|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Nutritional Composition and Assessment of Gracilaria lemaneiformis Bory显示文摘化学作文,矿物质元素,维生素,免费的丰满的酸和氨基酸可食的红水藻 Gracilaria lemaneiformis Bory 满足,在 Nan'ao 岛附近的海成年,广东省,在现在的学习被分析。Gracilaria lemaneiformis Bory 显示出 14.65% 的一个全部的糖内容。蛋白质内容是 21% ,哪个约 41% 决心是必要氨基酸(EAA ) 。主要氨基酸部件是 glutamic 酸,白氨酸,精氨酸,和丙氨酸。EAA assayed,蛋氨酸和半胱氨酸看起来与食物和联合国的农业组织提供的 EAA 模式相比是大多数限制氨基酸。全部的类脂化合物内容是 0.87% 并且包括了不饱和的丰满的酸(61%) 的一篇高作文,主要当罂酸的酸和油的酸,和一些多元不堡和总计丰满的酸;十六酸酸是浸透的酸的主要部件(39%) 。维生素 C,碘,磷,和锌相对高级也是在 G 的现在。lemaneiformis。在 G 之间的营养的作文。lemaneiformis 和 Nostoc flagelliforme,广泛地在中国社会被吃的稀罕水藻,被比较。结果建议那 N。flagelliforme 能被用代替由 G。lemaneiformis,不是仅仅因为他们的类似的形状,而且因为他们的近似营养的作文。Gracilaria lemaneiformis 以后可以可能在人的食谱用作潜在的健康食物。 | Xue Wen Changlian Peng Houcheng Zhou Zhifang Lin Guizhu Lin Shaowei Chen Ping Li | 2006 | Journal of Integrative Plant Biology2006，48，9： | 13 |
| 3 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 4 | Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant显示文摘Fully synthetic vaccine, in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure, is a new direction to develop carbohydrate-based vaccine against cancer and pathogens. Toll like receptor(TLR) agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines. In particular, remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLR1/2, TLR2/6 and TLR4 and tumor-associated carbohydrate antigens(TACAs). These di-, tri-or multi-component vaccine candidates showed attractive immunological properties. This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines, with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing. | Zhifang Zhou Hart Lin Chen Li Zhimeng Wu | 2018 | Chinese Chemical Letters2018，29，1： | 6 |
| 5 | Phosphonate-Decorated Covalent Organic Frameworks for Actinide Extraction: A Breakthrough Under Highly Acidic Conditions显示文摘Although solid-phase extraction is a useful approach for metal ion separation from aqueous solutions,existing sorbents suffer from low extraction effici-encies and/or instability when in contact with strong acidic media.We report here the first study on rational design and fabrication of phosphonate-decorated covalent organic frameworks,COF-IHEP1 and COF-IHEP2,for efficient and selective extraction of of uranium(VI)[U(VI)]and plutonium(IV)[Pu(IV)]from highly acidic solutions. | Jipan Yu Liyong Yuan Shuai Wang Jianhui Lan Lirong Zheng Chao Xu Jing Chen Lin Wang Zhiwei Huang Wuqing Tao Zhirong Liu Zhifang Chai John K.Gibson Weiqun Shi | 2019 | CCS Chemistry2019，1，3： | 3 |
| 6 | Clinical study of transcatheter occlusion in treating ventricular septal defect combined with right coronary cusp bulge显示文摘Background: Perimembranous ventricular septal defect combined with right coronary cusp bulge generally should be treated with surgical thoracotomy, owing to the potential aortic regurgitation. However, the minimally invasive method of transcatheter closure has always attracted the attention of cardiologists and patients. The present study aimed to apply transcatheter occlusion in treating ventricular septal defect with right coronary cusp bulge and further evaluate the clinical effect through follow-up. Materials and methods: A total of 40 children diagnosed as having a ventricular septal defect with right coronary cusp bulge, examined using transthoracic echocardiography and cardiovascular angiography, were enrolled in this study. The ventricular septal defects were closed by placing occluders through transcatheter occlusion treatment. During the operation process, the children underwent angiography and transthoracic echocardiography examinations to check the position of the occlude and the extent of aortic regurgitation. The influence of occlusion on the conduction system was evaluated using a surface electrocardiogram. The children were followed up after their procedures. Results: All 40 patients were immediately and successfully occluded. Three patients with filament residual shunts were observed during the operations. No major surgical complications occurred during the perioperative period. During the follow-up period, the positions of all the occluders were good, the residual shunts in the three patients disappeared, and no new or aggravated aortic regurgitation occurred. Electrocardiogram did not reveal any atrioventricular blocks. Only one patient suffered from an incomplete right bundle branch block. Conclusions: Children diagnosed with ventricular septal defect combined with right coronary cusp bulge could be considered for transcatheter occlusion. With appropriate indications and methods, the effect may be favorable. | Wei Ji Zhifang Zhang Wenchuo Zhao Jie Shen Lijun Fu Lin Shi Yiwei Chen Fen Li | 2018 | Journal of Interventional Medicine2018，1，4： | 3 |
