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| 1 | Porous nitrogen-doped carbon/MnO coaxial nanotubes as an efficient sulfur host for lithium sulfur batteries显示文摘As a promising candidate for next generation energy storage devices, lithium sulfur (Li-S) batteries still confrant rapid capacity degradation and low rate capability. Herein, we report a well-architected porous nitrogen-doped carbon/MnO coaxial nanotubes (MnO@PNC) as an efficient sulfur host material. The host shows excellent electron conductivity, sufficient ion transport channels and strong adsorption capability for the polysulfides, resulting from the abundant nitrogen-doped sites and pores as well as MnO in the carbon shell of MnO@PNC. The MnO@PNC-S composite electrode with a sulfur content of 75 wt.% deliveries a specific capacity of 802 mAh·g^-1 at a high rate of 5.0C and outstanding cycling stability with a capacity retention of 82% after 520 cycles at 1.0C. | Chao Lin Longbing Qu Jiantao Li Zhengyang Cai Haoyun Liu Pan He Xu Xu Liqiang Mai | 2019 | Nano Research2019，12，1： | 10 |
| 2 | Synthesis of High Pure Ti_3AlC_2 and Ti_2AlC Powders from TiH_2 Powders as Ti Source by Tube Furnace显示文摘Titanium aluminum carbide(Ti3AlC2 and Ti2AlC) powders were synthesized from TiH2 powders instead of Ti powders as Ti source by a tube furnace under argon atmosphere without preliminary dehydrogenation.95 wt% pure Ti3AlC2 powders were synthesized from TiH 2/1.1Al/2TiC at 1 450 ℃ for 120 min.High-purity Ti2AlC powders were also prepared from 3TiH2/1.5Al/C and 2TiH2/1.5Al/TiC powders at 1 400 ℃ for 120 min.The as-synthesized samples were porous and easy to be ground into powders.Sn or Si additives in starting materials increased the purity of synthesized Ti 3 AlC 2 obviously and expanded the temperature range for the synthesis of Ti3AlC2.With Si or Sn as additives,high pure Ti3AlC2 was synthesized at 1 200 ℃ for 60 min from TiH/x Si/Al/2TiC and TiH/x Sn/Al/2TiC(x=0.1,0.2),respectively. | 李良 周爱国 XU Lin LI Zhengyang WANG Libo | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，5： | 3 |
| 3 | Effects of marine sediment on the response of a submerged floating tunnel due to p- wave incidence显示文摘Submerged floating tunnel (SFT) is a novel type traffic structure for crossing long strait and deep lakes. To investigate the dynamic pressure acting on an SFT under compression (P) wave incidence, a theoretical analysis model considering marine sediment effect has been proposed. Based on displacement potential functions, the reflection and refraction coefficients of P wave in different media are derived. Numerical examples are employed to illustrate the effects of the thickness of sediment layer, the incident P wave angle, the tether stiffness and spacing, and the permeability of the sediment on the dynamic pressure loading on the SFT. The results show that dynamic pressure is related to the saturation of sediment and affected by the thickness of sediment. The partially saturated sediment will amplify the dynamic pressure loading on the SFT, and the resonance frequency increases a little with the fully saturated sediment. Besides, increasing the tether stiffness and decreasing in the tether spacing will lead to a dynamic pressure falling. Deepening the SFT position and reducing the permeability of the sediment are effective measures to reduce dynamic pressure acting on the SFT. | Heng Lin Yiqiang Xiang Zhengyang Chen Ying Yang | 2019 | Acta Mechanica Sinica2019，35，4： | 3 |
| 4 | Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs显示文摘A comprehensive understanding of the cellular heterogeneity and molecular mechanisms underlying the development,homeostasis,and disease of human intervertebral disks(IVDs)remains challenging.Here,the transcriptomic landscape of 108108 IVD cells was mapped using single-cell RNA sequencing of three main compartments from young and adult healthy IVDs,including the nucleus pulposus(NP),annulus fibrosus,and cartilage endplate(CEP).The chondrocyte subclusters were classified based on their potential regulatory,homeostatic,and effector functions in extracellular matrix(ECM)homeostasis.Notably,in the NP,a PROCR+resident progenitor population showed enriched colony-forming unit-fibroblast(CFU-F)activity and trilineage differentiation capacity.Finally,intercellular crosstalk based on signaling network analysis uncovered that the PDGF and TGF-βcascades are important cues in the NP microenvironment.In conclusion,a single-cell transcriptomic atlas that resolves spatially regulated cellular heterogeneity together with the critical signaling that underlies homeostasis will help to establish new therapeutic strategies for IVD degeneration in the clinic. | Yibo Gan Jian He Jun Zhu Zhengyang Xu Zhong Wang Jing Yan Ou Hu Zhijie Bai Lin Chen Yangli Xie Min Jin Shuo Huang Bing Liu Peng Liu | 2021 | Bone Research2021，9，3： | 3 |
