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| 1 | Far-field super-resolution imaging by nonlinearly excited evanescent waves显示文摘Abbe’s resolution limit,one of the best-known physical limitations,poses a great challenge for any wave system in imaging,wave transport,and dynamics.Originally formulated in linear optics,the Abbe limit can be broken using nonlinear optical interactions.We extend the Abbe theory into a nonlinear regime and experimentally demonstrate a far-field,label-free,and scan-free super-resolution imaging technique based on nonlinear four-wave mixing to retrieve near-field scattered evanescent waves,achieving a sub-wavelength resolution ofλ∕5.6.This method paves the way for numerous new applications in biomedical imaging,semiconductor metrology,and photolithography. | Zhihao Zhou Wei Liu Jiajing He Lei Chen Xin Luo Dongyi Shen Jianjun Cao Yaping Dan Xianfeng Chen Wenjie Wan | 2021 | Advanced Photonics2021，3，2： | 6 |
| 2 | Copper-catalyzed Meerwein carboarylation of alkenes with anilines to form 3-benzyl-3-alkyloxindole显示文摘A simple and direct route for double C–C bond formation by copper-catalyzed Meerwein carboarylation process has been developed. In the presence of Cu I(5 mol%), tert-butyl nitrite and anilines, a wide variety of N-arylacrylamides underwent tandem Meerwein arylation/C–H cyclization to produce pharmaceutically important 3-benzyl-3-alkyloxindole in moderate to good yield. | Shi Tang Dong Zhou Youlin Deng Zhihao Li You Yang Jianguang He Yingchun Wang | 2015 | Science China Chemistry2015，58，4： | 3 |
| 3 | Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp(Cyprinus carpio var. Jian)显示文摘The study was to explore the effect of the extracts of Angelica sinensis(EAs) on lipid oxidation in fish feeds compared with ethoxyquin(EQ) and the effect of dietary EAs on growth performance of carp(Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ethyl acetate extract(EAE), acetone extract, ethanol extract(EE) and aqueous extract(AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feed(P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation(P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ(P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp(mean weight: 12.10 ± 0.13 g) were in each replicate. The result indicated that dietary EAE improved the growth performance in carp(P < 0.05). The appropriate con centration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp. | Huatao Li Dandan Yang Zhihao Li Mingquan He Fengyi Li Jun Jiang Siyi Tang Peiyuan Peng Wenhao Du Yuting Ma Ying Liu | 2019 | Animal Nutrition2019，，1： | 2 |
| 4 | Engineering crystal phase of polytypic CuInS2 nanosheets for enhanced photocatalytic and photoelectrochemical performance显示文摘Crystal phase engineering on CulnS2(CIS)nanocrystals,especially polytypic structure,has become one of the research hotspots to design the advanced materials and devices for energy conversion and environment treatment.Here,the polytypic CIS nanosheets(NSs)including zincblende/wutzite and chalcopyrite/wurtzite types were first time achieved in a hot-injection system using oleic acid and liquid paraffin as the reaction media.As-obtained polytypic CIS NSs exhibit significantly enhanced light-absorption abillty and visible-light-driven photocatalytic performance originating from the rational hetero-crystalline interfaces and surface defect states,which efficiently inhibit the recombination of photo-generated carriers.Meanwhile,the polytypic CIS NSs were spin-coated onto the surface of fluorinated-tin oxide glass substrate and used as the photoelectrode,which shows an excellent photoelectrochemical(PEC)activity in aqueous solution.The present work not only provides a facile,rapid,low-cost,and environmental-friendly synthesis strategy to design the crystal phase and defect structure of ternary chalcogenides,but also demonstrates the relationships between the polytypic structure and photocatalytic/photoelectrochemical properties. | He Li Wenjiang Li Wei Li Minfang Chen Rony Snyders Carla Bittencourt Zhihao Yuan | 2020 | Nano Research2020，13，2： | 2 |
| 5 | An Inf-Sup Stabilized Finite Element Method by Multiscale Functions for the Stokes Equations显示文摘In the paper,an inf-sup stabilized finite element method by multiscale functions for the Stokes equations is discussed.The key idea is to use a PetrovGalerkin approach based on the enrichment of the standard polynomial space for the velocity component with multiscale functions.The inf-sup condition for P_(1)-P_(0)triangular element(or Q_(1)-P_(0)quadrilateral element)is established.The optimal error estimates of the stabilized finite element method for the Stokes equations are obtained. | Zhihao Ge Yinnian He Lingyu Song | 2009 | Advances in Applied Mathematics and Mechanics2009，1，2： | 1 |
