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| 1 | Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response显示文摘hepatocellular 癌(HCC ) 的预后是差的,甚至与药品切除术和辅助 chemoradiotherapy 的联合治疗。解决这个问题,许多生物学的治疗被调查了。船边交货 ligand (FasL, CD95L ) 主要在激活的 T 淋巴细胞和生来的杀手(NK ) 房间被表示,并且在调停房间的免疫和有免疫力的 downregulation 起一个中央作用。几研究证明了 FasL 在 HCC 被表示。在现在的报告,我们准备了 recombinant 人 pET-22b (+)/FasL 蛋白质并且在一个鼠科的 HCC 肿瘤模型在 vitro 并且在肿瘤生长上在 HCC 房间上调查了 FasL 的效果。著名细胞毒素的化学疗法的试剂 adriamycin (ADM ) 用作控制。我们发现 FasL 有效地压制了 H22 肿瘤房间的生存能力并且显著地导致了 H22 房间的 apoptosis。与 FasL-ADM 对待的细胞的 apoptotic 层次比独自与 FasL 或 ADM 对待的那些显著地高,并且 FasL-ADM 联合导致了一非常在这个模型的肿瘤生长延期上的添加剂效果。结果建议 FasL 和另外的化学疗法的代理人的那个联合处理可以是一条新途径为 HCC 改进化疗的功效。 | Zhongchen Liu Ruizhen Liu Jinhua Qiu Ping Yin Fanghong Luo Jinhua Su Wenzhu Li Caixia Chen Xin Fan Jiakai Zhang Guohong Zhuang | 2009 | Cellular & Molecular Immunology2009，6，3： | 4 |
| 2 | Removal of emulsion oil from oilfield ASP wastewater by internal circulation flotation and kinetic models 显示文摘 | Qi Weikang Yu Zhongchen Liu Yuyu | 2013 | Chemical Engineering Science2013，91，： | 1 |
| 3 | RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma显示文摘尽管有在动物模型获得的出色的结果,船边交货 ligand (FasL ) 的临床的使用被严重毒性作为 anticancer 药限制。死亡 ligands 的全身的毒性可以被使用编码膜界限死亡 ligands 的基因阻止,由指向的 transgene,通过也的表示指向了 transduction 或指向了抄写。肿瘤房间死亡的选择正式就职是有希望的 anticancer 策略。熔化蛋白质被熔化船边交货 ligand (FasL ) 的细胞外的领域到有选择地在肿瘤 endothelial 房间上指向 av3-integrins 的肽 arginine-glycine-aspartic 酸(RGD ) 创造。这研究的目的是在鼠科的 hepatocellular 癌(HCC ) 在肿瘤生长和幸存上评估 RGD-FasL 的效果肿瘤模型。有与 FasL 作为与那相比在 HCC 肿瘤模型上显示明显的镇压效果的 RGD-FasL 的处理(p < 0.05 ) 并且在这个模型在肿瘤生长延期上导致了更多的添加剂效果。RGD-FasL 处理显著地提高了老鼠幸存并且没引起有毒的效果,例如重量损失,机关失败,或另外的处理相关的毒性。Apoptosis 被流动 cytometric 分析和 TUNEL 试金检测;那些结果也证明 RGD-FasL 比 FasL 是为 H22 和 H9101 房间线的房间 apoptosis 的更多的有势力 inducer (p < 0.05 ) 。在结论, RGD-FasL 看起来是肿瘤房间死亡的低毒性的选择 inducer,它在现出症状之前的潜、临床的研究应得进一步的调查。而且,这条途径与治疗学的 recombinant 蛋白质为 complexing 目标 ligands 提供一种万用的技术。为了在 vivo,肿瘤和肝区分 FasL 的反肿瘤效果,纸巾被收获由染色的 Hematoxylin 和曙红(H&E ) 为坏死的房间,肿瘤房间,或 apoptotic 房间的证据检验。 | Zhongchen Liu Juan Wang Ping Yin Jinhua Qiu Ruizhen Liu Wenzhu Li Xin Fan Xiaofeng Cheng Caixia Chen Jiakai Zhang Guohong Zhuang | 2009 | Cellular & Molecular Immunology2009，6，4： | 1 |
| 4 | TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway显示文摘Dear Editor,Colorectal cancer(CRC)is the third most common malignant tumor in human,ranking third in cancer-related mortality.1 Most colon cancer patients die of metastasis.2 Intriguingly,the deregulation of tumor necrosis factorα‑induced protein 8(TIPE)has been shown to play a vital regulatory role in tumor cell growth,proliferation,invasion,and metastasis.3 TIPE is a kind of cytoplasmic protein of 23 kDa.A large number of studies have shown that TIPE is closely related to the development of colon cancer.4 In addition,decreased expression of TIPE was linked to down-regulation of matrix metallopeptidase-1(MMP-1),MMP-9,and vascular endothelial growth factor receptor-2 in breast cancer. | Huiyu Chen Yuhan Ye Yan Yang Mengya Zhong Lei Gu Zhaopu Han Jinhua Qiu Zhongchen Liu Xingfeng Qiu Guohong Zhuang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 5 | Solid-gas carbonate formation during dust events on Mars显示文摘For half a century,Mars missions have gathered abundant geological evidence for a wet,warm climate in the early history of Mars more than 3 billion years ago,including various fluvial landforms and exposed aqueous alteration minerals.It was supposed that Mars once had a dense,CO_(2)-rich atmosphere.However,present-day Mars has a much thinner atmosphere dominated by CO_(2). | Wenshuo Mao Xiaohui Fu Zhongchen Wu Jiang Zhang Zongcheng Ling Yang Liu Yu-Yan Sara Zhao Hitesh G.Changela Yuheng Ni Fabao Yan Yongliao Zou | 2023 | National Science Review2023，10，4： | 0 |
