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| 1 | Microstructure and mechanical properties of A356 alloy with yttrium addition processed by hot extrusion显示文摘The effects of the rare earth element yttrium(Y) and hot extrusion on the microstructure and mechanical properties of A356 alloy were investigated by mechanical properties testing and microstructure observation. The results indicate that the addition of Y improves the microstructure of the as-cast alloy. The distribution of primary α-Al is uniform and orderly. The long needle-like eutectic Si phases and β-Fe phases turn to strips and short rods. When the content of Y increases to 0.2 wt%, the mean diameter of aAl(40.3 μm) and the aspect ratio of the eutectic Si phase(2.3) reach the minimum values, which are68.9% and 86.1% lower, respectively, than that of the alloy without Y addition. Under extrusion stress, the shape of the eutectic Si phase is changed from long rod-like to near grain-like after solution treatment.The size of the eutectic Si phase is significantly reduced. The needle-like β-Fe phases are squeezed and broken. The mechanical properties of the as-extruded alloy are significantly improved compared to the as-cast alloy. When the rare earth content is 0.2 wt%, the ultimate tensile strength, hardness and elongation of the alloy reach the maximum values, which are 328.2 MPa, 110.4 HV and 21.3%, respectively, and increase by 42.01%, 37.71% and 481.91%, respectively, in comparison to the as-cast alloy without Y addition. | Zhifan Wei Yushun Lei Hong Yan Xihao Xu Jiajia He | 2019 | Journal of Rare Earths2019，37，6： | 11 |
| 2 | 乙肝病毒X蛋白对肝细胞生物钟基因的影响及其意义(英文)显示文摘Objective:The aim of this study was to investigate the influence of hepatitis B virus X protein (HBx) on the clock genes in LO2 cells and its significance.Methods:A cell line LO2-HBx,Stably transfected with HBx gene,was established.The levels of mRNA and protein expression of CLOCK and BMAL1 were detected by real-time PCR and western blot.Results:The expression of CLOCK mRNA and protein were increased in cell line LO2-HBx (P<0.05),while the expression of BMAL1 mRNA and protein were decreased in cell line LO2-HBx (P<0.05).Conclusion:The expressions of core clock gene CLOCK and BMAL1 have been changed by HBx,which breaks down the previous circadian rhythm of liver cells.This maybe one of the reasons leads to the formation of liver cancer. | Shengli Yang Xiaoli Pan Zhifan Xiong Bo Wei Hongyi Yao | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 6 |
| 3 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 4 | Total mesorectal excision with or without preoperative chemoradiotherapy for resectable mid/low rectal cancer: a long-term analysis of a prospective, single-center, randomized trial显示文摘Background:The preliminary results of our phase II randomized trial reported comparable functional sphincter pres-ervation rates and short-term survival outcomes between patients undergoing total mesorectal excision(TME)with or without preoperative concurrent chemoradiotherapy(CCRT).We now report the long-term results after a median follow-up of 71 months.Methods:Between March 23,2008 and August 2,2012,192 patients with T3-T4 or node-positive,resectable,mid/low rectal adenocarcinoma were randomly assigned to receive TME with or without preoperative CCRT.The following endpoints were assessed:cumulative rates of local recurrence and distant metastasis,disease-free survival(DFS),and overall survival(OS).Results:The data of 184 eligible patients were analyzed:94 patients in the TME group and 90 patients in the CCRT+TME group.In the whole cohort,the 5-year DFS and OS rates were 84.8%and 85.1%,respectively.The 5-year DFS rates were 85.2%in the CCRT+TME group and 84.3%in the TME group(P=0.969),and the 5-year OS rates were 83.5%in the CCRT+TME group and 86.5%in the TME group(P=0.719).The 5-year cumulative rates of local recur-rence were 6.3%and 5.0%(P=0.681),and the 5-year cumulative rates of distant metastasis were 15.0%and 15.7%(P=0.881)in the CCRT+TME and TME groups,respectively.No significant improvements in 5-year DFS and OS were observed with CCRT by subgroup analyses.Conclusions:Both treatment strategies yielded similar long-term outcomes.A selective policy towards preoperative CCRT is thus recommended for rectal cancer patients if high-quality TME surgery and enhanced chemotherapy can be performed. | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2018 | Cancer Communications2018，38，1： | 6 |