| 6 | Extracting drug-drug interaction from the biomedical literature using a stacked generalization-based approach显示文摘 | He Linna Yang Zhihao Zhao Zhehuan | 2013 | Plos One2013，8，65： | 1 |
| 7 | Partial delamination of the organo-montmorillonite with surfactant containing hydroxyl groups in maleated poly(propylene carbonate)显示文摘 | Zhihao Zhang Qiang Shi Juan Peng Jianbin Song Qingyong Chen Junliang Yang Yumei Gong Ronghua Ji Xiaofeng He Joong-Hee Lee | 2006 | Polymer2006，，26： | 1 |
| 8 | Structure and mechanism of a group-I cobalt energy coupling factor transporter显示文摘联合精力的因素(ECF ) transporters 是最近在微生物识别的 ATP 有约束力的盒子 transporters 的一个大家庭。为从环境的微量元素举起负责, ECF transporters 是由膜底层绑定部件 EcfS 和由不可分的膜支架部件 EcfT 和二细胞质的 ATP 绑定 / 水解作用的部件 EcfA/A 组成的一个 ECF 模块组成的模块化的 transporters。ECF transporters 被分类进组我和 II。当前,组的分子的理解 -- 我 ECF transporters 很被限制,部分由于 transporter 的缺乏复杂结构的信息。这里,我们现在的结构和这个组的基于结构的分析 -- 我钴 ECF transporter CbiMNQO,谁的组成的子单元 CbiM/CbiN, CbiQ,和 CbiO 分别地对应于 group-II ECF transporters 的 EcfS, EcfT,和 EcfA 部件。通过不同 CbiMNQO 子单元的宪法和相关 ATPase 和 transporter 活动的决心,底层绑定子单元 CbiM 被发现刺激 CbiQOs 基础 ATPase 活动。CbiMQO 建筑群的结构在它的里面打开符合构造和 CbiO 的被决定在, -methyleneadenosine 第 5-triphosphate-bou 关上的符合构造。基于结构的分析揭示了在不同部件, CbiM 的 L1 循环的底层门函数,和 ATP 绑定和产品版本在 CbiMNQO transporter 建筑群以内导致的 CbiO 的 conformational 变化之间的相互作用。这些调查结果使我们能建议 CbiMNQO transporter,运输过程在要求旋转的一个工作模型或倒下 CbiQ 和 CbiM,和在联合 conformational 的 CbiN 力量功能在 CbiQ 和 CbiM 之间变化。 | Zhihao Bao Xiaofeng Qi Sen Hong Ke Xu Fangyuan He Minhua Zhang Jiugeng Chen Daiyin Chao Wei Zhao Dianfan Li Jiawei Wang Peng Zhang | 2017 | Cell Research2017，27，5： | 1 |
| 9 | Environmental im- pacts of heavy metals (Co, Cu, Pb, Zn) in surficial sediments of estuary in Daliao River and Yingkou Bay (Northeast Chi- na) : concentration level and chemical fraction 显示文摘 | WU Zhihao HE Mengchang LIN Chunye | 2012 | Environ- mental Earth Sciences2012，66，8： | 1 |
| 10 | Distribution and speciation of four heavy metals (Cd, Cr, Mn and Ni) in the surficial sediments from estuary in Daliao River and Yingkou Bay显示文摘 | WU Zhihao HE Mengchang LIN Chunye | 2011 | Environmental Earth Sciences2011，63，1： | 1 |
| 11 | PROTACs:great opportunities for academia and industry (an update from 2020 to 2021)显示文摘PROteolysis TArgeting Chimeras(PROTACs)technology is a new protein-degradation strategy that has emerged in recent years.It uses bifunctional small molecules to induce the ubiquitination and degradation of target proteins through the ubiquitin–proteasome system.PROTACs can not only be used as potential clinical treatments for diseases such as cancer,immune disorders,viral infections,and neurodegenerative diseases,but also provide unique chemical knockdown tools for biological research in a catalytic,reversible,and rapid manner.In 2019,our group published a review article“PROTACs:great opportunities for academia and industry”in the journal,summarizing the representative compounds of PROTACs reported before the end of 2019.In the past 2 years,the entire field of protein degradation has experienced rapid development,including not only a large increase in the number of research papers on protein-degradation technology but also a rapid increase in the number of small-molecule degraders that have entered the clinical and will enter the clinical stage.In addition to PROTAC and molecular glue technology,other new degradation technologies are also developing rapidly.In this article,we mainly summarize and review the representative PROTACs of related targets published in 2020–2021 to present to researchers the exciting developments in the field of protein degradation.The problems that need to be solved in this field will also be briefly introduced. | Ming He Chaoguo Cao Zhihao Ni Yongbo Liu Peilu Song Shuang Hao Yuna He Xiuyun Sun Yu Rao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 12 | Microstructured capacitive sensor with broad detection range and long-term stability for human activity detection显示文摘In recent years,flexible stress sensors capable of monitoring diverse body movements and physiological signals have been attracting great attention in the fields of healthcare systems,human–machine interfaces,and wearable electronics.Inspired by the structure of natural eggshell inner membrane(ESIM),we developed a pressure sensor based on MXene(Ti_(3)C_(2)T_(x))/Ag NWs(silver nanowires)composite electrodes and the micro-structured dielectric layer to meet the application requirements of wide detection range and long-term stability for the sensors.In the light of the