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| 1 | Reverse reconciliation for continuous variable quantum key distribution显示文摘An efficient and practical post-processing technique based on reverse reconciliation for continuous variable quantum key distribution is proposed and simulated with low-density parity check (LDPC) codes. MultiLevel Coding/ MultiStage Decoding, which fully utilizes optimization technique such as vector quantization and iterative decoding and the optimal channel coding most close to the Shannon limit, was used to realize efficient reverse reconciliation algorithm. Simulation results showed that the proposed method can improve the secure key distribution rate to 2.2 kb/s and the coding efficiency to 0.89 over 20 km in single-mode optical fiber. Moreover, there still is room for much improvement. | LU ZhiXin 1,2 , YU Li 1,2 , LI Kang 1,2 , LIU BingCan 1,2,3 , LIN JianGui 1,2 , JIAO RongZhen 1,2 & YANG BoJun 1,21 School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China 2 Key Laboratory of Information Photonics and Optical Communication, Ministry of Education, Beijing University of Posts and Telecommunications, Beijing 100876, China 3 Department of Fundamental Courses, Academy of Armored Force Engineering, Beijing 100072, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 12 |
| 2 | Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer显示文摘Genetically modified pigs are valuable models of human disease and donors of xenotransplanted organs.Conventional gene targeting in pig somatic cells is extremely inefficient.Zinc-finger nuclease(ZFN)technology has been shown to be a powerful tool for efficiently inducing mutations in the genome.However,ZFN-mediated targeting in pigs has rarely been achieved.Here,we used ZFNs to knock out the porcineα-1,3-galactosyl-transferase(GGTA1)gene,which generates Gal epitopes that trigger hyperacute immune rejection in pig-to-human transplantation.Primary pig fibroblasts were transfected with ZFNs targeting the coding region of GGTA1.Eighteen mono-allelic and four biallelic knockout cell clones were obtained after drug selection with efficiencies of 23.4%and 5.2%,respectively.The biallelic cells were used to produce cloned pigs via somatic cell nuclear transfer(SCNT).Three GGTA1 null piglets were born,and one knockout primary fibroblast cell line was established from a cloned fetus.Gal epitopes on GGTA1 null pig cells were completely eliminated from the cell membrane.Functionally,GGTA1 knockout cells were protected from complement-mediated immune attacks when incubated with human serum.This study demonstrated that ZFN is an efficient tool in creating gene-modified pigs.GGTA1 null pigs and GGTA1 null fetal fibroblasts would benefit research and pig-to-human transplantation. | BAO Lei CHEN HaiDe JONG UiMyong RIM CholHo LI WenLing LIN XiJuan ZHANG Dan LUO Qiong CUI Chun HUANG HeFeng ZHANG Yan XIAO Lei FU ZhiXin | 2014 | Science China(Life Sciences)2014，57，2： | 9 |
| 3 | Robust consensus of multi-agent systems with noise显示文摘The consensus problem of multi-agent systems has attracted wide attention from researchers in recent years,following the initial work of Jadbabaie et al. on the analysis of a simplified Vicsek model. While the original Vicsek model contains noise effects,almost all the existing theoretical results on consensus problem,however,do not take the noise effects into account. The purpose of this paper is to initiate a study of the consensus problems under noise disturbances. First,the class of multi-agent systems under study is transformed into a general time-varying system with noise. Then,for such a system,the equivalent relationships are established among(i) robust consensus,(ii) the positivity of the second smallest eigenvalue of a weighted Laplacian matrix,and(iii) the joint connectivity of the associated dynamical neighbor graphs. Finally,this basic equivalence result is shown to be applicable to several classes of concrete multi-agent models with noise. | WANG Lin LIU ZhiXin | 2009 | Science in China(Series F)2009，52，5： | 5 |