| 5 | Natural amber, copal resin and colophony investigated by UV-VIS, infrared and Raman spectrum显示文摘Natural amber, copal resin and colophony are have investigated by UV-VIS, infrared and Raman spectrum. In order to distinguish the natural amber, copal resin and colophony, we have successfully used the nondestructive examination (NDE) technology. The results show that UV-VIS could not distinguish these compositions. The infrared spectra can distinguish them, but the technology may destroy the specimen. The Raman spectra show three characteristic peaks of vibration near position 932 cm-1 and position 1179 cm-1 of copal resin, which confirm the existence of terpenes compounds in it. In the Raman spectra of colophony, the vibration characteristic peak at position 1589 cm-1 , caused by the conjugate double bond of internal unsaturated resin acid, is the basis of the characteristic difference between colophony and natural amber. The advantages of the distinguished technology by Raman spectroscopy are convenient and nondestructive examination for natural amber, copal resin and colophony. | RAO ZhiFan DONG Kun YANG XiaoYun LIN JinChang CUI XiaoYing ZHOU RongFeng DENG Qing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 4 |
| 6 | Exploring on the optimal preparation conditions of activated carbon produced from solid waste produced from sugar industry and Chinese medicine factory显示文摘The waste biomass produced from sugar industry and Chinese medicine factory such as bagasse,reed root residue,pueraria residue and liquorice residue were selected as the raw material for the preparation of activated carbon with zinc chloride as activator.With the same activation time,the influence of temperature and impregnation ratio on the preparation of activated carbon was investigated and the reasonable preparation conditions of activated carbon were monitored and analyzed.The obtained activated carbon samples were characterized by scanning electron microscopy,Brunauer-Emmett-Teller,methylene blue adsorption,thermogravimetric analysis and nitrogen adsorption-desorption.Analysis from the experimental data,bagasse,reed root residue,pueraria residue are suitable for preparing activated carbon.For bagasse,the optimum preparation condition was 700℃ and the impregnation ratio was 1:1,the adsorption capacity of methylene blue reached 246.83 mg/g at the moment.For reed root residue,the optimum preparation condition was 600℃ and the impregnation ratio was 1:2,the adsorption capacity of methylene blue reached 268.07 mg/g at the moment.For Pueraria residue,the optimum preparation condition was 700℃ and the impregnation ratio was 1:2.The adsorption capacity of methylene blue reached 297.33 mg/g at the moment. | Zhen Li Qiang Han ZhiFan Zong Qi Xu KaiWei Wang | 2020 | Waste Disposal and Sustainable Energy2020，2，1： | 3 |
| 7 | Early Report of the Source Characteristics,Ground Motions,and Casualty Estimates of the 2023 Mw 7.8 and 7.5 Turkey Earthquakes显示文摘INTRODUCTION,At 01:17 UTC(04:17 on local time)on Feb.6,2023,a devastating earthquake with a moment magnitude(Mw)7.8 occurred in the Gaziantep,southern Turkey.The earthquake was located at 37.174°N and 37.032°E,with a hypocentral depth of 17.9 km as reported by the United States Geological Survey(USGS). | Wenkai Chen Gang Rao Dengjie Kang Zhifan Wan Dun Wang | 2023 | Journal of Earth Science2023，34，2： | 3 |