| 5 | Dissolution-precipitation growth of uniform and clean two dimensional transition metal dichalcogenides显示文摘Two dimensional transition metal dichalcogenides(TMDCs)have attracted much interest and shown promise in many applications.However,it is challenging to obtain uniform TMDCs with clean surfaces,because of the difficulties in controlling the way the reactants are supplied to the reaction in the current chemical vapor deposition growth process.Here,we report a new growth approach called’dissolution-precipitation’(DP)growth,where the metal sources are sealed inside glass substrates to control their feeding to the reaction.Noteworthy,the diffusion of metal source inside glass to its surface provides a uniform metal source on the glass surface,and restricts the TMDC growth to only a surface reaction while eliminating unwanted gas-phase reaction.This feature gives rise to highly uniform monolayer TMDCs with a clean surface on centimeter-scale substrates.The DP growth works well for a large variety of TMDCs and their alloys,providing a solid foundation for the controlled growth of clean TMDCs by the fine control of the metal source. | Zhengyang Cai Yongjue Lai Shilong Zhao Rongjie Zhang Junyang Tan Simin Feng Jingyun Zou Lei Tang Junhao Lin Bilu Liu Hui-Ming Cheng | 2021 | National Science Review2021，8，3： | 2 |
| 6 | Adult Secondhand Smoke Exposure—Shanghai Municipality,2018显示文摘Summary What is already known on this topic?The average secondhand smoke exposure rate was 68.1%in China in 2018.The World Health Organization suggests that legislation must be used to achieve a 100%smoke-free environment and protect nonsmokers from secondhand smoke.What is added by this report? | Yuanqiao Sun De Chen Jian Wang Lin Xiao Kun Xu Chenchen Xie Kunlei Le Zhengyang Gong Xiaoxian Jia Jingrong Gao Liming Wu | 2020 | China CDC weekly2020，2，22： | 1 |
| 7 | High-frequency enhanced response based on Sb_(2)Te_(3)topological insulators显示文摘Topological insulators represent a new quantum phase of matter with spin-polarized surface states that are protected from backscattering, exhibiting electronic responses to light, such as topological quantum phase transitions. However, the effects of high-frequency driving topological intrinsic systems have remained largely unexplored challenges experimentally for high-sensitivity terahertz detection. In this study, by integrating Sb2Te3 topological insulators with subwavelength metal antennas through micro-nano processing, a high-frequency terahertz detector with high sensitivity is proposed. The enhanced response originates from the asymmetric scattering of the surface electrons in the Sb_(2)Te_(3) flakes induced by the terahertz wave. The device displays room-temperature photodetection with a responsivity of 192 mA/W and equivalent noise power of less than 0.35 nW/Hz^(1/2) in the frequency range from 0.02 to 0.3 THz. These results pave the way for the exploitation of topological insulators for high-frequency operation in real-time imaging within long-wavelength optoelectronics. | SHI ZHANG CHAOFAN SHI WEIWEI TANG LIBO ZHANG LI HAN CHENGSEN YANG ZHENGYANG ZHANG JIAN WANG MIAO CAI GUANHAI LI CHANGLONG LIU LIN WANG XIAOSHUANG CHEN WEI LU | 2022 | Photonics Research2022，10，10： | 1 |
