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| 1 | Key gene and protein changes in the beta-amyloid pathway following Longyanshen polysaccharides treatment in a mouse model of Alzheimer's disease显示文摘BACKGROUND:During onset and development of Alzheimer's disease,β-amyloid(Aβ) precursor protein(APP),β-site amyloid precursor protein cleaving enzyme(BACE),andβ-amyloid are key genes and proteins in the Aβpathway,and over-expression of these genes can lead to Aβdeposition in the brain. OBJECTIVE:To observe the influence of Longyanshen polysaccharides on expression of BACE, APP,and Aβin the senescence-accelerated mouse prone/8(SAMP8) brain,and to compare these effects with huperzine A treatment. DESIGN,TIME AND SETTING:A randomized,controlled,neurobiochemical experiment was performed at the Department of Pharmacology and Scientific Experimental Center of Guangxi Medical University from September 2005 to January 2008. MATERIALS:Longyanshen polysaccharides powder was extracted from the dried slices of the medicinal plant Longyanshen.The active component,Longyanshen polysaccharides,was provided by the Department of Pharmacology,Guangxi Medical University;huperzine A was purchased from Yuzhong Drug Manufactory,China. METHODS:Healthy SAMP8 mice were used to establish a model of Alzheimer's disease.A total of 50 SAMP8 mice were randomly assigned to 5 groups(n = 10):SAMP8,huperzine A,low-,middle-, and high-dose polysaccharides.In addition,10 senescence-accelerated mouse resistant 1(SAMR1) mice were selected as normal controls.SAMP8 and SAMR1 mice were administered 30 mL/kg normal saline;the huperzine A group was administered 0.02 mg/kg huperzine A;the low-,middle-, and high-dose polysaccharides groups were respectively administered 45,90,and 180 mg/kg Longyanshen polysaccharides.Each group was treated by intragastric administration,once per day, for 50 consecutive days. MAIN OUTCOME MEASURES:One hour after the final administration,immunohistochemical analysis was used to determine Aβexpression in the cortex and hippocampus of SAMP8 mice. Reverse-transcription polymerase chain reaction was used to determine mRNA levels of BACE and APP in SAMP8 brain tissue. RESULTS:Compared with the SAMR1 group,Aβexpression in the cerebral cortex and hippocampus,as well as expression of BACE,APP mRNA in the brain was significantly increased in the SAMP8 group(P<0.05-0.01).Compared with the SAMP8 group,Aβexpression,as well as BACE and APP mRNA expression,were significantly decreased in the cerebral cortex and hippocampus of huperzine A and low-,middle-,and high-dose polysaccharides groups(P<0.05-0.01).In particular,the effect of high-dose polysaccharides was the most significant(P<0.05-0.01). CONCLUSION:Longyanshen polysaccharides reduced or inhibited over-expression of BACE,APP, and Aβin SAMP8 mice in a dose-dependent manner,and the effect was not worse than huperzine A. | Zhongshi Huang Shijun Zhang Haiyuan Xie Xing Lin Weizhe Jiang Renbin Huang | 2009 | Neural Regeneration Research2009，4，10： | 4 |
| 2 | Global Dynamics near the Resonance in the Sine-Gordon Equation显示文摘樱椋睿澹牵铮颍洌铮? EquationTX1IntroductionThenonlineardynamicsofthedampeddrivensine-Gordonequationut-uxx+sinu=-ε(αut+Γcosωt),(1.1)whe?.. | Huang Debin Liu Zengrong (Shanghai University) Cheng Zhongshi (Shanghai Administrative College for Trade Union Cadres) | 1998 | Advances in Manufacturing1998，，4： | 3 |
| 3 | Protective effect of Millettia pulchra polysaccharide on cognitive impairment induced by D-galactose in mice显示文摘 | Xing Lin Zhongshi Huang Xiaoyu Chen | 2014 | Carbohydrate Polymers:Scientific and Technological Aspects of Industrially Important Polysaccharides2014，101，4： | 1 |
| 4 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 5 | Can a global mean sea-level rise reduce the Last Interglacial model-data mismatch in East Asia?显示文摘末次间冰期有着丰富的重建和模拟资料,为研究未来温暖气候提供了一个理想的参考.然而,关于末次间冰期的东亚气候,模拟与重建的结果间长期存在着不匹配的情况,模拟结果普遍较重建结果更为冷干。本研究利用挪威地球系统模式(NorESM1-F),探讨了在末次间冰期模拟试验中纳入全球平均海平面上升能否减少模式-数据的不匹配.该试验结果表明,海平面上升情况下东亚地区会产生一定的增温增湿效应,但不足以消除模式-数据不匹配.基于这些结果,作者探讨了其它可能造成不匹配的因素以供进一步研究. | Zhiqi Qian Tianao Xu Zhongshi Zhang Chunju Huang | 2023 | Atmospheric and Oceanic Science Letters2023，16，5： | 0 |
| 6 | Protective Effect of Ethanol Extract from Sweet Potato Leaves on CCL_(4)-Induced Liver Injury in Mice显示文摘[Objectives]To investigate the protective effect of ethanol extract from sweet potato leaves on liver injury induced by CCl_(4)in mice.[Methods]25 ICR mice were randomly divided into blank group,model group,high-dose extract group(200 mg/kg),low-dose extract group(100 mg/kg)and positive control group(2 mg/kg colchicine),with 5 mice in each group.All groups except the blank group were given intraperitoneal injection of 20%CCl 4 olive oil solution(2 mL/kg),and the blank group was given the same dose of olive oil solution three times a week.After 4 weeks,each administration group was given the corresponding dose of drugs(10 mL/kg),and the blank group and model group were given the corresponding amount of normal saline for 2 weeks.After the last intragastric administration,fasting was required,but water was allowed,blood was taken from eyeballs,and upper serum was taken by static centrifugation.Serum AST,ALT,CRP,IL-6 and SOD levels were detected by the kit.[Results]Compared with the blank group,the serum AST and ALT levels in the model group were significantly increased;compared with the model group,the ethanol extract of sweet potato leaves could decrease the levels of ALT,AST,CRP,IL-6 and increase the level of SOD in serum.[Conclusions]The ethanol extract of sweet potato leaves had protective effect on the mice with liver injury induced by CCl_(4),and its mechanism may be to protect the liver by lowering enzymes,inhibiting inflammation and antioxidant stress. | Chenchen HUANG Haihua LU Ting ZHAO Xiangting QIN Ting WEI Yingjun HE Suoyi HUANG Zhongshi HUANG | 2023 | Medicinal Plant2023，14，5： | 0 |
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