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| 1 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 2 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 3 | Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer显示文摘MTUS1 (联系微导管的肿瘤 suppressor 1 ) 被识别了那能在许多恶意的肿瘤作为肿瘤 suppressor 基因工作。然而,位于 MTUS1 的规定下面的功能和机制是不清楚的。在现在的学习,我们报导 miR-19a 和 miR-19b (miR-19a/b ) 由指向 MTUS1 支持肺癌症房间的增长和移植。首先, MTUS1 被证明在肺癌症作为肿瘤 suppressor 工作并且被连接到房间增长和移植提升。第二,在 miR-19a/b 表示之间的反的关联和 MTUS1 mRNA/protein 表示在人的肺癌症纸巾被注意。第三, MTUS1 被生物信息学分析作为 miR-19a/b 的一个直接目标估价。第四,由在肺癌症房间的 miR-19a/b 的直接 MTUS1 规定被房间 transfection 试验性地肯定试金和酶记者试金。最后, miR-19a/b 被显示合作地镇压 MTUS1 表示并且 synergistically 调整 MTUS1 表示支持肺癌症房间增长和移植。在结论,我们的调查结果关于 miR-19a/b 的角色提供了第一线索,它看起来由 downregulating MTUS1 在肺癌症作为 oncomirs 工作。 | Yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei Liang Mengchao Yu Zhicong Liao Yong Zhou Chen-Yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen | 2017 | Protein & Cell2017，8，6： | 6 |
| 4 | Big Earth data analytics:a survey显示文摘Big Earth data are produced from satellite observations,Internet-ofThings,model simulations,and other sources.The data embed unprecedented insights and spatiotemporal stamps of relevant Earth phenomena for improving our understanding,responding,and addressing challenges of Earth sciences and applications.In the past years,new technologies(such as cloud computing,big data and artificial intelligence)have gained momentum in addressing the challenges of using big Earth data for scientific studies and geospatial applications historically intractable.This paper reviews the big Earth data analytics from several aspects to capture the latest advancements in this fast-growing domain.We first introduce the concepts of big Earth data.The architecture,various functionalities,and supporting modules are then reviewed from a generic methodology aspect.Analytical methods supporting the functionalities are surveyed and analyzed in the context of different tools.The driven questions are exemplified through cutting-edge Earth science researches and applications.A list of challenges and opportunities are proposed for different stakeholders to collaboratively advance big Earth data analytics in the near future. | Chaowei Yang Manzhu Yu Yun Li Fei Hu Yongyao Jiang Qian Liu Dexuan Sha Mengchao Xu Juan Gu | 2019 | Big Earth Data2019，3，2： | 3 |
| 5 | Mixture Toxicities of Three Pesticides Having Different Time-Toxicity Profiles显示文摘In the environment,chemical pollutants always exist as mixtures.To evaluate mixture toxicity,we should ex-amine the concentration ratios and the concentration levels of mixture components as well as the interactive time between the components and testing organism.Selecting three pesticides,metribuzin(MET),dodine(DOD)and ri-domil(RID),as mixture components,Vibrio qinghaiensis sp.-Q67 as testing organism,and 96-well microplate as exposure experiment carrier,the luminescence inhibition toxicities of the pesticides and their binary mixtures at six exposure time points(0.25,2,4,8,12,and 16 h)were determined.The results showed that the three pesticides have different time-toxicity profiles.The toxicity of MET increases over time,and those of DOD and RID show a slight decrease or increase in the first 4 h,respectively,and then remain unchanged to 16 h.The toxicities of the binary mixtures consisting of the three pesticides depend on not only the mixture composition but also the exposure time.The time-toxicity profiles of all rays in MET-DOD mixture system are U-shaped curves,those in MET-RID system are basically monotonically increased and those in DOD-RID system are basically monotonically decreased.How-ever,our findings indicate that for the test substances,mixture toxicity can be predicted by the extended concentra-tion addition model. | Mo Yu Shushen Liu Mengchao Wang Fu Chen Hanxiao Tang | 2014 | Chinese Journal of Chemistry2014，32，6： | 2 |
| 6 | Cold-induced retrotransposition of fish LINEs显示文摘Classes of retrotransposons constitute a large portion of metazoan genome. There have been cases reported that genomic abundance of retrotransposons is correlated with the severity of low environmental temperatures. However, the molecular mechanisms underlying such correlation are unknown. We show here by cell transfection assays that retrotransposition(RTP) of a long interspersed nuclear element(LINE) from an Antarctic notothenioid fish Dissostichus mawsoni(dmLl) could be activated by low temperature exposure, causing increased dmL1 copies in the host cell genome. The cold-induced dmL1 propagation was demonstrated to be mediated by the mitogen-activated protein kinases(MAPK)/p38 signaling pathway, which is activated by accumulation of reactive oxygen species(ROS) in cold-stressed conditions. Surprisingly, dmL1 transfected cells showed an increase in the number of viable cells after prolonged cold exposures than non-transfected cells. Features of cold inducibility of dmL1 were recapitulated in LINEs of zebrafish origin both in cultured cell lines and tissues, suggesting existence of a common cold-induced LINE amplification in fishes. The findings reveal an important function of LINES in temperature adaptation and provid insights into the MAPK/p38 stress responsive pathway that shapes LINE composition in fishes facing cold stresses. | Shue Chen Mengchao Yu Xu Chu Wenhao Li Xiujuan Yin Liangbiao Chen | 2017 | Journal of Genetics and Genomics2017，44，8： | 2 |
