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| 1 | Design of a new dynamical core for global atmospheric models based on some efficient numerical methods显示文摘A careful study on the integral properties of the primitive hydrostatic balance equations for baroclinic atmosphere is carried out, and a new scheme todesign the global adiabatic model of atmospheric dynamics ispresented. This scheme includes a method of weighted equal-areamesh and a fully discrete finite difference method with quadraticand linear conservations for solving the primitive equationsystem. Using this scheme, we established a new dynamical corewith adjustable high resolution acceptable to the availablecomputer capability, which can be very stable without anyfiltering and smoothing. Especially, some important integralproperties are kept unchanged, such as the anti-symmetries of thehorizontal advection operators and the vertical convectionoperator, the mass conservation, the effective energy conservationunder the standard stratification approximation, and so on. Somenumerical tests on the new dynamical core, respectively regardingits global conservations and its integrated performances inclimatic modeling, incorporated with the physical packagesfrom the Community Atmospheric Model Version 2 (CAM2) of NationalCenter for Atmospheric Research (NCAR), are included. | WANG Bin, WAN Hui, Jl Zhongzhen, ZHANG Xin, YU Rucong, YU Yongqiang & LIU HongtaoState Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Department of Computational Mathematics, Academy of Mathematics and System Sciences, Peking University, Beijing 100871, China | 2004 | Science China Mathematics2004，47，z1： | 92 |
| 2 | Upgrading Pathways of Intelligent Manufacturing in China:Transitioning across Technological Paradigms显示文摘Intelligent technologies are leading to the next wave of industrial revolution in manufacturing.In developed economies,firms are embracing these advanced technologies following a sequential upgrading strategy-from digital manufacturing to smart manufacturing(digital-networked),and then to newgeneration intelligent manufacturing paradigms.However,Chinese firms face a different scenario.On the one hand,they have diverse technological bases that vary from low-end electrified machinery to leading-edge digital-network technologies;thus,they may not follow an identical upgrading pathway.On the other hand,Chinese firms aim to rapidly catch up and transition from technology followers to probable frontrunners;thus,the turbulences in the transitioning phase may trigger a precious opportunity for leapfrogging,if Chinese manufacturers can swiftly acquire domain expertise through the adoption of intelligent manufacturing technologies.This study addresses the following question by conducting multiple case studies:Can Chinese firms upgrade intelligent manufacturing through different pathways than the sequential one followed in developed economies?The data sources include semistructured interviews and archival data.This study finds that Chinese manufacturing firms have a variety of pathways to transition across the three technological paradigms of intelligent manufacturing in nonconsecutive ways.This finding implies that Chinese firms may strategize their own upgrading pathways toward intelligent manufacturing according to their capabilities and industrial specifics;furthermore,this finding can be extended to other catching-up economies.This paper provides a strategic roadmap as an explanatory guide to manufacturing firms,policymakers,and investors. | Yuan Zhou Jiyuan Zang Zhongzhen Miao Tim Minshall | 2019 | Engineering2019，5，4： | 42 |
| 3 | A new method for judging the computational stability of the difference schemes of nonlinear evolution equations显示文摘For the non-conservative difference schemes of nonlinear evolution equations with aperiodic boundary conditions, taken one-dimensional nonlinear advection equation as an example, a new method for judging the computational stability is given. It is proved to be practical and effective through several numerical examples. The stability criteria obtained by this method are really the necessary conditions of computational stability. | LIN Wantao Jl Zhongzhen WANG Bin YANG Xiaozhong | 2000 | Chinese Science Bulletin2000，45，15： | 18 |
