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| 1 | Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction显示文摘证据建议 exosomes 能转移在房间之间的基因材料。然而,他们在肝炎 B 的角色病毒(HBV ) 感染遗体不清楚。这里,我们报导在长期的肝炎 B (CHB ) 病人的 sera 在场的 exosomes 包含了两 HBV nucleic 酸和 HBV 蛋白质,并且以一种活跃方式把 HBV 转移了到 hepatocytes。尤其是, HBV nucleic 酸在生来的杀手(NK ) 被检测从在到 HBV 积极的 exosomes 的暴露以后的 CHB 病人和健康施主的房间。通过即时荧光显微镜学和流动 cytometry, 1,1-dioctadecyl-3,3,3,3, -tetramethylindodicarbocyanine, 4-chlorobenzenesulfnate 盐() 标记的 exosomes 被观察与 NK 房间交往并且被 NK 房间收起,它被转变生长因素提高 -- 治疗。而且, HBV 积极的 exosomes 损害了 NK 房间功能,包括干扰素(IFN )- 生产, cytolytic 活动, NK 房间增长和幸存,以及房间到的应答 poly (我: C ) 刺激。HBV 感染压制了模式识别受体的表示,特别 retinoic 酸可诱导的基因我(RIG-I ) 在 NK 房间上,导致原子因素 B (NF-B ) 和 p38 阻抑激活 mitogen 的蛋白质 kinase 小径。我们的结果在 CHB 感染期间在 HBV 传播和 NK 房间机能障碍加亮 exosomes 的一个以前未得到欣赏的角色。 | Yinli Yang Qiuju Han Zhaohua Hou Cai Zhang Zhigang Tian Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，5： | 47 |
| 2 | The mechanism of barrier river reaches in the middle and lower Yangtze River显示文摘在它人工地或自然地被扰乱以后,冲积隧道总是以沉积运输的平衡国家调整了自己。怎么维持沉积运输的平衡国家并且使河政体稳定总是是河的 geomorphologists 的担心。在长江的中间、更低的活动范围的隧道被区分的河和单个线的河的蹒跚的分发描绘。河政体的变化比在单个线的河里在区分的河里猛烈地是更多。区分的河里的河政体的调整是否能通过单个线的河并且宣传到下游的活动范围,影响全面的河政体的稳定性。研究证明障碍河活动范围能阻止宣传到下游的活动范围接近在上游的隧道调整;因此,它在稳定河政体起一个关键作用。这研究在长江的中间、更低的活动范围调查 34 个单个线的河活动范围。根据长江的中间、更低的活动范围的河的进程的系统的摘要,障碍河活动范围的控制因素被总结并且提取:平面形态学单个线、蜿蜒地流;没有流动偏斜,节点在河活动范围的上面或中间的部分散布了;水力的几何系数是不到 4;纵的坡度比 12 大,凹面河岸的泥土内容比 9.5% 大,并且床沉积的中部的直径比 0.158 公里大。从海军司烧方程,流动的弯曲半径的计算公式动态轴被推出,然后这些的角色在限制流动的迁居上控制因素动态轴和障碍河活动范围的形成被分析。当时,障碍河活动范围被看作这到隧道边界的限制力量的动态轴是的流动的迁居力量的比率不到 1 在不同流动层次下面。障碍河活动范围的机制是以便甚至当在上游的河政体调整时,这个活动范围的隧道边界能总是抑制流动的移植振幅动态轴并且在不同的在上游的河政体条件下面集中主要的流线的平面位置,提供相对稳定的到来的流动为下游的活动范围调节,从而阻止宣传到下游的活动范围接近在上游的河政体调整。 | YOU Xingying TANG Jinwu ZHANG Xiaofeng HOU Weiguo YANG Yunping SUN Zhaohua WENG Zhaohui | 2017 | Journal of Geographical Sciences2017，27，10： | 9 |
| 3 | miR-146a negatively regulates NK cell functions via STAT1 signaling显示文摘It is known that natural killer(NK)cell function is downregulated in chronic hepatitis B(CHB)-infected patients and in hepatic carcinoma(HCC)patients,but the mechanisms underlying this functional downregulation are largely unclear.In this study,microRNA(miR)-146a expression increased in NK cells from CHB and HCC patients compared with NK cells from healthy donors,and miR-146a levels were negatively correlated to NK cell functions.Overexpression of miR-146a reduced NK cell-mediated cytotoxicity and the production of interferon(IFN)-γand tumor necrosis factor-α,which were reversed upon inhibition of miR-146a.In NK cells,miR-146a expression was induced by interleukin(IL)-10 and transforming growth factor-β,but reduced after treatment with interleukin-12,IFN-αand IFN-β.We further