|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 4 | WONCA研究论文摘要汇编——儿童急性呼吸道感染诊治的交流技巧和抗生素使用显示文摘目的探讨儿童急性呼吸道感染(ARTI)问诊过程中医生交流技巧与抗生素处方关系。方法采取横断面调查2007年11月—2009年4月西雅图10家诊所28名医生对1 285例ARTI患儿的诊疗过程。每次问诊结束后,对医生进行调查,调查内容包括患儿症状、查体结果、诊断和处方。同时对患儿家长进行调查,调查内容为医生的沟通技巧。结果不论是仅提出积极治疗建议〔OR=0.48,95%CI(0.24,0.95)〕,还是同时提出积极治疗建议和消极治疗建议(排除抗生素使用的需要)的医生〔OR=0.15,95%CI(0.06,0.40)〕,使用抗生素处方的概率均降低。结论医生同时提供积极和消极治疗建议可以降低病毒性ARTI患儿使用抗生素处方的风险。随着抗生素耐药的愈发严重,这一交流技巧可作为医生应对该医疗问题的举措之一。 | Mangione-Smith R Zhou C Robinson JD 本刊编辑部 | 2015 | 中国全科医学2015，18，23： | 8 |
| 5 | Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism显示文摘 | An H Xu H Zhang M Zhou J Feng T Qian C Qi R Cao X | 2006 | 第二军医大学学报2006，27，1： | 6 |
| 6 | 中国成年女性初潮年龄与高血压风险的关系:大型国家代表性群体研究结果显示文摘本研究纳入中国高血压调查中年龄≥18岁的女性234867例,旨在探索中国成年女性初潮年龄与高血压风险的相关性。参与者被要求完成标准问卷,血压测量和体格检查由经过培训的医务人员完成。采用Spearman相关性分析探索初潮年龄和其他个体特征的相关性。采用logistic回归根据初潮年龄计算高血压发生的OR。结果显示,中国女性平均初潮年龄为14.8岁。 | 袁源(摘译) 郑武洪(审校) Chen L Zhang L Chen Z Wang X Zheng C Kang Y Zhou H Wang Z Gao R | 2021 | 中华高血压杂志2021，29，10： | 3 |
| 7 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 8 | Dielectric and piezoelectric properties of bismuth-containing complex perovskite solid solution of Bi1/2Na1/2TiO3-Bi(Mg2/3Nb1/3)O3 显示文摘 | Zhou C R Liu X Y | 2008 | J Mater Sci2008，43，： | 1 |
| 9 | Two-echelon supply chain games in a fuzzy environment显示文摘 | Zhou C Zhao R Tang W | 2008 | Computers & Industrial Engineering2008，55，： | 1 |
| 10 | A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication显示文摘 | Xiang R Mizutani N Luo Y Chiodoni C Zhou H Mizutani M | 2005 | Cancer Res2005，65，： | 1 |
| 11 | Alexander experimental evaluation of a rotor flux oriented control algorithm for brushless doubly-fed machines显示文摘 | Zhou D Spee R Gerald C | 1997 | IEEE Trans Power Electronics1997，12，1： | 1 |
| 12 | Mechanism of hydroxyethyl starch on reducing pulmonary capillary permeability in a rat model of sepsis 显示文摘 | Lv R Zhou W Chu C | 2005 | Ann Clin Lab Sci2005，35，2： | 1 |
| 13 | Image quality assessment:from error visibility to structural similarity显示文摘 | WANG ZHOU BOVIK A C SHEIKH H R | 2004 | IEEE Transactions on Image Processing2004，13，4： | 1 |
| 14 | Nanotube Networks in Polymer Nanocomposites: Rheology and Electrical Conductivity显示文摘 | Du Fangming Scogna R C Zhou W | 2004 | Macromolecules2004，37，24： | 1 |
| 15 | Investigation on coal pyrolysis in CO2 atmosphere显示文摘 | DUAN L B ZHAO C S ZHOU W QU C R CHEN X P | 2009 | Energy Fuels2009，23，7： | 1 |
| 16 | Effect of particle structure on the peel strength and heat resistance properties of vinyl acetate/ acrylate latexes laminating adhesives显示文摘 | Zhou C L Che R S Zhong L | 2011 | Journal of Applied Polymer Science2011，119，5： | 1 |
| 17 | Charge trapping and detrapping in polymeric materials: trapping parameters显示文摘 | Zhou T C George C Liao R J | 2011 | Journal of Applied Physics2011，110，04： | 1 |
| 18 | Metal-organic frame- works for separations 显示文摘 | LI J R SCULLEY J L ZHOU H C | 2012 | Chem Rev2012，112，2： | 1 |
| 19 | Erbin inhibits TGF-β1- induced EMT in renal tubular epithelial cells through an ERK-dependent pathway显示文摘 | Zhou Q Zeng R Xu C | 2012 | J Mol Med (Berl)2012，90，5： | 1 |
| 20 | A temporal link between the Emeishan large igneous province (SW China) and the end-Guagalupian mass extinction 显示文摘 | Zhou M F Malpas J Song X Y Robinson P T Sun M Kennedy A K Lesher C M Keays R R | 2002 | Earth arut Planetary Science Letters2002，196，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员