| 8 | 中药逆转肝癌多药耐药的研究现状(英文)显示文摘Multi-drug resistance(MDR) is a major obstacle in the chemotherapy of hepatocellular carcinoma.Comparing with western reversal agents,traditional Chinese medicine have advantages of low cost,hypotoxicity,wide safety range,broad-spectrum and multi-targets,etc.Therefore,traditional Chinese medicine may be expected to open up a new path to reverse MDR of liver cancer.Studies about applying traditional Chinese medicine to reverse MDR in hepatocellular carcinoma are outlined below. | Shengli Yang Yunxia Wang Xiaoli Pan Zhifan Xiong | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，9： | 3 |
| 9 | SPH-BEM simulation of underwater explosion and bubble dynamics near rigid wall显示文摘A process of underwater explosion of a charge near a rigid wall includes three main stages: charge detonation, bubble pulsation and jet formation. A smoothed particle hydrodynamics(SPH) method has natural advantages in solving problems with large deformations and is suitable for simulation of processes of charge detonation and jet formation. On the other hand, a boundary element method(BEM) is highly efficient for modelling of the bubble pulsation process. In this paper, a hybrid algorithm, fully utilizing advantages of both SPH and BEM, was applied to simulate the entire process of free and near-field underwater explosions. First, a numerical model of the free-field underwater explosion was developed, and the entire explosion process–from the charge detonation to the jet formation–was analysed. Second, the obtained numerical results were compared with the original experimental data in order to verify the validity of the presented method. Third, a SPH model of underwater explosion for a column charge near a rigid wall was developed to simulate the detonation process. The results for propagation of a shock wave are in good accordance with the physical observations. After that, the SPH results were employed as initial conditions for the BEM to simulate the bubble pulsation. The obtained numerical results show that the bubble expanded at first and then shrunk due to a differences of pressure levels inside and outside it. Here, a good agreement between the numerical and experimental results for the shapes, the maximum radius and the movement of the bubble proved the effectiveness of the developed numerical model. Finally, the BEM results for a stage when an initial jet was formed were used as initial conditions for the SPH method to simulate the process of jet formation and its impact on the rigid wall. The numerical results agreed well with the experimental data, verifying the feasibility and suitability of the hybrid algorithm. Besides, the results show that, due to the effect of the Bjerknes force, a jet with a high speed was formed that may cause local damage to underwater structures. | ZHANG ZhiFan WANG Cheng ZHANG A-Man Silberschmidt Vadim V WANG LongKan | 2019 | Science China(Technological Sciences)2019，62，7： | 3 |
| 10 | 对可切除的中/低位直肠癌是/否进行术前放化疗的全直肠系膜切除术研究:一项前瞻性、单中心、随机试验的长期分析显示文摘背景与目的我们的Ⅱ期随机试验的初步研究结果显示,对进行全直肠系膜切除术(total mesorectal excision,TME)的患者是/否进行术前同步放化疗(concurrent chemoradiotherapy,CCRT),二者的功能性括约肌保留率和短期生存结局相近。在经过中位71个月的随访后,现报告这一长期试验的结果。方法在2008年3月23日至2012年8月2日期间,192例患有T3–T4或淋巴结阳性、可切除的中/低直肠腺癌患者被随机分为接受或不接受术前CCRT组,之后均进行TME。评估以下终点:局部复发和远处转移的累积率、无病生存(disease?free survival,DFS)和总生存(overall survival,OS)。结果对入组的184例患者资料进行分析,其中TME组有94例,CCRT+TME组有90例。在整个队列中,5年DFS和OS率分别为84.8%和85.1%。CCRT+TME组的5年DFS率为85.2%,TME组为84.3%(P=0.969);CCRT+TME组的5年OS率为83.5%,TME组为86.5%(P=0.719)。在CCRT+TME和TME组中,局部复发的5年累积率分别为6.3%和5.0%(P=0.681),远处转移的5年累积率分别为15.0%和15.7%(P=0.881)。通过亚组分析,接受CCRT未观察到5年DFS和OS的显著改善。结论两种治疗方案的长期结局相近。因此,如果可以进行高质量的TME手术和强化化疗,建议选择性地对直肠癌患者进行术前CCRT。 | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2019 | 癌症2019，38，5： | 2 |