| 7 | MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma显示文摘 | Shupeng Liu Weixing Guo Jie Shi Nan Li Xiya Yu Jie Xue Xiaohui Fu Kaijian Chu Chongde Lu Jiangsha Zhao Dong Xie Mengchao Wu Shuqun Cheng Shanrong Liu | 2011 | Journal of Hepatology2011，，2： | 2 |
| 8 | Experimental study on enhancement of the metastatic potential of portal vein tumor thrombus-originated hepatocellular carcinoma cells using portal vein serum显示文摘Objective: Portal vein metastasis of hepatocellular carcinoma(HCC) results in a poor prognosis and seriously affects the survival rate of patients. The mechanism underlying the formation of portal vein tumor thrombus(PVTT) is complex and is not yet fully understood. This study was conducted to investigate the impact of portal vein blood on the proliferation, metastasis, invasion and apoptosis of PVTT cells and to explore its possible mechanisms, which was expected to lay a foundation for ascertaining the mechanism underlying the portal vein metastasis of HCC.Methods: Peripheral blood and portal vein blood were collected from patients with HCC, and the sera from these two sources were used to culture the PVTT-originated HCC cell line CSQT-2. The cells were collected after 24 h, and flow cytometry was performed to detect cell proliferation, cell cycle stages and apoptosis. Transwell migration and invasion assays were applied to detect the metastasis and invasion of the cells in each group. The changes in the expression of MMP-2 and MMP-9 in cells were detected via Western blotting. The contents of IL-12, IFN-γ, IL-1β, IL-2 and TNF-α in the two groups of sera were quantified using corresponding kits. Results: Compared with the group of cells cultured with peripheral serum, the cells cultured with portal vein serum showed significantly lower apoptosis(P<0.01), significantly enhanced cell metastasis and invasion(P<0.01), whereas cell proliferation and the stages of the cell cycle did not differ significantly(P>0.05). A significantly increased expression level of MMP-2 has been observed in tumor cells treated portal vein serum. In addition, compared with peripheral serum, the content of IL-12 was significantly decreased in portal vein serum(P<0.05), while the contents of IFN-γ, IL-1β, IL-2, and TNF-α did not differ significantly(P>0.05). Conclusions: Portal vein serum from HCC patients could inhibit the apoptosis of PVTT-originated HCC cells and promote cell metastasis and invasion. This effect may be related to the lower level of IL-12 in portal vein serum. | Yufu Tang Hongming Yu Long Zhang Kang Wang Weixing Guo Jie Shi Shupeng Liu Mengchao Wu Hongyang Wang Shuqun Cheng | 2014 | Chinese Journal of Cancer Research2014，26，5： | 2 |
| 9 | The Mitochondrial Genome of Pseudocalotes microlepis (Squamata: Agamidae) and its Phylogenetic Position in Agamids显示文摘We describe the complete mitochondrial genome of a small-scaled forest agamid(Pseudocalotes microlepis), which is 17 873 bp in size, containing 13 PCGs, 2 r RNAs, 22 t RNAs and non-coding regions. The mitogenome has a typical gene order among squamates. 13 PCGs include 2 start codons(ATG and ATA), 3 stop codons(TAG, TAA and AGG), and an incomplete stop codon(T-). Codon usage analyses showed that CUA-Leu1 and CGG-Arg are the most frequently and rarely used codon, respectively. All 22 t RNAs were predicted to form canonical cloverleaf secondary structures, except for two t RNAs(t RNACys and t RNASer(AGY)) lacking the dihydorouridine(DHU) arm. The large noncoding region(control region) is 2 687 bp long(28.3% T, 18.2% C, 42.3% A, and 11.2% G), with four different types of repeating sequences. The phylogenetic tree resulting from BEAST analyses based on concatenated 2 r RNAs and 13 PCGs in sequence revealed that the newly sequenced P. microlepis, where the genus Acanthosaura were aggregated. Together with Calotes versicolor, they constitute the subfamily Draconinae. | Xiuli YU Yu DU Mengchao FANG Hong LI Longhui LIN | 2018 | Asian Herpetological Research2018，9，1： | 1 |
| 10 | Targeting UPR branches,a potential strategy for enhancing efficacy of cancer chemotherapy显示文摘Cancer cells are often exposed to cell intrinsic stresses and environmental perturbations that may lead to accumulation of unfolded and/or misfolded proteins in the lumen of endoplasmic reticulum(ER),a cellular condition known as ER stress.In response to ER stress,the cells elicit an adaptive process called unfolded protein response(UPR)to cope with the stress,supporting cellular homeostasis and survival.The ER stress sensors inositol requiring protein 1α(IRE1α),eukaryotic translation initiation factor 2 alpha kinase 3(EIF2AK3,also called PERK),and activating transcription factor 6(ATF6)constitute the three branches of UPR to resolve ER stress.IRE1α,PERK,and ATF6 play an important role in tumor cell growth and survival.They are also involved in chemotherapy resistance of cancers.These have generated widespread interest in targeting these UPR branches for cancer treatment.In this review,we provide an overview of the role of IRE1α,PERK,and ATF6 in cancer progression and drug resistance and we summarize the research advances in targeting these UPR branches to enhance the efficacy of chemotherapy of cancers. | Mengchao Yu Jie Lun Hongwei Zhang Lei Wang Gang Zhang Haisheng Zhang Jing Fang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 1 |
