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| 1 | Effect of rGO Coating on Interconnected Co_3O_4 Nanosheets and Improved Supercapacitive Behavior of Co_3O_4/rGO/NF Architecture显示文摘In this study, the effect of reduced graphene oxide(rGO) on interconnected Co_3O_4 nanosheets and the improved supercapacitive behaviors is reported. By optimizing the experimental parameters, we achieved a specific capacitance of ~1016.4 F g^(-1) for the Co_3O_4/rGO/NF(nickel foam) system at a current density of 1 A g^(-1). However, the Co_3O_4/NF structure without rGO only delivers a specific capacitance of ~520.0 F g^(-1)at the same current density. The stability test demonstrates that Co_3O_4/rGO/NF retains ~95.5% of the initial capacitance value even after 3000 charge–discharge cycles at a high current density of 7 A g^(-1). Further investigation reveals that capacitance improvement for the Co_3O_4/rGO/NF structure is mainly because of a higher specific surface area(~87.8 m^2g^(-1))and a more optimal mesoporous size(4–15 nm) compared to the corresponding values of 67.1 m^2g^(-1) and 6–25 nm,respectively, for the Co_3O_4/NF structure. rGO and the thinner Co_3O_4 nanosheets benefit from the strain relaxation during the charge and discharge processes, improving the cycling stability of Co_3O_4/rGO/NF. | Tinghui Yao Xin Guo Shengchun Qin Fangyuan Xia Qun Li Yali Li Qiang Chen Junshuai Li Deyan He | 2017 | Nano-Micro Letters2017，9，4： | 8 |
| 2 | Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D显示文摘Phospholipase D(PLD)hydrolyzes the phosphodiester bond of glycerophospholipids and produces phosphatidic acid(PA),which acts as a second messenger in many living organisms.A large number of PLDs have been identified in eukaryotes,and are viewed as promising targets for drug design because these enzymes are known to be tightly regulated and to function in the pathophysiology of many human diseases.However,the underlying molecular mechanisms of catalysis and regulation of eukaryotic PLD remain elusive.Here,we determined the crystal structure of full-length plant PLDα1 in the apo state and in complex with PA.The structure shows that the N-terminal C2 domain hydrophobically interacts with the C-terminal catalytic domain that features two HKD motifs.Our analysis reveals the catalytic site,substrate-binding mechanism,and a new Ca2+-binding site that is required for the activation of PLD.In addition,we tested several efficient small-molecule inhibitors against PLDα1,and suggested a possible competitive inhibition mechanism according to structure-based docking analysis.This study explains many long-standing questions about PLDs and provides structural insights into PLD-targeted inhibitor/drug design. | Jianxu Li Fang Yu Hui Guo Renxue Xiong Wenjing Zhang Fangyuan He Minhua Zhang Peng Zhang | 2020 | Cell Research2020，30，1： | 3 |
| 3 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 4 | Bifunctional flexible electrochromic energy storage devices based on silver nanowire flexible transparent electrodes显示文摘Flexible electrochromic energy storage devices(FECESDs)for powering flexible electronics have attracted considerable attention.Silver nanowires(AgNWs)are one kind of the most promising flexible transparent electrodes(FTEs)materials for the emerging flexible devices.Currently,fabricating FECESD based on AgNWs FTEs is still hindered by their intrinsic poor electrochemical stability.To address this issue,a hybrid AgNWs/Co(OH)_(2)/PEDOT:PSS electrode is proposed.The PEDOT:PSS could not only improve the resistance against electrochemical corrosion of AgNWs,but also work as functional layer to realize the color-changing and energy storage properties.Moreover,the Co(OH)_(2)interlayer further improved the color-changing and energy storage performance.Based on the improvement,we assembled the symmetrical FECESDs.Under the same