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| 1 | Diagonal-symmetrical and Midline-symmetrical Unit Cells with Same Porosity for Bone Implant: Mechanical Properties Evaluation显示文摘In this study, mechanical properties of bionic porous structures with diagonal-symmetrical and midline-symmetrical unit cells were studied when the porosities were same. Three typical unit cells (Diamond (DO), Rhombic Dodecahedron (RD), and Octet Truss (OT)) were selected, in which DO has diagonal-symmetrical shape, while RD and OT share midline-symmetrical structure. Based on the same porosity, corresponding models were designed, and Ti6Al4V samples were manufactured by electron beam melting. Then, using Mechanical Properties Testing (MPT) and Finite Element Analysis (FEA) methodologies, mechanical properties and transmissions of different porous structures were evaluated. Besides, composition and details before and after printing were analyzed with Energy Dispersive Spectrometer (EDS), X-ray diffraction (XRD) and Scanning Electron Microscope (SEM). MPT results showed that midline-symmetrical shape would have superior compressive performance than diagonal-symmetrical shape, but opposite trend for the torsion performance, which were in line with FEA prediction. Furthermore, effective modulus of DO, RD and OT were 2.59 GPa, 4.89 GPa, and 1.77 GPa, approximating the mechanical properties of human bones. Additionally, manufacturing defects and discrepancies between FEA and MPT were found. This study would provide great helps for unit cell selection and initial mechanical properties matching for optimum bone implants. | Jian Li Diansheng Chen Yingying Zhang Yan Yao Zhongjun Mo Lizhen Wang Yubo Fan | 2019 | Journal of Bionic Engineering2019，16，3： | 4 |
| 2 | Small-angle X-ray scattering study on the orientation of suspended sodium titanate nanofiber induced by applied electric field显示文摘Introduction Nanofiber orientation in suspensions determines the performance of nanoparticle suspensions which have potential applications in intelligent control.Material and method Na2Ti3O7 nanofibers were prepared with a hydrothermal method.The orientation degree of Na2Ti3O7 nanofibers in silicone oil has been studied by in situ small-angle X-ray scattering technique.Thünemann–Ruland method was used to extract the distribution widths of Na2Ti3O7 nanofibers in the suspensions.Conclution An empirical formula has been proposed to describe the dependence of nanofiber orientation degree on the external electric-field strength(E)and the nanofiber concentration(C).The results demonstrate that the response of nanofiber orientation to the electric field can be divided into exponential and linear stages before and after the inflection point of electric-field strength(Ec0.09 kV/mm).Low concentration of suspension is more sensitive to the external electric field.The increase in nanofiber concentration will decrease the response sensitivity of nanofiber orientation degree to the change of E.The critical concentration of Na2Ti3O7 nanofibers in the suspension is about 5 wt%.This study is expected to give new clue for the structurally responsive mechanism of anisotropic nanoparticles in suspensions to electric-field strength and particle concentration. | Jiayi Wang Xiaoyi Zhao Yunpeng Liu Lixiong Qian Lei Yao Xueqing Xing Guang Mo Quan Cai Zhongjun Chen Zhonghua Wu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 3 | Biome- chanical effects of cervical arthroplasty with U-shaped disc implant on segmental range of motion and loading of sur-rounding soft tissue 显示文摘 | MO Zhongjun ZHAO Yanbin WANG Lizhen | 2014 | Eur Spine J2014，23，3： | 1 |
| 4 | A novel SAXS/XRD/XAFS combined technique for in-situ timeresolved simultaneous measurements显示文摘Synchrotron radiation based combined technique can provide multiple structural information simultaneously,which is an important development direction of structural detection.In this study,a novel small-angle X-ray scattering/X-ray diffraction/X-ray absorption fine structure(SAXS/XRD/XAFS)combined setup was constructed,where an area detector,a curved detector,and a point detector are,respectively,used for the measurements of SAXS,XRD,and XAFS signals.A detailed description about the combined setup was given.A minitype diamond detector coupled to a SAXS beamstop was used to record the transmitted X-ray intensity,making the scattering(SAXS and XRD)signal measurement compatible with the absorption(XAFS)signal measurement,avoiding mechanical switching.The two-way sampling strategy was used to acquire XAFS signals,shortening the non-counting time.The two-way and one-way sampling strategies were discussed.High-frequency sampling scheme was used to collect experimental signals,improving the measurement efficiency and signal-to-noise ratio.A detailed description and discussion about the high-frequency scheme were also given in this paper.Except the rotation of monochromator,there is no mechanical movement in measurements,time resolution may reach the level of seconds.Using this SAXS/XRD/XAFS combined setup,SAXS,XRD,and XAFS signals can be acquired simultaneously.With some in-situ sample environment system,the newlydeveloped combined technique can be used to track the structure evolution in complex fluids.During the formation processes of(BiO)2CO3 and ZnAPO-34 particles,the changes of in-situ experimental data with reaction time demonstrate that SAXS/XRD/XAFS combined technique is feasible to track the dynamic process. | Zhonghua Wu Yunpeng Liu Xueqing Xing Lei Yao Zhongjun Chen Guang Mo Lirong Zheng Quan Cai Hao Wang Jiajun Zhong Yuecheng Lai Lixiong Qian | 2023 | Nano Research2023，16，1： | 0 |
