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| 1 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 2 | Colony development and physiological characterization of the edible blue-green alga,Nostoc sphaeroides (Nostocaceae,Cyanophyta)显示文摘可食的蓝绿色的水藻, Nostoc sphaeroides K ü t 精力,能形成微殖民地和球形的宏殖民地。它被用作因为它的 nutraceutical 和药理学,草药的药和饮食的补充几个世纪有益于的一个有势力。然而,有限信息在球形的宏殖民地和影响他们的结构的环境因素的发展是可得到的。这份报告描述了 N 的形态发生。从单个毛状体的 sphaeroides 到宏殖民地。在这个过程期间,各种各样的尺寸的宏殖民地的很结构的特征是稠密的斑点,戒指,紧缩的核心和液体核心的形成;并且在宏殖民地以内的细丝显示出取决于宏殖民地的尺寸的不同长度和数组。同时,温度和轻紧张强烈也影响了宏殖民地的内部结构。同样微的殖民地进一步在尺寸增加了形成 30 个公里宏殖民地,区分进不同的外部、中间、内部的层的殖民地。外部层的细丝内部层比那些显示出更高最大的光合的率,更高轻的浸透点,和更高光合的效率;而内部层的细丝有叶绿素的一个更高的内容 and phycobiliproteins 比那些外部层。在这研究获得的结果为 N 的集体耕作是重要的。sphaeroides 作为一个 nutraceutical 产品。 | Zhongyang Deng Qiang Hu Fan Lu Guoxiang Liu Zhengyu Hu | 2008 | Progress in Natural Science:Materials International2008，18，12： | 7 |
| 3 | LLDPE prepared by in situ polymerization using a dual-functional catalytic system of Ti(On-Bu)_4 /AlEt_3-Et(Ind)_2-ZrCl_2/MAO显示文摘Linear low-density polyethylene (LLDPE) was prepared by in situ polymerization using a dual-functional catalytic system containing Et(Ind)2ZrCl2/MAO and Ti(On-Bu)4 /AlEt3 used as co-polymerization catalyst and dimeriza-tion catalyst, respectively. The catalytic system showed high activity and the polymer with low melting point, narrow molecular weight distribution (MWD) and low crystallinity was produced. | LIU Zhongyang, XU Demin, GUO Cunyue, WANG Jun, HE Dawei & HU YouliangStale Key Lab of Engineering Plastics, Center for Molecular Science, Institute of Chemistry. Chinese Academy of Sciences, Beijing 100080, China Beijing Lab of Catalysis. China National Petroleum Corporation Key Lab of Catalysis, Beijing 100080, China | 2001 | Chinese Science Bulletin2001，46，24： | 7 |
| 4 | Preparation of long-branched polyethylene by in situ poly-merization using late transition metal and metallocene catalysts显示文摘An in situ polymerization method was investigated to prepare long-branched polyethylene (LBPE) with ethylene alone and a single cocatalyst, methylalumoxane (MAO), by using a dual functional catalytic system containing late transition metal oligomerization catalyst and metal-locene copolymerization catalyst. The obtained long-branched polyethylene has the characteristics of low melting point, high activity and well-dispersed sequence distribution. | LIU Zhongyang GUO Cunyue MAZhi WANG Jun XU Demin HE Dawei HU Youliang | 2001 | Chinese Science Bulletin2001，46，24： | 5 |
| 5 | Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer显示文摘Copy number variations(CNVs), which can affect the role of long non-coding RNAs(lncRNAs), are important genetic changes seen in some malignant tumors. We analyzed lncRNAs with CNV to explore the relationship between lncRNAs and prognosis in bladder cancer(BLCA). Messenger RNA(mRNA) expression levels, DNA methylation, and DNA copy number data of 408 BLCA patients were subjected to integrative bioinformatics analysis. Cluster analysis was performed to obtain different subtypes and differently expressed lncRNAs and coding genes. Weighted gene co-expression network analysis(WGCNA) was performed to identify the co-expression gene and lncRNA modules. CNV-associated lncRNA data and their influence on cancer prognosis were assessed with Kaplan-Meier survival curve. Multi-omics integration analysis revealed five prognostic lncRNAs with CNV, namely NR2 F1-AS1, LINC01138, THUMPD3-AS1, LOC101928489, and TMEM147-AS1, and a risk-score signature related to overall survival in BLCA was identified. Moreover, validated results in another independent Gene Expression Omnibus(GEO) dataset, GSE31684, were consistent with these results. Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis revealed that the mitogen-activated protein kinase(MAPK) signaling pathway, focal adhesion pathway, and Janus kinase-signal transducers and activators of transcription(JAK-STAT) signaling pathway were enriched in a high-risk score pattern, suggesting that imbalance in these pathways is closely related to tumor development. We revealed the prognosis-related lncRNAs by analyzing the expression profiles of lncRNAs and CNVs, which can be used as prognostic biomarkers for BLCA. | Wenwen ZHONG Dejuan WANG Bing YAO Xiaoxia CHEN Zhongyang WANG Hu QU Bo MA Lei YE Jianguang QIU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，8： | 2 |
| 6 | F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery显示文摘 | Quanyin Hu Guangzhi Gu Zhongyang Liu Mengyin Jiang Ting Kang Deyu Miao Yifan Tu Zhiqing Pang Qingxiang Song Lei Yao Huimin Xia Hongzhan Chen Xinguo Jiang Xiaoling Gao Jun Chen | 2013 | Biomaterials2013，，4： | 1 |
| 7 | 1,5-Anhydroglucitol Predicts Mortality in Patients with HBV-Related Acute-on-chronic Liver Failure显示文摘Background and Aims:1,5-Anhydroglucitol(1,5AG)activ-ity has been reported in chronic liver disease.Hepatitis B vi-rus(HBV)-related acute-on-chronic liver failure(HBV-ACLF)patients have a high mortality.We aimed to discover the re-lationship between serum 1,5AG and the prognosis of HBV-ACLF.Methods:Serum 1,5AG levels were determined in 333 patients with HBV-ACLF,300 without diabetes were allo-cated to derivation(n=206)and validation cohorts(n=94),and 33 were recruited to evaluate 1,5AG in those with diabe-tes.Forty patients with chronic hepatitis B,40 with liver cir-rhosis,and 40 healthy people were controls in the validation cohort.Results:In the derivation and validation cohorts,serum 1,5AG levels were significantly lower in nonsurvivors than in survivors.The AUC of 1,5AG for 28-day mortality was 0.811.In patients with diabetes,serum 1,5AG levels were also significantly lower in nonsurvivors than in survi-vors.In multivariate Cox regression analysis,serum 1,5AG levels were independently associated with 28-day mortal-ity.A novel predictive model(ACTIG)based on 1,5AG,age,TB,cholesterol,and INR was derived to predict mortality.In ACTIG,the AUC for 28-day mortality was 0.914,which was superior to some prognostic score models.ACTIG was also comparable to those prognostic score models in pre-dicting 6-month mortality.In mice with D-galactosamine/lipopolysaccharide-induced liver failure,1,5AG levels were significantly reduced in serum and significantly increased in urine and liver tissue.Conclusions:Serum 1,5AG levels are a promising predictor of short-term mortality in HBV-ACLF patients.The 1,5AG distribution changed in mice with D-galactosamine/lipopolysaccharide-induced liver failure. | Lingjian Zhang Yalei Zhao Zhongyang Xie Lanlan Xiao Qingqing Hu Qian Li Shima Tang Jie Wang Lanjuan Li | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 1 |
| 8 | Neuroprotective effects of willed-movement therapy in a rat model of cerebral ischemia/reperfusion显示文摘The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method.Rats performed willed-movement(climbing a ladder or wall in a box) when induced by food and water.Results revealed that Longa scores of neurological deficits significantly de-creased in the willed-movement group at 15 days after reperfusion,while expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion.Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43. | Deren Hou Jianfeng Liu Jinfeng Deng Zhongyang Hu Chao Feng Haixia Zhu | 2011 | Neural Regeneration Research2011，6，35： | 1 |
