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| 1 | Identification of the state-space model and payload mass parameter of a flexible space manipulator using a recursive subspace tracking method显示文摘The on-orbit parameter identification of a space structure can be used for the modification of a system dynamics model and controller coefficients. This study focuses on the estimation of a system state-space model for a two-link space manipulator in the procedure of capturing an unknown object, and a recursive tracking approach based on the recursive predictor-based subspace identification(RPBSID) algorithm is proposed to identify the manipulator payload mass parameter. Structural rigid motion and elastic vibration are separated, and the dynamics model of the space manipulator is linearized at an arbitrary working point(i.e., a certain manipulator configuration).The state-space model is determined by using the RPBSID algorithm and matrix transformation. In addition, utilizing the identified system state-space model, the manipulator payload mass parameter is estimated by extracting the corresponding block matrix. In numerical simulations, the presented parameter identification method is implemented and compared with the classical algebraic algorithm and the recursive least squares method for different payload masses and manipulator configurations. Numerical results illustrate that the system state-space model and payload mass parameter of the two-link flexible space manipulator are effectively identified by the recursive subspace tracking method. | Zhiyu NI Jinguo LIU Zhigang WU Xinhui SHEN | 2019 | Chinese Journal of Aeronautics2019，32，2： | 8 |
| 2 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 3 | FHY3 and FAR1 Integrate Light Signals with the miR156-SPL Module-Mediated Aging Pathway to Regulate Arabidopsis Flowering显示文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway). | Yurong Xie Qin Zhou Yongping Zhao Quanquan Li Yang Liu Mengdi Ma Baobao Wang Rongxin Shen Zhigang Zheng Haiyang Wang | 2020 | Molecular Plant2020，13，3： | 8 |
| 4 | Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation显示文摘Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals(NCs)to function as the fluorescent probes for early tumor diagnosis.However,the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications.To conquer this challenge,we herein introduce a nature inspired'stress-response'method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h.We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability,biocompatibility,and low cytotoxicity.Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis,and can highly anticipate the further in vivo biomedical applications that light up live cells. | Wentao Song Yiming Wang Bing Wang Yingfang Yao Wenguang Wang Jinhui Wu Qing Shen Wenjun Luo Zhigang Zou | 2020 | Nano Research2020，13，3： | 7 |
| 5 | Geochronology and geochemistry of Permo-Triassic sandstones in eastern Jilin Province(NE China): Implications for final closure of the Paleo-Asian Ocean显示文摘In the eastern part of the Central Asian Orogenic Belt(CAOB) in northeastern(NE) China, scattered outcrops of molasse deposits mark the ending of an orogeny and are crucial for understanding the evolution of the Paleo-Asian Ocean(PAO). However, the timing of tectonic events and the relationships among these strata remain controversial. To better constrain these geologic events, a comprehensive study of the detrital zircon U-Pb geochronology and geochemistry of the sandstones of the Kaishantun(KST) Formation and Kedao(KD) Group in eastern Jilin Province, NE