| 8 | High-lying excited states in ^10Be from the ^9Be(^9Be,^10Be)^8Be reaction显示文摘A transfer-reaction experiment of ~9Be(~9Be,^(10)Be)~8Be was performed at a beam energy of 45 Me V.Excited states in ^(10)Be up to 18.80 Me V are produced using missing mass and invariant mass methods.Most of the observed high-lying resonant states,reconstructed from theα+~6He and t+~7Li decay channels,agree with the previously reported results.In addition,two new resonances at 15.6 and 18.8 Me V are identified from the present measurement.The 18.55 Me V state is found to decay into both the t + ~7Lig:s: and t + ~7Li?(0.478 MeV) channels, with a relative branching ratio of 0:93 ± 0:33. Further theoretical investigations are encouraged to interpret this new information on cluster structure in neutron-rich light nuclei. | Wei Jiang YanLin Ye ZhiHuan Li ChengJian Lin QiTe Li YuCheng Ge JianLing Lou DongXing Jiang Jing Li ZhengYang Tian Jun Feng Biao Yang ZaiHong Yang Jie Chen HongLiang Zang Qiang Liu PengJie Li ZhiQiang Chen Yun Zhang Yang Liu XiaoHui Sun Jing Ma HuiMing Jia XinXing Xu Lei Yang NanRu Ma LiJie Sun | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 0 |
| 9 | Identification and Functional Analysis of Serum Specific miRNAs in Recurrent Aphthous Stomatitis Patients with Excess-heat or Yin-deficiency显示文摘Background:The treatment of Traditional Chinese Medicine(TCM)in recurrent aphthous stomatitis(RAS)based on syndrome differentiation has won the international acceptance,but the molecular mechanism of excess-heat syndrome and yin-deficiency syndrome of RAS remains unclear.Objective:To clarify specific microRNAs(miRNAs)and their functions in RAS patients with excess-heat or yin-deficiency.Methods:Serum samples were collected from patients meeting the RAS diagnostic criteria of excess-heat or yin-deficiency syndrome and healthy individuals.Core miRNAs were then identified under miRNA microarray anal-yses.Target prediction and bioinformatic analyses were carried out and gene-pathway-networks were visualized to better understand the relationship between different genes and pathways.Results:(1)90 individuals meeting the inclusion criteria were collected in this study.Among them,9 miRNAs were screened out in excess-heat syndrome group(EH group),with 1 upregulated and 8 downregulated.And four miRNAs(hsa-miR-20b-5p,hsa-miR-122-5p,hsa-miR-483-5p and hsa-miR-3197)were validated by real-time PCR method.14 miRNAs were screened out in yin-deficiency syndrome group(YD group)(7 upregulated and 7 downregulated).And hsa-miR-17-5p,hsa-miR-106-5p and hsa-miR-20b-5p were validated.(2)A total of 4,776 target genes were identified in EH group which enriched in GO categories including nervous system development and calcium ion binding and pathway such as PI3K-Akt signaling pathway and Calcium signaling pathway.10,172 target genes were identified in YD group which enriched GO categories included protein binding and positive regulation of transcription from RNA polymerase II promoter and pathway included MAPK signaling pathway and Ras signaling pathway.Conclusion:Hsa-miR-20b-5p in patients with RAS could act as the novel target for the classification of the syndrome.It is upregulated in RAS patients with excess-heat syndrome while downregulated in patients with yin-deficiency syndrome.The PI3K-Akt and MAPK signaling pathways and their related target genes may provide new insights into the molecular mechanisms of RAS with excess-heat syndrome or yin-deficiency syndrome,respectively. | Jie Bao Zhengyang Zhu Xizhao Zhang Lin Huang Li Xu Xiaobing Dou Yongsheng Fan | 2023 | Clinical Complementary Medicine and Pharmacology2023，3，4： | 0 |
| 10 | Disaster assessment for the“Belt and Road”region based on SDG landmarks显示文摘In this study,based on the EM-DAT(The Emergency Events Database)database,disaster assessment for the“Belt and Road”region was carried out in relation to the SDG_(13.1.1)indicator of the Sustainable Development Goals(SDGs)agenda launched in 2015.A new method for diagnosing trends in the SDG_(13.1.1)indicators based on the Theil-Sen median method is proposed.In addition,using the data available in the EM-DAT,an overview of disaster records is used to quantify disasters for a total of 73 countries.The disaster trends for the period 2015‒2019 were found to demon-strate the following.(1)As a result of geological and climate con-ditions,Asia and Africa are high-risk disaster areas and disasters have caused considerable economic losses and affected the popu-lations in developing and underdeveloped countries in these regions.(2)The clear positive value ofΔs_(13.1.1)found for China reflects the country’s encouraging achievements in disaster preven-tion and mitigation.(3)The value of SDG_(13.1.1)was observed to be increasing in South Asia,northwest Africa and South Africa,with the increase in India and Mauritania being the most serious.The new method proposed in this paper allows the real trend in the SDG_(13.1.1)indicator in various countries to be derived and provides critical intelligence support for international disaster risk reduction plans and sustainable development goals. | Li Wang Yuanhuizi He Yuelin Zhang Lei Wang Huicong Jia Quan Zhou Bo Yu Meimei Zhang Zhengyang Lin Fang Chen | 2022 | Big Earth Data2022，6，1： | 0 |