| 4 | Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients显示文摘Background: Epidermal growth factor receptor(EGFR) mutation is the key predictor of EGFR tyrosine kinase inhibitors(TKIs) efficacy in non-small cell lung cancer(NSCLC). We conducted this study to verify the feasibility of EGFR mutation analysis in cytological specimens and investigate the responsiveness to gefitinib treatment in patients carrying EGFR mutations.Methods: A total of 210 cytological specimens were collected for EGFR mutation detection by both direct sequencing and amplification refractory mutation system(ARMS). We analyzed EGFR mutation status by both methods and evaluated the responsiveness to gefitinib treatment in patients harboring EGFR mutations by overall response rate(ORR), disease control rate(DCR) and progression free survival(PFS).Results: Of all patients, EGFR mutation rate was 28.6%(60/210) by direct sequencing and 45.2%(95/210) by ARMS(P<0.001) respectively. Among the EGFR wild type patients tested by direct sequencing, 26.7% of them were positive by ARMS. For the 72 EGFR mutation positive patients treated with gefitinib, the ORR, DCR and median PFS were 69.4%, 90.2% and 9.3 months respectively. The patients whose EGFR mutation status was negative by direct sequencing but positive by ARMS had lower ORR(48.0% vs. 80.9%, P=0.004) and shorter median PFS(7.4 vs. 10.5 months, P=0.009) as compared with that of EGFR mutation positive patients by both detection methods. Conclusions: Our study verified the feasibility of EGFR analysis in cytological specimens in advanced NSCLC. ARMS is more sensitive than direct sequencing in EGFR mutation detection. EGFR Mutation status tested on cytological samples is applicable for predicting the response to gefitinib. Abundance of EGFR mutations might have an influence on TKIs efficacy. | Lin Li Zijin Zhang Zhixin Bie Zheng Wang Ping Zhang Xin Nie Yuanming Li Hui Wang Bin Ai Gang Cheng | 2015 | Chinese Journal of Cancer Research2015，27，3： | 5 |
| 5 | The Research on E-mail Users' Behavior of Participating in Subjects Based on Social Network Analysis显示文摘The e-mail network is a type of social network. This study analyzes user behavior in e-mail subject participation in organizations by using social network analysis. First, the Enron dataset and the position-related information of an employee are introduced, and methods for deletion of false data are presented. Next, the three-layer model(User, Subject, Keyword) is proposed for analysis of user behavior. Then, the proposed keyword selection algorithm based on a greedy approach, and the influence and propagation of an e-mail subject are defined. Finally, the e-mail user behavior is analyzed for the Enron organization. This study has considerable significance in subject recommendation and character recognition. | ZHANG Lejun ZHOU Tongxin Qi Zhixin GUO Lin XU Li | 2016 | China Communications2016，13，4： | 3 |
| 6 | Fate and protective effect of marrow stromal cells after subretinal transplantation显示文摘髓 stromal 房间(MSC ) 的嫁接为退化疾病作为一条治疗学的途径被建议了。在这研究,我们与评估移植 MSC 的使用对待网膜的退化的目的在生活视网膜调查了命运和 grafted MSC 的动态进步。约 | Hong Pan Xinjian Liu Jihong Wu Yuhua Tian Shenghai Zhang Zhixin Lin Qian Huang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 7 | Longitudinal patterns of spring-intermonsoon phytoplankton biomass,species compositions and size structure in the Bay of Bengal显示文摘Vertical distributions of phytoplankton biomass,compositions and size structure were investigated during the spring-intermonsoon (April 22 to 30) of 2010 along transact 10 N of the Bay of Bengal,northern Indian Ocean.Surface phytoplankton biomass (Chl a) was (0.065 ± 0.009) μg/L,being greater than 80% of which was contributed by pico-phytoplankton (<3 μm).The Chl a concentration vertically increased to the maximal values at deep chlorophyll maximum (DCM) layer that shoaled eastwards from 75 to 40 m.The Chl a biomass at DCM layer generally varied between 0.2 and 0.4 μg/L,reaching the maximum of 0.56 μg/L with micro-phytoplankton cells (>20 μm) accounting for 58% and nano-(3-20 μm) or pico-cells for 15% and 27%,respectively.In particular,the cells concentration coupling well with