China, was conducted. The KST Formation is traditionally considered a molasse deposit. The sandstones display low CIA, PIA and high ICV values and low Th/U and Rb/Sr ratios, which suggest that the rocks were derived from an immature intermediate-felsic igneous source and experienced a simple sedimentary recycling history with relatively weak chemical weathering. LA-ICP-MS U-Pb dating of detrital zircons from two samples of the KST Formation yields ages of 748-252 Ma, suggesting that the KST Formation was deposited between 254.5 Ma and 252 Ma in Late Permian. The zircons were mainly derived from the continental northern part of the North China Craton(NCC). In contrast, the U-Pb dating of detrital zircons from five samples of the KD Group yields ages of 2611-230 Ma, suggesting that the KD samples were deposited in the Early to Middle Triassic(ca. 248-233 Ma). The detrital zircon ages for the KD samples can be divided into groups with peaks at 2.5 Ga, 1.8 Ga, 800-1000 Ma, 500 Ma and 440-360 Ma, which suggest that the samples were derived from bidirectional provenances in the Jiamusi-Khanka Block and the NCC. These new data,combined with previously published results, suggest that at least three orogenic events occurred in central-eastern Jilin Province during the Early Permian(270-262 Ma), Early Triassic(254-248 Ma) and Middle-Late Triassic(242-227 Ma). The final closure of the PAO occurred during 242-227 Ma in the Middle-Late Triassic along the Changchun-Yanji suture zone. The detrital zircon geochronological data clearly record plate convergence and the scissor-like closure of the PAO in the eastern CAOB. | Qingxiang Du Zuozhen Han Xiaoli Shen Chao Han Zhigang Song Lihua Gao Mei Han Wenjian Zhong | 2019 | Geoscience Frontiers2019，10，2： | 6 |
| 6 | The alteration in the architecture of a T-DNA insertion rice mutant osmtd1 is caused by up-regulation of Micro RNA156f显示文摘Plant architecture is an important factor for crop production. Some members of micro RNA156(mi R156) and their target genes SQUAMOSA Promoter-Binding Protein-Like(SPL) were identi fi ed to play essential roles in the establishment of plant architecture. However, the roles and regulation of mi R156 is not well understood yet. Here, we identi fi ed a T-DNA insertion mutant Osmtd1(Oryza sativa multi-tillering and dwarf mutant). Osmtd1 produced more tillers and displayed short stature phenotype. We determined that the dramatic morphological changes were caused by a single T-DNA insertion in Osmtd1. Further analysis revealed that the T-DNA insertion was located in the gene Os08g34258 encoding a putative inhibitor I family protein. Os08g34258 was knocked out and Osmi R156 f was signi fi cantly upregulated in Osmtd1. Overexpression of Os08g34258 in Osmtd1 complemented the defects of the mutant architecture, while overexpression of Osmi R156 f in wild-type rice phenocopied Osmtd1. We showed that the expression of Os SPL3, Os SPL12,and Os SPL14 were signi fi cantly downregulated in Osmtd1 or Osmi R156 f overexpressed lines, indicating that Os SPL3,Os SPL12, and Os SPL14 were possibly direct target genes of Osmi R156 f. Our results suggested that Osmi R156 f controlledplant architecture by mediating plant stature and tiller outgrowth and may be regulated by an unknown protease inhibitor I family protein. | Qing Liu Gezhi Shen Keqin Peng Zhigang Huang Jianhua Tong Mohammed Humayun Kabir Jianhui Wang Jingzhe Zhang Genji Qin Langtao Xiao | 2015 | Journal of Integrative Plant Biology2015，57，10： | 5 |
