|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Big data challenge: a data management perspective显示文摘 | Jinchuan CHEN Yueguo CHEN Xiaoyong DU Cuiping LI Jiaheng LU Suyun ZHAO Xuan ZHOU | 2013 | Frontiers of Computer Science2013，7，2： | 21 |
| 2 | Source rupture process of Lushan M_S7.0 earthquake, Sichuan,China and its tectonic implications显示文摘The source rupture process of the MS7.0 Lushan earthquake was here evaluated using 40 long-period P waveforms with even azimuth coverage of stations.Results reveal that the rupture process of the Lushan MS7.0 event to be simpler than that of the Wenchuan earthquake and also showed significant differences between the two rupture processes.The whole rupture process lasted 36 s and most of the moment was released within the first 13 s.The total released moment is 1.9×1019N m with MW=6.8.Rupture propagated upwards and bilaterally to both sides from the initial point,resulting in a large slip region of 40 km×30 km,with the maximum slip of 1.8 m,located above the initial point.No surface displacement was estimated around the epicenter,but displacement was observed about 20 km NE and SW directions of the epicenter.Both showed slips of less than 40 cm.The rupture suddenly stopped at 20 km NE of the initial point.This was consistent with the aftershock activity.This phenomenon indicates the existence of significant variation of the medium or tectonic structure,which may prevent the propagation of the rupture and aftershock activity.The earthquake risk of the left segment of Qianshan fault is worthy of attention. | ZHAO CuiPing ZHOU LianQing CHEN ZhangLi | 2013 | Chinese Science Bulletin2013，58，28： | 13 |
| 3 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018，61，3： | 6 |
| 4 | Rupture process of the Wenchuan M8.0 earthquake of Sichuan, China: the segmentation feature显示文摘Moment tensor solution, rupture process and rupture characteristics of the great Wenchuan M8.0 earthquake are studied by using 39 long-period P and SH waveforms with evenly azimuth coverage of stations. Our results reveal that the Wenchuan M8.0 event consisted of 5 sub-events of Mw≥7.3 occurring succesively in time and space. Rupture started with a Mw7.3 introductory strike-slip faulting in the first 12 s, then within 12?40 s, two sub-events with Mw7.6 and Mw7.4 occurred within 80 km northeast from the initial point with the dominant rupture type of thrust moving. From 40 to 62 s, a Mw7.5 and Mw7.4 right-lateral strike-slip type of sub-events occurred on the two sides of Beichuan, 120 km away northeast from the initial point. The whole rupture process lasted 105 s and unilaterally propagated from the initial point on the WS section of the Yingxiu-Beichuan fault to the NE direction, resulting in a 230-km-long surface rupture zone and the average surface dislocation is up to 4 m. Two asperities are identified and the whole rupture process is formed by WS and NE parts. In the WS part named Dujiangyang-Wenchuan, where the initial point is located, the rupture process showed reverse faulting with the maximum slip of 8.2 m. Around Mianzhu, rupture changed to right-lateral strike slip faulting and formed a Beichuan-Qingchuan large slip area. The rupture area on this part is about 10 km in depth, shallower than on the WS part. The maximum slip is 6.53 m. Consequently, there formed 2 segments with the surface dislocation larger than 6 m. One is the Dujiangyan-Wenchuan segment with the maximum surface displacement of 6.44 m, the other is the Beichuan-Qingchuan segment with the maximum surface displacement of 6.53 m. This segmentation may have its geological and tectonic background. | ZHAO CuiPing CHEN ZhangLi ZHOU LianQing LI ZhiXiong KANG yin | 2010 | Chinese Science Bulletin2010，55，3： | 5 |
| 5 | Optimized prime editing efficiently generates glyphosate-resistant rice plants carrying homozygous TAP-IVS mutation in EPSPS显示文摘Dear Editor,Prime editing is a novel and universal CRISPR-Cas-derived precise genome-editing technology and has great potentials for applications in basic plant research and crop molecular breeding(Anzalone et al.,2019).Although low efficiency has restrained the original prime editors(PEs)from being used as a routine tool for precise genome editing in plants,an iterative update of the PEs is removing this obstacle(Lin et al.,2021;Xu et al.,2022).Recently,the Liu group reported three optimization strategies for improving prime editing efficiency(Chen et al.,2021;Nelson et al.,2022).The first strategy is based on engineered prime editing guide RNAs(epegRNAs),which were generated by incorporating structured RNA motifs to the 3′terminus of pegRNAs.This strategy enhances pegRNA stability and prevents degradation of the 3′extension(Nelson et al.,2022).The second strategy is based on the optimized PE2 protein(PEmax),which harbors a SpCas9 variant with increased nuclease activity,an additional nuclear localization signal(NLS)sequences,and a new linker between nCas9 and reverse transcriptase(Chen et al.,2021).The third strategy is based on inhibition of DNA mismatch repair(MMR)in cells(Chen et al.,2021).In this work,we tested the optimized PEs generated with these three strategies in rice,demonstrating that the optimized PEs greatly improved prime editing efficiency in rice.We named the two optimized PEs ePE3max and ePE5max:the former is comprised of the PEmax protein,an epegRNA with evopreQ1 appended to its 3′end,and a nicking sgRNA;the latter is comprised of the ePE3max system and a dominant negative OsMLH1 variant for inhibiting MMR.Using the two optimized PEs,we efficiently generated homozygous and heterozygous T173I,A174V,and P177S(TAP-IVS)mutation in EPSPS in rice,which lays a solid foundation for rice non-transgenic glyphosate-resistance breeding. | Yuanyuan Jiang Yiping Chai Dexin Qiao Junya Wang Cuiping Xin Wei Sun Zhenghong Cao Yu Zhang Yun Zhou Xue-Chen Wang Qi-Jun Chen | 2022 | Molecular Plant2022，15，11： | 3 |