revealed that miR-146a regulated NK cell functions by targeting STAT1.Taken together,upregulated miR-146a expression,at least partially,attributes to NK cell dysfunction in CHB and HCC patients.Therefore,miR-146a may become a therapeutic target with great potential to ameliorate NK cell functions in liver disease. | Dongqing Xu Qiuju Han Zhaohua Hou Cai Zhang Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，8： | 7 |
| 4 | Spatial pattern of modern sedimentation rate of Qinghai Lake and a preliminary estimate of the sediment flux显示文摘We investigated the spatiotemporal distribution of1 37Cs radioactivity in surface sediment of Qinghai Lake,and developed the spatial pattern of sedimentation rate.The1 37Cs inventory is higher near the estuary/bank area,but lower at the central lake.On the other hand,the average1 37Cs activity is lower near the estuary/bank area,but higher at the central lake.The mass accumulation rate(MAR) and the fluxes and contents of the terrestrial detritus(e.g.SiO2,Fe2O3,and Ti) are higher near the estuary/bank area,but lower at the central lake.The chemical/biogenic deposits(e.g.the autogenic carbonates) take up higher fractions at the central lake.These suggest that the spatial pattern of recent sedimentation rate is dominated by the deposition of terrestrial detritus.The average MAR(0.0337 g cm-2a-1) was estimated based on those of different cores of Qinghai Lake and was verified by a Ca mass-balance method.The fluxes of total lake sediments,terrestrial detritus,and direct atmospheric deposits were also estimated. | XU Hai LIU XiaoYan AN ZhiSheng HOU ZhaoHua DONG JiBao LIU Bin | 2010 | Chinese Science Bulletin2010，55，7： | 6 |
| 5 | Major ion chemistry of waters in Lake Qinghai catchments,NE Qinghai-Tibet plateau,China 显示文摘 | Hai Xu Zhaohua Hou Zhisheng An | 2010 | Quaternary International2010，212，： | 1 |
| 6 | Metallogeny by Trans-magmatic Fluids—Theoretical Analysis and Field Evidence显示文摘 | Zhaohua LUO Xuanxue MO Xinxiang LU Bihe CHEN Shan KE Zengqian HOU Wan JIANG | 2007 | Earth Science Frontiers2007，，3： | 1 |
| 7 | Identification of anthocyanins isolated from black rice ( Oryza sativa L.) and their degradation kinetics显示文摘 | Zhaohua Hou Peiyou Qin Yan Zhang Songhuan Cui Guixing Ren | 2011 | Food Research International2011，，： | 1 |
| 8 | All phase FFT spectrum analysis 显示文摘 | Wang Zhaohua Hou Zhengxin Su Fei | 2003 | Journal of China Institute of Com- munications2003，24，11： | 1 |
| 9 | Major ion chemistry of waters in Lake Qinghai catchments, NE Qinghai-Tibet plateau, China显示文摘 | Hai Xu Zhaohua Hou Zhisheng An Xiaoyan Liu Jibao Dong | 2008 | Quaternary International2008，，1： | 1 |
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