| 7 | Parthenolide inhibits LPS-induced inflammatory cytokines through the toll-like receptor 4 signal pathway in THP-1 cells显示文摘Parthenolide (PTL ) 显示出反煽动性的有势力和反癌症活动。在现在的学习, PTL 的活动的分子的机制在导致的 lipopolysaccharide (LPS ) 被探索人的白血病 monocytic THP-1 房间和人的主要单核白血球。3-(4,5-dimethylthiazol-2-yl )-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 盐(山) 试金被用来在 THP-1 房间生存能力上分析 PTL 的效果。连接酶的 immunosorbent 试金被用来在导致 LPS 的煽动性的 cytokine 分泌物上决定 PTL 的效果。流动 cytometry 和量的即时聚合酶链反应被用来在导致 LPS 的像使用费的受体上估计 PTL 的效果 4 (TLR4 ) 表示。表明分子的 Phosphorylation 层次被西方的污点分析决定。结果显示出那 PTL < 12.5 M 显著地没影响 THP-1 房间生存能力。LPS 治疗导致了 interleukin (IL ) 的一条显著起来规定 -6, IL-1, IL-8, IL-12p40,肿瘤坏死因素 -- , IL-18,并且没有在里面 THP-1 房间。然而, PTL 以一种剂量依赖者方式禁止了这些 cytokines 的表示,与 1.0912.620 M 的 IC 50 价值。PTL 与由流动 cytometry 分析决定了的 1.373 M 的 IC 50 值堵住了 TLR4 表示,并且这堵住的效果在蛋白质和 mRNA 层次被验证。另外的分子的表情的细胞外的调整信号的 kinase 1/2 ,6月N终端 kinase , p38 ,原子因素 B ( NF-B ) p65 ,和 IB 和起来规定的 phosphorylation 层次的起来规定(可诱导的氮的氧化物 synthase , TLR4 ,并且 TNF 联系受体的因素 6 )由 LPS 导致了被 PTL 以一种剂量依赖者方式废除。PTL 的反煽动性的机制通过表明小径的调停 TLR4 的激活 mitogen 的蛋白质 kinase 和 NF-B 部分操作。因此, TLR4 可以是为反发炎治疗的一个新目标。 | Shuangshuang Li Xiangli Gao Xiaoxin Wu Zhigang Wu Linfang Cheng Lifen Zhu Dan Shen Xiangmin Tong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 5 |
| 8 | SURFACE METALLIZATION OF CENOSPHERES AND PRECIPITATORS BY ELECTROLESS PLATING显示文摘This paper reports the use of a colloidal Pd0 catalysis system to metallize the surface of precipitators separated from coal fly-ash, and metals such as Cu, Ni etc. are deposited on the precipitators surface. Alternatively, according to the characteristic surface of cenospheres, an Ag coating catalysis system is adopted to first deposit Ag on the cenospheres surface, followed, if necessary, by the deposition of other metals such as Cu, Ni, etc. on the Ag coating to produce monolayer and multilayer metal-coated cenospheres. The surface characteristics and the morphologies of the metal coatings are examined in detail with scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS) techniques. It can be shown that the quality of metal coatings derived from the Ag coating catalysis system, is better than that of the colloidal Pd0 catalysis system. | Chujiang Cai, Zhigang Shen*, Mingzhu Wang, Shulin Ma and Yushan Xing Beijing Key Laboratory for Powder Technology Research and Development, Beijing University of Aeronautics and Astronautics, Beijing 100083, P. R. China | 2003 | China Particuology2003，1，4： | 5 |
| 9 | Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor显示文摘 | SHEN Xizhou HE Huajun YANG Bowen ZHAO Zhigang SHAO Kaiyuan HU Wenxiang | 2017 | Chemical Research in Chinese Universities2017，33，5： | 5 |
| 10 | Atorvastatin protects cardiomyocytes from oxidative stress by inhibiting LOX-1 expression and cardiomyocyte apoptosis显示文摘冠的动脉疾病(CAD ) 是世界范围的一个主要健康问题。CAD 的最严重的形式是急性冠的症候群(交流) 。最近的研究在交流表明了 atorvastatin 的有益的角色;然而,位于这效果下面的机制充分没被澄清。成长证据显示氧化低密度的脂蛋白 receptor-1 (LOX-1 ) 玩的象 lectin 一样的那激活在氧化导致压力的 cardiomyocyte apoptosis 的一个重要角色在交流期间。在这研究,我们检验了 atorvastatin 是否禁止 H 2 O 2-induced LOX-1 表示和 H9c2 cardiomyocyte apoptosis,并且调查了内在的发信号小径。有 H 2 O 2 导致了 LOX-1 mRNA 和蛋白质的提高的表示,以及增加了 caspase-3 和 -9 蛋白质表示和房间 apoptosis。H 2 O 2-induced LOX-1 表示, caspase 蛋白质表示,和 cardiomyocyte apoptosis 被预告的处理与 atorvastatin 稀释。Atorvastatin 激活 H 2 以一种集中依赖者方式的 Akt 的 O 2-inhibited phosphorylation。Akt 禁止者, LY294002,在导致 Akt phosphorylation 上并且在压制 H 2 O 2-mediated caspase 起来规定和房间 apoptosis。这些调查结果显示 atorvastatin 经由 LOX-1 的抑制保护 cardiomyocyte 免受氧化应力的伤害表示和 apoptosis,和 H 2 Akt 的 O 2-inhibited phosphorylation 可以在 atorvastatin 的保护的功能起一个重要作用。 | Lei Zhang Linfang Cheng Qiqi Wang Dongchen Zhou Zhigang Wu Ling Shen Li Zhang Jianhua Zhu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 4 |