| 11 | Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species显示文摘Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex II.Chlorpropamide delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and mice.In addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP channels.Increased levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated worms.Moreover,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity signal.This study provides mechanistic insight into the anti-aging effects of sulfonylureas in C.elegans. | Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 12 | Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons显示文摘 | Fang Qiu Ting-Ting Liu Zu-Wei Qu Chun-Yu Qiu Zhifan Yang Wang-Ping Hu | 2014 | European Journal of Pharmacology2014，，： | 2 |
| 13 | On the Cross-Correlation Distribution of d-Ary Generalized Legendre-Sidelnikov Sequences显示文摘The cross-correlation distribution of constant multiple sequences of the d-ary generalized LegendreSidelnikov sequences is investigated via character sums. An upper on the cross-correlation values of the sequences is then presented. As a byproduct, the autocorrelation distribution of d-ary Sidelnikov sequence is completely determined, which is only known in a special case. | KE Pinhui YE Zhifan ZHANG Shengyuan CHANG Zuling | 2018 | Chinese Journal of Electronics2018，27，2： | 2 |
| 14 | Tyrosine phosphatase Shp2 regulates pi 15RhoGEF/Rhodependent dendritic cell migration显示文摘The orchestrated migration of dendritic cells(DCs)to secondary lymphoid organs relies on C-C chemokine receptor type 7(CCR7)and its ligand C-C motif chemokine ligand 19(CCL19),and DC migration to lymph nodes is crucial for the initiation and progression of adaptive immune responses. | Yun Xu Yun Zhang Yanyan Yang Yanqi Liu Qiaoying Tian Pan Liu Zhifan Ding Hongqiang Cheng Xue Zhang Yuehai Ke | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 15 | siRNA epidermal growth factor receptor silencing in U251 glioma cells显示文摘BACKGROUND: Dicer, a large multidomain ribonuclease, is responsible for processing double-stranded RNAs (dsRNAs) to 20-bp-long small interfering RNAs (siRNAs), which act as effectors during RNA interference (RNAi). OBJECTIVE: To observe the efficacy of siRNA cocktails generated by recombinant human Dicer on the down-regulation of epidermal growth factor receptor (EGFR) expression in human glioma cells. DESIGN, TIME AND SETTING: The following in vitro experiment was performed at the Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin Neurological Institute. MATERIALS: Mini-RNA isolation kit, human placenta complimentary DNA (cDNA) was produced by Tiangen Biotech (Beijing, China), human glioblastoma U251-MG cells were produced by the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. METHODS: A PCR product from the human EGFR, which corresponded to the tyrosine kinase domain of the 3'-end fragment, was used as the T7-promotor for in vitro transcription. siRNA cocktails were generated by in vitro dicing of double stranded RNA. A total of 500, 250 and 125 μg siRNA cocktails were transiently transfected into U251 glioma cells through the use of the GeneSilencer. MAIN OUTCOME MEASURE: Expression of EGFR was detected by real-time PCR. RESULTS: The total PCR product of the human EGFR, corresponding to the tyrosine kinase domain, is approximately 680 bp in length. The PCR transcriptants included GCC leader sequences and a T7 promoter sequence, with a fragment of EGFR cDNA at the center. The T7 promoter was prepared for in vitro transcription of dsRNA. After dicing for 24 hours, the 21-nt siRNA cocktails were verified by 4% agarose gel. The difference between threshold cycle of a sample assay and threshold cycle of the corresponding endogenous reference (ΔCt) among parental U251 cells and cells transfected with different doses of siRNA cocktails were determined to be 3.06, 7.35, and 10.31 cycles, respectively. These results indicated effective silencing of EGFR expression by siRNA cocktails through transient transfection. CONCLUSION: The siRNA cocktails significantly suppressed exogenous expression of EGFR in U251 glioblastoma cells in a dose-dependent manner, thereby providing a more promising RNAi methodology for glioma therapy. | Chunsheng Kang Zhiyong Zhang Zhifan Jia Qiang Huang Guangxlu Wang Mingzhe Qiu Peiyu Pu | 2008 | Neural Regeneration Research2008，3，6： | 2 |
