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| 1 | LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival显示文摘Objective: To elucidate the role and prognostic significance of lymphocyte activation-gene-3(LAG-3) in soft tissue sarcoma(STS).Methods: The expression of LAG-3 in patient and matched normal blood samples was analyzed by flow cytometry. The localization and prognostic values of LAG-3^+ cells in 163 STS patients were analyzed by immunohistochemistry. In addition, the expression of tumor-infiltrating CD3^+ T, CD4^+ T, and CD8^+ T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model.Results: Peripheral CD8^+ and CD4^+ T cells from STS patients expressed higher levels of LAG-3 than those from healthy donors.LAG-3 expression in STS was significantly associated with a poor clinical outcome(P = 0.038) and was correlated with high pathological grade(P < 0.001), advanced tumor stage(P = 0.016). Additionally, LAG-3 expression was highly correlated with CD8^+ T-cell infiltration(r = 0.7034, P < 0.001). LAG-3 was expressed in murine tumor-infiltrating lymphocytes, and its blockade decreased tumor growth and enhanced secretion of interferon-gamma by CD8^+ and CD4^+ T cells.Conclusions: LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS. | Yi Que Zhixin Fang Yuanxiang Guan Wei Xiao Bushu Xu Jingjing Zhao Huoying Chen Xinke Zhang Musheng Zeng Yao Liang Xing Zhang | 2019 | Cancer Biology & Medicine2019，16，2： | 9 |
| 2 | Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics显示文摘Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological malignancies.Here,we constructed a spatiotemporal transcriptome map of mouse fetal liver(FL)as a platform for hypothesis generation and subsequent experimental validation of novel regulatory mechanisms.Single-cell transcriptomics revealed three transcriptionally heterogeneous HSC/MPP subsets,among which a CD93-enriched subset exhibited enhanced stem cell properties.Moreover,by employing integrative analysis of single-cell and spatial transcriptomics,we identified novel HSC/MPP‘pocket-like’units(HSC PLUS),composed of niche cells(hepatoblasts,stromal cells,endothelial cells,and macrophages)and enriched with growth factors.Unexpectedly,macrophages showed an 11-fold enrichment in the HSC PLUS.Functionally,macrophage-HSC/MPP co-culture assay and candidate molecule testing,respectively,validated the supportive role of macrophages and growth factors(MDK,PTN,and IGFBP5)in HSC/MPP expansion.Finally,cross-species analysis and functional validation showed conserved cell-cell interactions and expansion mechanisms but divergent transcriptome signatures between mouse and human FL HSCs/MPPs.Taken together,these results provide an essential resource for understanding HSC/MPP development in FL,and novel insight into functional HSC/MPP expansion ex vivo. | Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu | 2022 | Cell Research2022，32，1： | 4 |
| 3 | Phonon scattering and exciton localization: molding exciton flux in two dimensional disorder energy landscape显示文摘Two dimensional excitonic devices are of great potential to overcome the dilemma of response time and integration in current generation of electron or/and photon based systems.The ultrashort diffusion length of exciton arising from ultrafast relaxation and low carrier mobility greatly discounts the performance of excitonic devices.Phonon scattering and exciton localization are crucial to understand the modulation of exciton flux in two dimensional disorder energy landscape,which still remain elusive.Here,we report an optimized scheme for exciton diffusion and relaxation dominated by phonon scattering and disorder potentials in WSe2 monolayers.The effective diffusion coefficient is enhanced by>200%at 280 K.The excitons tend to be localized by disorder potentials accompanied by the steadily weakening of phonon scattering when temperature drops to 260 K,and the onset of exciton localization brings forward as decreasing temperature.These findings identify that phonon scattering and disorder potentials are of great importance for long-range exciton diffusion and thermal management in exciton based systems,and lay a firm foundation for the development of functional excitonic devices. | Pengfei Qi Yang Luo Beibei Shi Wei Li Donglin Liu Liheng Zheng Zhixin Liu Yanglong Hou Zheyu Fang | 2021 | eLight2021，1，1： | 3 |