| 6 | Compositions and possible sources of lunar meteorite NWA 4884显示文摘1 Introduction Lunar mare basalts represent the products of partial remelting of deep mantle sources and provide windows into the compositions of lunar interior.Nine Apollo andLuna missions returned large amounts of mare basaltic samples,while remote sensing suggests that sampled basalts may cover only a small number of the lunar | CHEN Jian LING Zongcheng LI Bo SUN Lingzhi ZHANG Jiang HUANG Yihang WU Zhongchen NI Yuheng LIU Jianzhong | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 7 | Lunar absolute reflectance as observed by Chang'E-1 Imaging Interferometer显示文摘Lunar absolute reflectance, which describes the fraction of solar radiation reflected by the Moon, is fundamental for the Chang'E-1 Imaging Interferometer(IIM) to map lunar mineralogical and elemental distributions. Recent observations made by the Spectral Irradiance Monitor(SIM) onboard the Solar Radiation and Climate Experiment(SORCE) spacecraft indicate that temporal variation in the solar radiation might have non-negligible influence on reflectance calculation, and the SIM measurements are different from the two previously used solar irradiances, i.e., ATLAS3 and Newkur. To provide reliable science results, we examined solar irradiance variability with the SIM daily observations, derived lunar absolute reflectances from the IIM 2A radiance with the SIM, ATLAS3 and Newkur data, and compared them with the Chandrayaan-1 Moon Mineralogy Mapper(M3), the Robotic Lunar Observatory(ROLO) and the Kaguya Multispectral Imager(MI) results. The temporal variability of the SIM solar irradiance is 0.25%–1.1% in the IIM spectral range, and less than 0.2% during the IIM observations. Nevertheless, the differences between the SIM measurements and the ATLAS3 and Newkur data can respectively rise up to 8% and 5% at particular IIM bands, resulting in discrepancy between which might affect compositional mapping. The IIM absolute reflectance we derived for the Moon using the SIM data, except for the last two bands, is consistent with the ROLO and the MI observations, although it is lower. | ZHANG Jiang LING ZongCheng LIU JianZhong WU ZhongChen LI Bo NI YuHeng | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，8： | 0 |
| 8 | Geopolymer-based modification of blasting sealing materials and optimization of blasting block size in coal seams of open pit mines显示文摘This research proposes the utilization of a geopolymer-based blasting sealing material to improve the profitability of coal sales and reduce the rate of coal fragmentation during blasting in open pit mines.The study first focused on optimizing the strength of the sealant material and reducing curing time.This was achieved by regulating the slag doping and sodium silicate solution modulus.The findings demonstrated that increasing slag content and improving the material resulted in an early rise in strength while increasing the modulus of the sodium silicate solution extended the curing time.The slag doping level was fixed at 80 g,and the sodium silicate solution modulus was set at 1.5.To achieve a strength of 3.12 MPa,the water/gel ratio was set at 0.5.The initial setting time was determined to be 33 min,meeting the required field test duration.Secondly,the strength requirements for field implementation were assessed by simulating the action time and force destruction process of the sealing material during blasting using ANSYS/LS-DYNA software.The results indicated that the modified material meets these requirements.Finally,the Shengli Open Pit Coal Mine served as the site for the field test.It was observed that the hole-sealing material’s hydration reaction created a laminated and flocculated gel inside it.This enhanced the density of the modified material.Additionally,the pregelatinized starch,functioning as an organic binder,filled the gaps between the gels,enhancing the cohesion and bonding coefficient of the material.Upon analyzing the post-blasting shooting effect diagram using the Split-Desktop software,it was determined that the utilization of the modified blast hole plugging material resulted in a decrease in the rate of coal fragmentation from 33.2%to 21.1%.This reduction exhibited a minimal error of 1.63%when compared to the field measurement,thereby providing further confirmation of the exceptional plugging capabilities of the modified material.This study significantly contributes to establishing a solid theoretical basis for enhancing the blasting efficiency of open pit mines and,in turn,enhancing their economic advantages. | Xiaohua Ding Zhongchen Ao Wei Zhou Hao Qin Zhongao Yang Wen An Xiaoshuang Li Honglin Liu | 2023 | International Journal of Mining Science and Technology2023，33，12： | 0 |