| 6 | Shugan Huoxue Huayu Fang(疏肝活血化瘀方)attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting transforming growth factor-β1/Smad signaling显示文摘OBJECTIVE:To investigate the potential mechanism by which Shugan Huoxue Huayu Fang(疏肝活血化瘀方,SGHXHYF)ameliorates liver fibrosis.METHODS:Liver fibrosis was induced in rats by intraperitoneal injection of carbon tetrachloride(CCl_(4))in peanut oil solution(40%,3 m L/kg body weight)twice a week for 8 weeks.A normal control group received the same volume of peanut oil alone.During weeks 5-8,the CCl_(4)-injected rat groups were administered saline(vehicle control),colchicine(0.1 mg/mL,1 mg/kg,positive control),or SGHXHYF(0.1 mg/mL;0.3,0.6 and 1.2 mg/kg)once daily by oral gavage.Rats were sacrificed 24 h after the last treatment.Blood samples were collected for measurement of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),albumin(ALB),collagenⅠ,and collagenⅢlevels.Liver samples were analyzed by histopathological staining,Masson's staining of extracellular matrix proteins,and immune-ohistochemical staining ofα-smooth muscle actin(α-SMA).TGF-β1/Smad protein and mRNA levels were analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction analysis,respectively.In vitro experiments were also performed using rat hepatic stellate cells(HSCs).RESULTS:Compared with the control animals,CCl_(4)-exposed rats exhibited elevated serum levels of ALT,AST,ALP,collagenⅠ,and collagenⅢ;reduced serum levels of ALB;and increased collagen deposition andα-SMA expression in liver sections,reflecting liver fibrosis.CCl_(4) also increased expression of TGF-β1 and the activated(phosphorylated)forms of Smad2 and Smad3 but reduced expression of the negative regulator Smad7 in the liver.Notably,concomitant administration of SGHXHYF to CCl_(4)-exposed rats was found to significantly reverse or abolish the pro-fibrotic effects of CCl_(4) in the liver and reduced serum transferase levels.Analysis of HSCs in vitro confirmed that,mechanistically,SGHXHYF inhibited activation of the TGF-β1/Smad signaling pathway by downregulating phosphorylated Smad2 and Smad3 and upregulating Smad7 levels.CONCLUSION:SGHXHYF ameliorated CCl_(4)-induced liver fibrosis by inhibiting the TGF-β1/Smad signaling pathway.These findings suggest that SGHXHYF may have clinical utility for the treatment or prevention of liver fibrosis. | LIU Lei GUO Hanbin SHAO Cuiping WANG Lin XU Youqing ZHOU Yiming | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 2 |
| 7 | Wendan decoction improves learning and memory deficits in a rat model of schizophrenia显示文摘An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment. | Cuiping Yang Changchun Cai Xiaojin Yang Yanping Yang Zhigang Zhou Jianhua Liu Heping Ye HongjiaoWan | 2012 | Neural Regeneration Research2012，7，15： | 2 |
| 8 | Global expression analysis during late stage of embryonic pancreatic development of rats with microarray technique显示文摘Objective: To define gene expression profiles during late stage of embryonic pancreatic development of rats and to find out key genes in rat pancreatic functional development. Methods: Pancreata of rats in embryonic day 15.5(E15.5) and 18.5(E18.5) were dissected under microscope respectively. Genechips from Affymetrix company were applied to study gene expression profiles. Some differentially expressed genes were verified by RT-PCR. Results: Comparing E18.5 to E15.5, 8.3% genes were expressed differently 2-fold above, in which, 50.3% were up-regulated, including transcriptions related to metabolic development and various kinds of enzymes and hormones (both endocrine and exocrine) and 49.7% were down-regulated, including transcriptions related to cell differentiation. The percentage of genes having definite function was 63%, and that of expressed sequence tag(EST) was 37%. The result of RT-PCR is accordant to that of genechips. Conclusion: The metabolic function of rat pancreas may be further accomplished during late stage of embryonic day. | Qingxin Yuan Chao Liu Yah Zhong Cuiping Liu Li Yuan Jinyong Zhou Li-ping Teng Jingjing Hu Wei De | 2006 | Journal of Nanjing Medical University2006，20，1： | 2 |
| 9 | Impact of allelopathic rice seedlings on rhizospheric microbial populations and their functional diversity显示文摘 | Lin Ruiyu Rong Hong Zhou Junjian Yu Cuiping Ye Chenying Chen Liangsheng Lin Wenxiong | 2007 | Acta Ecologica Sinica2007，，9： | 1 |