| 4 | ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation显示文摘Ischemic stroke is an acute and serious cerebral vascular disease,which greatly affects people’s health and brings huge economic burden to society.Microglia,as important innate immune components in central nervous system(CNS),are double-edged swords in the battle of nerve injury,considering their polarization between pro-inflammatory M1 or anti-inflammatory M2 phenotypes.High mobility group box 1(HMGB1)is one of the potent pro-inflammatory mediators that promotes the M1 polarization of microglia.18β-glycyrrhetinic acid(GA)is an effective intracellular inhibitor of HMGB1,but of poor water solubility and dose-dependent toxicity.To overcome the shortcomings of GA delivery and to improve the efficacy of cerebral ischemia therapy,herein,we designed reactive oxygen species(ROS)responsive polymer-drug conjugate nanoparticles(DGA)to manipulate microglia polarization by suppressing the translocation of nuclear HMGB1.DGA presented excellent therapeutic efficacy in stroke mice,as evidenced by the reduction of infarct volume,recovery of motor function,suppressed of M1 microglia activation and enhanced M2 activation,and induction of neurogenesis.Altogether,our work demonstrates a close association between HMGB1 and microglia polarization,suggesting potential strategies for coping with inflammatory microglia-related diseases. | Lulu Jin Zhixin Zhu Liangjie Hong Zhefeng Qian Fang Wang Zhengwei Mao | 2023 | Bioactive Materials2023，，1： | 3 |
| 5 | Effect of Cooling Water Flow Path on the Flow and Heat Transfer in a 660 MW Power Plant Condenser显示文摘The effect of the cooling water flow path on the flow and heat transfer in a double tube-pass condenser for a 660 MW power plant unit was numerically investigated based on a porous medium model. The results were used to analyze the streamline, velocity, air mass fraction and heat transfer coefficient distributions. The simulations indicate that the cooling water flow path is important in large condensers. For the original tube arrangement, the heat transfer with the lower-upper cooling water flow path is better than that with the upper-lower cooling water flow path. The reason is that the steam cannot flow into the internal of upper tube bundle and the air fractions are higher in the upper tube bundle with the upper-lower cooling water flow path. An improvement tube arrangement was developed for the upper-lower cooling water flow path which reduced the back pressure by 0.47 kPa compared to the original scheme. Thus, the results show that the tube arrangements should differ for different cooling water flow paths and the condenser heat transfer can be improved for the upper-lower cooling water flow path by modifying the tube arrangement. | ZHONG Dawen MENG Ji'an QIN Peng QIU Xiaolong JIANG Ping LI Zhixin YUAN Fang | 2019 | Journal of Thermal Science2019，28，2： | 3 |
| 6 | Recent Progress on Metal-Enhanced Photocatalysis:A Review on the Mechanism显示文摘Metal-enhanced photocatalysis has recently received increasing interest,mainly due to the ability of metal to directly or indirectly degrade pollutants.In this review,we briefly review the recent breakthroughs in metal-enhanced photocatalysis.We discussed the recent progress of surface plasmon resonance(SPR)effect and small size effect of metal nanoparticles on photocatalysis;in particular,we focus on elucidating the mechanism of energy transfer and hot electron injection/transfer effect of metal nanoparticles and clusters while as photocatalysts or as cophotocatalysts.Finally,we discuss the potential applications of metal-enhanced photocatalysis,and we also offer some perspectives for further investigations. | Ming Fang Xiaoli Tan Zhixin Liu Baowei Hu Xiangke Wang | 2021 | Research2021，，1： | 2 |
| 7 | 显示文摘 | Wang Fang Mori K Kang Zhixin | 2007 | Heteroatom Chemistry2007，18，1： | 1 |
| 8 | Moho depth inversion in the Tibetan Plateau from high-precision gravity data显示文摘The Tibetan Plateau(TP)is the youngest orogenic belt resulting from a continental collision on the Earth.It is a natural laboratory for studying continental dynamics,such as continental convergence,plate subduction,and plateau uplift.Investigating the deep structure of the TP has always been a popular issue in geological research.The Moho is the boundary between the crust and the mantle and therefore plays a crucial role in the Earth’s structure.Parameters such as depth and lateral variation,as well as the fine structure of the crust-mantle interface,reveal the lithospheric dynamics in the TP.Two methods are generally employed to study the Moho surface:seismic detection and gravity inversion.Seismic detection has the characteristic of high precision,but it is limited to a few cross-sectional lines and is quite costly.It is not suitable for and cannot be carried out over a large area of the TP.The Moho depth over a large area can be obtained through gravity inversion,but this method is affected by the nature of gravity data,and the accuracy of the inversion method is lower than that of seismic detection.In this work,a high-precision gravity field model was