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| 1 | RAPD analysis of wild stock of penaeid shrimp (Penaeus chinensis )in Chinese coastal waters of the Huanghai Sea and coastal waters of the Bohai Sea显示文摘Genetic diversity of 32 individuals of P. chinensis in the Chinese coastal waters of the Huanghai and Bobal Seas was detected by RAPD technique. Twenty decamer primers of OPI were used for DNA amplification for each individual. The results showed that: Seventeen primers obtained reproducible fingerprints, and the bands were clear. Thirty--nine of 106 loci detected were polymorphic, amounting to 36. 8 %. Mean genetic distance was 0. 094 1 0. 020 6; 68 markers (63. 2 % of the total) showed stable homogeneity in all of the 32 individuals. | Liu Ping Kong Jie Shi Tuo Zhuang Zhimeng Deng Jingyao (l. Huanghai Sea Fisheries Research institute , Chinese Academy of Fishery Sciences, Qingdao 266071, China) | 2000 | Acta Oceanologica Sinica2000，19，1： | 18 |
| 2 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 3 | Porosity and mechanical properties of porous titanium fabricated by gelcasting显示文摘有为生物医学的应用程序的大尺寸和复杂形状的多孔的 Ti 协议被控制 gelcasting 参数和 sintering 条件从 40.5% ~ 53.8% 在孔范围制作。试验性的结果证明全部的孔和多孔的钛的开的孔与 34 vol.% 固体在 1100 点装载和 sintered 从 Ti 泥浆压缩 | LI Yan GUO Zhimeng HAO Junjie REN Shubin | 2008 | Rare Metals2008，27，3： | 15 |
| 4 | Microstructure and properties of ultrafine WC-10Co composites with chemically doped VC显示文摘Vanadium carbide is the most effective grain growth inhibitor for ultrafine WC-Co composites due to its high solubility and mobility in the cobalt phase at relatively low temperatures;however,there are still some debates over the best way to introduce it into the WC-Co formulation.In this paper,the differences between admixed and chemically doped grain growth inhibitors on the microstructural development and properties of an ultrafine WC-10Co composite are discussed.The densification rate of chemically doped samples is slower in the early stage of sintering and the WC grain sizes of the sintered alloys are finer than those of admixed samples,leading to the increase of hardness and transverse rupture strength of the sintered alloys.The effectiveness of the chemically doped inhibitor is attributed to the formation of vanadium rich layers on the surfaces of tungsten carbide powders during reduction and carbonization,which alters the surface and interface energies of WC grains,impedes the contact with each other of WC grains and contributes to the resistance to W diffusion across the layer during sintering,resulting in the inhibition of nanosized particle coalescence. | PANG Cholsong LUO Ji GUO Zhimeng | 2011 | Rare Metals2011，30，2： | 6 |
| 5 | Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant显示文摘Fully synthetic vaccine, in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure, is a new direction to develop carbohydrate-based vaccine against cancer and pathogens. Toll like receptor(TLR) agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines. In particular, remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLR1/2, TLR2/6 and TLR4 and tumor-associated carbohydrate antigens(TACAs). These di-, tri-or multi-component vaccine candidates showed attractive immunological properties. This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines, with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing. | Zhifang Zhou Hart Lin Chen Li Zhimeng Wu | 2018 | Chinese Chemical Letters2018，29，1： | 6 |
| 6 | Application of the gel casting process in iron powder metallurgy显示文摘The effects of various gel casting process parameters such as the dispersant and solid loading on the rheology of Fe slurries, molding, and sintering behaviors were studied. The relationship between solid loading and viscidity in the process of iron base powder metallurgy was researched to obtain better microstructure and properties. The results showed that the viscosity of Fe slurries is obviously reduced with the increase of the dispersant. The suitable parameters are as follows: the solid loading is 61% and sintering temperature is 1180℃. Iron parts with relatively high density and better properties were obtained by the gel casting process. | Chengchang Jia Weihua Liu Zhimeng Guo | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 5 |
