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| 1 | FTIR Characterization of the Secondary Structure of Insulin Encapsulated within Liposome显示文摘Aim:To determine the secondary structure of insulin encapsulated within liposome.Methods:The secondary structure of native insulin,mixture of insulin with liposome(sample I) and insulin encapsulated within liposome(sample Ⅱ) were determined by FTIR(Fourier Transform Infrared) spectroscopy.Results:The secondary structure of insulin encspsulated within liposome(Ⅱ) are similar with the secondary structure of native insulin.The difference existed in the amount of α-helices (from 36% of insulin to 31% of sample Ⅱ)and β-sheet(from 48% of insulin to 51% of sample Ⅱ).The content of α-helices and β-sheet of insulin in sample I was found to be very close to that of sample Ⅱ.The results revealed that the insulin encapsulated within liposome possibly spread on the surface of liposome,without inserting into the liposome membrane.Coclusion:The secondary structure of insulin encapsulated within liposome is similar with the native insulin. | ZHANGXuan HUANGLi-xin NIESong-qing QIXian-rong ZHANGQiang | 2003 | Journal of Chinese Pharmaceutical Sciences2003，12，1： | 24 |
| 2 | Impacts of grassland fence on the behavior and habitat area of the critically endangered Przewalski's gazelle around the Qinghai Lake显示文摘The trend of fencing grassland as livestock paddocks is spreading on the Eurasian steppe,however,its impacts on grassland wildlife are little known.In order to explore such impacts,we carried out a field study on how grassland fencing impacts Przewalski's gazelle(Procapra przewalskii),a species listed as EN(Endangered) by SSC/IUCN,on the Qinghai-Tibet Plateau.The results revealed that(1) in the fenced areas,daily movement distance of Przewalski's gazelle was 5081±1187 m(Hudong-Ketu) and 4110±912 m(Yuanzhe),which was much shorter than the 7223±546 m recorded in an unfenced area(Kuaierma);(2) the feeding bout duration of Przewalski's gazelle was much shorter in the fenced habitat;(3) the frequency of walking along both high or low fence lines reached about 81%;while the frequency of jumping across the low fence line was only about 1.2% and frequency of crawling through the bottom of the high fence lines was about 17.8%;(4) the size of post-fencing habitat decreased to about 20% and 6% of the sizes of pre-fencing habitat in Hudong-Ketu and Yuanzhe areas respectively,but no clear change in the size of habitat area was found in the unfenced Kuaierma area;and(5) the fence lines impaired the possibility of gazelles to escape from predators and occasionally trapped the Przewalski's gazelle which failed to jump over the fence lines.Death occurrence of Przewalski's gazelle in the intensively fenced area,including gazelles strangled by fence lines and predated by wolves,reached 5% of the population size in Yuanzhe and up to 15%-20% in Hudong-Ketu.This study highlights the negative impacts of grassland fencing on Przewalski's gazelle and proposes measures for integrating conservation of this gazelle with livestock management practice. | YOU ZhangQiang JIANG ZhiGang LI ChunWang MALLON David | 2013 | Chinese Science Bulletin2013，58，17： | 11 |
| 3 | Formation Mechanism of 'Drag Depressions' and Irregular Boundaries in Intraplate Deformation显示文摘Almost all intraplate caprocks experienced strong deformation during the convergence of microplates, and then disintegrated into many secondary geologic units with the special characters, such as irregular boundaries and particular structural assemblages. In order to understand the formation mechanism of these special phenomena, a rheological experiment on the structural scenery of the Tongling area is carried out. The result shows that the primary regular and uniform boundaries of the Tongling area becomes irregular because of the enclosing and confinement of surrounding geological units in the process of 'compression-shearing-rotation-drag'; simultaneously, two specific 'drag depressions' developed at two opposite comers of the block. The former and the later phenomena can be regarded as a typical regional-scale rheological effect and necessary outcome of intraplate deformation respectively. | DENGJun HUANGDinghua WANGQingfei HOUZengqian LüQingtian YAOLingqing XINHongbo ZHANGQiang WEIYanguang | 2004 | Acta Geologica Sinica(English Edition)2004，78，1： | 11 |
