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| 1 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 2 | Emerging Variants of B.1.617 Lineage Identified Among Returning Chinese Employees Working in India—Chongqing Municipality,China,April 2021显示文摘On April 22 and 23,2021,3 confirmed COVID-19 cases in passengers on an arriving airplane from Nepal were reported by Chongqing Public Health Medical Center.Preliminary epidemiological investigation revealed these 3 patients,males aged 20-30 years,were coworkers of a cellphone company that has a manufacturing base in Noida,India,where they worked with their Indian colleagues since late 2019. | Sheng Ye Yongjun Zhang Xiang Zhao Zhen Yu Yang Song Zhangping Tan Yun Tang Shuang Chen Mingyue Wang Hua Ling | 2021 | China CDC weekly2021，3，19： | 4 |
| 3 | SINGULAR PERTURBATION OF THREE-POINT BOUNDARY VALUE PROBLEM FOR THIRD ORDER DIFFERENTIAL EQUATIONS显示文摘In this paper, by the theory of differential inequalities, we study the existence and uniqueness of the solution to the three-point boundary value problem for third order differential equations. Furthermore we study the singular perturbation of three-point boundary value problem to third order quasilinear differential equations, construct the higher order asymptotic solution and get the error estimate of asymptotic solution and perturbed solution. | Xu Guoan Yu Zhangping Zhou Zheyan | 2005 | Annals of Differential Equations2005，21，3： | 2 |
| 4 | Three-dimen- sional microstructure-based discrete element viscoe- lastic modeling of creep compliance tests for asphalt mixtures显示文摘 | You Zhangping Liu Yu Dai Qingli | 2011 | Journal of Materials in Civil Engineer-ing2011，，： | 1 |
| 5 | When Will the New Campaign to Invest in China Come?显示文摘Foreign investment has played a more and more important role in promoting the economic development in China. But a full decline in foreign-capital attraction appeared for the first time in 1999. Experts predict that foreign investment in China has not fallen to the lowest point. | Li Zhangping Ma Yu | 2000 | China's Foreign Trade2000，，3： | 0 |
| 6 | Three Cases Infected with Avian Influenza A(H5N6)Virus-Chongqing Municipality,China,January-September,2021显示文摘Summary What is already known about this topic?The World Health Organization(WHO)has reported a total of 48 cases by October 15,2021.The continuous genomic reassortments of H5N6 and other subtype avian influenza viruses(AIVs)pose a long-term threat to public health and the poultry industry.What is added by this report?Three new cases of H5N6 that occurred from January to September 2021 in Chongqing Municipality,China were reported in this study.Epidemiological information of the three cases showed raising poultry and visiting live poultry market contributed to these infections,and there was no evidence of human-to-human transmission of H5N6 currently but a potential spatial cluster.An increase of H5N6 cases was recorded in the area.What are the implications for public health practice?In case of unexplained pneumonia or severe respiratory infection,the patients’epidemiological history of contact with poultry or live poultry markets(LPMs)may be an important interrogation to help diagnose.Extensive and long-term surveillance of avian influenza viruses in LPMs is essential. | Kun Su Zhen Yu Yu Lan Ju Wang Shuang Chen Li Qi Yaokai Chen Yun Tang Yu Xiong Zhangping Tan Mingyue Wang Sheng Ye Dayan Wang Hua Ling William JLiu Xiaoni Zhong Qin Li Wenge Tang | 2022 | China CDC weekly2022，4，1： | 0 |
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