| 7 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 8 | Synthesis of nanosized tungsten carbide from phenol formaldehyde resin coated precursors显示文摘Nanosized 钨碳化物从酚甲醛树脂(PF ) 被综合涂的钨先锋。这个过程有 nanosized 钨粒子是第一的三在步与 PF 涂,然后,先锋在 950 点被使渗碳# | LUO Ji GUO Zhimeng GAO Yuxi LIN Tao | 2008 | Rare Metals2008，27，2： | 4 |
| 9 | Synthesis of spherical Li_(1.167)Ni_(0.2)Co_(0.1)Mn_(0.533)O_2 as cathode material for lithium-ion battery via co-precipitation | Xiangqing Liu,Zhimeng Guo Advanced Material&Technology Institute,University of Science and Technology Beijing,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 4 |
| 10 | Magnetic properties of Nd_2Fe_(14)B/α-Fe nanocomposite magnets with yttrium addition显示文摘The phase evolution and magnetic properties of Nd9?xYxFe72Ti2Zr2B15 (x = 0,0.5,1,and 2) melt-spun nanocomposite ribbons were studied.It is found that Y addition not only enhances the formability of amorphous phase in the alloy,but also stabilizes the amorphous phase during the annealing treatment.The appropriate content of Y addition effectively enhances the remanence (Jr) of the annealed sample.The residual amorphous intergranular phase in the annealed sample optimizes the squareness of the loop,resulting in an larger maximum energy product (BH)max.The best magnetic properties,Jr = 0.78 T,Hci (coercivity) = 923.4 kA/m,and (BH)max = 98.5 kJ/m3,were obtained from the Nd8YFe72Ti2Zr2B15 ribbon spun at Vs = 4 m/s and annealed at 700°C for 10 min,which is composed of Nd2Fe14B,α-Fe,and amorphous phase. | CHEN Zhi'an SUI Yanli GUO Zhimeng | 2010 | Rare Metals2010，29，3： | 3 |
| 11 | SEMIPARAMETRIC ANALYSIS OF ISOTONIC ERRORS-IN-VARIABLES REGRESSION MODELS WITH RANDOMLY RIGHT CENSORED RESPONSE显示文摘This paper considers the estimation of a semiparametric isotonic regression model when the covariates are measured with additive errors and the response is randomly right censored by a censoring time.The authors show that the proposed estimator of the regression parameter is rootn consistent and asymptotically normal.The authors also show that the isotonic estimator of the functional component,at a fixed point,is cubic root-n consistent and converges in distribution to the slope at zero of the greatest convex minorant of the sum of a two-sided standard Brownian motion and the square of the time parameter.A simulation study is carried out to investigate the performance of the estimators proposed in this article. | SUN Zhimeng ZHANG Zhongzhan DU Jiang | 2013 | Journal of Systems Science & Complexity2013，26，3： | 3 |
| 12 | A Secure MAKAP for Wireless Communication显示文摘A mutual authentication and key establishment protocol proposed by Aydos et al, for wireless communication based on elliptic curve cryptography can provide authentication between the user and server and they agreement a session key in the end of it. Unfortunately, Mangipudi pointed out Aydos’ scheme was incurred the man-in-middle attack denial-of-service attack and impersonation based on man-in-middle attack. Then he proposed an improved scheme to overcome the above weakness. However, there is an attack which can forge the message required in the protocol and impersonation a valid user to the server. | LIU Zhimeng ZHAO Yanli FAN Hui | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 3 |
| 13 | Evaluation of reference genes for quantitative real-time PCR analysis of gene expression during early development processes of the tongue sole(Cynoglossus semilaevis)显示文摘Differential expression of genes is crucial to growth and development of fish.To select the appropriate genes for gene normalization during Cynoglossus semilaevis early developmental process,eight candidate reference genes(ACTB,B2 M,EF1 A,GADPH,RPL7,TUBA,UBCE and 18S) were tested for their adequacy by using quantitative real-time PCR.The results showed that the expression of all the examined genes exhibited tissue dependent variations in the mature C.semilaevis.EF1 A was listed as the most stable reference among the 14 tissues by Ref Finder.Furthermore,the recommended comprehensive ranking of the stability determined by Ref Finder showed that 18 S was the most stable gene during the early developmental stages(from oosphere to 90 days old) in this study.However,when divided the Ct value data of the above mentioned early developmental stages into two separate periods(embryo and post-hatching periods),TUBA and 18 S represented the most stable references of these two developmental periods,respectively.Consequently,the reference gene should be carefully and accurately chosen even for studies of the same species at various developmental processes.The relevant data may help in selecting appropriate reference genes for m RNA expression analysis,and is of great value in the studies of fish growth and development. | MA Qian ZHUANG Zhimeng FENG Wenrong LIU Shufang TANG Qisheng | 2015 | Acta Oceanologica Sinica2015，34，10： | 3 |
