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| 1 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 2 | Size-Dependent Reaction Mechanism ofλ-MnO_(2) Particles as Cathodes in Aqueous Zinc-Ion Batteries显示文摘Manganese dioxide(MnO_(2))with different crystal structures has been widely investigated as the cathode material for Zn-ion batteries,among which spinelλ-MnO_(2)is yet rarely reported because Zn-ion intercalation in spinel lattice is speculated to be limited by the narrow three-dimensional tunnels.In this work,we demonstrate that Zn-ion insertion in spinel lattice can be enhanced by reducing particle size and elucidate an intriguing electrochemical reaction mechanism dependent on particle size.Specifically,λ-MnO_(2)nanoparticles(NPs,~80 nm)deliver a high capacity of 250 mAh/g at 20 mA/g due to large surface area and solid-solution type phase transition pathway.Meanwhile,severe water-induced Mn dissolution leads to the poor cycling stability of NPs.In contrast,micron-sizedλ-MnO_(2)particles(MPs,~0.9μm)unexpectedly undergo an activation process with the capacity continuously increasing over the first 50 cycles,which can be attributed to the formation of amorphous MnOx nanosheets in the open interstitial space of the MP electrode.By adding MnSO_(4)to the electrolyte,Mn dissolution can be suppressed,leading to significant improvement in the cycling performance of NPs,with a capacity of 115 mAh/g retained at 1 A/g for over 500 cycles.This work pinpoints the distinctive impacts of the particle size on the reaction mechanism and cathode performance in aqueous Zn-ion batteries. | Zhichu Tang Wenxiang Chen Zhiheng Lyu Qian Chen | 2022 | Energy Material Advances2022，，1： | 1 |
| 3 | Shape-Controlled Synthesis of Copper Nanocrystals for Plasmonic,Biomedical,and Electrocatalytic Applications显示文摘CONSPECTUS:As a metal that can occur in nature in the elemental form,copper(Cu)has been used by humans since ca.8000 BC.With most properties matching those of Ag and Au,Cu has played a more significant role in commercial applications owing to its much higher(the 25th among all elements)abundance in Earth’s crust and thus more affordable price.In addition to its common use as a conductor of heat and electricity,it is a constituent of various metal alloys for hardware,coins,strain gauges,and thermocouples. | Zhiheng Lyu Yuxin Shang Younan Xia | 2022 | Accounts of Materials Research2022，3，11： | 0 |
| 4 | Performance analysis of frequency‑mixed PPP‑RTK using low‑cost GNSS chipset with different antenna configurations显示文摘Low-cost Global Navigation Satellite System(GNSS)devices offer a cost-effective alternative to traditional GNSS systems,making GNSS technology accessible to a wider range of applications.Nevertheless,low-cost GNSS devices often face the challenges in effectively capturing and tracking satellite signals,which leads to losing the observations at certain frequencies.Moreover,the observation peculiarities of low-cost devices are in contradistinction to those of traditional geodetic GNSS receivers.In this contribution,a low-cost PPP-RTK model that considers the unique characteristics of different types of measurements is developed and its performance is fully evaluated with u-blox F9P receivers equipped with three distinctive antenna configurations:vertical dipole,microstrip patch,and helix antennas.Several static and kinematic experiments in different scenarios are conducted to verify the effectiveness of the proposed method.The results indicate that the mixed-frequency