| 2 | Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of Traditional Chinese Medicine显示文摘OBJECTIVE: This study investigated how polypeptide 2B1 is involved in regulating and governing dampness in rat models with dampness pattern defined in terms ofTraditional Chinese Medicine.METHODS: We randomly divided 48 SPF10-week-old male Sprague-Dawley(SD) rats into a normal group, normal + Aristolochic acid I(AA-I) for5 min group, normal + AA-I for 60 min group,dampness pattern group(DS-Group), dampness pattern + AA-I for 5 min group, and dampness pattern + AA-I for 60 min group. Groups were then treated accordingly. We took out the lung, stomach, liver, spleen, kidney, large intestine, and small intestine tissues to detect gene and protein expression of organic anion transporter polypeptide 2B1(OATP2B1).RESULTS: Gene expression of OATP2B1 in spleen,kidney, and small intestine of rats with dampness pattern was lower than that in normal rats(P<0.05).The gene expressions of OATP2B1 in liver, stomach,large intestine, and small intestine were lower than that in control rats at different time points after being stimulated by AA-I(P<0.05).CONCLUSION: There is coordination among multiple viscera in handling the condition of dampness,and the mechanism underlying the action may rely on regulating the expression of OATP2B1. | Zhangbin Yang Ting Xiang Shijun Zhang Hongrui Zhan Zexiong Chen Baoguo Sun Xiaoling Chen Jingli Shi Bin Ren | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 3 |
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