2： | 2 |
| 3 | Pro- ductivity growth and environmental regulations-accounting for undesirable outputs: analysis of China's thirty provincial regions using the malmquist-luenbcrger index显示文摘 | ZHANGC H LIU H Y BRESSERS H T A | 2011 | Ecologi- cal Economics2011，70，12： | 1 |
| 4 | Palaeozoiccollisionaltectonicsandmagmatism oftheChineseTienShan,centralAsia显示文摘 | ALLENMB WINDLEYBF ZHANGC | 1993 | Tectonophysics1993，220，1： | 1 |
| 5 | 显示文摘 | 张春(ZhangC) 郑炎松(ZhengYS) 梅付名(MeiFM) 李光兴(LiGX) | | 化学进展0，，： | 1 |
| 6 | Denovo RNA synthesis bya recombinant classical swine fever virus RNA - dependent RNA polymerase显示文摘 | Yi G H ZhangC Y Cao S | 2003 | European Journal of Biochemistry2003，270，24： | 1 |
| 7 | A Fuzzy-Based Genetic Ap-proach to the Diagnosis of Manufacturing Systems显示文摘 | Khoo L P Angb C L Zhangc J | 2000 | Engineering Appli-cations of Artificial Intelligence2000，13，3： | 1 |
| 8 | Recent developments in application of stable isotope analysis on agro product authen- ticity and traceability 显示文摘 | Yan Zhao Bin Zhangc Gang Chen et ai | 2014 | Food Chemistry2014，145，： | 1 |
| 9 | LentivirusmediatedRNAinterferenceofDCSTAMPexpressioninhibitsthefusionandresorptiveactivityofhumanosteoclasts显示文摘 | ZengZ ZhangC ChenJ | 2013 | JBoneMinerMetab2013，31，4： | 1 |
| 10 | A comparativebiomechanicalstudyofproximalfemoralnail(InterTAN) andproximalfemoralnailantirotationforintertrochantericfractures显示文摘 | HuangY ZhangC LuoY | 2013 | IntOrthop2013，37，12： | 1 |
| 11 | Thermal error of a hydrostatic spindle显示文摘 | Dongju Chena Marc Bonisb Feihu Zhangc | 2011 | Precision Engineering2011，35，3： | 1 |
| 12 | Shape memory effect and mechanical properties of carbon nanotube/ shape memory polymer nanocomposites显示文摘 | NiQQ ZhangC S Fu Y | 2007 | Composite Structures2007，81，2： | 1 |
| 13 | 显示文摘 | 肖鹏(XiaoP) 杨乐(YangL) 张成(ZhangC) 王江云(WangJY) 孙金鹏(SunJP) | | 生物化学与生物物理进展0，，： | 1 |
| 14 | 显示文摘 | 张晨(ZhangC) 赵美萍(ZhaoM) | 2010 | 化学进展2010，22，： | 1 |
| 15 | Panel estimation for urbanization, energy consumption and C02emissions: a regionalanalysis in China 显示文摘 | ZHANGC G LIN Y | 2012 | EnergyPolicy2012，49，48： | 1 |
| 16 | A critical review on the technique and mechanism of microwave-based denitrification in flue gas显示文摘Microwave radiation has received extensive attention due to its significant thermal and nonthermal effects, and the development of MW-based denitrification in flue gas has become one of the most promising methods to avoid the defects of ammonia escape, high temperature and cost in traditional SCR. This review introduces the thermal and non-thermal effects of microwaves and divides MW-based denitrification methods into MW reduction and oxidation denitrification, systematically summarizes these denitrification methods, including MW discharge reduction, MW-induced catalytic reduction using active carbon, molecular sieves, metal oxides(transition metals, perovskites, etc.), MW-induced oxidation denitrification with and without additional oxidant, and discusses their removal pathway and mechanism. Finally, several research prospects and directions regarding the development of microwave-based denitrification methods are provided. | Bo Yuan Zhen Qian Zili Zhangc Le Fu Shihang Pan Runlong Hao Yi Zhao | 2022 | Journal of Environmental Sciences2022，34，10： | 1 |
| 17 | Adouble blind, placebo controlled study of house dust mite immunotherapy in Chinese asthmatic patients显示文摘 | Wang H LinX HaoC ZhangC etal | 2006 | Allergy2006，61，2： | 1 |
| 18 | ApathologicstudyofdegenerationoftherodandconepopulationsoftherhodopsinPro347Leutransgenicpigs显示文摘 | 23,TsoMO LiWW ZhangC etal | 1997 | TransAmOphthalmolSoc19971997，，： | 1 |
| 19 | Differentiation of benign from malignant tyroid lesions:calculation of the strain ratio on thyroid sonoelastography显示文摘 | XingP WuL ZhangC etal | 2011 | J Ultrasound Med2011，30，： | 1 |
| 20 | FacilesynthesisofMWC-NT-ZnFe2O4 nanocompositesasanodematerialsforlithiumionbatteries显示文摘 | SuiJH ZhangC HongD etal | 2012 | JournalofMaterialsChemistry2012，22，13： | 1 |
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