| 11 | Optimization-inspired manual architecture design and neural architecture search显示文摘Neural architecture has been a research focus in recent years due to its importance in deciding the performance of deep networks.Representative ones include a residual network(Res Net)with skip connections and a dense network(Dense Net)with dense connections.However,a theoretical guidance for manual architecture design and neural architecture search(NAS)is still lacking.In this paper,we propose a manual architecture design framework,which is inspired by optimization algorithms.It is based on the conjecture that an optimization algorithm with a good convergence rate may imply a neural architecture with good performance.Concretely,we prove under certain conditions that forward propagation in a deep neural network is equivalent to the iterative optimization procedure of the gradient descent algorithm minimizing a cost function.Inspired by this correspondence,we derive neural architectures from fast optimization algorithms,including the heavy ball algorithm and Nesterov’s accelerated gradient descent algorithm.Surprisingly,we find that we can deem the Res Net and Dense Net as special cases of the optimization-inspired architectures.These architectures offer not only theoretical guidance,but also good performances in image recognition on multiple datasets,including CIFAR-10,CIFAR-100,and Image Net.Moreover,we show that our method is also useful for NAS by offering a good initial search point or guiding the search space. | Yibo YANG Zhengyang SHEN Huan LI Zhouchen LIN | 2023 | Science China(Information Sciences)2023，66，11： | 0 |
| 12 | Newton design:designing CNNs with the family of Newton's methods显示文摘Nowadays,convolutional neural networks(CNNs)have led the developments of machine learning.However,most CNN architectures are obtained by manual design,which is empirical,time-consuming,and non-transparent.In this paper,we aim at offering better insight into CNN models from the perspective of optimization theory.We propose a unified framework for understanding and designing CNN architectures with the family of Newton’s methods,which is referred to as Newton design.Specifically,we observe that the standard feedforward CNN model(PlainNet)solves an optimization problem via a kind of quasi-Newton method.Interestingly,residual network(ResNet)can also be derived if we use a more general quasi-Newton method to solve this problem.Based on the above observations,we solve this problem via a better method,the Newton-conjugate-gradient(Newton-CG)method,which inspires Newton-CGNet.In the network design,we translate binary-value terms in the optimization schemes to dropout layers,so dropout modules naturally appear in the derived CNN structures with specific locations,rather than being an empirical training strategy.Extensive experiments on image classification and text categorization tasks verify that Newton-CGNets perform very competitively.Particularly,Newton-CGNets surpass their counterparts ResNets by over 4%on CIFAR-10 and over 10%on CIFAR-100,respectively. | Zhengyang SHEN Yibo YANG Qi SHE Changhu WANG Jinwen MA Zhouchen LIN | 2023 | Science China(Information Sciences)2023，66，6： | 0 |
