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| 1 | Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction显示文摘证据建议 exosomes 能转移在房间之间的基因材料。然而,他们在肝炎 B 的角色病毒(HBV ) 感染遗体不清楚。这里,我们报导在长期的肝炎 B (CHB ) 病人的 sera 在场的 exosomes 包含了两 HBV nucleic 酸和 HBV 蛋白质,并且以一种活跃方式把 HBV 转移了到 hepatocytes。尤其是, HBV nucleic 酸在生来的杀手(NK ) 被检测从在到 HBV 积极的 exosomes 的暴露以后的 CHB 病人和健康施主的房间。通过即时荧光显微镜学和流动 cytometry, 1,1-dioctadecyl-3,3,3,3, -tetramethylindodicarbocyanine, 4-chlorobenzenesulfnate 盐() 标记的 exosomes 被观察与 NK 房间交往并且被 NK 房间收起,它被转变生长因素提高 -- 治疗。而且, HBV 积极的 exosomes 损害了 NK 房间功能,包括干扰素(IFN )- 生产, cytolytic 活动, NK 房间增长和幸存,以及房间到的应答 poly (我: C ) 刺激。HBV 感染压制了模式识别受体的表示,特别 retinoic 酸可诱导的基因我(RIG-I ) 在 NK 房间上,导致原子因素 B (NF-B ) 和 p38 阻抑激活 mitogen 的蛋白质 kinase 小径。我们的结果在 CHB 感染期间在 HBV 传播和 NK 房间机能障碍加亮 exosomes 的一个以前未得到欣赏的角色。 | Yinli Yang Qiuju Han Zhaohua Hou Cai Zhang Zhigang Tian Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，5： | 47 |
| 2 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 3 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 4 | miR-146a negatively regulates NK cell functions via STAT1 signaling显示文摘It is known that natural killer(NK)cell function is downregulated in chronic hepatitis B(CHB)-infected patients and in hepatic carcinoma(HCC)patients,but the mechanisms underlying this functional downregulation are largely unclear.In this study,microRNA(miR)-146a expression increased in NK cells from CHB and HCC patients compared with NK cells from healthy donors,and miR-146a levels were negatively correlated to NK cell functions.Overexpression of miR-146a reduced NK cell-mediated cytotoxicity and the production of interferon(IFN)-γand tumor necrosis factor-α,which were reversed upon inhibition of miR-146a.In NK cells,miR-146a expression was induced by interleukin(IL)-10 and transforming growth factor-β,but reduced after treatment with interleukin-12,IFN-αand IFN-β.We further revealed that miR-146a regulated NK cell functions by targeting STAT1.Taken together,upregulated miR-146a expression,at least partially,attributes to NK cell dysfunction in CHB and HCC patients.Therefore,miR-146a may become a therapeutic target with great potential to ameliorate NK cell functions in liver disease. | Dongqing Xu Qiuju Han Zhaohua Hou Cai Zhang Jian Zhang | 2017 | Cellular & Molecular Immunology2017，14，8： | 7 |
| 5 | hELP3 Subunit of the Elongator Complex Regulates the Transcription of HSP70 Gene in Human Cells显示文摘人的 Elongator 建筑群显著地类似于它在几个方面的酵母对应物。在以前的研究,我们分析了人的延伸蛋白质的功能 3 (hELP3 ) 由使用的人的 Elongator 的子单元一在里面 vivo 酵母 complementationsystem.However,为在在人的房间调整基因表达的 hELP3 功能的直接证据没被获得。在这研究,我们使用了 hELP3 反感觉寡核苷酸禁止者将 hELP3gene 表示击倒在人的 293T 房间调查它的函数。结果证明 hELP3 mRNA 和蛋白质的那特定的减小引起了 HSP70-2 基因表达的重要抑制,并且这被伴随由嘘一 H3 hypoacetylation 和减少的 RNA 聚合酶 II 在 theHSP70-2 的密度基因。而且,数据也证明 hELP3 施加了 transcriptional 规章在 HSP70-2 基因上通过它的存在直接工作。在这份报告介绍的数据在人的房间在 HSP70-2 基因 transcriptionalelongation 提供进一步的卓见和 hELP3 的函数的直接证据。 | Qiuju HAN Xiaozhe HOU Dongmei SU Lina PAN Jizhou DUAN Liguo CUI Baiqu HUANG Jun LU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，6： | 3 |
| 6 | Comparative study of mutation spectrums ofMT-RNR1m.1555A〉G, GJB2, and SLC26A4 between familial and sporadic patients with nonsyndromic sensorineural hearing loss in Chinese Han显示文摘 | Li Qian Ji Yubin Han Bing Zong Liang Lan Lan Zhao Yali Wang Hongyang Wang Dayong Wang Qiuju | 2014 | Chinese Medical Journal2014，，18： | 3 |
