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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 4 | 人乳头瘤病毒16型E6通过下调NHERF1基因促进宫颈癌细胞迁移和侵袭显示文摘高危型人乳头瘤病毒(HPV)E6的PDZ结合基序(PBM)在宫颈癌的发生、发展中起重要作用。HPV16 E6通过其PBM区与Na+/H+交换器调节因子1(NHERF1)相互作用,并诱导NHERF1降解。NHERF1通过下调辅肌动蛋白α4(ACTN4)的表达来延缓细胞骨架的组装,从而抑制宫颈癌细胞在细胞和小鼠模型中的迁移和侵袭。HPV16 E6通过下调NHERF1的表达,提高了ACTN4水平,促进了肌动蛋白聚合,增强了宫颈癌细胞的迁移和侵袭能力。宫颈癌标本的基因集富集分析还表明,HPV16 E6与肌动蛋白细胞骨架组装显著相关,而HPV18 E6没有发现此种关联。HPV16 E6下调NHERF1基因促进细胞骨架组装和细胞侵袭,是宫颈癌发生发展的重要原因。 | Wang Q Song R Zhao C 高雯(编译) | 2020 | 中华预防医学杂志2020，54，1： | 2 |
| 5 | Two-echelon supply chain games in a fuzzy environment显示文摘 | Zhou C Zhao R Tang W | 2008 | Computers & Industrial Engineering2008，55，： | 1 |
| 6 | Allelopathic interactions between the macroalga Ulva pertusa and eight microalgal species 显示文摘 | Nan C R Zhang H Z Zhao G Q | 2004 | Journal of Sea Research2004，52，4： | 1 |
| 7 | Long-term evaluation of adsorption capacity in a biological activated carbon fluidized bed reactor system 显示文摘 | Zhao X Hickey R F Voice T C | 1999 | Water Research1999，33，： | 1 |
| 8 | The relaxin gene-knockout mouse: a model of progressive fibrosis 显示文摘 | SAMUEL C S ZHAO C BATHGATE R A | 2005 | Ann N Y Acad Sci2005，1041，1： | 1 |
| 9 | Production of Zn powder by alkaline treatment of smithsonite Zn-Pb ores显示文摘 | ZHAO Y C STANFORTH R | 2000 | Hydrometallurgy2000，56，： | 1 |
| 10 | Sorption and cosorption of organic contaminant on surfactant modified soils 显示文摘 | Gao B Wang X R Zhao J C | 2001 | Chemosphere2001，43，8： | 1 |
| 11 | Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues 显示文摘 | Wang R Xu C Zhao W | 2003 | Eur J Biochem2003，270，12： | 1 |
| 12 | Investigation on coal pyrolysis in CO2 atmosphere显示文摘 | DUAN L B ZHAO C S ZHOU W QU C R CHEN X P | 2009 | Energy Fuels2009，23，7： | 1 |
| 13 | Simultaneous strain and temperature measurement using a highly birefringence fi- ber loop mirror and a long-period grating written in a photonic crystal fiber显示文摘 | Zhao C L Zhao J R Jin W | 2009 | Optics Communication2009，282，： | 1 |
| 14 | Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia 显示文摘 | Chao MP Alizadeh AA Tang C Jan M Weissman-Tsukamoto R Zhao F | 2011 | Cancer Res2011，71，4： | 1 |
| 15 | Separation of fenoxaprop-p-ethyl biodegradation products by HPTLC显示文摘 | Song L Y Zhao Y C Hua R M | 2005 | J Planar Chromatogr2005，18，： | 1 |
| 16 | Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis显示文摘 | SAMUEL C S ZHAO C BATHGATE R A | 2003 | FASEB J2003，17，1： | 1 |
| 17 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 18 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 19 | Influence of modified soils on the removal of diesel fuel oil from water and the growth of oil degradation micro-organism显示文摘 | GAO B YANG L Y WANG X R ZHAO J C SHENG G Y | 2000 | Chemosphere2000，41，3： | 1 |
| 20 | Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1 显示文摘 | Zhao C Yu DH Shen R | 1999 | J Biol Chem1999，274，19： | 1 |
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