| 13 | Minimally invasive bioprinting for in situ liver regeneration显示文摘In situ bioprinting is promising for developing scaffolds directly on defect models in operating rooms,which provides a new strategy for in situ tissue regeneration.However,due to the limitation of existing in situ biofabrication technologies including printing depth and suitable bioinks,bioprinting scaffolds in deep dermal or extremity injuries remains a grand challenge.Here,we present an in vivo scaffold fabrication approach by minimally invasive bioprinting electroactive hydrogel scaffolds to promote in situ tissue regeneration.The minimally invasive bioprinting system consists of a ferromagnetic soft catheter robot for extrusion,a digital laparoscope for in situ monitoring,and a Veress needle for establishing a pneumoperitoneum.After 3D reconstruction of the defects with computed tomography,electroactive hydrogel scaffolds are printed within partial liver resection of live rats,and in situ tissue regeneration is achieved by promoting the proliferation,migration,and differentiation of cells and maintaining liver function in vivo. | Yueying Yang Zhengyang Yu Xiaohuan Lu Jiahao Dai Cheng Zhou Jing Yan Lin Wang Zheng Wang Jianfeng Zang | 2023 | Bioactive Materials2023，，8： | 0 |
| 14 | Lck/Hck/Fgr介导的TBK1酪氨酸磷酸化负调TBK1功能及抗病毒天然免疫应答显示文摘抗病毒天然免疫通路的激活,传统上认识是由蛋白泛素化和蛋白丝苏氨酸磷酸化所介导,对于蛋白酪氨酸磷酸化修饰的作用与生理功能,未有深入探索和认知。课题组发现病毒感染过程中,在多种器官来源的细胞中都观察到细胞内源TBK1有动态的酪氨酸磷酸化修饰,并与TBK1激活与抑制紧密相关。 | Shengduo Liu Shasha Chen Xinran Li Shiying Wu Qian Zhang Qiuheng Jin Lin Hu Ruyuan Zhou Zhengyang Yu Fansen Meng Siwen Wang Yaowei Huang Sheng Ye Li Shen Zongping Xia Jian Zou Xin-Hua Feng 徐平龙 | 2018 | 科学新闻2018，0，4： | 0 |
| 15 | The compatibly large nonlinear optical effect and high laser-induced damage threshold in a thiophosphate CsInP_(2)S_(7)constructed with[P_(2)S_(7)]^(4-)and[InS_(6)]^(9-)显示文摘It is challenging to cooperatively improve the nonlinear optical(NLO)efficiency and the laser-induced damage threshold(LIDT).This work reports a novel IR NLO materials CsInP_(2)S_(7)(CIPS)designed by combination the strategies of alkali metals substitution and microscopic NLO units PS4 introduction based on AgGaS_(2).CIPS was composed of strongly distorted[InS_(6)]^(9-)octahedra and[P_(2)S_(7)]4-dimers constructed by corner-sharing[PS_(4)]^(3-),which increase the NLO efficiency and decrease thermal expansion anisotropy simultaneously.Compared with AgGaS_(2),CIPS exhibited strong phase matchable NLO response ca.1.1×AGS@2.1μm,high LIDT ca.20.8×AgGaS_(2),and IR transparency up to 15.3μm.Structural analysis and theoretical investigation confirmed that large SHG effect and ultrahigh LIDT of CIPS originated from the synergistic contribution of[InS_(6)]^(9-)octahedra and[P_(2)S_(7)]4-dimers.These results indicate that CIPS is a promising NLO candidate in the mid-IR region,and this study provides a new approach for developing potential NLO-LIDT compatible materials. | Mengjia Luo Xiaohui Li Xingxing Jiang Zheshuai Lin Zhengyang Zhou | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 16 | UM15 reinforces a lymphocyte-mimicking nanotrap for precise HIV-1 inhibition显示文摘Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected because these nanotraps displayed no obvious advantages compared with the infinite host cells.Herein,a glycoprotein 120(gp120)-targeting polypeptide UM15 reinforced lymphocyte-mimicking nanotrap was constructed,and its improved HIV-1 inhibiting efficacy was validated.According to the results,the constructed nanotraps exhibited evident escaping ability from uptake of the mononuclear phagocyte system and highly improved binding ability with gp120 proteins.The constructed nanotraps neutralized all tested HIV-1 pseudo typed viruses with IC80 of 21.0μg/mL,and inhibited both X4-tropic and R5-tropic HIV-1 with IC80 of 34.4 and 20.6μg/mL,respectively.Approximately 40%of gp120 was observed to be shed from pseudo virus,and above 40%bystander T cells were prevented from gp120-induced death by the constructed nanotraps.The safety of the constructed nanotraps was confirmed both in vitro and in mice.Therefore,the constructed nanotraps could specifically neutralize free HIV-1,selectively bind with gp120 expressing HIV-1 infected cells,cause gp120 shedding,inhibit gp120-induced bystander T cell killing on the premise of safety,and were considered as promising therapeutic agents for precise inhibition of HIV. | Jinbang Zhang Zhengyang Li Jiaxin Li Hui Li Junwei Che Te Zhao Pengfei Zou Jingwan Han Yang Yang Meiyan Yang Yuli Wang Wei Gong Haihua Xiao Zhiping Li Lin Li Chunsheng Gao | 2023 | Nano Research2023，16，7： | 0 |
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