| 1 | Role of MR-DWI and MR-PWI in the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbits显示文摘Objective: To detect the activity of tumor cells and tumor blood flow before and after the radiotherapy of implanted pulmonary VX-2 carcinoma in rabbit models by using magnetic resonance diffusion-weighted imaging(MR-DWI) and magnetic resonance perfusion weighted imaging(MR-PWI), and to evaluate the effectiveness and safety of the radiotherapy based on the changes in the MR-DWI and MR-PWI parameters at different treatment stages.Methods: A total of 56 rabbit models with implanted pulmonary VX-2 carcinoma were established, and then equally divided into treatment group and control group. MR-DWI and MR-PWI were separately performed using a Philips Acheiva 1.5T MRI machine(Philips, Netherland). MRI image processing was performed using special perfusion software and the WORKSPACE advanced workstation for MRI. MRDWI was applied for the observation of tumor signals and the measurement of apparent diffusion coefficient(ADC) values; whereas MR-PWI was used for the measurement of wash in rate(WIR), wash out rate(WOR), and maximum enhancement rate(MER). The radiation treatment was performed using Siemens PRIMUS linear accelerator. In the treatment group, the radiotherapy was performed 21 days later on a once weekly dosage of 1,000 c Gy to yield a total dosage of 5,000 c Gy.Results: The ADC parameters in the region of interest on DWI were as follows: on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values at the center and the edge of the lesions were 1.352 and 1.461 in the treatment group and control group(P>0.05). During weeks 0-1 after treatment, the t values at the center and the edge of the lesions were 1.336 and 1.137(P>0.05). During weeks 1-2, the t values were 1.731 and 1.736(P<0.05). During weeks 2-3, the t values were 1.742 and 1.749(P<0.05). During weeks 3-4, the t values were 2.050 and 2.127(P<0.05). During weeks 4-5, the t values were 2.764 and 2.985(P<0.05). The ADC values in the treatment group were significantly higher than in the control group. After the radiotherapy(5,000 c Gy), the tumors remarkably shrank, along with low signal on DWI, decreased signal on ADC map, and remarkably increased ADC values. As shown on PWI, on the treatment day for the implanted pulmonary VX-2 carcinoma, the t values of the WIR, WOR, and MER at the center of the lesions were 1.05, 1.31, and 1.33 in the treatment group and control group(P>0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.35, 1.07, and 1.51(P>0.05). During weeks 0-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 1.821, 1.856, and 1.931(P<0.05); in addition, the t values of the WIR, WOR, and MER at the edge of the lesions were 1.799, 2.016, and 2.137(P<0.05). During weeks 1-1 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.574, 2.156, and 2.059(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 1.869, 2.058, and 2.057(P<0.05). During weeks 2-3 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.461, 2.098, and 2.739(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.951, 2.625, and 2.154(P<0.05). During weeks 3-4 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.584, 2.107, and 2.869(P<0.05) and the t values of the WIR, WOR, and MER at the edge of the lesions were 2.057, 2.637, and 2.951(P<0.05). During weeks 4-5 after treatment, the t values of the WIR, WOR, and MER at the center of the lesions were 2.894, 2.827, and 3.285(P<0.05) and the t values of the WIR, WOR, andMER at the edge of the lesions were 3.45, 3.246, and 3.614(P<0.05). After the radiotherapy(500 c Gy), the tumors shrank on the T1 WI, WIR, WOR, and MER; meanwhile, the PWI parameter gradually decreased and reached its minimum value.Conclusions: MR-DWI and MR-PWI can accurately and directly reflect the inactivation of tumor cells and the tumor hemodynamics in rabbit models with implanted pulmonary VX-2 carcinoma, and thus provide theoretical evidences for judging the clinical effectiveness of radiotherapy for the squamous cell carcinoma of the lung. | Qiang Zhang Mingmin Zhang Zhaoxin Liu Baoqi Shi Fuliang Qi Haijiang Wang Yuan Lv Haijiao Jin Weijing Zhang | 2014 | Chinese Journal of Cancer Research2014，26，5： | 5 |
| 2 | Dynamic Airy imaging through high_efficiency broadband phase microelements by femtosecond laser direct writing显示文摘Manipulating Airy beams to symmetric Airy beams(SABs)with abruptly autofocusing and self accelerating properties has attracted much attention.With such a particular propagation dynamic,SABs may provide great potential in dynamic signal imaging.On the other hand,the generation of SABs by spatial light modulators suffers from the limitations of phase gradient accuracy,low optical efficiency(<40%),and a bulky footprint.Therefore,exploring imaging applications and optimal generation methods of these Airy-type beams deserves further research.Here,based on the coordinate transformation of SAB,an asymmetric Airy beam(AAB)is realized.Symmetric/asymmetric cubic phase microplates(SCPPs/ACPPs)are designed and fabricated for generating SAB/AAB.The SCPP/ACPP demonstrates superior performance:compact construction(60μm × 60μm × 1.1μm),continuous variation of phase,high efficiency(~81%at 532 nm),and broadband operation from 405 to 780 nm.Dynamic imaging under monochromatic and polychromatic lights is realized by the SAB/AAB,indicating various results at different propagation distances with a certain initial signal.Further investigation reveals that the SCPP on a soft substrate maintains its physical dimensions and optical properties unchanged during stretching.Our work enables wide potential applications in integrated optics,beam manipulation,and imaging. | ZE CAI XINBO QI DENG PAN SHENGYUN JI JINCHENG NI ZHAOXIN LAO CHEN XIN JIAWEN LI YANLEI HU DONG Wu JIARU CHI | 2020 | Photonics Research2020，8，6： | 3 |
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