| 4 | Paleo-environmental changes in the Yangtze Delta during past8000 years显示文摘The Yangtze Delta is one of the economically most developed areas in China. It is located in the eastern China monsoon region. Archaeological excavations and environment-archaeology studies over many years in this region provide exceptional information about climate changes, development of human civilization and also human-environment interactions. Archaeological excavations made in the study region reveal that the development of Neolithic cultures is not continuous, which may be a result of extreme climatic events. The analysis of 14 C-dated buried paleotrees, peat and shell ridges show the rise and fall of human civilization in the study area. The research results presented in this paper confirm that human civilization collapsed six times in the Yangtze Delta, matching six high sea level epoches, peat accumulation and buried paleotrees formation periods respectively. This indicates that human activities in the Yangtze Delta are controlled by local climate changes and changing hydrological conditions. The collapse of the Liangzhu culture (5000 aBP-3800 aBP) in about 4000 aBP, after a tremendous flooding event, followed by a relatively backward Maqiao culture (3800 aBP-3200 aBP) confused researchers and aroused their great interest. The research results in this paper show that the collapse of the Liangzhu culture is a result of several factors, for example war and food shortage, but the flooding event occurred in the late Liangzhu culture epoch is the main factor therein. | ZHANGQiang JIANGTong SHIYafeng LorenzKING LIUChunling MartinMETZLER | 2004 | Journal of Geographical Sciences2004，14，1： | 9 |
| 5 | Potential control of climatic changes on flood events in the Yangtze Delta during1100-2002显示文摘Wide collection on the historic records of the climatic changes and flood events is performed in the Yangtze Delta. Man-Kendall (MK) method is applied to explore the changing trends of the time series of the flood discharge and the maximum high summer temperature. The research results indicate that the flood magnitudes increased during the transition from the medieval warm interval into the early Little Ice Age. Fluctuating climate changes of the Little Ice Age characterized by arid climate events followed by the humid and cold climate conditions give rise to the frequent flood hazards. Low-lying terrain made the study region prone to the flood hazards, storm tide and typhoon. MK analysis reveals that the jumping point of the time series of the flood discharge changes occurred in the mid-1960s, that of the maximum summer temperature changes in the mid-1990s, and the exact jump point in 1993. The flood discharge changes are on negative trend before the 1990s, they are on positive tendency after the 1990s; the maximum high summer temperature changes are on negative trend before the 1990s and on positive tendency after the 1990s. These results indicate that the trend of flood discharge matches that of the maximum high summer temperature in the Yangtze Delta. The occurrence probability of the maximum high summer temperature will be increasing under the climatic warming scenario and which will in turn increase the occurrence probability of the flood events. More active solar action epochs and the higher sea surface temperature index (SST index) of the south Pacific Ocean area lying between 4 o N-4 o S and 150 o W-90 o W correspond to increased annual precipitation, flood discharge and occurrence frequency of floods in the Yangtze Delta. This is partly because the intensified solar activities and the higher SST index give rise to accelerated hydrological circulation from ocean surface to the continent, resulting in increased precipitation on the continent. | JIANGTong ZHANGQiang YvesGUERNOND | 2004 | Journal of Geographical Sciences2004，14，1： | 5 |
| 6 | ENVIRONMENTAL CHANGE AND ITS IMPACTS ON HUMAN SETTLEMENT IN THE CHANGJIANG RIVER DELTA IN NEOLITHIC AGE显示文摘Dating data, altitude of Neolithic sites, climatic changes from sedimentary records and previous research results were collected and analyzed to detect possible connections between climatic changes and human activities in the Changjiang River Delta in the Neolithic Age. The results indicated that hydrological changes greatly impacted the human activities in the study region. Low-lying geomorphology made the floods and sea level changes become the important factors affecting human activities, especially the altitude change of human settlements. People usually moved to higher places during the periods characterized by high sea level and frequent floods to escape the negative influences from water body expansion, which resulted in cultural hiatus in certain profiles. However, some higher-altitude settlements were not the results of climatic changes but the results of social factors, such as religious ceremony and social status. Therefore, further research will be necessary for the degree and types of impacts of climatic changes on human activities in the study area at that time. | ZHANGQiang LIUChun-ling ZHUCheng JIANGTong | 2004 | Chinese Geographical Science2004，14，3： | 4 |