| 5 | The bone alterations in hind limb amputation rats in vivo显示文摘Osteoporosis,which is characterized by bone loss,increases the risk of fractures and s and seriously affected the amputee’s health.Muscle mass is an important factor affecting bone mineral density(BMD).Muscular atrophy and decreased muscle mass can cause BMD to fall.The bone quantity and quality are used to assess by Microcomputer tomography(micro-CT)with non-destructive.To investigate the performance of micro-CT in evaluating amputation-induced osteopenia in rats,the micro-CT was used to evaluate the change of the microstructure in trabecular bone and cortical bone of amputation.Muscle morphology was analyzed by micro-CT and transmission electron microscopy.Female Sprague–Dawley rats(8 week old)were divided into two groups:control(CON)groups and left hind limb amputation(LHLA).At 35 days,microstructure and volumetric bone mineral density(vBMD)of the tibia and femur were detected through micro-CT.The results showed:(1)the trabecular and cortical vBMD of the proximal tibia and distal femur in the LHLA group were significantly lower than those in the CON group.(2)Compared with the CON group,the trabecular number,bone volume fraction and trabecular thickness of proximal tibia and distal femur in LHLA group decreased significantly,whereas the trabecular separation,structure model index and bone surface/bone volume increased significantly in LHLA group.(3)The whole cross-sectional area(CSA)of whole calf muscles of left limb in LHLA group decreased significantly compared with CON group.In general,hind limb amputation could cause bone loss,changes in the microstructure of trabecular bone and muscle atrophy.Micro-CT is sensitive in evaluating bone microstructure destruction caused by amputation,and can be used for early diagnosis or monitor the development of bone loss in amputation in vivo. | Huiqin Luan Huiru gu Zhongjun Mo Weiyan Ren Huan Guo Zhaowei Chu Yubo Fan | 2020 | Medicine in Novel Technology and Devices2020，，4： | 0 |
| 6 | Effects of different concentrations of TiAl6V4 particles on MC3T3-E1 cells and bone in rats显示文摘Three-dimensional(3D)-printed porous Ti6Al4V implants have good mechanical properties and excellent biocompatibility.As such,these implants are widely used in orthopedics.Particles adhere between the sintered and nonsintered interfaces of the porous samples during 3D printing.These excess particles can be cleaned by blowing the particles and via ultrasound,but the excess internal particles of complex structural parts are difficult to remove.During long-term cyclic loading,stress and strain can cause residual Ti6Al4V particles in the pores of the implant to shed.These detached Ti6Al4V particles are in extensive contact with osteoblasts and scattered around the implant.In this study,we examined the effects of different concentrations of Ti6Al4V particles on osteoblasts and bones.MC3T3-E1 cells were used to evaluate the effects of different concentrations of Ti6Al4V particles on cells after 72 h on the basis of the expression levels of genes,involving osteopontin,alkaline phosphatase,bone morphogenetic protein-2 and runt-related transcription factor-2.Microtubule-associated protein 1 light chain 3 was used to detect the autophagy of MC3T3-E1 with different concentrations of Ti6Al4V particles.The distal femoral defects of rats were examined to examine bone growth with different concentrations of Ti6Al4V particles.All rats were accepted by micro-CT and biochemical analyses after 12 weeks.The results indicated that 10 and 100μg/ml of Ti6Al4V particles may improve osteogenic differentiation.Micro-CT revealed that low concentrations of Ti6Al4V particles may improve the osteogenesis of the rats.However,the(cortical and trabecular)BMD of middle and high dose groups was no significant change compared with control group.In conclusion,low-dose residual particles do not inhibit osteoblast differentiation and do not decrease the bone mineral density of rats. | Huiqin Luan Zhanyong Yu Jian Li Jingfang Bi Zhongjun Mo Weiyan Ren Zengyong Li | 2020 | Medicine in Novel Technology and Devices2020，，3： | 0 |
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