| 11 | Coating metals on micropowders by magnetron sputtering显示文摘Magnetron sputtering was used to coat various metals on micropowder surfaces. By using this method, the fine particles are better dispersed and can therefore be coated more homogeneously. The micro-powders used include cenospheres from fly ash of coal-burning electric power plants (diameter 40-200 m and particle density 0.7 ± 0.1 g/cm3), as well as carborundum particles of different sizes. Aluminum, silver, copper, cobalt and nickel were used as the coating metals. Tests showed that the coated metal film was compact adhering tightly on the base powders, and the coated powders possess adequate flow properties. | Zheng Xu Xiaozheng Yu Zhigang Shen | 2007 | China Particuology2007，5，5： | 4 |
| 12 | New Evidence of Detrital Zircon Ages for the Final Closure Time of the Paleo-Asian Ocean in the Eastern Central Asian Orogenic Belt(NE China)显示文摘Objective The NE China is located in the eastern segment of the Central Asian Orogenic Belt(CAOB),which is a large accretionary orogen between the Siberian Craton and the North China Craton(NCC).Many researches have discussed about the evolution of the Paleo-Asian Ocean(PAO)in the eastern CAOB.However,the timing of | DU Qingxiang HAN Zuozhen SHEN Xiaoli HAN Chao SONG Zhigang GAO Lihua HAN Mei ZHONG Wenjian YAN Junlei | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 4 |
| 13 | Magnetic resonance imaging tracing of transplanted bone marrow mesenchymal stem cells in a rat model of cardiac arrest-induced global brain ischemia显示文摘<正>BACKGROUND:Numerous studies have shown that magnetic resonance imaging(MRI) can detect survival and migration of super paramagnetic iron oxide-labeled stem cells in models of focal cerebral infarction. OBJECTIVE:To observe distribution of bone marrow mesenchymal stem cells(BMSCs) in a rat model of global brain ischemia following cardiac arrest and resuscitation,and to investigate the feasibility of tracing iron oxide-labeled BMSCs using non-invasive MRI. DESIGN,TIME AND SETTING:The randomized,controlled,molecular imaging study was performed at the Linbaixin Medical Research Center,Second Affiliated Hospital,Sun Yat-sen University,and the Institute of Cardiopulmonary Cerebral Resuscitation,Sun Yat-sen University, China from October 2006 to February 2009. MATERIALS:A total of 40 clean,Sprague Dawley rats,aged 6 weeks and of either gender,were supplied by the Experimental Animal Center,Sun Yat-sen University,China,for isolation of BMSCs. Feridex(iron oxide),Gyroscan Inetra 1.5T MRI system,and cardiopulmonary resuscitation device were used in this study. METHODS:A total of 30 healthy,male Sprague Dawley rats,aged 6 months,were used to induce ventricular fibrillation using alternating current.After 8 minutes,the rats underwent 6-minute chest compression and mechanical ventilation,followed by electric defibrillation,to establish rat models of global brain ischemia due to cardiac arrest and resuscitation.A total of 24 successful models were randomly assigned to Feridex-labeled and non-labeled groups(n=12 for each group).At 2 hours after resuscitation,5×10~6 Feridex-labeled BMSCs,with protamine sulfate as a carrier,and 5×10~6 non-labeled BMSCs were respectively transplanted into both groups of rats through the right carotid artery(cells were harvested in 1 mL phosphate buffered saline). MAIN OUTCOME MEASURES:Feridex-labeled BMSCs were observed by Prussian blue staining and electron microscopy.Signal intensity,celluar viability,and proliferative capacity of BMSCs were measured using MRI,Trypan blue