| 4 | Dynamic Field Division of Hydrocarbon Migration,Accumulation and Hydrocarbon Enrichment Rules in Sedimentary Basins显示文摘Hydrocarbon distribution rules in the deep and shallow parts of sedimentary basins are considerably different, particularly in the following four aspects. First, the critical porosity for hydrocarbon migration is much lower in the deep parts of basins: at a depth of 7000 m, hydrocarbons can accumulate only in rocks with porosity less than 5%. However, in the shallow parts of basins (i.e., depths of around 1000 m), hydrocarbon can accumulate in rocks only when porosity is over 20%. Second, hydrocarbon reservoirs tend to exhibit negative pressures after hydrocarbon accumulation at depth, with a pressure coefficient less than 0.7. However, hydrocarbon reservoirs at shallow depths tend to exhibit high pressure after hydrocarbon accumulation. Third, deep reservoirs tend to exhibit characteristics of oil (-gas)-water inversion, indicating that the oil (gas) accumulated under the water. However, the oil (gas) tends to accumulate over water in shallow reservoirs. Fourth, continuous unconventional tight hydrocarbon reservoirs are distributed widely in deep reservoirs, where the buoyancy force is not the primary dynamic force and the caprock is not involved during the process of hydrocarbon accumulation. Conversely, the majority of hydrocarbons in shallow regions accumulate in traps with complex structures. The results of this study indicate that two dynamic boundary conditions are primarily responsible for the above phenomena: a lower limit to the buoyancy force and the lower limit of hydrocarbon accumulation overall, corresponding to about 10%-12% porosity and irreducible water saturation of 100%, respectively. These two dynamic boundary conditions were used to divide sedimentary basins into three different dynamic fields of hydrocarbon accumulation: the free fluid dynamic field, limit fluid dynamic field, and restrain fluid dynamic field. The free fluid dynamic field is located between the surface and the lower limit of the buoyancy force, such that hydrocarbons in this field migrate and accumulate under the influence of, for example, the buoyancy force, pressure, hydrodynamic force, and capillary force. The hydrocarbon reservoirs formed are characterized as 'four high,' indicating that they accumulate in high structures, are sealed in high locations, migrate into areas of high porosity, and are stored in reservoirs at high pressure. The basic features of distribution and accumulation in this case include hydrocarbon migration as a result of the buoyancy force and formation of a reservoir by a caprock. The limit fluid dynamic field is located between the lower limit of the buoyancy force and the lower limit of hydrocarbon accumulation overall; the hydrocarbon migrates and accumulates as a result of, for example, the molecular expansion force and the capillary force. The hydrocarbon reservoirs formed are characterized as 'four low,' indicating that hydrocarbons accumulate in low structures, migrate into areas of low porosity, and accumulate in reservoirs with low pressure, and that oil(-gas)-water inversion occurs at low locations. Continuous hydrocarbon accumulation over a large area is a basic feature of this field. The restrain fluid dynamic field is located under the bottom of hydrocarbon accumulation, such that the entire pore space is filled with water. Hydrocarbons migrate as a result of the molecular diffusion force only. This field lacks many of the basic conditions required for formation of hydrocarbon reservoirs: there is no effective porosity, movable fluid, or hydrocarbon accumulation, and potential for hydrocarbon exploration is low. Many conventional hydrocarbon resources have been discovered and exploited in the free fluid dynamic field of shallow reservoirs, where exploration potential was previously considered to be low. Continuous unconventional tight hydrocarbon resources have been discovered in the limit fluid dynamic field of deep reservoirs; the exploration potential of this setting is thought to be tremendous, indicating that future exploration should be focused primarily in this direction. | PANG Xiongqi LIU Keyu MA Zhongzhen JIANG Zhenxue XIANG Caifu HUO Zhipeng PANG Hong CHEN Junqing | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 13 |
| 5 | Superabsorbent Fibers for Comfortable Disposable Medical Protective Clothing显示文摘Disposable medical protective clothing for 2019-nCoV mainly consists of stacked layers with nanopore films,polymer coated nonwoven fabrics and melt-blown nonwoven fabrics against anti-microbial and anti-liquid penetration.However,such structures lack moisture permeability and breathability leading to an uncomfortable,stuffy wearing experience.Here,we propose a novel medical protective clothing material with a superabsorbent layer to enhance moisture absorption.Poly(acrylic acid-co-acrylamide)/polyvinyl alcohol superabsorbent fibers(PAAAM/PVA fibers)were prepared via wet spinning.And the superabsorbent composite layer was stacked from PAAAM/PVA fibers,bamboo pulp fibers(BPF)and ethylene-propyl-ene side by side fibers(ESF).The novel disposable medical protective composite fabric was obtained through gluing the superabsorbent