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您的检索式：作者名="Zheling Chen"
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| 1 | Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment显示文摘Mechanical forces in the tumor microenvironment(TME)are associated with tumor growth,proliferation,and drug resistance.Strong mechanical forces in tumors alter the metabolism and behavior of cancer cells,thus promoting tumor progression and metastasis.Mechanical signals are transformed into biochemical signals,which activate tumorigenic signaling pathways through mechanical transduction.Cancer immunotherapy has recently made exciting progress,ushering in a new era of“chemo-free”treatments.However,immunotherapy has not achieved satisfactory results in a variety of tumors,because of the complex tumor microenvironment.Herein,we discuss the effects of mechanical forces on the tumor immune microenvironment and highlight emerging therapeutic strategies for targeting mechanical forces in immunotherapy. | Pengfei Zhu Hongrui Lu Mingxing Wang Ke Chen Zheling Chen Liu Yang | 2023 | Cancer Biology & Medicine2023，20，1： | 1 |
| 2 | One-step ethylene separation from ternary C_(2) hydrocarbon mixture with a robust zirconium metal-organic framework显示文摘One-step separation of high-purity ethylene(C_(2)H_(4))from C_(2) hydrocarbon mixture is critical but challenging because of the very similar molecular sizes and physical properties of C_(2)H_(4),ethane(C_(2)H_(6)),and acetylene(C_(2)H_(2)).Herein,we report a robust zirconium metal-organic framework(MOF)Zr-TCA(H3TCA=4,4',4'-tricarboxytriphenylamine)with suitable pore size(0.6 nm×0.7 nm)and pore environment for direct C_(2)H_(4) purification from C_(2)H_(4)/C_(2)H_(2)/C_(2)H_(6) gas-mixture.Computational studies indicate that the abundant oxygen atoms and non-polar phenyl rings created favorable pore environments for the preferential binding of C_(2)H_(2) and C_(2)H_(6) over C_(2)H_(4).As a result,Zr-TCA exhibits not only high C_(2)H_(6)(2.28 mmol·g^(-1))and C_(2)H_(2)(2.78 mmol·g^(-1))adsorption capacity but also excellent C_(2)H_(6)/C_(2)H_(4)(2.72)and C_(2)H_(2)/C_(2)H_(4)(5.64)selectivity,surpassing most of one-step C_(2)H_(4) purification MOF materials.Dynamic breakthrough experiments confirm that Zr-TCA can produce high-purity C_(2)H_(4)(>99.9%)from a ternary gas mixture(1/9/90 C_(2)H_(2)/C_(2)H_(6)/C_(2)H_(4))in a single step with a high C_(2)H_(4) productivity of 5.61 L·kg^(-1). | Yuan Liu Hanting Xiong Jingwen Chen Shixia Chen Zhenyu Zhou Zheling Zeng Shuguang Deng Jun Wang | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
| 3 | Low-coordinated Ni-N_(1)-C_(3)sites atomically dispersed on hollow carbon nanotubes for efficient CO_(2)reduction显示文摘Low-coordinated single atom catalysts compared to M-N4 are appealing in optimized electronic structure for CO_(2)electroreduction,but the preparation is still very challenging.Herein,a novel single Ni atom catalyst with Ni-N_(1)-C_(3)configuration is in-situ evolved on curved carbon nanotubes.The obtained Ni-N_(1)-C_(3)catalyst exhibits a superior CO Faradaic efficiency of 97%and turnover frequency of 2,890 h^(−1)at−0.9 V versus the reversible hydrogen electrode,as well as long-term stability over 45 h.High current densities exceeding 200 mA·cm^(−2)and CO Faradaic efficiency of 99%are achieved in flow-cell.Moreover,in-situ potentialand time-dependent Raman spectra identify the key intermediates of*COOH and*CO during CO_(2)-to-CO conversion.Theoretical calculations reveal that the upward-shifted d-band center and charge-rich Ni sites of Ni-N_(1)-C_(3)facilitate the electron transfer to*COOH and thus reduce the*COOH formation energy barrier.This work demonstrates a strategy for modulating the coordination environment for efficient CO_(2)reduction. | Fangqi Yang Haoming Yu Yun Su Jingwen Chen Shixia Chen Zheling Zeng Shuguang Deng Jun Wang | 2023 | Nano Research2023，16，1： | 0 |
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