selected.The Parker-Oldenburg interface inversion method was used,within the constraints of seismic observations,and the Bott iteration method was introduced to enhance the inversion efficiency.The Moho depth in the TP was obtained with high precision,consistent with the seismic detection results.The research results showed that the shape of the Moho in the TP is complex and the variation range is large,reaching 60−80 km.In contrast with the adjacent area,a clear zone of sharp variation appears at the edge of the plateau.In the interior of the TP,the buried depth of the Moho is characterized by two depressions and two uplifts.To the south of the Yarlung Zangbo River,the Moho inclines to the north,and to the north,the Moho depresses downward,which was interpreted as the Indian plate subducting to the north below Tibet.The Moho depression on the north side of the Qiangtang block,reaching 72 km deep,may be a result of the southward subduction of the lithosphere.The Moho uplift of the Qiangtang block has the same strike as the Bangong−Nujiang suture zone,which may indicate that the area is compensated by a low-density and low-velocity mantle. | HuiYou He Jian Fang HePing Sun DongMei Guo ZhiXin Xue Jing Hou | 2023 | Earth and Planetary Physics2023，7，4： | 1 |
| 9 | The Determination of NIRDRS Characteristic Wavelength of Oil in Instant Noodles显示文摘 | Xiong Zhixin Fang Ruming Chen Bin | 1999 | Journal of Jiangsu University of Science and Technology1999，20，： | 1 |
| 10 | 显示文摘 | Liu Yinghui Kang Zhixin Fang Gang | 2010 | Journal of Functional Materials2010，41，11： | 1 |
| 11 | Effect of a Cr Underlayer on the Magnetic Properties of TbCo Amorphous Films with Perpendicular Anisotropy[J]显示文摘 | Huang Zhixin(黄致新),Li Zuoyi(李佐宜),Jin Fang(晋芳)et al | 2002 | Chin Phys Lett(物理快报)2002，，10： | 1 |
| 12 | Magnetic field effects on the polymerization of 6-N, N- dioctylamino- 1, 3, 5-triazine-2, 4-dithiol 显示文摘 | Fang Wang Kunio Mori Zhixin Kang Yoshiyuki Oishi | 2007 | Heteroatom Chemistry2007，18，： | 1 |
| 13 | A genome wide association study between copy number variation (CNV) and human height in Chinese population显示文摘Copy number variation (CNV) is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height (with borderline significant p value: 0.013, 0.011, 0.024, 0.049; respectively). However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number (more than 2 copies) at 8p23.3-23.2 was associated with lower height (normal copy number vs. gain of copy number: 161.2 cm vs. 153.7 cm, p = 0.011), which accounted for 0.9% of height variation. Loss of copy number (less than 2 copies) at 6p21.3 was associated with 0.8% lower height (loss of copy number vs. normal copy number: 154.5 cm vs. 161.1 cm, p = 0.013). Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Xi Li Lijun Tan Xiaogang Liu Shufeng Lei Tielin Yang Xiangding Chen Fang Zhang Yue Fang Yan Guo Liang Zhang Han Yan Feng Pan Zhixin Zhang Yumei Peng Qi Zhou Lina He Xuezhen Zhu Jing Cheng Lishu Zhang Yaozhong Liu Qing Tian Hongwen Deng | 2010 | Journal of Genetics and Genomics2010，37，12： | 1 |
| 14 | Application potential of a newly isolated indigenous aerobic denitrifier for nitrate and ammonium removal of eutrophic lake water显示文摘 | Guo Liyun Fang Fei Hu Zhixin | 2013 | Bioresource Technology2013，142，16： | 1 |
| 15 | 显示文摘 | Huang Zhixin Li Zuoyi Jin Fang | 2002 | Chin Phys Lett2002，19，10： | 1 |
| 16 | Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus显示文摘Gestational diabetes mellitus(GDM) is characterized by glycemia and insulin disorders.Bile acids(BAs) have emerged as vital signaling molecules in glucose metabolic regulation.BA change in GDM is still unclear,which exerts great significance to illustrate the change of BAs in GDM.GDM patients and normal pregnant women were enrolled during the oral glucose tolerance test(OGTT) screening period.Fasting serums were sampled for the measurement of BAs.BA metabolism profiles were analyzed in both pregnant women with GDM and those with normal glucose tolerance(NGT).Delivery characteristics,delivery gestational age,and infant birthweight were extracted from medical records.GDM patients presented distinctive features compared with NGT patients,including higher body mass index(BMI),elevated serum glucose concentration,raised insulin(both fasting and OGTT),and increased hemoglobin A1 c(HbA1c) levels.Higher homeostasis model assessment of insulin resistance(HOMA-IR) and decreased β-cell compensation(i.e.,oral disposition index(DIo)) were also prevalent in this group.Total BAs(TBAs) remained stable,but glycodeoxycholic acid(GDCA) and taurodeoxycholic acid(TDCA) levels declined significantly in GDM.GDCA was inversely correlated with HOMA-IR and positively correlated with DIo.No obvious differences in clinical outcome between the GDM and NGT groups were observed.However,GDM patients with high HOMA-IR and low DIo tended to have a higher cesarean delivery rate and younger delivery gestational age.In conclusion,GDCA provides a valuable biomarker to evaluate HOMA-IR and DIo, and decreased GDCA levels predict poorer clinical outcomes for GDM. | Bo ZHU Zhixin MA Yuning ZHU Lei FANG Hong ZHANG Hongwei KONG Dajing XIA | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 1 |
