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| 1 | Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice显示文摘BackgroundHyperhomocysteine 是冠的心疾病(CHD ) 的一个独立风险因素。然而, hyperhomocysteine 是否影响动脉粥样硬化的前进,是不清楚的。在现在的学习,我们在低密度的脂蛋白在动脉粥样硬化的形成上检验了 hyperhomocysteine 的效果受体缺乏(LDLr −/−) mice.MethodsForty -- 八只 7-week-old LDLr −/− 老鼠被分到下列组:老鼠喂了一本标准啮齿类动物食谱(控制组) ,老鼠喂了一本高蛋氨酸的食谱(高蛋氨酸的组) ,老鼠喂了一本高脂肪的食谱(高脂肪的组) ,并且老鼠在蛋氨酸和脂肪(高蛋氨酸、高脂肪的组) 高喂了一本食谱。在 19, 23,和 27 个星期岁时,在在每个组的每间隔的四个鼠标是 sacrificed.ResultsAt 学习的结束,鼠标没在大动脉的湾穴和大动脉的表面显示出动脉粥样硬化患者损害直到在控制组旧的 27 个星期。然而,动脉粥样硬化患者损害在 19 个星期在另外的三个组发展了。大动脉的表面上的动脉粥样硬化患者损害的数量比在高脂肪的组在高蛋氨酸的组是更低的(P <0.001 ) 。在高蛋氨酸、高脂肪的组的大动脉的表面上的动脉粥样硬化患者损害是最严重的。在大动脉的湾穴的动脉粥样硬化患者损害的吝啬的区域比在高脂肪的组在高蛋氨酸的组与大动脉的表面上的动脉粥样硬化患者损害相比是更低的(P <0.001 ) 。在在高蛋氨酸、高脂肪的组的大动脉的湾穴的动脉粥样硬化患者损害是大多数 severe.ConclusionsHomocysteinemia 加速动脉粥样硬化患者损害并且在 LDLr −/− 老鼠独立地导致早动脉粥样硬化。减少 homocysteinemia 的水平可能为 CHD 的预防和处理是有益的。 | Hang-Yuan GUO Fu-Kang XU Hai-Tao LV Long-Bin LIU Zheng JI Xiao-Ya ZHAI Wei-Liang TANG Ju-Fang CH | 2014 | Journal of Geriatric Cardiology2014，11，1： | 23 |
| 2 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 3 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 4 | Effect of Qinling granule in treatment of 102 patients with chronic hepatitis B显示文摘EfectofQinlinggranuleintreatmentof102patientswithchronichepatitisBHUANGZhengMing1,YANGXinBo1,CAOWenBin1,ZHOUYiJun2andLULi... | HUANG Zheng Ming 1, YANG Xin Bo 1, CAO Wen Bin 1, ZHOU Yi Jun 2 and LU Li Yan 2 1Department of Pharmacology, Chinese PLA Beijing Medical School, Beijing 100071, China 2Chinese PLA 184 Hospital, Yingtan 350000, Jiangxi Province, Ch | 1998 | World Journal of Gastroenterology1998，4，1： | 7 |
| 5 | Real-time imaging of trapping and ureasedependent transmigration of Cryptococcus neoformans in mouse brain显示文摘 | Shi M Li SS Zheng C Jones GJ Kim KS Zhou H Kubes P Mody CH | 2010 | J Clin Invest2010，120，5： | 1 |
| 6 | Effects of non-cytotoxic drugs on the growth of multidrug-resistance human gastric carcinomacellline显示文摘 | Wang CH Zheng WB Qiang O | 2009 | JDigDis2009，10，2： | 1 |
| 7 | Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis显示文摘 | Yi CH Zheng T Leaderer D | | 0，，02： | 1 |
| 8 | Efect of a lipidic extract from Lepidium meyenii on sexual behaviorin mice and rats显示文摘 | He K Kim CH | 2000 | Urology2000，55，4： | 1 |
| 9 | A protein delivery system : biodegradable atginate-chitosan-poly ( lactic-co-glycolic acid) composite microspheres 显示文摘 | ZHENG CH GAO JQ ZHANG YP | 2004 | Biochem Biophys Res Commun2004，323，4： | 1 |
| 10 | Evaluation of the prognostic value and functional roles of CD44v6 in gastric cancer 显示文摘 | Xie JW Chen PC Zheng CH | 2015 | J Cancer Res Clin 0ncol2015，141，10： | 1 |
| 11 | Effects of additives and processing parameters on the initial burst release of protein from poly ( lactic-co-glycolic acid ) microspheres 显示文摘 | ZHENG CH GAO JQ LIANG WQ | 2006 | PDA J PharmSciTechnol2006，60，1： | 1 |
| 12 | Inhibitory effect of epigallocatechin 3 - O- gallate on vascular smooth muscle cellhypertrophy induced by angiotensin Ⅱ 显示文摘 | Zheng Y Song HJ Kim CH | 2004 | J Cardiovasc Pharmacol2004，43，2： | 1 |
| 13 | Implication algebra on a partiarlly ordered set and heyting Mgebra显示文摘 | Li Z W Zheng Ch Y | 2003 | Systems Science and Systems Engineering(Proceedings of ICSSSE'' 03)2003，，： | 1 |
| 14 | Construction of a three-dimensional pharmacophore for Bcl-2 inhibitors by flexible docking and the multiple copy simultaneous search method 显示文摘 | ZHENG CH ZHOU YJ ZHU J | 2007 | Bioorg Med Chem2007，15，19： | 1 |
| 15 | Implication algebra and heyting algebra显示文摘 | Li Z W Zheng Ch Y | 2002 | Internation Congress of Mathe- matics: Abstracts of Short Communications and Poster Sessions2002，，： | 1 |
| 16 | A new cheaper dynamic light scattering particle sizing method u- sing counting hoard显示文摘 | YANG H ZHENG G LI M CH | 2008 | Lasers in Engineering2008，18，34： | 1 |
| 17 | Modeling the environmental behavior and performance of livestock farmers in China:An ABM approach显示文摘 | ZHENG CH LIU Y BLUEMLING B | 2013 | Agricultural Systems2013，122，11： | 1 |
| 18 | Effects of CYP3A5 and CYP2D6 genetic polymorphism on the pharmaeokineties of diltiazem and its metabolites in Chinese subjects 显示文摘 | Zheng T Su CH Zhao J | 2013 | Pharmazie2013，68，4： | 1 |
| 19 | Phase behavior of the microemulsions and the stability of the chloramphenicol in the microemulsion-based ocular drug delivery system显示文摘 | Zheng LQ Tung CH | 2005 | Int J Pharm2005，301，12： | 1 |
| 20 | Regulation of focal adhesion kinase by a novel protein inhibitor FIP200显示文摘 | Smita A Hiroki U Zheng CH | 2002 | Mol Biol Cell2002，13，9： | 1 |
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