5篇
您的检索式：作者名="Zhou Aiying"
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| 1 | Synthesis and Fungicidal Activity of (E)-5-[1-(2-Oxo- 1 -oxaspiro[4,5]dec/non-3-en-3-yl)ethylidene]-2- aminoimidazolin-4-one Derivatives显示文摘 | Bo Tang Aiying Guan Yu Zhao Jiazhen Jiang Mingan Wang Ligang Zhou | 2017 | Chinese Journal of Chemistry2017，35，7： | 3 |
| 2 | Urbanization Effects on Observed Surface Air Temperature Trends in North China显示文摘 | Ren Guoyu Zhou Yaqing Chu Ziying Zhou Jiangxing Zhang Aiying Guo Jun Liu Xuefeng | 2008 | Journal of Climate2008，，6： | 1 |
| 3 | Three-dimensional Simulation and pattern making of collar using geometric model显示文摘 | Hou Dongyu Zhou Aiying | 2000 | Journal of Don Hua University2000，18，3： | 1 |
| 4 | Urbanization Effects on Observed Surface Air Temperature Trends in North China显示文摘 | Ren Guoyu Zhou Yaqing Chu Ziying Zhou Jiangxing Zhang Aiying Guo Jun Liu Xuefeng | 2008 | Journal of Climate2008，，： | 1 |
| 5 | Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1Α pathway显示文摘Metabolic reprogramming is a common phenomenon in cancer,with aerobic glycolysis being one of its important characteristics.Hypoxia-inducible factor-1α(HIF1Α)is thought to play an important role in aerobic glycolysis.Meanwhile,naringin is a natural flavanone glycoside derived from grapefruits and many other citrus fruits.In this work,we identified glycolytic genes related to HIF1Αby analyzing the colon cancer database.The analysis of extracellular acidification rate and cell function verified the regulatory effects of HIF1Αoverexpression on glycolysis,and the proliferation and migration of colon cancer cells.Moreover,naringin was used as an inhibitor of colon cancer cells to illustrate its effect on HIF1Αfunction.The results showed that the HIF1Αand enolase 2(ENO2)levels in colon cancer tissues were highly correlated,and their high expression indicated a poor prognosis for colon cancer patients.Mechanistically,HIF1Αdirectly binds to the DNA promoter region and upregulates the transcription of ENO2;ectopic expression of ENO2 increased aerobic glycolysis in colon cancer cells.Most importantly,we found that the appropriate concentration of naringin inhibited the transcriptional activity of HIF1Α,which in turn decreased aerobic glycolysis in colon cancer cells.Generally,naringin reduces glycolysis in colon cancer cells by reducing the transcriptional activity of HIF1Αand the proliferation and invasion of colon cancer cells.This study helps to elucidate the relationship between colon cancer progression and glucose metabolism,and demonstrates the efficacy of naringin in the treatment of colon cancer. | Guangtao PAN Ping ZHANG Aiying CHEN Yu DENG Zhen ZHANG Han LU Aoxun ZHU Cong ZHOU Yanran WU Sen LI | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，3： | 0 |
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