| 17 | Magnetic field effects on the polymerization of 6-N, N- dioetylamino-1,3,5-triazine-2,4-dithiol显示文摘 | Fang Wang Kunio Mori Zhixin Kang Yoshiyuki Oishi | 2007 | H eteroatom Chem2007，18，： | 1 |
| 18 | Fabrication of dodecagonal pyramid on nitrogen face GaN and its effect on the light extraction显示文摘Wet etching has been widely used in defect evaluation for Ga-face GaN and surface roughness for N-face GaN dodecagonal pyramids has been fabricated on laser-lift-off N-face GaN by hot phosphor acid etching.The dodecagonal pyramid shows twelve facets including six{20-2-3}and six{22-4-5}planes.From cross-sectional TEM image,it is shown that the pyramid corresponds to the top of the edge dislocation.Compared with hexagonal pyramid-surface light emitting diodes(LEDs)etched by commonly used photoelectrochemical(PEC)process in KOH aqueous,the dodecagonal pyramid-surface LEDs show improved light extraction efficiency because of more facets,which effectively reduces the total internal reflection. | QI ShengLi,CHEN ZhiZhong,SUN YongJian,FANG Hao,TAO YueBin,SANG LiWen,TIAN PengFei,DENG JunJing,ZHAO LuBing,YU TongJun,QIN ZhiXin&ZHANG GuoYi State Key Laboratory for Artificial Microstructure and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China | 2010 | Science China(Technological Sciences)2010，53，3： | 0 |
| 19 | Self-design of arbitrary polarization-control waveplates via deep neural networks显示文摘The manipulation of polarization states beyond the optical limit presents advantages in various applications.Considerable progress has been made in the design of meta-waveplates for on-demand polarization transformation,realized by numerical simulations and parameter sweep methodologies.However,due to the limited freedom in these classical strategies,particular challenges arise from the emerging requirement for multiplex optical devices and multidimensional manipulation of light,which urge for a large number of different nanostructures with great polarization control capability.Here,we demonstrate a set of self-designed arbitrary wave plates with a high polarization conversion efficiency.We combine Bayesian optimization and deep neural networks to design perfect halfand quarter-waveplates based on metallic nanostructures,which experimentally demonstrate excellent polarization control functionalities with the conversion ratios of 85%and 90%.More broadly,we develop a comprehensive wave plate database consisting of various metallic nanostructures with high polarization conversion efficiency,accompanying a flexible tuning of phase shifts(0-2π)and group delays(0-10 fs),and construct an achromatic metalens based on this database.Owing to the versatility and excellent performance,our self-designed wave plates can promote the performance of multiplexed broadband metasurfaces and find potential applications in compact optical devices and polarization division multiplexing optical communications. | ZHENGCHANG LIU ZHIBO DANG ZHIXIN LIU YU LI XIAO HE YUCHEN DAI YUXIANG CHEN PU PENG ZHEYU FANG | 2023 | Photonics Research2023，11，5： | 0 |
| 20 | Field distribution of the Z_(2)topological edge state revealed by cathodoluminescence nanoscopy显示文摘Photonic topological insulators with robust boundary states can enable great applications for optical communication and quantum emission,such as unidirectional waveguide and single-mode laser.However,because of the diffraction limit of light,the physical insight of topological resonance remains unexplored in detail,like the dark line that exists with the crys-talline symmetry-protected topological edge state.Here,we experimentally observe the dark line of the Z_(2)photonic topo-logical insulator in the visible range by photoluminescence and specify its location by cathodoluminescence characteriza-tion,and elucidate its mechanism with the p-d orbital electromagnetic field distribution which calculated by numerical sim-ulation.Our investigation provides a deeper understanding of Z_(2)topological edge states and may have great signific-ance to the design of future on-chip topological devices. | Xiao He Donglin Liu Hongfei Wang Liheng Zheng Bo Xu Biye Xie Meiling Jiang Zhixin Liu Jin Zhang Minghui Lu Zheyu Fang | 2022 | Opto-Electronic Advances2022，5，4： | 0 |
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