| 14 | Gelcasting of 316L stainless steel显示文摘A novel near-net process, gelcasting, was successfully used to prepare larger size 316L stainless steel parts with complex shape. In this study, the effects of process parameters on the viscosity of the slurry and the dry green strength were investigated. The results show that gas atomization (GA) powder is more suitable for gelcasting compared with water atomization (WA) powder. The maximum solid loading is 55vol% for ball-milled slurry with GA powders. And the optimum amounts of monomers (acrylamide (AM)+methylenebisacrylamide (MBAM); the mass ratio, 30:1) and initiator in the AM system are 1.8% (based on the weight of metal powder) and 0.8%-1.4% (based on the weight of monomers), respectively, at which, the maximum green strength obtained is 33.7 MPa. The mechanical properties of the sintered specimen are as follows: ultimate tensile strength, 493 MPa; yield strength, 162 MPa; and HRB, 72. | Yan Li Zhimeng Guo Junjie Hao | 2007 | Journal of University of Science and Technology Beijing2007，14，6： | 3 |
| 15 | Effects of osmotic stress on the expression profiling of aquaporin genes in the roughskin sculpin(Trachidermus fasciatus)显示文摘Aquaporins(AQPs)are a family of integral membrane proteins that have been shown to be important for osmoregulation in many vertebrates.To identify potential stress resistance-related aqp genes in salinity adaptation of the roughskin sculpin Trachidermus fasciatus,we investigated the time-course expression dynamics of seven aquaporin genes(aqp1,4,7,8,10,11 and 12)in three osmoregulatory tissues(kidney,gill and intestine)and one metabolic tissue(liver).The fish were subjected to two different acute osmotic treatments(seawater-tofreshwater transfer respectively achieved in 1 h and 24 h,namely,E-acute and acute group).The expression profiling of the seven aqp genes were performed using quantitative real-time PCR(qRT-PCR).At the time of all sampling time points(0 h,12 h,24 h and 48 h),no expression of aqp4 was found in the gill,liver and intestine;no expression of aqp7 was found in the gill and liver.Significant differences of aqp expression were determined in the four target tissues,and the mRNA levels were largely variable among gene members and tissues.Similar patterns of the time-course expression were detected in most of the aqp genes in T.fasciatus between the two acute groups,except that only one gene(aqp12)in the kidney and three genes(aqp7,aqp8 and aqp10)in the intestine revealed different expression patterns.These results suggest that the expression response of aqp genes was similar under osmotic changes with different rates. | Qian Ma Xinfu Liu Ang Li Shufang Liu Zhimeng Zhuang | 2020 | Acta Oceanologica Sinica2020，39，6： | 3 |
| 16 | Shaking Table Test Study on Dynamic Characteristics of Bridge Foundation Reinforcement on Slopes显示文摘With the fast development of bridge construction in mountainous and seismic areas,it is necessary to conduct related research. Based on the design of a shaking table model test,here are the following test results: the filtering effect exists in soil and is affected by the dynamic constraint conditions,the amplitude is strengthened around the natural frequency and weakened in other frequency bands in the Fourier spectrum. Since the acceleration scaling effect occurred on a sloped surface,the acceleration response decreases from the outside to the inside in soil. The dynamic response is relatively strong near the slip surface in bedrock due to the reflection of seismic waves. The failure mode of landslide is decided by the slope angle and slipping mass distribution, and the test shows the front row stabilizing piles should keep a proper distance from bridge foundation so that seismic resistance can be guaranteed for the bridge foundation. | Lei Da Qi Zhihui Jiang Guanlu Wang Zhimeng Li Anhong | 2017 | Earthquake Research in China2017，31，3： | 3 |