condition,the areal capacitance(0.8 mF cm^(−2))and coloration efficiency(269.80 cm^(2)C−1)of AgNWs/Co(OH)_(2)/PEDOT:PSS FECESDs were obviously higher than AgNWs/PEDOT:PSS FECESDs.Furthermore,the obtained FECESDs exhibited excellent stability against the mechanical deformation.The areal capacitance remained stable during 1000 times cyclic bending with a 25 mm curvature radius.These results demonstrated the broad application potential of the AgNWs/Co(OH)_(2)/PEDOT:PSS FECESD for the emerging portable and multifunctional electronics. | He Zhang Fangyuan Sun Ge Cao Dongyan Zhou Guofan Zhang Jiayun Feng Shang Wang Fengyu Su Yanqing Tian Yan Jun Liu Yanhong Tian | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 5 | InP-based directly modulated monolithic integrated few-mode transmitter显示文摘A monolithic integrated few-mode transmitter comprising of two directly modulated distributed feedback lasers and a multimode-interference-coupler-based mode converter-multiplexer with 66% mode conversion efficiency was designed and demonstrated. A fundamental TE0 mode and a first-order TE1 mode were successfully generated from the transmitter, with the output power of 4 and 5.5 mW at a pump current of around 150 mA, respectively,at the common output port. The small signal modulation bandwidth of the TE0 and TE1 channels reached 17.4 and 14.7 GHz, respectively. Error-free 2 × 10-Gbit∕s direct modulation of the two-mode transmitter was demonstrated, with a power penalty of 4.3 dB between the TE0 mode and the TE1 mode at the bit error rate of 1 × 10^(-9). | ZHAOSONG LI DAN Lu YIMING HE FANGYUAN MENG XULIANG ZHOU JIAOQING PAN | 2018 | Photonics Research2018，6，5： | 1 |
| 6 | Structure and mechanism of a group-I cobalt energy coupling factor transporter显示文摘联合精力的因素(ECF ) transporters 是最近在微生物识别的 ATP 有约束力的盒子 transporters 的一个大家庭。为从环境的微量元素举起负责, ECF transporters 是由膜底层绑定部件 EcfS 和由不可分的膜支架部件 EcfT 和二细胞质的 ATP 绑定 / 水解作用的部件 EcfA/A 组成的一个 ECF 模块组成的模块化的 transporters。ECF transporters 被分类进组我和 II。当前,组的分子的理解 -- 我 ECF transporters 很被限制,部分由于 transporter 的缺乏复杂结构的信息。这里,我们现在的结构和这个组的基于结构的分析 -- 我钴 ECF transporter CbiMNQO,谁的组成的子单元 CbiM/CbiN, CbiQ,和 CbiO 分别地对应于 group-II ECF transporters 的 EcfS, EcfT,和 EcfA 部件。通过不同 CbiMNQO 子单元的宪法和相关 ATPase 和 transporter 活动的决心,底层绑定子单元 CbiM 被发现刺激 CbiQOs 基础 ATPase 活动。CbiMQO 建筑群的结构在它的里面打开符合构造和 CbiO 的被决定在, -methyleneadenosine 第 5-triphosphate-bou 关上的符合构造。基于结构的分析揭示了在不同部件, CbiM 的 L1 循环的底层门函数,和 ATP 绑定和产品版本在 CbiMNQO transporter 建筑群以内导致的 CbiO 的 conformational 变化之间的相互作用。这些调查结果使我们能建议 CbiMNQO transporter,运输过程在要求旋转的一个工作模型或倒下 CbiQ 和 CbiM,和在联合 conformational 的 CbiN 力量功能在 CbiQ 和 CbiM 之间变化。 | Zhihao Bao Xiaofeng Qi Sen Hong Ke Xu Fangyuan He Minhua Zhang Jiugeng Chen Daiyin Chao Wei Zhao Dianfan Li Jiawei Wang Peng Zhang | 2017 | Cell Research2017，27，5： | 1 |
| 7 | Anthraquinone Covalently Modified Carbon Nanotubes for Efficient and Steady Electrocatalytic H2O2 Generation显示文摘Anthraquinone(AQ)modified carbon materials could be endowed with significantly improved oxygen re-duction reaction(ORR)activity.However,the application of these materials in the generation of hydrogen peroxide(H2O2)has been rarely investigated.For this motivation,AQ covalently modified carbon nanotube(AQ-CNT)was pur-posely synthesized for H2O2 generation.It was found that the cumulative H2O2 concentration reached up to 187.18 mg(Lh)over AQ(40)-CNT catalyst,nearly 2.0 times higher than that over CNT,and being superior to those over most carbon materials reported.The enhanced activity stemmed from the improved mass transfer fficiency of oxygen and the enhanced electrocatalytic activity.Noteworthily,the AQ(40)-CNT material exhibited satisfactory stability for H2O2 generation,which was ascribed to the strong interaction force of C-N covalent bond.The present work could provide a vital idea for designing electrode material with simultancously improved activity and stability for H2O2 gencration. | YU Fangyuan WANG Kai WANG Chuan HE Xinxia LIAO Yang ZHAO Shilin MAO Hui LI Xiaoting MA Jun | 2020 | Chemical Research in Chinese Universities2020，36，6： | 1 |