| 7 | Tuning the luminous properties and optical thermometry of Cs_(2)SnCl_(6) phosphor microcrystals via Bi and Sb codoping显示文摘The toxicity and instability of lead halide perovskite seriously limit its commercial application in lighting,although it has high photoluminescence(PL)efficiency and adjustable emission.Here,lead-free bismuth(Bi)and antimony(Sb)codoped Cs_(2)SnCl_(6)(BSCSC)microcrystals(MCs)are prepared successfully by a solvothermal method.The PL spectrum is composed of dual emission bands with the peak at 485 and 650 nm,of which relative intensity can be tunable through the change of Bi and Sb feeding contents,respectively.Because of the phonon–electron interaction,the PL intensity is enhanced as the temperature rises within the range of 80–260 K.Then,the nonradiative transition is intensified until 380 K,which results in decrease in PL intensity.Simultaneously,combining with time-resolved PL,it is concluded that the emission peak at 485 nm is attributed to the[Bi_(Sn)+V_(Cl)]as the luminescent centers with the lifetime of hundreds of nanoseconds,and the emission peak at 650 nm is attributed to microsecond-timescale self-trapped excitons.The maximum values of relative sensitivity(S_(R))and absolute sensitivity(S_(A))values obtained are 3.82%K^(-1) and 5.11 ns·K^(-1),which for the first time to our knowledge demonstrate that BSCSC MCs can be novel luminescent materials for developing better optical thermometry.Whitelight-emitting diodes(WLEDs)are constructed using BSCSC MCs only combined with an LED chip,the Commission Internationale de L’Eclairage color coordinates of which are(0.30,0.37).It provides a novel scheme for the lighting field to realize WLEDs without adding additional commercial phosphors. | SHUNFA GONG RUIRUI WU SEN YANG LIFANG WU MINMIN ZHANG QIUJU HAN WENZHI WU | 2021 | Photonics Research2021，9，11： | 2 |
| 8 | Magnetic solid base catalyst CaO/CoFe,04 for biodiesel production: Influence of basicity and wettability of the catalyst in cata?lytic performance显示文摘 | Zhang Pingbo Han Qiuju Fan Mingrning | 2014 | Applied Surface Science2014，317，： | 1 |
| 9 | Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease显示文摘Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness. | LI Yanwei LU Yunrui NIAN Mozuo SHENG Qiuju ZHANG Chong HAN Chao DOU Xiaoguang DING Yang | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 1 |
| 10 | Magnetic solid base catalyst CaO/CoFe204 for biodiesel production:Influence of basici- ty and wettability of the catalyst in catalytic performance显示文摘 | Zhang Pingbo Han Qiuju Fan Mingming | 2014 | Appl Surf Sci o2014，317，： | 1 |
| 11 | A novel waste water scale-derived solid base catalyst for biodiesel production显示文摘 | Zhang Pingbo Han Qiuju Fan Mingrning | 2014 | Fuel2014，124，： | 1 |
| 12 | Process Evaluation, Tensile Properties and Fatigue Resistance of Chopped and Continuous Fiber Reinforced Thermoplastic Composites by 3D Printing显示文摘The aim of this article was to comprehensively evaluate the manufacturing process,tensile properties and fatigue resistance of the chopped and continuous fiber reinforced thermoplastic composites(CFRTPCs)by 3D printing.The main results included:the common defects of the printed CFRTPCs contained redundant and accumulation defects,scratch and warping defects;the continuous fiber contributed to the dimensional stability and accuracy of width and thickness;associations between mass percentage of fiber reinforcement and the averages of elastic mod-ulus,strain at break and ultimate tensile strength were approximately linear based on tensile test results;the fati-gue resistance improved with the increasing fiber reinforcement based on fatigue test results.As for specimens with four fiber rings,there was a good linear relationship between the stress level and logarithm value of cycles during the whole life while those of pure matrix and specimens with one and two fiber rings were piecewise linear,taking about 10,000 cycles as boundary.The micro morphology showed that the fatigue failure behaved as matrix fracture,large and small fiber bundles and single fibers extracted from matrix.Under the tension-tension fatigue load,the deformations where easily concentrating stress behaved as sunken surfaces along thickness and width directions,and the deformation along width direction was greater than that along thickness direction. | Wei Chen Qiuju Zhang Han Cao Ye Yuan | 2022 | Journal of Renewable Materials2022，10，2： | 1 |