layer to the inner surface of strong antistatic polypropylene nonwoven fabric.The resultant composite fabric possesses excellent absorption and retention capacity for sweat,up to 12.3 g/g and 63.8%,and a maximum hygroscopic rate of 1.04 g/h,higher than that of the conventional material(only 0.53 g/h).The moisture permeability of the novel material reached 12,638.5 g/(m^(2) d),which was 307.6%of the conventional material.The novel material can effectively reduce the humidity inside the protective clothing and significantly improve the comfort of medical staff. | Lin Yang Hong Liu Shuai Ding Jiawei Wu Yan Zhang Zhongzhen Wang Lili Wei Mingwei Tian Guangming Tao | 2020 | Advanced Fiber Materials2020，2，3： | 11 |
| 6 | Down-regulation of Sonic hedgehog signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and motility inhibition in Hep3B cells显示文摘声音的刺猬(嘘) 小径在正常胚胎开始和 carcinogenesis 起一个关键作用,但是它在与 5 氟尿嘧啶(5-FU ) 对待的癌症房间的功能仍然保持未知。我们检验了表明小径基因的嘘的一个子集的表示,包括嘘, SMO, PTC1,苏(Fu ) 和在人的 hepatocellular 癌(HCC ) 的臀部房间线, Hep3BandHepG2,由反向的抄写聚合酶链反应与 5-FU 对待。用尝试平底锅蓝色分析, 3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazoliumbromide 试金和终端 deoxynucleotidyl 调停 transferase 的 digoxigenin-dUTP 刻痕结束标记试金,我们也检测了源于表示向量与 5-FU 治疗相结合的 pCS2-Glil 的 transfection 的 Hep3B 房间的 apoptosis。房间的活动性被擦伤创伤闭合试金检测。在 5-FU 对待的 Hep3B 房间的 PTC1 蛋白质的细胞的地点也是的表示和潜水艇由西方的污点分析和免疫调查了荧光灯的显微镜学。结果显示在送信人 RNA 和蛋白质层次的嘘小径目标分子的表示在与 5-FU 对待的 Hep3B 房间是显然下面调整的。过去图形用户界面的表示恢复房间生存能力并且到某程度,移植能力由 5-FU 禁止了。而且, 5-FU 处理影响潜水艇 PTC1 蛋白质的细胞的本地化,在嘘发信号的一个关键成员小径。我们的数据证明表明小径活动的嘘的下面规定在激活刺猬的 HCC 房间线涉及 5-FU-induced apoptosis 和活动性的抑制。这暗示表明小径禁止者和 5-FU-based 化疗的嘘的联合可能对 HCC 代表更有希望的策略。 | Qiyu Wang Shuhong Huang Ling Yang Ling Zhao Yuxia Yin Zhongzhen Liu Zheyu Chen Hongwei Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，9： | 10 |
| 7 | Facile synthesis of magnetic-plasmonic nanocomposites as T1 MRI contrast enhancing and photothermal therapeutic agents显示文摘 | Zhongzhen Yang Xianguang Ding Jiang Jiang | 2016 | Nano Research2016，9，3： | 6 |
| 8 | Tuning Superhydrophobic Materials with Negative Surface Energy Domains显示文摘Hydrophobic/superhydrophobic materials with intrinsic water repellence are highly desirable in engineering fields including antiicing in aerocrafts,antidrag and anticorrosion in ships,and antifog and self-cleaning in optical lenses,screen,mirrors,and windows.However,superhydrophobic material should have small surface energy(SE)and a micro/nanosurface structure which can reduce solid-liquid contact significantly.The low SE is generally found in organic materials with inferior mechanical properties that is undesirable in engineering.Intriguingly,previous theoretical calculations have predicted a negative SE forθ-alumina(θ-Al_(2)O_(3)),which inspires us to use it as a superhydrophobic material.Here,we report the experimental evidence of the small/negative SE ofθ-Al_(2)O_(3) and aθ-Al_(2)O_(3)-based superhydrophobic coating prepared by one-step scalable plasma arcing oxidation.The superhydrophobic coating has complete ceramic and desired micro/nanostructure and therefore exhibits excellent aging resistance,wear resistance,corrosion resistance,high-temperature tolerance,and burning resistance.Owing to the rarity of the small/negative SE in inorganic materials,the concept to reduce SE byθ-Al_(2)O_(3) may foster a blowout to develop robust superhydrophobicity by complete inorganic materials. | Zhongzhen Wu Liangliang Liu Shunning Li Shunping Ji Pinghu Chen Suihan Cui Zhengyong Ma Yuchang Weng Qian Huang Zhongcan Wu Hao Wu Yuan Lin Ricky KYFu Hai Lin Xiubo Tian Paul KChu Feng Pan | 2019 | Research2019，，1： | 6 |
| 9 | Three-dimensional variational data assimilation implemented in numerical modeling for Wuhan torrential rain in July 1998显示文摘On July 20~21, 1998, a torrential rain with 24-hour rainfall of 286 mm occurred in Wuhan, Hubei Province of China. In this study, a three-dimensional variational data assimilation system developed at the Fifth-Generation Pennsylvania State University/National Center for Atmospheric Research Mesoscale Model (MM5) along with conventional rawinsonde sounding and surface observation is used for modeling the heavy rain. It successfully incorporates observational data of temperature, humidity and wind, and provides an optimal analysis being in favor of the formation of heavy rain. The 24-hour rainfall predicted by the new scheme is 109 mm rather than 2.5 mm forecasted by control experiment. Furthermore, the forecasted accuracy of location and time-variation of hourly rainfall reproduced by this model is also improved. | ZHANG Xin , WANG Bin, JI Zhongzhen and LIN Wantao(LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China) | 2002 | Progress in Natural Science:Materials International2002，12，6： | 5 |
