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| 1 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 2 | PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1显示文摘 | Xiaoyang Hou Ying Zhang Ying H. Shen Tongbao Liu Shangming Song Lianqun Cui Peili Bu | 2013 | European Journal of Pharmacology2013，，： | 1 |
| 3 | Nitrogen-doped pyrogenic carbonaceous matter facilitates azo dye decolorization by sulfide: The important role of graphitic nitrogen显示文摘Pyrogenic carbonaceous matter(PCM) catalyzes azo dye decolorization by sulfide, but the nitrogen doping catalytic mechanisms are poorly understood. In this study, we found that stagnate time of azo dye methyl orange(MO) decolorization was reduced to 0.54-18.28 min in the presence of various nitrogen-doped graphenes(NGs), remarkably lower compared to graphene itself. Particularly, graphitic nitrogen played a critical role in NGs-catalyzed MO decolorization by sulfide. Gas chromatography-mass spectrometry and in-situ surface Raman analysis demonstrated that doping nitrogen, especially graphite one facilitated reactive intermediate polysulfides formation. This is attributed to the improved electron conductivity through graphitic nitrogen doping, and the enhanced interactions between sulfide and carbon atoms bonded to graphitic nitrogen. This study not only provides a better understanding of PCM impact on transformations and fates of organic pollutants in natural environments, but also offer a new regulation strategy for more efficient wastewater treatment processes in PCM-catalyzed engineering systems. | Han-Qing Zhao Wen-Qiang Li Nannan Hou Lei Li Yiran Wang Peili Lu Yang Mu | 2023 | Chinese Chemical Letters2023，34，2： | 1 |
| 4 | Application of Femtosecond Laser in Ocular Surgery显示文摘The femtosecond laser is a type of laser that can produce pulses of light of extremely short duration.The application of femtosecond laser in surgery results in no thermal effect or shock wave,so that this laser is unlikely to cause tissue injuries outside the irradiation area of the laser beam. The femtosecond laser shows promising applications in refractive surgery and corneal transplantation due to its high precision and predictability. In this paper, we review the clinical application of the femtosecond laser in refractive surgery and corneal transplantation. | Peili Hou Yan Lu Fen Ye Wen Lan Zhenping Huang | 2013 | Eye Science2013，28，2： | 1 |
| 5 | CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation显示文摘The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in metabolism.However,its function in the antiviral innate immune response remains to be determined.In this study,we report that CD97 inhibits virus-induced type-I interferon(IFN-I)release and enhances RNA virus replication in cells and mice.CD97 was identified as a new negative regulator of the innate immune receptor RIG-I,and RIG-1 degradation led to the suppression of the IFN-I signaling pathway.Furthermore,overexpression of CD97 promoted the ubiquitination of RIG-I,resulting in its degradation,but did not impact its mRNA expression.Mechanistically,CD97 upregulates RNF125 expression to induce RNF125-mediated RIG-I degradation via K48-linked ubiquitination at Lys181 after RNA virus infection.Most importantly,CD97-deficient mice are more resistant than wild-type mice to RNA virus infection.We also found that sanguinarine-mediated inhibition of CD97 effectively blocks VSV and SARS-CoV-2 replication.These findings elucidate a previously unknown mechanism through which CD97 negatively regulates RIG-I in the antiviral innate immune response and provide a molecular basis for the development of new therapeutic strategies and the design of targeted antiviral agents. | Huasong Chang Peili Hou Xuefeng Wang Aibiao Xiang Hao Wu Wenjing Qi Rukun Yang Xue Wang Xingyu Li Wenqi He Guimin Zhao Weiyang Sun Tiecheng Wang Daniel Chang He Hongmei Wang Yuwei Gao Hongbin He | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 6 | 优势种对藏北草原群落稳定性具有主导作用显示文摘优势种作为群落动态和生态系统的重要驱动因素,对生物条件以及与其他物种的相互作用具有强烈的影响,这一现象在高寒草地生态系统中尤其明显。