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| 1 | Epoxidized methyl ricinoleate bio-plasticizer with a pendant acetate ester for PVC artificial material:circumventing existing limit on achievable migration resistance显示文摘Processing polyvinyl chloride(PVC)artificial material requires plasticizer that softens the PVC coating.Currently,utilizing unsaturated fatty acid methyl esters to obtain epoxidized fatty acid methyl ester(EFAME)bio-plasticizers constitutes an environmentally responsible solution to substitute conventional ortho-phthalates that are endocrine disruptors or probable carcinogens.However,commercial EFAMEs,even with the highest epoxy value(ca.5.5-5.8%)so far,still suffer from fast leaching from the PVC matrix,burdening the environment and shortening lifespan of the artificial material.Here,we report a proof-of-principle demonstration of a new strategy to obtain migration-resistant EFAME that harnesses the midchain hydroxyl of methyl ricinoleate and covalently attachment of a pendant acetate ester.Despite a low epoxy value(3.0%),the engineered bio-plasticizer displays significantly suppressed migration in multiple scenarios compared with one conventional EFAME with much higher epoxy value(5.8%).Circumventing the limit confronting previous strategy that highlights the sole contribution of epoxy value to achievable migration resistance,the rationale herein may provide guidance for designing new EFAMEs with comparable performance to ortho-phthalates,thus bringing the old and oft-maligned PVC artificial material industry one step closer to sustainability. | Siyu Pan Delong Hou Gaofu Yang Qiuping Xie Sunxian Yan Qi Zeng Zhonghui Wang Yi Chen Haojun Fan | 2019 | Journal of Leather Science and Engineering2019，1，1： | 3 |
| 2 | Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait,China显示文摘 | Zheng Zhonghui Zeng Wei Huang Yaojian et a1 | 2000 | FEMS Microbiol Lett2000，188，： | 1 |
| 3 | A light-activatable antibiotic with high activation efficiency and uncompromised bactericidal potency in the activated state显示文摘Achieving activatable antibiotics represents one promising solution to tackle the occurrence of side effects,one major issue now plaguing antibiotic usage in collagen-based biomaterials.Despite considerable effort,however,rationale design of activatable antibiotics that display high activation efficiency and uncompromised bactericidal potency in the activated state remains difficult.Here,we demonstrate a design principle that helps to address this challenge.This strategy differs from previous attempts by underscoring photolytic removal of a functionality directly conjugated to the pharmacophore of an antibiotic,enabling not only an activation efficiency significantly improved beyond previous light-activatable antibiotics,but also bactericidal activity in the activated state as potent as the parent drug. | Delong Hou Rui Wang Zhonghui Wang Gaofu Yang Zhou Xu Qi Zeng Yi Chen | 2021 | Journal of Leather Science and Engineering2021，3，1： | 1 |
| 4 | OGG1 inhibition suppresses African swine fever virus replication显示文摘African swine fever virus(ASFV)is an important pathogen that causes a highly contagious and lethal disease in swine,for which neither a vaccine nor treatment is available.The DNA repair enzyme 8-oxoguanine DNA glycosylase 1(OGG1),which excises the oxidative base lesion 8-oxo-7,8-dihydroguanine(8-oxoG),has been linked to the pathogenesis of different diseases associated with viral infections.However,the role of OGG1-base excision repair(BER)in ASFV infection has been poorly investigated.Our study aimed to characterize the alteration of host reactive oxygen species(ROS)and OGG1 and to analyse the role of OGG1 in ASFV infection.We found that ASFV infection induced high levels and dynamic changes in ROS and 8-oxoG and consistently increased the expression of OGG1.Viral yield,transcription level,and protein synthesis were reduced in ASFV-infected primary alveolar macrophages(PAMs)treated by TH5487 or SU0268 inhibiting OGG1.The expression of BER pathway associated proteins of ASFV was also suppressed in OGG1-inhibited PAMs.Furthermore,OGG1 was found to negatively regulate interferonβ(IFN-β)production during ASFV infection and IFN-βcould be activated by OGG1 inhibition with TH5487 and SU0268,which blocked OGG1 binding to 8-oxoG.Additionally,the interaction of OGG1 with viral MGF360-14-L protein could disturb IFN-βproduction to further affect ASFV replication.These results suggest that OGG1 plays the crucial role in successful viral infection and OGG1 inhibitors SU0268 or TH5487 could be used as antiviral agents for ASFV infection. | Jie Fan Xinqian Lv Saixia Yang Shuxian Geng Jifei Yang Yaru Zhao Zhonghui Zhang Zhijie Liu Guiquan Guan Jianxun Luo Qiaoying Zeng Hong Yin Qingli Niu | 2023 | Virologica Sinica2023，38，1： | 1 |