| 13 | A novel waste water scale-derived solid base catalyst for biodiesel production显示文摘 | Pingbo Zhang Qiuju Han Mingming Fan Pingping Jiang | 2014 | Fuel2014，，： | 1 |
| 14 | HBeAg-negative Patients with Chronic Hepatitis B Virus Infection and Normal Alanine Aminotransferase:Wait or Treat?显示文摘Alanine aminotransferase(ALT)is a common clinical indicator of liver inflammation.The current Chinese guidelines for the management of chronic hepatitis B(CHB)recommend antiviral treatment for patients with detectable hepatitis B virus(HBV)DNA and persistent ALT levels(ALTs)exceeding the upper limit of normal.However,it has been recently reported that patients with chronic HBV infection,especially HBeAg-negative patients with persistently normal ALTs,may have liver biopsy findings of significant inflammation and fibrosis.For HBeAg-negative patients with chronic HBV infection and normal ALTs,many controversial questions have been asked.To treat or not?When to initiate the treatment?Which drug is appropriate?In this review,we summarize the available data on the management of HBeAg-negative patients with chronic HBV infection and normal ALTs with the aim of improving the current clinical management. | Qiuju Sheng Ning Wang Chong Zhang Yaoxin Fan Yanwei Li Chao Han Ziyi Wang Shuqi Wei Xiaoguang Dou Yang Ding | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 15 | Clinical and molecular analysis of a four-generation Chinese family with aminoglycoside-induced and nonsyndromic hearing loss associated with the mitochondrial 12S rRNA C1494T mutation显示文摘 | Qiuju Wang Qing-Zhong Li Dongyi Han Yali Zhao Lidong Zhao Yaping Qian Hu Yuan Ronghua Li Suoqiang Zhai Wie-Yen Young Min-Xin Guan | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
| 16 | Clue to a New Deafness Gene:A Large Chinese Nonsyndromic Hearing Loss Family Linked to DFNA4显示文摘Hereditary hearing loss is one of the most common neurosensory defects in humans.Approximately 70%of cases are nonsyndromic and could be inherited in autosomal dominant, autosomal recessive,mitochondrial,X-linked,and Y-linked manners(Wang et al.,2004;Alford,2011).The autosomal dominant type,comprising 15%-20%of nonsyndromic hearing loss,is monogenic and genetically heterogeneous.Since the first dominant deafness | Liang Zong Chunye Lu Yali Zhao Qian Li Dongyi Han Weiyan Yang Yan Shen Qingyin Zheng Qiuju Wang | 2012 | Journal of Genetics and Genomics2012，39，12： | 0 |
| 17 | Ladder-Type Thienoacenaphthopyrazine-Based Molecules:Synthesis,Properties,and Application to Construct High-Performance Polymer for Organic Solar Cells显示文摘We present a new design strategy to synthesize ladder-type thienoacenaphthopyrazine(TAP)-based monomers through two different coupling reactions from starting material 5,6-dibromoacenaphthylene-1,2-dione.By bringing varous electron-deficient groups together(such as five-membered aromatic rings,pyrazine,fluorine,and thiadiazols),this new family of molecules exhibits good stability in ambient conditions and easily tunes the electronic,photophysical and film-forming properties of polymers.The unique molecular shape with its extendedπ-conjugated backbone perpendicular to the polymer chain,offers a remarkable platform for the development of a semiconducting polymer with rare geometry.The planar and enlarged conjugated backbone enables TAP-based copolymers PTAP1 and PTAP2 to exhibit distinguishing solubility properties that are different from small-molecule-based polymers,indicating the advantages of novel ladder-type monomers.Their insolubility in chloroform supports orthogonal solvent processing to fabricate layer-by-layer organic solar cells(LBL-OSCs).Owing to its shorterπ–πstacking distance,higher hole mobility,and more favorable phase separation caused bymultifluorine substitution,polymer PTAP1-based LBL-OSC exhibits the highest efficiency of 17.14%by using Y6-BO as the electron acceptor while the efficiency for the PTAP2-based device is 14.20%.This high efficiency indicates the tremendous potential of these novel building units. | Pengwei Han Man Lin Qiuju Jiang Haijun Ning Mingbin Su Li Dang Feng He Qinghe Wu | 2023 | CCS Chemistry2023，5，6： | 0 |
