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| 1 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 2 | Dynamics Analysis of the Baiyun Sag in the Pearl River Mouth Basin,North of the South China Sea显示文摘摘要:Baiyun 下垂是在珍珠河嘴盆的斜坡上发展的深的。它水平地作为合成 graben 发生,并且由二亚 sags 对亚 sags 构成低高举。垂直地,沉积建筑学能被划分成三层,即底部,在中间的差错可锻的拉长层和顶上的 draping 层上的指责的层。sag 的主要 rifting 阶段应当被可锻的扩展描绘并且外壳变瘦。特殊变丑模式可能被归因于事实 Baiyun 下垂位于弱地区,使 sag 成为了一个强烈使变形的区域,由极大地变瘦的岩石圈和活跃 magmatism 描绘了的先存在的转移地区。在 Baiyun 下面的高度升起的披风下垂应该是为可锻的变丑负责的重要机制,它引起了上面的披风的部分融化。Upwelling 到上面的外壳和沉积的层,部分融化材料提供了 extensional 紧张并且引起了非指责的垂直沉淀。岩浆在 rifting 的第一个阶段以后在转移地区下面被收集,并且沿着趋势 NW 基础差错在对对 sag 和 upwelled 的 ENE 和 WSW 部分的扩展垂直的一个方向旁边地转了,在的地方趋势 WNW 砍差错在群发展了。指责的活动和 Baiyun 的沉积历史下垂可能被海洋山脉影响了在 24 妈和海地板在 16 妈附近传播的停止附近跳。 | SUN Zhen ZHONG Zhihong ZHOU Di PANG Xiong HUANG Chunju CHEN Changmin HE Min XU Hehua | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 13 |
| 3 | Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China显示文摘Crimean-Congo hemorrhagic fever(CCHF)caused by the CCHF virus(CCHFV)is a tick-borne natural focal disease with a mortality rate of approximately 50%.CCHFV is widely prevalent in Africa,southern Asia,the Middle East,and southeast Europe.CCHF outbreaks have been reported previously in Xinjiang province,China,especially in its southern region.Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks,rodents,and infected individuals from cities and counties in southern Xinjiang.Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype,based on complete sequences of the S segments of its negative-stranded RNA genome.The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang.Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses;these analyses indicated that the genotype of both strains was different from that of other Chinese strains.Furthermore,previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed.CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years,and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains.Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains. | Yanfang Zhang Shu Shen Yaohui Fang Jinliang Liu Zhengyuan Su Jinhao Liang Zhong Zhang Qiaoli Wu Cheng Wang Abulikemu Abudurexiti Zhihong Hu Yujiang Zhang Fei Deng | 2018 | Virologica Sinica2018，33，1： | 8 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | Engineering rock mechanics practices in the underground powerhouse at JinpingⅠhydropower station显示文摘Based on the analyses of data obtained from the underground powerhouse at Jinping Ⅰ hydropower station,a comprehensive review of engineering rock mechanics practice in the underground powerhouse is first conducted.The distribution of strata,lithology,and initial geo-stress,the excavation process and corresponding rock mass support measures,the deformation and failure characteristics of the surrounding rock mass,the stress characteristics of anchorage structures in the cavern complex,and numerical simulations of surrounding rock mass stability and anchor support performance are presented.The results indicate that the underground powerhouse of Jinping Ⅰ hydropower station is characterized by high to extremely high geo-stresses during rock excavation.Excessive surrounding rock mass deformation and high stress of anchorage structures,surrounding rock mass unloading damage,and local cracking failure of surrounding rock masses,etc.,are mainly caused by rock mass excavation.Deformations of surrounding rock masses and stresses in anchorage structures here are larger than those found elsewhere:20%of extensometers in the main powerhouse record more than 50 mm with the maximum at around 250 mm observed in the downstream sidewall of the transformer hall.There are about 25%of the anchor bolts having recorded stresses of more than 200 MPa.Jinping Ⅰ hydropower plant is the first to have an underground powerhouse construction conducted in host rocks under extremely high geo-stress conditions,with the ratio of rock mass strength to geo-stress of less than 2.0.The results can provide a reference to underground powerhouse construction in similar geological conditions. | Aiqing Wu Jimin Wang Zhong Zhou Shuling Huang Xiuli Ding Zhihong Dong Yuting Zhang | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 4 |