| 11 | Lineage diversification and niche evolution in the Reeves’Butterfly Lizard Leiolepis reevesii(Agamidae)显示文摘We used mitochondrial cytochrome b and ND4 genes and 9 microsatellite loci to determine genetic diversity,population structure,evolutionary history,and migration patterns within the Reeves’butterfly lizard Leiolepis reevesii(Agamidae).Considering molecular-based phylogeographical lineages,we then performed niche equivalency and similarity tests between divergent lineages.Phylogenetic analyses based on mitochondrial DNA(mtDNA)data revealed 2 lineages(A and B)diverging≈0.84 million years ago and,respectively,restricted to the northern and southern portions of the Wuzhishan and Yinggeling mountain ranges.Lineage B contains individuals from southern Hainan;Lineage A includes individuals from all other localities and can be further divided into 3 clusters according to microsatellite data.The null hypothesis that the 2 lineages shared identical niches was rejected in all niche equivalency tests,indicating niche shifts during genetic divergence.Similarity tests provided evidence of niche conservatism,suggesting that the 2 lineages share more characteristics of their niche spaces than randomly expected.The niche similarity and equivalency tests indicated a complex niche pattern in which both lineages share a main portion of their ecological spaces.The climatic niche of Lineage B represented a marginal and specialized fraction of the entire ecological space of the climatic niche of Lineage A,with warmer conditions.Isolation caused by orogenesis and subsequent niche divergence,together with local adaptation,may have led to genetic differentiation and further lineage sorting in L.reevesii. | Xiaming ZHU Lei HUA Mengchao FANG Yu DU Chixian LIN Longhui LIN Xiang JI | 2021 | Integrative Zoology2021，16，3： | 1 |
| 12 | A straightforward spectral emissivity estimating method based on constructing random rough surfaces显示文摘Spectral emissivity is an essential and sensitive parameter to characterize the radiative capacity of the solid surface in scientific and engineering applications,which would be non-negligibly affected by surface morphology.However,there is a lack of assessment of the effect of roughness on emissivity and a straightforward method for estimating the emissivity of rough surfaces.This paper established an estimating method based on constructing random rough surfaces to predict rough surface(Geometric region)emissivity for metal solids.Based on this method,the emissivity of ideal gray and non-gray body surfaces was calculated and analyzed.The calculated and measured spectral emissivities of GH3044,K465,DD6,and TC4 alloys with different roughness were compared.The results show that the emissivity increases with the roughness degree,and the enhancement effect weakens with the increase of roughness or emissivity due to the existing limit(emissivityε=1.0).At the same time,the roughness would not change the overall spectral distribution characteristics but may attenuate the local features of the spectral emissivity.The estimated results are in good agreement with the experimental data for the above alloys'rough surfaces.This study provides a new reliable approach to obtaining the spectral emissivity of rough surfaces.This approach is especially beneficial for measuring objects in extreme environments where emissivity is difficult to obtain.Meanwhile,this study promotes an understanding of surface morphology's effect mechanism on emissivity. | Zezhan Zhang Mengchao Chen Lichuan Zhang Hongzu Li Hairui Huang Zilong Zhang Peifeng Yu Yi Niu Shan Gao Chao Wang Jing Jiang | 2023 | Light(Science & Applications)2023，12，12： | 0 |
| 13 | A Spatiotemporal Interactive Processing Bias Correction Method for Operational Ocean Wave Forecasts显示文摘Numerical models and correct predictions are important for marine forecasting,but the forecasting results are often unable to satisfy the requirements of operational wave forecasting.Because bias between the predictions of numerical models and the actual sea state has been observed,predictions can only be released after correction by forecasters.This paper proposes a spati-otemporal interactive processing bias correction method to correct numerical prediction fields applied to the production and release of operational ocean wave forecasting products.The proposed method combines the advantages of numerical models and Forecast Discussion;specifically,it integrates subjective and objective information to achieve interactive spatiotemporal correc-tions for numerical prediction.The method corrects the single-time numerical prediction field in space by spatial interpolation and sub-zone numerical analyses using numerical model grid data in combination with real-time observations and the