| 8 | Lithium titanate hybridized with trace amount of graphene used as an anode for a high rate lithium ion battery显示文摘 | Hai-Yong Dong Yan-Bing He Baohua Li Chen Zhang Ming Liu Fangyuan Su Wei Lv Feiyu Kang Quan-Hong Yang | 2014 | Electrochimica Acta2014，，： | 1 |
| 9 | Quantifying Hypochlorous Acid Concentration in Environmental Water Using Smartphone Colorimetry显示文摘In this study,we developed an eff ective method to detect hypochlorite acid(HClO)by using methylene blue(MB)derivative(BPY1).BPY1 was selectively oxidized through HClO,and the solution color changed from colorless to blue.In the presence of HClO,the ultraviolet–visible(UV–vis)spectra and concentration of HClO had a linear relationship with a detection limit of 0.5μM.Furthermore,a test paper for HClO monitoring was successfully prepared using the BPY1 probe,and the observed detection limit by the naked eye was estimated at 5μM.Additionally,using the BPY1 probe,HClO could also be detected through smartphone colorimetry,and the method showed a good recovery ranging from 98.7 to 104.0%for HClO detection in an actual water sample.Especially for developing countries,such a low-cost and highly sensitive detection method provides a simple and practical method for monitoring HClO in water. | Shuai He Hui Dong Yuanqiang Hao Yintang Zhang Yanli Zhou Fangyuan Zhang Jie Li Yingying Jia Guoqing Xiao Maotian Xu | 2021 | Journal of Analysis and Testing2021，5，4： | 1 |
| 10 | Flexible and planar graphene conductive additives for lithium-ion batteries显示文摘 | Su Fangyuan You Conghui He Yanbing | 2010 | J Mater Chem2010，20，43： | 1 |
| 11 | Supplementing Qi and activating blood circulation method to treat vertebrobasilar dolichoectasia with posterior circulatory watershed infarction:a case report of two patients显示文摘Vertebrobasilar dolichoectasia(VBD),a rare posterior circulation vascular variant disease,is an important risk factor for many acute cerebrovascular diseases.An insufficient understanding of VBD often leads to misdiagnose.Two cases of VBD that were initially diagnosed as posterior circulation watershed infarction are reported here.Absence of common causes of stroke including hypoperfusion,blood system diseases,carotid and aortic dissection,and eosinophil elevation,the symptoms of the 2 patients met the diagnostic criteria of VBD.Both patients displayed symptoms that were in line with the Traditional Chinese Medicine(TCM)syndrome pattern of'Qi deficiency and blood stasis'.Accordingly,they were comprehensively treated with Supplementing Qi and activating blood circulation method.The clinical manifestations of the 2 patients were remarkably improved and no recurrence of watershed infarction was found in a 1-year follow-up.A detailed medical history and laboratory examination are capable of improving diagnostic accuracy of VBD.TCM treatment based on syndrome identification might be a promising candidate for VBD management. | LI He SU Wenquan LI Shanshan JI Hanrui CHENG Jiangyan CUI Fangyuan TANG Lu ZHOU Li GAO Ying DONG Xinglu | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
| 12 | 建立具有体内胚内和胚外发育潜能的多能干细胞显示文摘文章简介在已知的体外培养的干细胞类型当中,多能干细胞具有最高的发育潜能,能够形成构成成年个体的所有细胞类型。但是,多能干细胞很难在体内发育过程中形成胚外的胎盘组织。 | Yang Yang Bei Liu Jun Xu Jinlin Wang Jun Wu Cheng Shi Yaxing Xu Jiebin Dong Chengyan Wang Weifeng Lai Jialiang Zhu Liang Xiong Dicong Zhu Xiang Li Weifeng Yang Takayoshi Yamauchi Atsushi Sugawara Zhongwei Li Fangyuan Sun Xiangyun Li Chen Li Aibin He Yaqin Du Ting Wang Chaoran Zhao Haibo Li Xiaochun Chi Hongquan Zhang Yifang Liu Cheng Li Shuguang Duo Ming Yin 沈浣 Juan Carlos Izpisua Belmonte 邓宏魁 | 2018 | 科学新闻2018，0，4： | 0 |
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