test,and MTT assay,respectively.Distribution of transplanted cells was observed in rats utilizing MRI and Prussian blue staining prior to and 1,3,7,and 14 days after transplantation. RESULTS:Prussian blue staining displayed many blue granules in the Feridex-labeled BMSCs. High density of iron granules was observed in the cytoplasm under electron microscopy.According to MRI results,and compared with the non-labeled group,the signal intensity was decreased in the Feridex-labeled group(P<0.05).The decrease was most significant in the 50μg/mL Feridex-labeled group(P<0.01).There were no significant differences in celluar viability and proliferation of BMSCs between the Feridex-labeled and non-labeled groups after 1 week(P>0.05). Low-signal lesions were detected in the rat hippocampus and temporal cortex at 3 days after transplantation.The low-signal lesions were still detectable at 14 days,and positively stained cells were observed in the hippocampus and temporal cortex using Prussian blue staining.There were no significant differences in signal intensity in the non-labeled group. CONCLUSION:BMSC transplantation traversed the blood-brain barrier and distributed into vulnerable zones in a rat model of cardiac arrest-induced global brain ischemia.MRI provided a non-invasive method to in vivo dynamically and spatially trace Feridex-labeled BMSCs after transplantation. | Yue Fu Xiangshao Fang Tong Wang Jiwen Wang Jun Jiang Zhigang Luo Xiaohui Duan Jun Shen Zitong Huang | 2009 | Neural Regeneration Research2009，4，9： | 4 |
| 14 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 15 | Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community显示文摘Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management. | Yue Li Dongyun Shen Wei Zhang Yimin Wang Hongmei Li Jie Geng Liying Yang Zhijun Xiao Yan Liu Zhigang Feng Linying Cao Yan Jin Lixia Shi | 2014 | Family Medicine and Community Health2014，2，2： | 4 |
| 16 | Multidimensional reconciliation protocol for continuous-variable quantum key agreement with polar coding显示文摘Continuous-variable quantum key distribution(CVQKD)[1-7]allows two remote parties(Alice and Bob)to share a secret key,even in the presence of an eavesdropper(Eve)with unlimited computational power[8-17].While,a highly efficient reconciliation protocol[18-21]is crucial in a | ShengMei Zhao ZhiGang Shen Hong Xiao Le Wang | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，9： | 3 |
| 17 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 18 | Cholera Caused by a New Clone of Serogroup O1 Vibrio cholerae-Beijing Municipality,China,June 2021显示文摘Several lineages have been identified in the population of serogroup O1 Vibrio cholerae(V.cholerae)(1-3).The strains,which were responsible for the ongoing seventh cholera pandemic,were in Lineage 2.Nearly all the V.cholerae strains in this lineage carried genes coding cholera toxin(ctxAB)(1-2).Lineage 3b consists of strains isolated from different continents and the vast majority of strains in this lineage lack the ctxAB genes. | Hanqiu Yan Bo Pang Xin Lu Zhiyong Gao Pan Lu Xin Zhang Mengyu Wang Lingyu Shen Wenxuan Zhao Jianhong Zhao Weili Liang Lei Jia Haijian Zhou Zhigang Cui Xiaoli Du Biao Kan Quanyi Wang | 2022 | China CDC weekly2022，4，2： | 3 |
| 19 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 20 | Efficient Synthesis of Functionalized Benzimidazoles and Perimidines: Ytterbium Chloride Catalyzed CmC Bond Cleavage显示文摘 | Cai, Lijian Ji, Xiaofeng Yao, Zhigang Xu, Fan Shen, Qi | 2011 | Chinese Journal of Chemistry2011，29，9： | 2 |
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