artificial judg-ment of forecasters to achieve numerical prediction accuracy.The difference between the original numerical prediction field and the spatial correction field is interpolated to an adjacent time series by successive correction analysis,thereby achieving highly efficient correction for multi-time forecasting fields.In this paper,the significant wave height forecasts from the European Centre for Medium-Range Weather Forecasts are used as background field for forecasting correction and analysis.Results indicate that the proposed method has good application potential for the bias correction of numerical predictions under different sea states.The method takes into account spatial correlations for the numerical prediction field and the time series development of the numerical model to correct numerical predictions efficiently. | AI Bo YU Mengchao GUO Jingtian ZHANG Wei JIANG Tao LIU Aichao WEN Lianjie LI Wenbo | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 14 | A Review of Solid Electrolyte Interphase(SEI)and Dendrite Formation in Lithium Batteries显示文摘Lithium-metal batteries with high energy/power densities have significant applications in electronics,electric vehicles,and stationary power plants.However,the unstable lithium-metal-anode/electrolyte interface has induced insufficient cycle life and safety issues.To improve the cycle life and safety,understanding the formation of the solid electrolyte interphase(SEI)and growth of lithium dendrites near the anode/electrolyte interface,regulating the electrodeposition/electrostripping processes of Li^(+),and developing multiple approaches for protecting the lithium-metal surface and SEI layer are crucial and necessary.This paper comprehensively reviews the research progress in SEI and lithium dendrite growth in terms of their classical electrochemical lithium plating/stripping processes,interface interaction/nucleation processes,anode geometric evolution,fundamental electrolyte reduction mechanisms,and effects on battery performance.Some important aspects,such as charge transfer,the local current distribution,solvation,desolvation,ion diffusion through the interface,inhibition of dendrites by the SEI,additives,models for dendrite formation,heterogeneous nucleation,asymmetric processes during stripping/plating,the host matrix,and in situ nucleation characterization,are also analyzed based on experimental observations and theoretical calculations.Several technical challenges in improving SEI properties and reducing lithium dendrite growth are analyzed.Furthermore,possible future research directions for overcoming the challenges are also proposed to facilitate further research and development toward practical applications. | Borong Li Yu Chao Mengchao Li Yuanbin Xiao Rui Li Kang Yang Xiancai Cui Gui Xu Lingyun Li Chengkai Yang Yan Yu David P.Wilkinson Jiujun Zhang | 2023 | Electrochemical Energy Reviews2023，6，1： | 0 |
| 15 | Macroecological Patterns of Climatic Niche Breadth Variation in Lacertid Lizards显示文摘Measuring climatic niche position and breadth may help to determine where species can occur over space and time. Using GIS-based and phylogenetic comparative methods, we investigated global patterns of variation in climatic niche breadth in lacertid lizards to test the following three hypotheses about climatic niche widths. First, does a species' temperature or precipitation niche breadth relate to its temperature or precipitation niche position(the mean value of annual mean temperature or annual precipitation across sampled localities in the range of each species)? Second, are there trade-offs between a species' temperature niche breadth and precipitation niche breadth? Third, does a species' temperature or precipitation niche breadth relate to altitude or latitude? We expect that:(1) species distributed in cold regions are specialized for low-temperature environments(i.e. narrow niche breadth center around low temperatures);(2) a negative relationship between species niche breadth on temperature and precipitation axes according to the tradeoff hypothesis(i.e. species that tolerate a broad range of precipitation regimes cannot also tolerate a broad range of temperatures);(3) precipitation niche breadth decreases with altitude or latitude, whereas temperature climatic niche breadth increases with altitude or latitude. Based on the analytical results we found that:(1) temperature niche breadth and position are negatively related, while precipitation niche breadth and position are positively related;(2) there is no trade-off between temperature and precipitation niche breadths; and (3) temperature niche breadth and latitude/altitude are positively related, but precipitation niche breadth and latitude/altitude are not significantly related. Our results show many similarities with previous studies on climatic niche widths reported for amphibians and lizards, which provide further evidence that such macroecological patterns of variation in climatic niche breadths may be widespread. | Mengchao FANG Xiaming ZHU Yu DU Lin ZHANG Longhui LIN | 2019 | Asian Herpetological Research2019，10，1： | 0 |
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