| 5 | Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait,China显示文摘 | Zheng Zhonghui Zeng Wei Huang Yaojian | 2000 | FEMS Microbiol Lett2000，188，： | 1 |
| 6 | Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait, China显示文摘 | ZHENG Zhonghui ZENG Wei HUANG Yaojian | 2000 | FEMS Mierobiol Lett2000，188，1： | 1 |
| 7 | Plant functional trait diversity and structural diversity co-underpin ecosystem multifunctionality in subtropical forests显示文摘Tree species diversity is assumed to be an important component in managing forest ecosystems because of effects on multiple functions or ecosystem multifunctionality.However,the importance of tree diversity in determining multifunctionality in structurally complex subtropical forests relative to other regulators(e.g.,soil microbial diversity,stand structure,and environmental conditions)remains uncertain.In this study,effects of aboveground(species richness and functional and structural diversity)and belowground(bacterial and fungal diversity)biodiversity,functional composition(community-weighted means of species traits),stand structure(diameter at breast height and stand density),and soil factors(pH and bulk density)on multifunctionality(including biomass production,carbon stock,and nutrient cycling)were examined along a tree diversity gradient in subtropical forests.The community-weighted mean of tree maximum height was the best predictor of ecosystem multifunctionality.Functional diversity explained a higher proportion of the variation in multifunctionality than that of species richness and fungal diversity.Stand structure-played an important role in modulating the effects of tree diversity on multifunctionality.The work highlights that species composition and maximizing forest structural complexity are effective strategies to increase forest multifunctionality while also conserving biodiversity in the management of multifunctional forests under global environmental changes. | Shuai Ouyang Mengmeng Gou Pifeng Lei Yue Liu Liang Chen Xiangwen Deng Zhonghui Zhao Yelin Zeng Yanting Hu Changhui Peng Wenhua Xiang | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 8 | Clinical Report on the Treatment of Post-stroke Cognitive Impairment Based on Microbe-Gut-Brain Axis Theory显示文摘Based on the close relationship between MGBA and PSCI,one PSCI related case is reported,and it is emphasized to improve clinicians'understanding of MGBA theory in the treatment of PSCI,thereby providing new ideas for exploring pathogenesis and treatment of PSCI. | Zhonghui ZENG Lingyun ZHOU Zeyu ZHANG | 2022 | Medicinal Plant2022，13，2： | 0 |
| 9 | A simple approach with scale-up potential towards intrinsically flame-retardant biobased co-plasticizer for PVC artificial materials显示文摘As an imitation of genuine leather,polyvinyl chloride(PVC)artificial materials are versatile,but suffers from being flammable due to the presence of large amounts of combustible plasticizers.Under such circumstance,intrinsically flame-retardant plasticizers displaying dual functions have been a subject of intensive research interest.However,previous strategies attempting to covalently attach flame-retardant moiety to plasticizers invariably required either expensive starting materials or laborious and tedious procedures,ultimately limiting their scale-up application in industry.In addition,driven by escalating demand of halogen-free flame retardants worldwide from an environmental health perspective,previously reported intrinsically flame-retardant plasticizers were mainly halogenfree,less attractive in PVC artificial material industry simply because PVC itself is a halogen-containing polymer.Here,we report an approach to introduce chlorine moieties into unsaturated fatty acid methyl ester by a simple addition reaction occurring on carbon-carbon double bonds,yielding a chlorine-containing,intrinsically flameretardant bio-plasticizer.When combined with di-(2-ethylhexyl)phthalate(DOP)in PVC formulations,the chlorinated fatty acid methyl ester is qualified as a co-plasticizer while conferring flame retardancy upon the PVC coatings.This approach involves only a one-step procedure that employs renewable fatty acid methyl esters and cheap chlorine gas as raw materials,thus being of great potential to enable intrinsically flame-retardant bioplasticizers on a large scale to manufacture functional PVC artificial materials for application in fire-prone scenarios. | Yong Xu Songhang Wang Jinming Chang Zhou Xu Qi Zeng Zhonghui Wang Jun Yan Yi Chen | 2020 | Journal of Leather Science and Engineering2020，2，1： | 0 |
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