| 6 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 7 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 8 | Super broadband absorbing hierarchical CoFe alloy/porous carbon@carbon nanotubes nanocomposites derived from metal-organic frameworks显示文摘The exploitation of electromagnetic wave absorption(EMA) materials has attracted ever-increasing attention,not only because electromagnetic wave(EMW) originated from overuse of electronic products has threatened human' health seriously,but also because EMA materials can effectively protect radar stealth from being detected.However,it is still a challenge to obtain broadband and efficient EMA materials to satisfy practical applications.In this work,we developed a series of hierarchical CoFe alloy/porous carbon@carbon nanotubes(CoFe/PC@CNTs) nanocomposites through revising the proportion of Fe^(2+) in the metal-organic frameworks(MOFs)(CoFe-ZIF) precursor and one-step simple pyrolysis process.The cross deposition between CoFe alloy,carbon nanotubes(CNTs),and porous carbon(PC) formed a double conductive network,favoring for achieving excellent EMA property.Surprisingly,when the filler mass ratio is only 10 wt%,the optimized CoFe/PC@CNTs nanocomposites display the best EMA capability,whose minimum reflection loss(RL_(min)) value is-68.94 dB at 13.69 GHz and the effective absorption band(EAB,<-10 dB) reaches up 9.14 GHz with a matching thickness of 2.63 mm.In addition,the largest EAB can achieve up to 11 GHz(3.35-14.35 GHz) during all matching thicknesses.The splendid EMA performance benefits the favorable dielectric loss provided by the double conductive network,the good magnetic loss benefited from the evenly distributed CoFe alloy,the excellent impedance matching,rich transmission paths,and multiple polarization.Therefore,such EMA materials with super broadband absorbing provide desirable candidates for lightweight and high-efficient microwave absorbers. | Siyao Guo Yunfeng Bao Ying Li Hailong Guan Dongyi Lei Tiejun Zhao Baomin Zhong Zhihong Li | 2022 | Journal of Materials Science & Technology2022，，23： | 2 |
| 9 | Construction of homozygous diploid potato through maternal haploid induction显示文摘Reinventing the tetraploid potato into a seed-propagated,diploid,hybrid potato would significantly accelerate potato breeding.In this regard,the development of highly homozygous inbred lines is a prerequisite for breeding hybrid potatoes,but self-incompatibility and inbreeding depression present challenges for developing pure inbred lines.To resolve this impediment,we developed a doubled haploid(DH)technology,based on mutagenesis of the potato DOMAIN OF UNKNOWN FUNCTION 679 membrane protein(StDMP)gene.Here,we show that a deficiency in StDMP allows the generation of maternal haploids for generating diploid potato lines.An exercisable protocol,involving hybridization,fluorescent marker screening,molecular and flow cytometric identification,and doubling with colchicine generates nearly 100%homozygous diploid potato lines.This dmp-triggered haploid induction(HI)system greatly shortens the breeding process and offers a robust method for generating diploid potato inbred lines with high purity. | Jinzhe Zhang Jian Yin Jiayi Luo Die Tang Xijian Zhu Jie Wang Zhihong Liu Pei Wang Yu Zhong Chenxu Liu Canhui Li Shaojiang Chen Sanwen Huang | 2022 | aBIOTECH2022，3，3： | 2 |
| 10 | Sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells显示文摘Sericin from discarded silkworm cocoons of silk reeling has been used in different fields,such as cosmetology,skin care,nutrition,and oncology.The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose (25 mg/kg) streptozotocin.After intragastrical perfusion of sericin for 35 days,blood glucose levels significantly declined,and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased.However,the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats.These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells,and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells. | Chengjun Song Zhenjun Yang Meirong Zhong Zhihong Chen | 2013 | Neural Regeneration Research2013，8，6： | 2 |
