| 2 | Induction of CD4+CD25+Foxp3+ regulatory T cell response by glatiramer acetate in type 1 diabetes显示文摘Glatiramer 醋酸盐(GA ) 是过去常对待多重硬化的 immunomodulatory 肽药。它的处理效果被扩展了到象 uveoretinitis,煽动性的肠疾病,接枝拒绝和肝的纤维变性那样的另外的自体免疫的条件。这里,我们报导 GA 在在 cyclophosphamide (CY ) 改变糖尿病的临床的功课是有效的加强的非肥胖的糖尿病患者(CY 点头) 老鼠。有显著地减少的 GA 的治疗在老鼠和改善 insulitis 的糖尿病的率,它与增加的 CD4+CD25+Foxp3+ T 房间反应与一致在对待老鼠。GA 处理导致了抄写因素 Foxp3 的增加的表示并且在 vivo 并且在 vitro 提高了 interleukin-4 (IL-4 ) 的生产。Foxp3 的起来规定上的 GA 的效果通过 IL-4 部分被调停,是明显的。IL-4 被发现维持 Foxp3 表示和 CD4+CD25+ 规章的 T 房间(Tregs ) 的规章的功能。这研究提供 GA 通过 Tregs 的正式就职为类型 1 糖尿病有处理潜力,那增加的 IL-4 生产为提高的 Treg 在 GA 处理的功能部分负责的新证据。 | Guoliang Cui Yuebo Zhang Zhenwei Gong Jingwu Z Zhang Ying Qin Zang | 2009 | Cell Research2009，19，5： | 1 |
| 3 | Mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study显示文摘Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived COVID-19.Apart from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the world.The current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 survivors.Methods The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,2021.The demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the participants.Descriptive analyses,Pearson correlation analysis and Structural Equation Modeling were used to make data description and analysis.Results A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the analysis.Perceived stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,P<0.001),depression(r=0.325,P<0.001)and post-traumatic stress disorder(PTSD)(r=0.384,P<0.001).It has a direct effect on COVID-19 survivors’anxiety(β=0.326,P<0.001),depression(β=0.314,P<0.001),PTSD(β=0.385,P<0.001)and their resilience(β=−0.114,P<0.01).Resilience partially mediated the association between perceived stigma and anxiety(β=0.020,P<0.01),depression(β=0.020,P<0.01),and PTSD(β=0.014,P<0.01)among COVID-19 survivors.Conclusion Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 survivors.Based on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience. | Weijun Xiao Xiaoyang Liu Hao Wang Yiman Huang Zhenwei Dai Mingyu Si Jiaqi Fu Xu Chen Mengmeng Jia Zhiwei Leng Dan Cui Winnie W.S.Mak Liming Dong Xiaoyou Su | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
| 4 | Seasonal diet and microbiome shifts in wild rhesus macaques are better correlated at the level of nutrient components than food items显示文摘Food supply is one of the major drivers of animal behavior,and the gut microbiome is an important mediator be-tween food supply and its effects on physiology.However,predicting the outcome of diet change on microbiome and consequences for the animal has proven extremely challenging.We propose this reflects processes occurring at different scales.Inadequate accounting for the multi-level complexity of nutrition(nutrients,foods,diets)obscures the diet influence on microbiome and subsequently animal.Here,we present a detailed year-round,multi-level analysis of diet and microbiome changes in a wild population of a temperate primate,the rhesus macaque(Macaca mulatta).Total daily food and nutrient intake of 6 male and 6 female macaques was monitored in each of the 4 sea-sons(total 120 days observations).For each individual,we found significant variation in the microbiome between all 4 seasons.This response was more strongly correlated with changes in macronutrient intake than with food items and much of the response could be explained at the level of 6 ecological guilds—sets of taxa sharing similar responses to nutrient intake.We conclude that study of diet,microbiome,and animal performance in ecology will more effectively identify patterns if diet is recorded at the level of nutrient intake.Although microbiome response to diet does show variation in species-level taxa in response to food items,there is greater commonality in response at the level of guilds.A goal for microbiome researchers should be to identify genes encoding microbial attributes that can define such guilds. | Zhenwei CUI Andrew JHOLMES Wenjuan ZHANG Dalong HU Qi SHAO Zhenlong WANG Jiqi LU David RAUBENHEIMER | 2022 | Integrative Zoology2022，17，6： | 0 |
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