|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer显示文摘MTUS1 (联系微导管的肿瘤 suppressor 1 ) 被识别了那能在许多恶意的肿瘤作为肿瘤 suppressor 基因工作。然而,位于 MTUS1 的规定下面的功能和机制是不清楚的。在现在的学习,我们报导 miR-19a 和 miR-19b (miR-19a/b ) 由指向 MTUS1 支持肺癌症房间的增长和移植。首先, MTUS1 被证明在肺癌症作为肿瘤 suppressor 工作并且被连接到房间增长和移植提升。第二,在 miR-19a/b 表示之间的反的关联和 MTUS1 mRNA/protein 表示在人的肺癌症纸巾被注意。第三, MTUS1 被生物信息学分析作为 miR-19a/b 的一个直接目标估价。第四,由在肺癌症房间的 miR-19a/b 的直接 MTUS1 规定被房间 transfection 试验性地肯定试金和酶记者试金。最后, miR-19a/b 被显示合作地镇压 MTUS1 表示并且 synergistically 调整 MTUS1 表示支持肺癌症房间增长和移植。在结论,我们的调查结果关于 miR-19a/b 的角色提供了第一线索,它看起来由 downregulating MTUS1 在肺癌症作为 oncomirs 工作。 | Yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei Liang Mengchao Yu Zhicong Liao Yong Zhou Chen-Yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen | 2017 | Protein & Cell2017，8，6： | 6 |
| 2 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 3 | In situ plasmonic&electrochemical fiber-optic sensor for multi-metal-ions detection显示文摘High precision and high throughput detection of heavy metal ions is essential for water quality monitoring and assessment.Herein,we propose a plasmonic&electrochemical dual-mode fiber sensing probe for label-free and real-time detection of multiple ions(Pb^(2+)and Cu^(2+)as examples).This sensor comprises a multimode fiber-single mode fiber reflection probe,the outer surface of which is coated with a gold nanofilm to excite the surface plasmon resonance(SPR)optically and simultaneously serves as an electrochemical working electrode.In traditional electrochemical detection,the enrichment of ions cannot be detected in real-time.However,by utilizing the plasmonic&electrochemical dual-mode detection method,various kinds of metal ions can be deposited onto the gold nanofilm and selectively oxidized during forward potential scanning,and the entire electrochemical process can be monitored by SPR measurement.We experimentally demonstrate that the sensor can simultaneously detect Pb^(2+)and Cu^(2+)in a mixed solution in real-time,providing a linear response over the ion concentration range from 10^(-12)to 10^(-7)M and offering an excellent detection limit(1.69×10^(-14)–5.49×10^(-13)M).The proposed dual-mode fiber sensor has the benefits of remote sensing,compact footprint,and cost-effectiveness and shows excellent potential for water quality risk management in difficult-to-reach environments. | Xiaoling PENG Zhiyong YANG Bo PENG Zhi LI Zhicong REN Xicheng WANG Jiahai LI Zhencheng LI Liang CHEN Daotong YOU Kaiwei LI Jianqing LI Tuan GUO | 2024 | Science China(Information Sciences)2024，67，1： | 0 |
| 4 | Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics显示文摘Dear Editor,Recent study showed that around 80%of coronavirus disease-19(COVID-19)patients are moderate cases who will recover with or without conventional treatment,while the remaining 20%developed severe disease requiring intensive care.1 Early and accurate screening of new COVID-19 patients to identify those who will develop severe disease will facilitate decision-making on appropriate treatment regimens and reasonable allocation of limited healthcare resources.Therefore,novel predictive factors for disease progress from moderate to severe are urgently needed. | Biao Di Hongling Jia Oscar Junhong Luo Fangqin Lin Kuibiao Li Yuanliang Zhang Huadong Wang Huiying Liang Jun Fan Zhicong Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 5 | Learning to Combine Answer Boundary Detection and Answer Re-ranking for Phrase-Indexed Question Answering显示文摘Phrase-indexed question answering(PIQA)seeks to improve the inference speed of question answering(QA)models by enforcing complete independence of the document encoder from the question encoder,and it shows that the constrained model can achieve significant efficiency at the cost of its accuracy.In this paper,we aim to build a model under the PIQA constraint while reducing its accuracy gap with the unconstrained QA models.We propose a novel framework-AnsDR,which consists of an answer boundary detector(AnsD)and an answer candidate ranker(AnsR).More specifically,AnsD is a QA model under the PIQA architecture and it is designed to identify the rough answer boundaries;and AnsR is a lightweight ranking model to finely rerank the potential candidates without losing the efficiency.We perform the extensive experiments on public datasets.The experimental results show that the proposed method achieves the state of the art on the PIQA task. | WEN Liang SHI Haibo ZHANG Xiaodong SUN Xin WEI Xiaochi WANG Junfeng CHENG Zhicong YIN Dawei WANG Xiaolin LUO Yingwei WANG Houfeng | 2022 | Chinese Journal of Electronics2022，31，5： | 0 |
| 6 | Expanding our understanding of marine viral diversity through metagenomic analyses of biofilms显示文摘Recent metagenomics surveys have provided insights into the marine virosphere.However,these surveys have focused solely on viruses in seawater,neglecting those associated with biofilms.By analyzing 1.75 terabases of biofilm metagenomic data,3974 viral sequences were identified from eight locations around the world.Over 90%of these viral sequences were not found in previously reported datasets.Comparisons between biofilm and seawater metagenomes identified viruses that are endemic to the biofilm niche.Analysis of viral sequences integrated within biofilm-derived microbial genomes revealed potential functional genes for trimeric autotransporter adhesin and polysaccharide metabolism,which may contribute to biofilm formation by the bacterial hosts.However,more than 70%of the genes could not be annotated.These findings show marine biofilms to be a reservoir of novel viruses and have enhanced our understanding of natural virus-bacteria ecosystems. | Wei Ding Ruojun Wang Zhicong Liang Rui Zhang Pei-Yuan Qian Weipeng Zhan | 2021 | Marine Life Science & Technology2021，3，3： | 0 |
| 7 | mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a显示文摘Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts,blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors.Due to these adverse effects,preosteoblast senescence is a crucial target for the treatment of age-related bone loss;however,the underlying mechanism remains unclear.We found that mTORC1 accelerated preosteoblast senescence in vitro and in a mouse model.Mechanistically,mTORC1 induced a change in the membrane potential from polarization to depolarization,thus promoting cell senescence by increasing Ca^(2+)influx and activating downstream NFAT/ATF3/p53 signaling.We further identified the sodium channel Scn1a as a mediator of membrane depolarization in senescent preosteoblasts.Scn1a expression was found to be positively regulated by mTORC1 upstream of C/EBPα,whereas its permeability to Na^(+)was found to be gated by protein kinase A(PKA)-induced phosphorylation.Prosenescent stresses increased the permeability of Scn1a to Na^(+)by suppressing PKA activity and induced depolarization in preosteoblasts.Together,our findings identify a novel pathway involving mTORC1,Scn1a expression and gating,plasma membrane depolarization,increased Ca^(2+)influx and NFAT/ATF3/p53 signaling in the regulation of preosteoblast senescence.Pharmaceutical studies of the related pathways and agents might lead to novel potential treatments for agerelated bone loss. | Ajuan Chen Jian Jin Shasha Cheng Zezheng Liu Cheng Yang Qingjing Chen Wenquan Liang Kai Li Dawei Kang Zhicong Ouyang Chenfeng Yao Xiaochun Bai Qingchu Li Dadi Jin Bin Huang | 2022 | Bone Research2022，10，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员