| 9 | SET1A催化YAP甲基化修饰调控YAP细胞核转运和促进肿瘤发生显示文摘文章简介YAP作为Hippo信号通路主要效应因子之一,在Hippo通路受抑的条件下,从细胞质转运至细胞核调控基因表达和促进肿瘤发生。虽然YAP锚定在细胞质中的调控机制已经被广泛研究,但是YAP激活后入核在细胞核中持续积累的分子机制并不十分清楚。 | 方兰 滕鸿琦 王益林 廖光红 Linjun Weng Yaxu Li Xinbo Wang Jiali Jin Chenchen Jiao Lei Chen Xiaoping Peng Jiayu Chen Yongzhi Yang Houqin Fang Dongyan Han Cheng Li Xueling Jin Shihao Zhang Zhongchen Liu Min Liu Qing Wei Lujian Liao Xin Ge Bin Zhao Dawang Zhou HuanLong Qin Jun Zhou 王平 | 2019 | 科学新闻2019，0，2： | 0 |
| 10 | A Method for Calculating Bottom Backscattering Strength Using Omnidirectional Projector and Omnidirectional Hydrophone显示文摘A method of obtaining bottom backscattering strength by employing an omnidirectional projector and omnidirectional hydrophone is proposed. The backscattering strength is extracted from monostatic backscattering data. The method was adopted in an experiment conducted in the South Yellow Sea of China. The seafloor surface was relatively smooth and covered by a small quantity of shell fragments, as observed through a digital camera system. Sampling data showed that the main component of the sediment at this experimental site was fine sand. In this paper, we detail the calculation method. Preliminary results of backscattering strength as a function of grazing angle(20?–70?) in the frequency range of 6–24 kHz are presented. The measured backscattering strength increased with the grazing angle and changed more rapidly at large grazing angles(60?–70?). A comparison of the data at different frequencies reveals that the measured backscattering strength substantially rises with the increase of acoustic frequency. A fitting curve of Lambert's law against the measured data shows that the backscattering strength deviates from Lambert's law at large grazing angles. | YU Kaiben YU Shengqi LIU Baohua LIU Zhongchen YANG Zhiguo KAN Guangming ZONG Le | 2019 | Journal of Ocean University of China2019，18，2： | 0 |
| 11 | Identification of a Novel OsCYP2 Allele that Was Involved in Rice Response to Low Temperature Stress显示文摘Cyclophilin(CYP)plays an important role in plant response to stress,and OsCYP2,one gene of cyclophlilin family,is involved in auxin signal transduction and stress signaling in rice.However,the mechanism that OsCYP2 is involved in rice response to low temperature is still unclear.We identified a new OsCYP2 allelic mutant,lrl3,with fewer lateral roots,and the differences in shoot height,primary root length and adventitious root length increased with the growth process compared to the wild-type plant.Auxin signaling pathway was also affected and became insensitive to gravity.The transgenic rice plants with over-expression of OsCYP2 were more tolerant to low temperature than the wild-type plants,suggesting that OsCYP2 was involved in the low temperature response in rice.In addition,OsCYP2 negatively regulated the expression of OsTPS38,a terpene synthase gene,and was dependent on the OsCDPK7-mediated pathway in response to low temperature stress.OsTPS38-overexpressed transgenic line ox-2 was more sensitive to low temperature.Therefore,OsCYP2 may negatively regulate OsTPS38 through an OsCDPK7-dependent pathway to mediate the response to low temperature in rice.These results provide a new basis for auxin signaling genes to regulate rice response to low temperature stress. | Hongxiu Gao Lin Zhu Tianqi Liu Xueyu Leng Zhenxing Zhu Wei Xie Haitao Lv Zhengxun Jin Ping Wu Zhongchen Zhang | 2023 | Phyton-International Journal of Experimental Botany2023，92，6： | 0 |
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