| 16 | Dynamic Backup Sharing Scheme of Service Function Chains in NFV显示文摘Service function chains(SFC)mapping takes the responsibility for managing virtual network functions(VNFs).In SFC mapping,existing solutions duplicate VNFs with redundant instances to provide high availability in response to failures.However,as a compromise,these solutions result in high resource consumption due to device maintenance.In this paper,we propose a novel method named dynamic backup sharing(DBS)that allows SFCs to dynamically share backups to reduce resource consumption.DBS formulates the problem of sharing backups among different VNFs as an integer linear programming(ILP).Thereafter,we design a novel online algorithm based on dynamic programming to solve the problem.The experimental results indicate that DBS outperforms state-ofthe-art works by reducing resource consumption and improving the number of accepted requests. | Dong Zhang Zhifan Zheng Xiang Lin Xiang Chen Chunming Wu | 2022 | China Communications2022，19，5： | 2 |
| 17 | Home Planting Techniques of Green and Healthy Rape Sprouts显示文摘With the continuous development of society and the continuous improvement of people s income levels,consumers demand for agricultural products has also changed.Rape sprouts as a new type of green and pollution-free health food meet people s needs.In this paper,we summarized a set of home cultivation techniques for green and healthy rape sprouts.The techniques are simple to operate and low in cost.Growers can notonly experience the fun of planting and but also taste green and healthy food. | Nian LIU Tianze TANG Yan ZHU Qixin FAN Daqing MENG Yingchun LI Zhifan LI Jun CHEN | 2021 | Agricultural Biotechnology2021，10，5： | 1 |
| 18 | MicroRNA-221 and -222 Regulate Radiation Sensitivity by Targeting the PTEN Pathway显示文摘 | Chunzhi Zhang Chunsheng Kang Ping Wang Yongzhen Cao Zhonghong Lv Shizhu Yu Guangxiu Wang Anling Zhang Zhifan Jia Lei Han Chunying Yang Hiromichi Ishiyama Bin S. Teh Bo Xu Peiyu Pu | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 1 |
| 19 | Squeezing bandwidth controllable twin beam light and phase sensitive nonlinear interferometer based on atomic ensembles显示文摘We review our recent experimental progress in quantum technology employing amplification effect of four-wave mixing in a rubidium vapor. We have produced an intensity difference squeezed light source at frequencies as low as 1.5 kHz which is so far the lowest frequency at which squeezing has been observed in an atomic system. Moreover, we find that the bandwidth of our squeezed light source can be controlled with light intensity pumping. Using our non-classical light source, we have further developed a nonlinear Mach-Zehnder (MZ) interferometer, for which the maximum fringe intensity depends quadratically on the intensity of the phase-sensing field at the high-gain regime, leading to much better sensitivity than a linear MZ interferometer in which the beam splitters have the same phase-sensing intensity. The quantum technologies developed by our group could have great potential in areas such as precision measurement and quantum information. | JING JieTai LIU CunJin ZHOU ZhiFan HUDELIST Florian YUAN ChunHua CHEN LiQing LI XiaoYun QIAN Jing ZHANG KeYe ZHOU Lu MA HongMei DONG GuangJiong OU ZeYu ZHANG WeiPing | 2012 | Chinese Science Bulletin2012，57，16： | 1 |
| 20 | Fiber-bragggrating-based seismic geophone for oil/gas prospecting显示文摘 | Zhang Yan Li Sanguo Yin Zhifan | | 0，，08： | 1 |
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