| 7 | Thermoelectric thin films:Promising strategies and related mechanism on boosting energy conversion performance显示文摘Thermoelectrics can be capable of direct and reversible conversion between heat and electricity.Low dimensional thermoelectric materials,especially two dimensional(2D)thin films,have been considered as a breakthrough to decouple the correlations between electronic and thermal transport,contributing to the optimization of thermoelectric performance.During the past few decades,some effective strategies combined with physical concepts like quantum confinement effect,energy filtering effect,band structure tuning and interface engineering are introduced to design high performance thermoelectrics.Having a thorough understanding the underlyingmechanisms is essential to develop thermoelectric materials.Here,our review summarizes the major strategies that can be utilized in thermoelectric thin films,including fabrication of superlattice structure,formation of two-dimensional electron gas(2DEG)system,orientation regulation,strain engineering and magnetic manipulation,from the aspects of deep mechanisms analyses,recent progress and prospects,inspiring significant improvement of thermoelectric properties. | Xuxuan Chen Zhifang Zhou Yuan-Hua Lin Cewen Nan | 2020 | Journal of Materiomics2020，6，3： | 3 |
| 8 | Electrochemical Lithium Storage Performance of Molten Salt Derived V_(2)SnC MAX Phase显示文摘MAX phases are gaining attention as precursors of two-dimensional MXenes that are intensively pursued in applications for electrochemical energy storage.Here,we report the preparation of V_(2)SnC MAX phase by the molten salt method.V_(2)SnC is investigated as a lithium storage anode,showing a high gravimetric capacity of 490 mAh g−1 and volumetric capacity of 570 mAh cm^(−3) as well as superior rate performance of 95 mAh g^(−1)(110 mAh cm^(−3))at 50 C,surpassing the ever-reported performance of MAX phase anodes.Sup-ported by operando X-ray diffraction and density functional theory,a charge storage mechanism with dual redox reaction is proposed with a Sn-Li(de)alloying reaction that occurs at the edge sites of V_(2)SnC particles where Sn atoms are exposed to the electrolyte followed by a redox reaction that occurs at V_(2)C layers with Li.This study offers promise of using MAX phases with M-site and A-site elements that are redox active as high-rate lithium storage materials. | Youbing Li Guoliang Ma Hui Shao Peng Xiao Jun Lu Jin Xu Jinrong Hou Ke Chen Xiao Zhang Mian Li Per OÅPersson Lars Hultman Per Eklund Shiyu Du Zhifang Chai Zhengren Huang Na Jin Jiwei Ma Ying Liu Zifeng Lin Qing Huang | 2021 | Nano-Micro Letters2021，13，10： | 2 |
| 9 | Morphology of the anterior mesorectum:a new predictor for local recurrence in patients with rectal cancer显示文摘Background:Pre-operative assessment with high-resolution magnetic resonance imaging(MRI)is useful for assessing the risk of local recurrence(LR)and survival in rectal cancer.However,few studies have explored the clinical importance of the morphology of the anterior mesorectum,especially in patients with anterior cancer.Hence,the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer.Methods:A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery.Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI:(1)linear type:the anterior mesorectum was thin and linear;and(2)triangular type:the anterior mesorectum was thick and had a unique triangular shape.Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology.Results:Morphometric analysis showed that 90(51.1%)patients had linear type anterior mesorectal morphology,while 86(48.9%)had triangular type anterior mesorectal morphology.Compared to triangular type anterior mesorectal morphology,linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI(35.6%[32/90]vs.16.3%[14/86],P=0.004)and a higher 5-year LR rate(12.2%vs.3.5%,P=0.030).In addition,the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR(odds ratio=4.283,P=0.014).Conclusions:The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum.The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection. | Xiaojie Wang Zhifang Zheng Min Chen Jing Lin Xingrong Lu Ying Huang Shenghui Huang Pan Chi | 2022 | Chinese Medical Journal2022，135，20： | 2 |