PPP-RTK model outperforms the traditional dual-frequency one with higher positioning accuracy and fixing percentage.Among the three low-cost antennas tested,the vertical dipole antenna demonstrates the best performance under static conditions and shows a comparable performance as geodetic antennas with a positioning accuracy of 0.02 m,0.01 m and 0.07 m in the east,north,and up components,respectively.Under low-speed kinematic scenarios,the helix antenna outperforms the other two with a positioning accuracy of(0.07 m,0.07 m,0.34 m).Furthermore,the helix antenna is also proved to be the best choice for vehicle navigation with an ambiguity fixing rate of over 95%and a positioning accuracy of(0.13 m,0.14 m,0.36 m). | Xingxing Li Hailong Gou Xin Li Zhiheng Shen Hongbo Lyu Yuxuan Zhou Hao Wang Qian Zhang | 2023 | Satellite Navigation2023，4，3： | 0 |
| 5 | 中国桑科植物物种多样性格局及其主导因子显示文摘理解物种多样性大尺度格局及其驱动机制是生态学的核心议题之一。以往研究已提出了多种解释物种多样性格局的假说,其中包括水热动态假说、热带生态位保守假说、Janzen假说以及包含能量、水分、季节性和生境异质性的综合假说,但各假说对不同类别(如不同生活型、不同分布区大小的物种)植物物种多样性格局的相对贡献仍存在争议,这阻碍了我们理解驱动物种多样性格局形成的一般规律。本研究以桑科植物为对象,评估了以上假说对不同类别桑科植物物种多样性格局的相对影响。我们收集整理了中国164种桑科植物的物种分布图(空间分辨率50 km×50 km)及其生活型(即灌木、小乔木和大乔木)。在此基础上,估算了整个科、不同生活型以及不同分布区大小物种(广域种和狭域种)的物种多样性格局,分析了环境变量对物种多样性格局的影响,比较了不同假说对各类别桑科植物物种多样性格局的相对解释率。不同类别桑科植物的物种多样性格局高度一致,四川省、广州省和海南省的物种多样性较高,形成了该科物种多样性热点。气候季节性是桑科物种多样性格局的主导因素。在所有假说中,包含能量、水分、季节性和生境异质性的综合假说对不同生活型和不同分布区大小物种的多样性格局具有最高的解释率。需要指出的是,对除狭域种外的其他所有物种组的物种多样性格局来说,这些模型均具有较高的共享解释率,但较低的独立解释率(<5%)。这些结果说明,与其他物种组相比,狭域种物种多样性格局及其形成机制可能是不同的。本研究为保护桑科植物、特别是狭域桑科植物提供了理论依据。 | Hua-Feng Wang Xiaoting Xu Xia-Lan Cheng Yunpeng Liu Ao Luo Tong Lyu Wen-Long Wang Mir Muhammad Nizamani Zhiheng Wang | 2022 | Journal of Plant Ecology2022，15，6： | 0 |
| 6 | Global multifaceted biodiversity patterns,centers,and conservation needs in angiosperms显示文摘The Convention on Biological Diversity seeks to conserve at least 30%of global land and water areas by 2030,which is a challenge but also an opportunity to better preserve biodiversity,including flowering plants(angiosperms).Herein,we compiled a large database on distributions of over 300,000 angiosperm species and the key functional traits of 67,024 species.Using this database,we constructed biodiversity-environment models to predict global patterns of taxonomic,phylogenetic,and functional diversity in terrestrial angiosperms and provide a comprehensive mapping of the three diversity facets.We further evaluated the current protection status of the biodiversity centers of these diversity facets.Our results showed that geographical patterns of the three facets of plant diversity exhibited substantial spatial mismatches and nonoverlapping conservation priorities.Idiosyncratic centers of functional diversity,particularly of herbaceous species,were primarily distributed in temperate regions and under weaker protection compared with other biodiversity centers of taxonomic and phylogenetic facets.Our global assessment of multifaceted biodiversity patterns and centers highlights the insufficiency and unbalanced conservation among the three diversity facets and the two growth forms(woody vs.herbaceous),thus providing directions for guiding the future conservation of global plant diversity. | Ao Luo Yaoqi Li Nawal Shrestha Xiaoting Xu Xiangyan Su Yichao Li Tong Lyu Kilara Waris Zhiyao Tang Xiaojuan Liu Luxiang Lin Yongsheng Chen Kuiling Zu Wenqi Song Shijia Peng Niklaus E.Zimmermann Loïc Pellissier Zhiheng Wang | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
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