nanoscale-microarray of the dielectric layer and the rough surface of electrode materials,this pressure sensor is expected to allow great and persistent deformation during the loading process.As a result,the device is characterized by an improved sensitivity,fast response(in the millisecond range),wide detection range(0–600 kPa),and long-term stability.The outstanding performance of the proposed sensor makes it possible to detect various human activities,such as speaking,air blowing,clenching,walking,finger/knee/elbow bending,and striking,demonstrating its good application prospects in wearable and flexible electronic devices. | Xin He Zhihao Liu Gengzhe Shen Xiang He Jionghong Liang Yu Zhong Tianlong Liang Jie He Yue Xin Chi Zhang Dongdong Ye Guofa Cai | 2021 | npj Flexible Electronics2021，5，1： | 1 |
| 13 | Diffusion effect and stability analysis of a predator-prey system described by a delayed reaction-diffusion equations显示文摘 | He Yinnian | 2008 | J Math Anal Appl2008，339，2： | 1 |
| 14 | Biocatalytic synthesis of ethyl (S)-4-chloro-3-hydroxy butanoate in an aqueous-organic solvent biphasic system using Aureobasidium pullulans CGMCC 1244显示文摘 | He Junyao Sun Zhihao Ruan Wenquan | 2006 | Process Biochemistry2006，41，： | 1 |
| 15 | Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway显示文摘Primary hepatic carcinoma is a common malignant tumor.The classic molecular targeted drug sorafenib is costly and is only effective for some patients.Therefore,it is of great clinical significance to search for new molecular targeted drugs.Eupalinolide B(EB)from Eupatorium lindleyanum DC.is used to treat chronic tracheitis in clinical practice.However,the role of EB in hepatic carcinoma is unknown.In this study,we first measure the effect of EB on tumor growth in a xenograft model and PDX model.The cell proliferation and migration are also detected in human hepatocarcinoma cell lines(SMMC-7721 and HCCLM3).Then,we investigate cell cycle,cell apoptosis,cell necrosis,cell autophagy,and ferroptosis by flow cytometry,western blot analysis and electron microscopy.The results demonstrate that EB exerts anti-proliferative activity in hepatic carcinoma by blocking cell cycle arrest at S phase and inducing ferroptosis mediated by endoplasmic reticulum(ER)stress,as well as HO-1 activation.When HO-1 is inhibited,EB-induced cell death and ER protein expression are rescued.The migration-related mechanism consists of activation of the ROS-ER-JNK signaling pathway and is not connected to ferroptosis.In summary,we first discover that EB inhibits cell proliferation and migration in hepatic carcinoma,and thus EB is a promising anti-tumor compound that can be used for hepatic carcinoma. | Yonghui Zhang Haoyang Zhang Jinage Mu Meiyue Han Zhihao Cao Feng Dong Tingting Wang Lian Pan Wujing Luo Jiaxin Li Huan Liu Lishan Jin Wenxuan Ding Yong Wei Xuesong Deng Dan Liu Xiuzhen He Yi Pang Xiao Mu Zhongjun Wu Dilong Chen | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 16 | Thermal behavior of Mongolian low-rank coals during pyrolysis显示文摘Low temperature pyrolysis behavior of four low-rank coals from the biggest deposits of Mongolia were studied using a fixed-bed reactor and Gray-King retort.The coal samples and resultant chars were analyzed using Fourier transform infrared spectroscopy(FTIR),^(13)C nuclear magnetic resonance(^(13)C NMR)to explore the structure changes and thermogravimetric analyzer coupled with mass spectrometry(TG-MS)was used to investigate the pyrolysis reactivity of coal during thermal decomposition process.The results showed that the aliphatic structure in coal was significantly reduced and the carboxyl groups almost completely decomposed during pyrolysis process at 600℃.The tar yield of Gray-king test is higher than that obtained from the fixed-bed reactor.The gaseous evolution measured by TG-MS during pyrolysis showed that the maximum peaks of evolution of CH_(4),H_(2),C_(2)H_(2),C_(2)H_(5),CO,and CO_(2) gases were well corresponded to the maximum rate of weight loss in the range 428-445℃. | Ariunaa Alyeksandr Zongqing Bai Jin Bai Narangerel Janchig Purevsuren Barnasan Zhihao Feng Ranran Hou Chong He | 2021 | Carbon Resources Conversion2021，4，1： | 1 |