| 10 | Lattice Boltzmann method for simulating the viscous flow in larger distensible blood vessels 显示文摘 | Fang Haiping Wang Zhi Lin Zhifang | 2002 | Phys Rev E2002，65，05： | 1 |
| 11 | Expanding high reflection range in a dielectric multilayer reflector by disorder and inhomogeneity显示文摘 | Xu Jianjun Fang Haiping Lin Zhifang | 2001 | Journal of Physics D:Applied Physics2001，34，4： | 1 |
| 12 | Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer显示文摘Reversal of cancer drug resistance remains a critical challenge in chemotherapy.Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer.To overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung cancer.Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors.As a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice.This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance. | Lifo Ruan Jun Chen Chuanchao Du Huiru Lu Jiayu Zhang Xiaomeng Cai Rui Dou Wenchu Lin Zhifang Chai Guangjun Nie Yi Hu | 2022 | Bioactive Materials2022，7，7： | 1 |
| 13 | Theory of Optical Trapping by an Optical Vortex Beam 显示文摘 | JACK N LIN Zhifang CHAN Cheting | 2010 | Phys Rev Lett2010，104，10： | 1 |
| 14 | Optical Pulling Force显示文摘 | Chen Jun Jack Ng Lin Zhifang | 2011 | Nature Photon2011，5，： | 1 |
| 15 | TRAILS ON A REGULAR DIFFUSION-LIMITED AGGREGATION FRACTAL显示文摘By an exact renormalization method the trail problem on a regular fractal for the diffusion-limited aggregation is considered,and the mean square end-toend distance critical exponent v is obtained.It is indicated that self-avoiding trails and self-avoiding walks are in different universality classes on this irreversible kinetic growth fractal. | WANG Xiaomin ZHENG Dafang LIN Zhifang TAO Ruibao | 1990 | Chinese Physics Letters1990，7，5： | 1 |
| 16 | A pointer logic and certifying compiler显示文摘 | Yiyun Chen Lin Ge Baojian Hua Zhaopeng Li Cheng Liu Zhifang Wang | 2007 | Frontiers of Computer Science in China2007，，3： | 1 |
| 17 | Hierarchical and self-supporting honeycomb LaNi_5 alloy on nickel foam for overall water splitting in alkaline media显示文摘Ni-based metallic foams possessing large specific surfaces and open cell structures are of specific interest as catalysts or catalyst carriers for electrolysis of water.Traditional fabrication of Nickel foam limits the element modification choices to several inert transition metals only on polymer foam precursor and subsequent preparation of foam-based catalysts in aqueous solution or organic electrolyte.To expand the modification horizon,molten salt with wide electrochemical window and fast ion diffusion can achieve the reduction of highly active elements.Herein,we reported is a general and facile method to deposit directly of highly reactive element La and prepare hierarchical honeycomb LaNi_(5) alloy on Ni foam(ho-LaNi_(5)/NF).This self-supporting electrode presents excellent electrical coupling and conductivity between the Ni foam and LaNi_(5),which provides a 3D self-supported heterostructure with outstanding electrocatalytic activity and excellent durability for the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).It exhibits excellent overpotential(1.86 V)comparable to commercial coupled IrO_(2)//Pt/C(1.85 V)at a high current density of 100 m A cm^(-2).This work may pave the way for fabricating novel 3D self-supported honeycomb alloy that can be applied as electrode for usage of clean energy. | Yanze Wu Yalan Liu Kui Liu Lin Wang Lei Zhang Degao Wang Zhifang Chai Weiqun Shi | 2022 | Green Energy & Environment2022，7，4： | 1 |
| 18 | Preparation and spectroscopic characterization of Lu2O3:Eu^3+ nanopowders and ceramics 显示文摘 | WANG Zhifang ZHANG Weiping LIN Lin | 2008 | Opt Mater2008，30，1： | 1 |
| 19 | Refrigerant flow characteristics of electronic expansion valve based on thermodynamic analysis and experiment 显示文摘 | ZHIFANG X LIN S HONGFEI O | 2008 | Applied Thermal Engineering2008，28，23： | 1 |
| 20 | Lattice Boltzmann simulation on particle suspensions in a two-dimensional symmetric stenotic artery 显示文摘 | Li Huabing Fang Haiping Lin Zhifang | 2004 | Phys Rev2004，69，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员