然而,不同生态系统中优势种对群落稳定性的影响作用却知之甚少。本文研究了藏北草原4大高寒草地(高寒草甸、高寒草甸草原、高寒草原和高寒荒漠草原)地上生产力的时间稳定性(2014-2020年)和群落稳定性机制,并分析了群落特征和物种组成的变化。研究结果表明,高寒草甸的群落稳定性显著高于其他3种草地。这种差异主要归因于高寒草甸较高的补偿效应和选择效应。此外,优势种通过增加其稳定性和异步性来维持群落稳定性。这些研究结果表明了优势种作为群落的基础物种,可能在塑造高寒草原群落稳定性方面发挥着主导作用。因此,在日益加剧的环境波动下,保护优势种对于脆弱生态系统稳定生态系统功能至关重要。 | Ge Hou Peili Shi Tiancai Zhou Jian Sun Ning Zong Minghua Song Xianzhou Zhang | 2023 | Journal of Plant Ecology2023，16，3： | 0 |
| 7 | Effects of twin orientation and twin boundary spacing on the plastic deformation behaviors in Ni nanowires显示文摘Spreading twins throughout nano metals has been proved to effectively mediate the mechanical behaviors in face-centered-cubic(fcc)metals.However,the experimental investigation concerning the roles of twin boundary(TB)during deformation is rarely reported.Here,with the joint efforts of in-situ nanomechani-cal testing and theoretical studies,we provide a systematic investigation regarding the effects of TB orien-tation(θ,the angle between tensile loading direction and the normal of TB)and spacing on deformation mechanisms in Ni nanowires(NWs).As compared with single-crystalline counterparts,it is found that nano-twinned(nt)NWs withθ∼0°exhibit limited ductility,whereas TB can serve as an effective block-age to the dislocation propagation.In contrast,in nt NWs withθ∼20°and 55°,TB migration/detwinning induced by TB-dislocation reaction or partial dislocation movement dominates the plasticity,which con-tributes to enhanced NW ductility.Regarding nt NWs withθ∼90°,dislocations are found to be able to transmit through the TBs,suggesting the limited effect of TB on the NW stretchability.Furthermore,de-creasing TB spacing(λ)can facilitate the detwinning process and thus greatly enhance the ductility of NW withθ∼55°.This study uncovers the distinct roles that TB can play during mechanical deforma-tions in fcc NWs and provides an atomistic view into the direct linkage between macroscopic mechanical properties and microscopic deformation modes. | Ying Zhang Yuxuan Hou He Zheng Ligong Zhao Shuangfeng Jia Kaixuan Li Huayu Peng Peili Zhao Lei Li Weiwei Meng Renhui Jiang Jianbo Wang | 2023 | Journal of Materials Science & Technology2023，，4： | 0 |
| 8 | Orientation-dependent ductility and deformation mechanisms in body-centered cubic molybdenum nanocrystals显示文摘The knowledge regarding anisotropic mechanical behaviors in nanoscale body-centered cubic (bcc) metals remains obscure. Herein, we report the orientation-dependent ductility in bcc Mo nanocrystals (NCs), which exhibit poor ductility along [110] direction but possess relatively better ductility along the [001] and [112] orientations. The origin of different deformability can be traced down to the distinct deformation mechanisms: the unexpected crack nucleation and propagation induce premature fractures in [110]-oriented NCs;in contrast, deformation twinning could contribute to the enhanced ductility in [001]-oriented NCs;interestingly, we find the activation of multiple dislocation slips in [112]-oriented NCs with the highest ductility. Further molecular dynamics simulations provide deeper insights into the defect dynamics that are closely interlinked with experimental observations. Our findings advance the basic understanding of orientation-dependent mechanical properties and help to guide endeavors to architecture the microstructures of bcc metals with enhanced ductility. | Huayu Peng Yuxuan Hou He Zheng Ligong Zhao Ying Zhang Weiwei Meng Ting Liu Peili Zhao Shuangfeng Jia Jianbo Wang | 2023 | Journal of Materials Science & Technology2023，，23： | 0 |
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