| 7 | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening显示文摘ryanodine 受体(RyRs ) 是为从 sarcoplasmic/endoplasmic 蜂窝胃(SR/ER ) 的 Ca 2+ 的快速的版本负责的细胞内部的钙隧道到细胞质,它为心脏、骨胳的肌肉联合的刺激收缩(E-C ) 是必要的。关上的 RyR1 的在原子附近的决定结构披露了这条庞大的隧道的分子的详情,当远程的 allosteric gating 机制等候说明时。这里,我们报导在三的兔子 RyR1 的 cryo 他们结构在大约 4 Å 关上了符合构造;在 5.7 Å 的分辨率和一个开的状态;。关上的 RyR1 结构的比较显示出细胞质的站台的一个呼吸运动,当隧道领域和它的连续中央领域仍然保持将近未改变时。户外和关上的结构的比较在导致隧道开的细胞质的门显示出 S6 tetrahelical 捆的膨胀。在毛孔开始期间,细胞质的 “ O-ring”隧道领域的主题和中央领域展览的 U 主题联合了运动,当中央领域经历域明智的排水量时。这些结构的分析提供重要卓见进在骨胳的肌肉联合的 E-C 并且作为联合细胞质的平台的 conformational 变化到中央毛孔的 gating 的变换器识别中央域。 | Xiao-Chen Bai Zhen Yan Jianping Wu Zhangqiang Li Nieng Yan | 2016 | Cell Research2016，26，9： | 4 |
| 8 | Location of rut stands vs. mating opportunities in Przewalski's gazelle: A field test of the "Resource-based Hypothesis" and "Female Traffic Version of the Hotspot Hypothesis"显示文摘 | Zhangqiang YOU Zhigang JIANG Chunwang LI | 2011 | Current Zoology2011，57，6： | 4 |
| 9 | Tunable Yb-Doped Double-Clad Fibre Laser Based on Fibre Bragg Grating with Narrow Linewidth显示文摘A tunable Yb-doped double-clad fibre (YDCF) laser by tuning the fibre Bragg grating (FBG) is successfully demonstrated. The FBG was fabricated in the YDCF directly, resulting in low splicing loss and compact configuration. A continuous tuning range of 15.6nm from 1046.6nm to 1062.2nm is achieved. The laser linewidth is smaller than 0.1 nm in the whole tuning range. A maximum output power 117mW is achieved when the pump power is332 mW. The laser oscillation is quite stable in the whole operation. | FUSheng-Gui FANWan-De ZHANGQiang WANGZhi LILi-Jun ZHANGChun-Shu YUANShu-Zhong DONGXiao-Yi | 2004 | Chinese Physics Letters2004，21，7： | 2 |
| 10 | Observed climatic changes in Shanghai during 1873-2002显示文摘Variation characteristics of temperature and precipitation in January and July and annual mean temperature and annual precipitation are analyzed with the help of cumulative anomalies, Mann-Kendall analysis and wavelet analysis. The research results indicate that January precipitation presents an increasing trend after 1990, wavelet analysis result suggests that this increasing trend will continue in the near future. The changes of July precipitation present different features. During 1900-1960, July precipitation is in a rising trend, but is in a declining trend after 1960. Wavelet analysis shows that this declining trend will go on in the near future. Temperature variations in Shanghai are in fluctuations with 2 to 3 temperature rising periods. Mann-Kendall analysis indicates that temperature variations have the obvious abrupt change time when compared with precipitation changes in Shanghai during the past 100 years. The abrupt change time of January temperature lies in 1985, and that of July temperature lies in 1931-1933 and annual mean temperature has the abrupt change time in 1923-1930. Except July precipitation, the precipitation in January, temperature in January, July and annual mean temperature, and annual precipitation are also in a rising trend in the near future. The research results in this paper may be meaningful for future further climatic changes of Shanghai and social mitigation of climatic disasters in the future. | ZHANGQiang CHENJiaqi ZHANGZengxin | 2005 | Journal of Geographical Sciences2005，15，2： | 2 |
| 11 | Relationship between the exposure dose of high intensity focused ultrasound and the heated necrosis element显示文摘Heated necrosis element of tissues is the basis for treating tumor by high intensity focused ultrasound (HIFU), so study on the relationship between the HIFU exposure dose and the heated necrosis element of tissues is of great significance for both HIFU clinical applications and basic research. Using Pennes and Rayleigh formulae the relationship between the exposure dose of an annular focused transducer and the heated necrosis element (i.e. biological focused region) in a bovine liver in vitro at a depth of 2 cm is simulated in an exposure dose range with radiation sound intensity of 7000~25400 W/cm 2 and exposure time of 0~20 s. The theoretical results appear to be in quite good agreement with the experimental ones. It is shown that on the basis of existing theories the heated necrosis element produced by HIFU exposure can be predicted. The deviation of the theory from the experiments under higher exposure dose has also been discussed. | FENGRuo ZHANGQiang LIFaqi ZHENGXiaozheng BAIJin XUJianyi WANGYaojun WANGZhibiao | 2004 | Progress in Natural Science:Materials International2004，14，8： | 2 |