| 10 | Construction and numerical tests of the multi-conservation difference scheme显示文摘A difference scheme with four conservation properties for solving the spherical barotropic shallow water equations is constructed, based on a proper formulae of the equations and a skillful correction on the spatial difference parts of the semi-discrete equations with which the number of the conservation properties of these equations is increased from three to four. Numerical tests are included, and good results are achieved in this study. | WANG Bin & JI Zhongzhen LASG, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2003 | Chinese Science Bulletin2003，48，10： | 5 |
| 11 | Tissue-based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro-dissection显示文摘Achyranthes bidentata and Achyranthes aspera are saponin and steroid rich medicinal plants, used extensively for therapeutic treatments in Traditional Chinese Medicine(TCM) and Ayurveda. A. bidentata is reported to be one of the rare and extensively exploited medicinal plant species that face the issue of being endangered.Finding qualitative substitute with identical phyto-constituents contributing to similar composition and pharmacological benefits will help in reducing the burden of exploitation of the natural habitats of such plants.In the present study, a comparative metabolite analysis of the whole drug and specific tissues isolated by laser micro-dissection(LMD) was carried out for both the selected species, by use of ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-QTOF MS). The results of the study indicate that the cortex and the medullary ray tissues are rich in their content of steroidal and saponin constituents such as(25 S)-inokosterone-20,22-acetonide, ginsenoside Ro, bidentatoside II and achyranthoside B.Metabolite profiling of the whole tissues of both the species indicates presence of identical constituents. Thus,it is inferred that A. bidentata and A. aspera can be used as qualitative substitutes for each other. | Yogini Jaiswal Zhitao Liang Alan Ho Hubiao Chen Leonard Williams Zhongzhen Zhao | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 5 |
| 12 | Chemical profiling and histochemical analysis of Bupleurum marginatum roots from different growing areas of Hubei province显示文摘Bupleuri Radix has been widely used in traditional Chinese medicine.In the current herbal market,the species Bupleurum marginatum Wall.ex DC.is the main source of Bupleuri Radix.Although Bupleuri Radix from the roots of B.marginatum grown wild in the North West of Hubei province has higher quality compared with those from other regions according to the previous investigations,the exhaustive exploitation driven by increasing demand has drastically reduced the wild resource.As a result,germplasm evaluation and quality resource exploration are important for the sustainable utilization and cultivation of B.marginatum.A preliminary study indicated differences in the tissue structure of B.marginatum grown in different areas of North Western Hubei province.In the current study,various tissues of the roots of B.marginatum grown in different areas of North Western Hubei were subjected to laser microdissection and analyzed by microscopy and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry(UHPLC–Q-TOF-MS).The results show that wild plants from Maqiao Town,Baokang County contain the most saikosaponins distributed mainly in cork,cortex and phloem.This study provides key chemical information for evaluating the quality of B.marginatum roots. | Zhitao Liang Jian Zhang Guangyi Yang Hubiao Chen Zhongzhen Zhao | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 4 |
| 13 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial显示文摘 | Ann-Lii Cheng Zhongzhen Guan Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Tsai-Sheng Yang Won Young Tak Hongming Pan Shiying Yu Jianming Xu Fang Fang Jessie Zou Giuseppe Lentini Dimitris Voliotis Yoon-Koo Kang | 2011 | European Journal of Cancer2011，，10： | 4 |
| 14 | Progress and mechanism of breaking glycoconjugates by glycosidases in skin for promoting unhairing and fiber opening-up in leather manufacture.A review显示文摘The glycoconjugates,herein glyco-proteins,existing in animal skins are closely related to the effectiveness of unhairing and fiber opening-up.Glycosidases have been used in leather making processes to reduce pollutants and improve leather quality.But the selection of glycosidases is still blind because the related mechanisms are not well understood yet.Hence,the animal skin structures and glycoconjugates components,the advances in the methods and mechanisms of removing glycoconjugates related to unhairing and fiber opening-up in leather manufacture,the kinds,compositions,structures and functions of typical glycoconjugates in skin are summarized.Then the approaches to destroy them,possible glycosidases suitable for leather making and their acting sites are analyzed based on the recognition of glycoconjugates in skin and the specificities of glycosidases toward substrates.It is expected to provide useful information for the optimization of glycosidases and the development of new enzymes and the cleaner technologies of unhairing and opening up fiber bundles assisted by glycosidases. | Fengxiang Luo Xiang Zhong Mengchu Gao Biyu Peng Zhongzhen Long | 2020 | Journal of Leather Science and Engineering2020，2，1： | 4 |