| 17 | Centrifuge modelling of ground-borne vibrations induced by railway traffic in underground tunnels显示文摘Increased attention has been given to ground-borne vibrations induced by railway vehicles and to the effects of these vibrations as they propagate through the ground into nearby buildings.Various studies,mainly based on numerical methods as well as physical modelling,have been carried out to investigate this problem.To study the dynamic response of tunnels and the surrounding soil due to train-induced vibration loads,a centrifuge test was conducted with a small-scale model in 1 g and 50 g stress field environments.An aluminum tube was embedded in sand to model the underground tunnel.A small parallel pre-stressed actuator(PPA)was employed to apply vibration loads on the tunnel invert.The model responses were measured using accelerometers.Both time and frequency domain analyzes were performed.The test results demonstrated that electronic noise had a clear impact on the test results and should be eliminated.It also found that the dynamic response of both the tunnel and soil were affected by the stress field.Therefore,it is important to account for the stress field effects when assessing the ground-borne vibration from tunnels. | Yang Wenbo Qian Zhihao Tu Jiulin Zhou Ziyang Yan Qixiang Fang Yong He Chuan | 2022 | Earthquake Engineering and Engineering Vibration2022，21，2： | 1 |
| 18 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 19 | A novel grey wolf optimizer and its applications in 5G frequency selection surface design显示文摘In fifth-generation wireless communication system(5G),more connections are built between metaheuristics and electromagnetic equipment design.In this paper,we propose a self-adaptive grey wolf optimizer(SAGWO)combined with a novel optimization model of a 5G frequency selection surface(FSS)based on FSS unit nodes.SAGWO includes three improvement strategies,improving the initial distribution,increasing the randomness,and enhancing the local search,to accelerate the convergence and effectively avoid local optima.In benchmark tests,the proposed optimizer performs better than the five other optimization algorithms:original grey wolf optimizer(GWO),genetic algorithm(GA),particle swarm optimizer(PSO),improved grey wolf optimizer(IGWO),and selective opposition based grey wolf optimization(SOGWO).Due to its global searchability,SAGWO is suitable for solving the optimization problem of a 5G FSS that has a large design space.The combination of SAGWO and the new FSS optimization model can automatically obtain the shape of the FSS unit with electromagnetic interference shielding capability at the center operating frequency.To verify the performance of the proposed method,a double-layer ring FSS is designed with the purpose of providing electromagnetic interference shielding features at28 GHz.The results show that the optimized FSS has better electromagnetic interference shielding at the center frequency and has higher angular stability.Finally,a sample of the optimized FSS is fabricated and tested. | Zhihao HE Gang JIN Yingjun WANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，9： | 0 |
| 20 | A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on Amniotic Fluid Metabolites显示文摘Background and purpose The prenatal diagnosis of cleft palate is an important component of sequential therapy,but the relevant diagnostic methods are still limited.We aimed here,to explore the possibility of an early prenatal diagnosis of cleft palate by assessing metabolites in pregnant mice.Methods Twenty-four inseminated females were randomly divided into retinoic acid(RA)-treated(treated with retinoic acid at 10.5 gestation days)and control groups.The metabolites of the embryonic palatal tissue,maternal amniotic fluid,and serum were characterized using 9.4T magnetic resonance spectroscopy in vitro.Then,a predictive model was established through the principal component analysis(PCA),and the correlations between the metabolites of amniotic fluid and palatal tissue were explored using orthogonal-2 partial least squares(O2-PLS).Results The incidences of cleft palate were 100%and 0%in the RA-treated and control groups,respectively.A predictive PCA model with a high specificity and sensitivity was established for the early prenatal diagnosis of isolated cleft palate using amniotic fluid metabolic data.Between RA-treated and control mice,we found that two metabolites in the amniotic fluid and palatal tissue were correlated.Creatinine showed the same trend in the palatal tissue and amniotic fluid,while choline showed opposite trends in the two tissues.However,the data for serum metabolites could not be used to establish a prediction model.Conclusion This study indicates that assessing the metabolites of amniotic fluid is a potential approach for the prenatal diagnosis of isolated cleft palate. | Wancong ZHANG Lewen JIANG Zhiwei SHEN Jiasheng CHEN Xiaoping ZHONG Weiping ZENG Jianda ZHOU Zhihao HE Shijie TANG | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，2： | 0 |
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