phosphate level was observed at middle layer (75-100 m) of 87 to 89 E,dominated by micro-cells diatoms (e.g.,Chaetoceros atlanticus v.neapolitana,Chaetoceros femur and Pseudonitzschia sp.) and cyanobacteria (i.e.,Trichodesmium hildebrandtii),with the cells concentration reached as high as 4.0 × 10 4 and 4.3 × 10 4 cells/L.At the rest of the transact however,dinoflagellates (e.g.,Amphisdinium carterae and Prorocentrum sp.) were the dominant species,with the cells concentration varying from 0.3 × 10 3 to 6.8 × 10 3 cells/L.Our results also indicate that the regulation of large cells (micro-,nano-) on phytoplankton biomass merely occurred at DCM layer of the Bay. | LI Gang KE Zhixin LIN Qiang NI Guangyan SHEN Pingping LIU Huaxue YIN Jianqiang LI Kaizhi HUANG Liangmin TAN Yehui | 2012 | Acta Oceanologica Sinica2012，31，2： | 2 |
| 8 | Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction显示文摘 | Longxiang Su Lin Feng Qing Song Hongjun Kang Xingang Zhang Zhixin Liang Yanhong Jia Dan Feng Changting Liu Lixin Xie Celeste C. Finnerty | 2013 | Mediators of Inflammation2013，，： | 2 |
| 9 | Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma显示文摘因为这个过程涉及肿瘤抑制并且被许多化学疗法的代理人导致了,加速的老朽是重要的。基于铂的化学疗法的代理人 cisplatin 显示大量 antitumor 活动。然而,在 hepatocellular 癌(HCC ) 的导致 cisplatin 的加速的老朽的分子的机制仍然保持不清楚。在现在的学习,生长 HepG2 和 SMMC-7721 细胞上的 cisplatin 的禁止的效果被 3-(4,5-dimethylthiazol-2-yl ) 检测 -2,5-diphenyltetrazolium 溴化物试金。细胞的老朽然后被牛乳糖试金估计。包括 p53, p21,和 p16,老朽相关的因素被量的反向的抄写聚合酶链反应评估。反应的氧种类(ROS ) 被流动 cytometry 分析。我们的结果表明 cisplatin 在一个剂量依赖者和时间依赖者举止减少了 HepG2 和 SMMC-7721 房间的增长。在 cisplatintreated hepatoma 房间观察的衰老的显型依赖于 p53 和 p21 激活然而并非在 p16 激活上。而且, cisplatininduced 加速了取决于的老朽细胞内部的 ROS 产生。ROS scavenger N-acetyl-L-cysteine 显著地也压制了 HepG2 和 SMMC-7721 房间的导致 cisplatin 的老朽。在结论,我们的结果揭示了在细胞内部的 ROS 产生和导致 cisplatin 的加速的老朽之间的一个功能的连接,并且这个连接可以被用作 HCC 的一个潜在的目标。 | Kai Qu Ting Lin Zhixin Wang Sinan Liu Hulin Chang Xinsen Xu Fandi Meng Lei Zhou Jichao Wei Minghui Tai Yafeng Dong Chang Liu | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 10 | Peginterferon-α2a combined with response-guided short-term lamivudine improves response rate in hepatitis B e antigen-positive hepatitis B patients: a pilot study显示文摘 | Zhanlian Huang Hong Deng Qiyi Zhao Yubao Zheng Liang Peng Chaoshuang Lin Zhixin Zhao Zhiliang Gao | 2013 | European Journal of Gastroenterology & Hepatology2013，，10： | 1 |
| 11 | Analysis of collinear regions of Oryza AA and CC genomes显示文摘Comparative analyses of genome structure and sequence of closely related species have yielded insights into the evolution and function of plant genomes. A total of 103,844 BAC end sequences delegated ~73.8 Mb of O. officinalis that belongs to the CC genome type of the rice genus Oryza were obtained and compared with the genome sequences of rice cultivar,O. sativa ssp. japonica cv. Nipponbare. We found that more than 45% of O. officinalis genome consists of repeat sequences,which is higher than that of Nipponbare cultivar. To further investigate the evolutionary divergence of AA and CC genomes,two BAC-contigs of O. officinalis were compared with the collinear genomic regions of Nipponbare. Of 57 genes predicted in the AA genome orthologous regions,39 had orthologs in the regions of the CC genome. Alignment of the orthologous regions indicated that the CC genome has undergone expansion in both genic and intergenic regions through primarily retroelement insertion. Particularly,the density of RNA transposable elements was 17.95% and 1.78% in O. officinalis and O. sativa,respectively. This explains why the orthologous region is about 100 kb longer in the CC genome in comparison to the AA genome. | Qi Feng Tao Huang Qiang Zhao Jingjie Zhu Zhixin Lin Bin Han | 2009 | Journal of Genetics and Genomics2009，36，11： | 1 |
| 12 | Heparinloaded zein microsphere film and hemocompatibility显示文摘 | WANG Huajie LIN Zhixin LIU Xinming | 2005 | Journal of Controlled Release2005，105，12： | 1 |