| 15 | Design, Synthesis and Insecticidal Activities of Novel 5-Alkoxyfuran-5(H)-one Derivatives显示文摘A series of novel 5?alkoxyfuran-2(5H)-one derivatives was synthesized, and characterized by 1H NMR, 13C NMR and HRMS. Biological activities of all the title compounds were evaluated systematically. Preliminary bioassays indicated that most of the compounds exhibited moderate insecticidal activities against Aphis craccivora and Nilaparvata lugens at 100 mg/L. Compounds 4h and 4w exhibited 100% mortality rate against Aphis craccivora at 100 mg/L, and compound 4h exhibited good mortality rate against Aphis craccivora and Nilaparvata lugens (60% and 75%, respectively) even at 4 mg/L. The results demonstrated the impact of various chemical groups on insecticidal activities and provided a potential clue for further exploring novel high-effective broad-spectrum insecticides. | WANG Xianhao LI Jianguo WANG Guangjian HAN Xianzheng LI Dongmei TIAN Zhongzhen | 2019 | Chemical Research in Chinese Universities2019，35，5： | 3 |
| 16 | The relationship between short-range motion of atmosphere and ocean and conservative and nonconservative scheme显示文摘Taking one-dimensional shallow water wave equation as an example, a comparative analysis on the computational stability related to the short-range motion of atmosphere and ocean is carried out for the conservative and nonconservative scheme, and it is pointed out that the computational stability of conservative scheme is absolutely different from that of the nonconservative scheme. The relationship between the short-range motion of atmosphere and ocean and the conservative and nonconservative scheme is further discussed. The constructed conservative scheme is proved to be stable by the numerical experiment for the short-range motion of atmosphere and ocean while the CTCS scheme is unstable. So that the conservative scheme for the solution of this kind of problem has more advantages. | LIN Wantao, JI Zhongzhen & WANG Bin LASG,Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China | 2003 | Chinese Science Bulletin2003，48，10： | 3 |
| 17 | A review on SRAM-based computing in-memory:Circuits,functions,and applications显示文摘Artificial intelligence(AI)processes data-centric applications with minimal effort.However,it poses new challenges to system design in terms of computational speed and energy efficiency.The traditional von Neumann architecture cannot meet the requirements of heavily datacentric applications due to the separation of computation and storage.The emergence of computing inmemory(CIM)is significant in circumventing the von Neumann bottleneck.A commercialized memory architecture,static random-access memory(SRAM),is fast and robust,consumes less power,and is compatible with state-of-the-art technology.This study investigates the research progress of SRAM-based CIM technology in three levels:circuit,function,and application.It also outlines the problems,challenges,and prospects of SRAM-based CIM macros. | Zhiting Lin Zhongzhen Tong Jin Zhang Fangming Wang Tian Xu Yue Zhao Xiulong Wu Chunyu Peng Wenjuan Lu Qiang Zhao Junning Chen | 2022 | Journal of Semiconductors2022，43，3： | 2 |
| 18 | Synthesis of aminoisoquinolines via Rh-catalyzed[4+2]annulation of benzamidamides with vinylene carbonate显示文摘A new strategy is developed for the synthesis of 1-aminoisoquinoline derivatives.This Rh(III)-catalyzed[4+2]annulation reaction employs benzamidines as efficient directing groups and the vinylene carbonate as an acetylene surrogate.Additionally,the reaction features broad substrate scopes and good yields,only producing carbonate anion as byproduct. | Xin Huang Yingying Xu Jianglian Li Ruizhi Lai Yi Luo Qiantao Wang Zhongzhen Yang Yong Wu | 2021 | Chinese Chemical Letters2021，32，11： | 2 |
| 19 | Integrating simulation and optimization to schedule loading operations in container terminals显示文摘 | Zeng Qingcheng Yang Zhongzhen | 2009 | Computers & Operations Research2009，36，6： | 1 |
| 20 | Macroscopic identification of Chinese medicinal materials:Traditional experiences and modern understanding显示文摘 | Zhao Zhongzhen Liang Zhitao Guo Ping | 2011 | J Ethnopharmacol2011，134，3： | 1 |
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