| 9 | Factors impacting gaseous mercury speciation in postcombustion 显示文摘 | ZHOU Jingsong LUO Zhongyang HU Changxing | 2007 | Energy Fuels2007，21，2： | 1 |
| 10 | Factors impacting gaseous mercury speciation in postcombustion 显示文摘 | Zhou Jinsong Luo Zhongyang Hu Changxing | 2007 | Energy & Fuels2007，21，： | 1 |
| 11 | Sta-bility of mercury on three activated carbon sorbents显示文摘 | LUO Zhongyang HU Changxing ZHOU Jinsong | 2006 | FuelProcessing Technology2006，87，8： | 1 |
| 12 | Lipid accumulation and growth of Chlorella zofingiensis in flat plate photobioreactors outdoors显示文摘 | Pingzhong Feng Zhongyang Deng Zhengyu Hu Lu Fan | 2011 | Bioresource Technology2011，，22： | 1 |
| 13 | Stability of mercury on three activated carbon sorbents显示文摘 | Luo Zhongyang Hu Changxing Zhou Jinsong | 2006 | Fuel Processing Technology2006，87，8： | 1 |
| 14 | Growth kinetics of 1–2?mm and 3–4?mm colonies of Nostoc sphaeroides (Cyanophyta) in outdoor culture显示文摘 | Zhongyang Deng Chunlan Yan Fan Lu Qiang Hu Zhengyu Hu | 2008 | Biotechnology Letters2008，，10： | 1 |
| 15 | Characterization of Chlorococcum pamirum as a potential biodiesel feedstock显示文摘 | Pingzhong Feng Zhongyang Deng Zhengyu Hu Zhongming Wang Lu Fan | 2014 | Bioresource Technology2014，，： | 1 |
| 16 | F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery显示文摘 | Quanyin Hu Guangzhi Gu Zhongyang Liu Mengyin Jiang Ting Kang Deyu Miao Yifan Tu Zhiqing Pang Qingxiang Song Lei Yao Huimin Xia Hongzhan Chen Xinguo Jiang Xiaoling Gao Jun Chen | 2013 | Biomaterials2013，，4： | 1 |
| 17 | Lipid accumulation and growth characteristics of Chlorella zofingiensis under different nitrate and phosphate concentrations显示文摘 | Pingzhong Feng Zhongyang Deng Lu Fan Zhengyu Hu | 2012 | Journal of Bioscience and Bioengineering2012，，4： | 1 |
| 18 | Lipid accumulation and growth of Chlorella zofingiensis in flat plate photobioreactors outdoors显示文摘 | Pingzhong Feng Zhongyang Deng Zhengyu Hu Lu Fan | 2011 | Bioresource Technology2011，，22： | 1 |
| 19 | Effect of chemical activation of an activated carbon using zinc chloride on elemental mercury adsorption显示文摘 | Changxing Hu Jinsong Zhou Sheng He Zhongyang Luo Kefa Cen | 2009 | Fuel Processing Technology2009，，6： | 1 |
| 20 | Experimental study on DX pile performance in frozen soils under lateral loading显示文摘Experiments about working mechanism and mechanical characteristics of the DX model pile foundation under lateral dynamic and static loading were conducted by using a model system of the dynamic frozen soil-pile interaction. The horizontal displacement-force relationship of the pile head and bending moment distribution along the body in frozen soils of different temperatures were discussed. According to test results, both the horizontal displacement-force relationship of the DX pile head and bending moment distribution of the DX pile body are smaller than that of equal-diameter piles under same lateral loads. The piles with different plate positions show different displacements and bending moments. This phenomenon is mainly related to the soil temperature and bearing plates locations. Thus, dynamic response analysis of the pile foundation should be taken into account. | XiaoBing Liu LiHong Chen ZhongYang Yu JianXiao Hu Wen Peng | 2013 | Research in Cold and Arid Regions2013，5，5： | 0 |
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