| 17 | Consolidation and properties of ultrafine binderless cemented carbide by spark plasma sintering显示文摘由于金属文件夹的缺席,无文件夹的 cemented 碳化物更高有穿,腐蚀,和氧化抵抗。有 200 nm 的一种平均粒子尺寸和活跃元素的小数量的 WC-0.3VC- 0.5Cr3C2 粉末被火花血浆 sintering 巩固。sintered 微观结构表明平均 WC 谷物尺寸是 0.24 m,它与起始的好粉末几乎一致。XRD 的结果证明那个 W2C 阶段被形成。极其细小的无文件夹的 cemented 碳化物的将近完全的 densification 被 sintering 在 1400 点完成 ? 鞌 ? | LIU Xiangqing LIN Tao Shao Huiping GUO Zhimeng LUO Ji HAO Junjie | 2008 | Rare Metals2008，27，3： | 2 |
| 18 | Expression profiles of sex-related genes in gonads of genetic male Takifugu rubripes after 17β-estradiol immersion显示文摘Estradiol treatment during early life stages of tiger puffer Takifugu rubripes induces feminization in genetic males.However,the ovaries in genetic males may revert to testes once estradiol treatment is halted.Therefore studies should investigate molecular mechanisms underlying ovary-to-testis recovery in genetic males after treatment.In the present study,tiger puffer were exposed to 10,and 100μg/L 17β-estradiol(E 2)from 15 to 100 days post-hatching(dph),then gonad phenotypes and expression profi les of six sex-related genes(cyp19a,foxl2,dmrt1,amh,sox9a,and sox9b)were characterized after the exposure.Results showed that both 10 and 100μg/L E2 induced ovarian development in genetic males at 100 dph.However,all ovaries induced by 10μg/L E2 first developed into intersexual gonads and subsequently reverted to testes after the exposure.As for treatment of 100μg/L E2,while the rest of the ovaries maintained morphological stability,percentages of intersexual gonads reached 38%-57%,and none were reverted to testes.Increased mRNA levels of cyp19a,foxl2 and sox9b and decreased mRNA levels of dmrt1,amh,and sox9a were observed during the ovarian development in genetic males.While contrary gene expression profiles were detected during ovary-to-testis transformation.The mRNA levels of all the six genes were increased during the development of intersexual gonads.These results indicated that up-regulation of dmrt1,amh and sox9a is associated with initial ovary-to-intersexual transformation,and suppression of foxl2,cyp19a and sox9b is essential for complete ovary-to-testis recovery in genetic males.This research will help to trace the molecular processes underlying gonadal transformation in teleosts. | HU Peng LIU Bin MA Qian LIU Shufang LIU Xinfu ZHUANG Zhimeng | 2019 | Journal of Oceanology and Limnology2019，37，3： | 2 |
| 19 | Genetic Variation Among White Croaker Populations显示文摘To investigate the genetic structures and differentiation of different wild populations of white croaker (Pennahia argen- tata), horizontal starch gel electrophoresis was performed on 133 individuals collected from five different locations in China and Japan. The eleven enzyme systems revealed 15 loci, of which eleven were polymorphic. The percentage of polymorphic loci of white croaker populations varied from 6.67% to 53.33%; the mean observed and expected heterozygosity ranged from 0.0033 to 0.0133 and 0.0032 to 0.0191, respectively. The expected heterozygosity revealed a low genetic variability for white croaker in comparison with other marine fishes. The genetic distances between populations ranged from 0.00005 to 0.00026. A weak differentiation was observed within each clade and between clades; and no significant differences in gene frequencies among populations were observed in white croaker. Among the five populations, three Chinese populations showed more genetic diversity than that in Japanese populations. | HAN Zhiqiang GAO Tianxiang ZHUANG Zhimeng TANG Qisheng | 2008 | Journal of Ocean University of China2008，7，1： | 2 |
| 20 | Densification and properties of ODS-iron based alloy显示文摘Y_2O_3 dispersion strengthened iron-based powders and oxide dispersion strengthened(ODS) alloys were prepared by hydrothermal synthesis and spark plasma sintering(SPS),respectively.The effects of Y_2O_3,vibratory milling treatment,and Ti element on the microstructure and mechanical properties of the materials were investigated by scanning electron microscope(SEM) and micro-electronic universal tester.The results show that the best mechanical properties are obtained with 1 wt.% Y_2O_3 addition.The size of agglomerated particles can be decreased to a certain degree by vibratory milling treatment.With the addition of Ti element,the tensile strength and hardness of the samples were improved. | Guo, Zhimeng Liu, Qing Yang, Weiwei Guo, Leichen | 2012 | Rare Metals2012，31，4： | 2 |
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