| 13 | Game-theoretical explorations of the mesoscale flow structure and regime transitions in bubble columns显示文摘Understanding the mesoscale structure and regime transition in bubble columns is of great significance for reactor design and scaleup.Based on the energy-minimization multiscale(EMMS)model,a noncooperative game model with constraints is proposed to investigate the structural properties of gas-liquid systems in which small and large bubbles are chosen as players and the energy consumption form the objective function.The conservation equations of the system can be regarded as the constraints of the game.For the formulated noncooperative game model,the concept of the generalized Nash equilibrium(GNE)is used to characterize the solution.An algorithm is developed to numerically compute the GNE and some important structural parameters in the system.The numerical results show the existence of the GNE for all values of the superficial gas velocity Ug.As Ug varies,the trends in the state variables can be observed and the critical point of Ug identified.The overall trend of the flow regime transition agrees with the original EMMS model and experimental results,although the GNE calculation also reveals different single-bubble dominant mechanisms with increasing Ug. | Shuo Yuan Yifen Mu Xiaoping Guan Zhixin Liu Jianhua Chen Ning Yang Lin Zhang | 2020 | Particuology2020，18，1： | 1 |
| 14 | An approach to the uniform dispersion of a high volume fraction of carbon nanotubes in aluminum powder显示文摘 | Lin Jiang Genlian Fan Zhiqiang Li Xizhou Kai Di Zhang Zhixin Chen Sam Humphries Greg Heness Wing Yiu Yeung | 2011 | Carbon2011，，6： | 1 |
| 15 | Research on Monitoring and Refusing Methods for Abnormal Traffic in Routers显示文摘 | SUN Zhixin CHENG Yuan GONG Jing JIAO Lin | 2006 | Chinese Journal of Electronics2006，15，2： | 1 |
| 16 | An approach to the uniform dispersion of a high volume fraction of carbon nanotubes in aluminum powder显示文摘 | Lin Jiang Genlian Fan Zhiqiang Li Xizhou Kai Di Zhang Zhixin Chen Sam Humphries Greg Heness Wing Yiu Yeung | 2011 | Carbon2011，，6： | 1 |
| 17 | Prevalence and characterization of antimicrobial resistance of foodborne Listeria monocytogenes isolates in Hebei province of Northern China, 2005–2007显示文摘 | He Yan Sucharit Basu Neogi Ziyao Mo Wenying Guan Zhixin Shen Shuhong Zhang Lin Li Shinji Yamasaki Lei Shi Nanshan Zhong | 2010 | International Journal of Food Microbiology2010，，2： | 1 |
| 18 | Flutter and Buffeting-based Selection for Long-span Bridges 显示文摘 | GU Ming X1ANG Haifan LIN Zhixin | 1999 | Journal of Wind Engineering and Industrial Aerodynamics1999，80，： | 1 |
| 19 | Flow-Injection Microcolumn on-Line Preconcentration for theDetermination of Chromium(Ⅵ)显示文摘A rapid and sensitive on-line preconcentration method for spectrophotometric determination of chromium (VI) in nature water is described. Preconcentration and determination are based on (i) the quantitative and fast adsorption of chromium (VI) on the high surface area nanometer-size TiO2 (anatase) powders, which prepared by a sol-gel method from hydrolysis of TiCI4 and (ii) the quantitative and reproducible elution of Cr (VI) by 2. 0 mol. L-1 HCI. A mini-column system for preconcentration is developed, Cr(VI)on the mini-column is eluted and merged with a stream water and DPCB (1, 5-diphenylcarbazide ) as the chromogenic reagent. The Proposed system permits throughputs of 6 sample h--l (0. 001 μg mL-1 Cr(VI) ) or 20 sample h-1 (0. 1 μg mL-1Cr (VI) . The preconcentration factor is 55. The detection limit is 0. 8 ng·mL-1 Cr(VI). The reproducibility is satisfactory with a relative standard deviation of less than 3. 35% (0. Of μg’mL-1Cr (VI), n = 5). | Ma Wanhong Cat Ruxiu Lin Zhixin(College of Chemistry, Wuhan University. Wuhan 430072, China) | 1998 | Wuhan University Journal of Natural Sciences1998，3，4： | 1 |
| 20 | Pose Synchronization of Multiple Rigid Bodies Under Average Dwell Time Condition显示文摘这份报纸在交换在哪儿的拓扑学下面考虑一组动人的僵硬身体的姿势同步问题每拓扑学的居住时间可以没有非零更低的界限。作者介绍一个平均居住时间条件描绘图在被连接的时间间隔的长度。由设计尖速度和线性速度的分布式的控制法律,有交换拓扑学的多重僵硬身体的靠近环的动力学能被变换成一个混合动态系统。作者采用 Lyapunov 稳定性定理,并且证明姿势同步能在平均居住时间条件下面被到达。而且,作者在一个类似的平均居住时间条件下面调查领导人追随者模型的姿势同步问题。模拟例子被给说明结果。 | DENG Juan WANG Lin LIU Zhixin HU Xiaoming | 2018 | Journal of Systems Science & Complexity2018，31，1： | 1 |
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