| 12 | PRELIMINARY STUDY ON THE FLOODING AND DROUGHT CLAMITY DURING PAST 1500 YEARS IN THE HAI′AN REGION,JIANGSU PROVINCE显示文摘Collection and arrangement of the historical records of climatic changes and environment evolution,espectial-lyin the aspect of calamities,are made on the history documents of past 1500 years about Haiˊan region,Jiangsu Province.There existed two obvious flooding-drought frequently-occurring periods:one was from 1550 AD to 1850 AD and another was 100 AD to 1200AD.The period of 1550 AD to1850 AD is interrupted by two relatively arid and cold climatic periods:one was from 1630 AD to 1700 AD and another was 1750 AD to 1820 AD.The main characteristic of the calamity periods is that they occurred by turns,and sometimes,both drought and flooding occurred in the same year.The instability of the climatic changes in the Little Ice Age may be the main reason of the frequently-occurring flooding and drought in Haiˊan region.Research results also show that the frequently-occurring periods of flooding and drought is in close relationship with the solar activity,and therefore,occurrence of the flooding and drought may be in relation with the intensity of the solar activity.This hypothesis may need further study in the future. | ZHANGQiang CHENGJi 等 | 2002 | Chinese Geographical Science2002，12，2： | 2 |
| 13 | Simvastatin Regulates Myocardial Cytokine Expression and Improves Ventricular Remodeling in Rats after Acute Myocardial Infarction显示文摘 | Jinying Zhang Xiang Cheng Yu-Hua Liao MD Baojun Lu Yali Yang Bin Li Hongxia Ge Min Wang Ying Liu Zhangqiang Guo Ling Zhang | 2005 | Cardiovascular Drugs and Therapy2005，，1： | 1 |
| 14 | 显示文摘 | CHENQiu-sheng LIUYe-tong ZHANGQiang etal(陈秋生 刘烨潼 张强 等) | 2013 | 理化检验:化学分册2013，49，6： | 1 |
| 15 | 显示文摘 | ZHANGQiang(张强) NIUQuan-wen(柳全文) TIANJing-gen(田景根) | 2001 | 药物分析杂志2001，21，： | 1 |
| 16 | Study on the heat hazard of deep exploitation in high-temperature mines and its evaluation index 显示文摘 | Su Zhaogui Jiang Zhongan Sun Zhangqiang | 2009 | Procedia Earth and Planetary Science2009，，1： | 1 |
| 17 | Parameters of land surface processes on Gobi in Northwest China显示文摘 | ZhangQiang Huang Ronghui | 2004 | Boundary- Layer Meterology2004，110，3： | 1 |
| 18 | 显示文摘 | ZHANGQiang(张强) CHENGXin-Bing(程新兵) HUANGJia-Qi(黄佳琦) etal | 2014 | 新型碳材料2014，29，4： | 1 |
| 19 | 显示文摘 | ZhangQiang(张强) JiangLongtao(姜龙涛) ChenGuoqin(陈国钦)etal | 2011 | 稀有金属材料与工程2011，40，2： | 1 |
| 20 | Forest ecosystem health assessment and analysis in China显示文摘Based on more than 300 forest sample plots surveying data and forestry statistical data, remote sensing information from the NOAA AVHRR database and the daily meteorological data of 300 stations, we selected vigor, organization and resilience as the indicators to assess large-scale forest ecosystem health in China and analyzed the spatial pattern of forest ecosystem health and influencing factors. The results of assessment indicated that the spatial pattern of forest ecosystem health showed a decreasing trend along latitude gradients and longitude gradients. The healthy forests are mainly distributed in natural forests, tropical rainforests and seasonal rainforests; secondarily orderly in northeast national forest zone, subtropical forest zonation and southwest forest zonation; while the unhealthy forests were mainly located in warm temperate zone and Xinjiang-Mongolia forest zone. The coefficient of correction between Forest Ecosystem Health Index (FEHI) and annual average precipitation was 0.58 (p<0.01), while the coefficient of correlation between FEHI and annual mean temperatures was 0.49 (p<0.01), which identified that the precipitation and temperatures affect the pattern of FEHI, and the precipitation’s effect was stronger than the temperature’s. We also measured the correlation coefficient between FEHI and NPP, biodiversity and resistance, which were 0.64, 0.76 and 0.81 (p<0.01) respectively. The order of effect on forest ecosystem health was vigor, organization and resistance. | XIAOFengjin OUYANGHua ZHANGQiang FUBojie ZHANGZhicheng | 2004 | Journal of Geographical Sciences2004，14，1： | 1 |
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