| 18 | Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction显示文摘Chronic hepatitis B(CHB)infection remains a serious public health problem worldwide;however,the relationship between cholesterol levels and CHB remains unclear.We isolated peripheral blood mononuclear cells from healthy blood donors and CHB patients to analyze free cholesterol levels,lipid raft formation,and cholesterol metabolism-related pathways.Hepatitis B virus(HBV)-carrier mice were generated and used to confirm changes in cholesterol metabolism and cell-surface lipid raft formation in dendritic cells(DCs)in the context of CHB.Additionally,HBV-carrier mice were immunized with a recombinant HBV vaccine(rHBVvac)combined with lipophilic statins and evaluated for vaccine efficacy against HBV.Serum samples were analyzed for HBsAg,anti-HBs,and alanine aminotransferase levels,and liver samples were evaluated for HBV DNA and RNA and HBcAg.CHB reduced free cholesterol levels and suppressed lipid raft formation on DCs in patients with CHB and HBV-carrier mice,whereas administration of lipophilic statins promoted free cholesterol accumulation and restored lipid rafts on DCs accompanied by an enhanced antigen-presentation ability in vitro and in vivo.Cholesterol accumulation on DCs improved the rHBVvac-mediated elimination of serum HBV DNA and intrahepatic HBV DNA,HBV RNA,and HBcAg and promoted the rHBVvac-mediated generation and polyfunctionality of HBV-specific CD11a^(hi) CD8α^(lo) cells,induction of the development of memory responses against HBV reinfection,and seroconversion from HBsAg to anti-HBs.The results demonstrated the important role of cholesterol levels in DC dysfunction during CHB,suggesting that strategies to increase cholesterol accumulation on DCs might enhance therapeutic vaccine efficacy against HBV and support development toward clinical CHB treatment. | Huajun Zhao Yating Yu Yucan Wang Lianhui Zhao Ailu Yang Yifei Hu Zhaoyi Pan Zixuan Wang Jiarui Yang Qiuju Han Zhigang Tian Jian Zhang | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
| 19 | Validation Study of LPDDR2 SDRAM Based on TD-LTE Baseband chip显示文摘In recent years,as China has finished the updating of the fourth generation of network,for guaranteeing the information security of the state,communication chip with complete independent intellectual property right must be possessed to support the advancement of such project.TD-LTE Baseband Chip is a super-large-scale integrated circuit designed basing on SOC,which needs to carry out coding,etc to the transmitted baseband signal,or carry out decoding,etc to the received baseband signal.LPDDR2 SDRAM is used in the chip design process due to its low power dissipation,high capacity and high reliability.As PHY in the controller architecture of LPDDR2 SDRAM adopts hard core design,it cannot be achieved in Virtex-7 2000T prototype verification platform.This design mainly builds on such prototype verification platform to propose the verification scheme of LPDDR2 SDRAM controller in TD_LTE baseband chip,so as to guarantee that prototype verification in FPGA can be carried out by TD_LTE baseband system,and meanwhile high capacity storage space can be provided to the system. | Wang ChengZhi Wang QiuJu Han Juan | 2014 | 无线互联科技2014，11，10： | 0 |
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