| 11 | System Architecture and Key Technologies of Network Security Situation Awareness System YHSAS显示文摘Network Security Situation Awareness System YHSAS acquires,understands and displays the security factors which cause changes of network situation,and predicts the future development trend of these security factors.YHSAS is developed for national backbone network,large network operators,large enterprises and other large-scale network.This paper describes its architecture and key technologies:Network Security Oriented Total Factor Information Collection and High-Dimensional Vector Space Analysis,Knowledge Representation and Management of Super Large-Scale Network Security,Multi-Level,Multi-Granularity and Multi-Dimensional Network Security Index Construction Method,Multi-Mode and Multi-Granularity Network Security Situation Prediction Technology,and so on.The performance tests show that YHSAS has high real-time performance and accuracy in security situation analysis and trend prediction.The system meets the demands of analysis and prediction for large-scale network security situation. | Weihong Han Zhihong Tian Zizhong Huang Lin Zhong Yan Jia | 2019 | Computers, Materials & Continua2019，，4： | 1 |
| 12 | Effect of joining temperature on the microstructure and strength of tungsten/ferritic steel joints diffusion bonded with a nickel interlayer显示文摘 | Zhong Zhihong Jung Hunchea Hinoki Tatsuya | | 0，，13： | 1 |
| 13 | Microstructure and mechanical properties of diffusion bonded joints between tungsten and F82H steel using a titanium interlayer显示文摘 | Zhong Zhihong Hinoki Tatsuya Nozawa Takashi | | 0，，02： | 1 |
| 14 | Genome-wide expression profiles of seasonal bud dormancy at four critical stages in Japanese apricot显示文摘 | Wenjun Zhong Zhihong Gao Weibing Zhuang Ting Shi Zhen Zhang Zhaojun Ni | 2013 | Plant Molecular Biology2013，，3： | 1 |
| 15 | Pre-, Peri-, and Postoperative Oral Administration of Branched-Chain Amino Acids for Primary Liver Cancer Patients for Hepatic Resection: A Systematic Review显示文摘 | Jianyuan Meng Jianhong Zhong Hanguang Zhang Wenhe Zhong Zhihong Huang Yuanming Jin Jing Xu | 2014 | Nutrition and Cancer2014，，3： | 1 |
| 16 | Metabolic and proteostatic differences in quiescent and active neural stem cells显示文摘Adult neural stem cells are neurogenesis progenitor cells that play an important role in neurogenesis.Therefore,neural regeneration may be a promising target for treatment of many neurological illnesses.The regenerative capacity of adult neural stem cells can be chara cterized by two states:quiescent and active.Quiescent adult neural stem cells are more stable and guarantee the quantity and quality of the adult neural stem cell pool.Active adult neural stem cells are chara cterized by rapid proliferation and differentiation into neurons which allow for integration into neural circuits.This review focuses on diffe rences between quiescent and active adult neural stem cells in nutrition metabolism and protein homeostasis.Furthermore,we discuss the physiological significance and underlying advantages of these diffe rences.Due to the limited number of adult neural stem cells studies,we refe rred to studies of embryonic adult neural stem cells or non-mammalian adult neural stem cells to evaluate specific mechanisms. | Jiacheng Yu Gang Chen Hua Zhu Yi Zhong Zhenxing Yang Zhihong Jian Xiaoxing Xiong | 2024 | Neural Regeneration Research2024，19，1： | 1 |
| 17 | 3D analogue modeling of the South China Sea, a discussion on breakup pattern显示文摘 | Sun Zhen Zhong Zhihong Keep M | 2009 | Jour- nal of Asian Earth Seiences2009，34，4： | 1 |
| 18 | Microstructure and mechanical properties of diffusion bonded joints between tungsten and F82H steel using a titanium interlayer显示文摘 | Zhihong Zhong Tatsuya Hinoki Takashi Nozawa Yi-Hyun Park Akira Kohyama | 2009 | Journal of Alloys and Compounds2009，，2： | 1 |
| 19 | Effect of joining temperature on the microstructure and strength of tungsten/ferritic steel joints diffusion bonded with a nickel interlayer显示文摘 | Zhihong Zhong Hun-chea Jung Tatsuya Hinoki Akira Kohyama | 2010 | Journal of Materials Processing Tech2010，，13： | 1 |
| 20 | Effect of holding time on the microstructure and strength of tungsten/ferritic steel joints diffusion bonded with a nickel interlayer显示文摘 | Zhihong Zhong Tatsuya Hinoki Akira Kohyama | 2009 | Materials Science & Engineering A2009，，1： | 1 |
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