| 10 | Trans- dermal delivery of insulin using microneedle rollers in vivo显示文摘 | Zhou CuiPing Liu YuLing Wang HongLiang | 2010 | Int J Pharm2010，392，12： | 1 |
| 11 | Cloning and sequence diversity analysis of GmHs1 pro-1 in Chinese domesticated and wild soybeans显示文摘 | Cuiping Yuan Guoan Zhou Yinghui Li Kejing Wang Zhi Wang Xianghua Li Ruzhen Chang Lijuan Qiu | 2008 | Molecular Breeding2008，，4： | 1 |
| 12 | Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes显示文摘 | Cong Tao Weimin Wang Ping Zhou Tian Xia Xiang Zhou Cuiping Zeng Qingde Zhang Bang Liu | 2013 | Journal of Applied Genetics2013，，1： | 1 |
| 13 | A Comparative Investigation of Single Crystal and Polycrystalline Ni-Rich NCMs as Cathodes for Lithium-Ion Batteries显示文摘Nickel-rich LiNi_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM,1-x-y≥0.6)is known as a promising cathode material for lithium-ion batteries since its superiority of high voltage and large capacity.However,polycrystalline Ni-rich NCMs suffer from poor cycle stability,limiting its further application.Herein,single crystal and polycrystalline LiNi_(0.84)Co_(0.07)Mn_(0.09)O_(2)cathode materials are compared to figure out the relation of the morphology and the electrochemical storage performance.According to the Li^(+)diffusion coefficient,the lower capacity of single crystal samples is mainly ascribed to the limited Li+diffusion in the large bulk.In situ XRD illustrates that the polycrystalline and single crystal NCMs show a virtually identical manner and magnitude in lattice contraction and expansion during cycling.Also,the electrochemically active surface area(ECSA)measurement is employed in lithium-ion battery study for the first time,and these two cathodes show huge discrepancy in the ECSA after the initial cycle.These results suggest that the single crystal sample exhibits reduced cracking,surface side reaction,and Ni/Li mixing but suffers the lower Li^(+)diffusion kinetics.This work offers a view of how the morphology of Ni-rich NCM effects the electrochemical performance,which is instructive for developing a promising strategy to achieve good rate performance and excellent cycling stability. | Xianming Deng Rui Zhang Kai Zhou Ziyao Gao Wei He Lihan Zhang Cuiping Han Feiyu Kang Baohua Li | 2023 | Energy & Environmental Materials2023，6，3： | 1 |
| 14 | A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau显示文摘Dear Editor,The Qinghai-Tibet Plateau(QTP)is the highest and largest plateau in the world;its altitude exceeds 4500 m on average,posing great physiological challenges such as severe hypoxia for endemic wild mammals on the plateau.1 To cope with such a harsh environment,the phylogenetically distant QTP endemic mammals have independently evolved similar morphological and physiological traits. | Donqming Xu Cuiping Yang Qiushuo Shen Shengkai Pan Zhen Liu Tongzuo Zhang Xin Zhou Menglong Lei Peng Chen Hui Yang Tao Zhang Yuanting Guo Xiangjiang Zhan Yongbin Chen Peng Shi | 2021 | Cell Research2021，31，9： | 1 |
| 15 | Machine learning-based automatic construction of earthquake catalog for reservoir areas in multiple river basins of Guizhou province,China显示文摘Large reservoirs have the risk of reservoir induced seismicity.Accurately detecting and locating microseismic events are crucial when studying reservoir earthquakes.Automatic earthquake monitoring in reservoir areas is one of the effective measures for earthquake disaster prevention and mitigation.In this study,we first applied the automatic location workflow(named LOCFLOW)to process 14-day continuous waveform data from several reservoir areas in different river basins of Guizhou province.Compared with the manual seismic catalog,the recall rate of seismic event detection using the workflow was 83.9%.Of the detected earthquakes,88.9%had an onset time difference below 1 s,81.8%has a deviation in epicenter location within 5 km,and 77.8%had a focal depth difference of less than 5 km,indicating that the workflow has good generalization capacity in reservoir areas.We further applied the workflow to retrospectively process continuous waveform data recorded from 2020 to the first half of 2021 in reservoir areas in multiple river basins of western Guizhou province and identified five times the number of seismic events obtained through manual processing.Compared with manual processing of seismic catalog,the completeness magnitude had decreased from 1.3 to 0.8,and a b-value of 1.25 was calculated for seismicity in western Guizhou province,consistent with the b-values obtained for the reservoir area in previous studies.Our results show that seismicity levels were relatively low around large reservoirs that were impounded over 15 years ago,and there is no significant correlation between the seismicity in these areas and reservoir impoundment.Seismicity patterns were notably different around two large reservoirs that were only impounded about 12 years ago,which may be explained by differences in reservoir storage capacity,the geologic and tectonic settings,hydrogeological characteristics,and active fault the reservoir areas.Prominent seismicity persisted around two large reservoirs that have been impounded for less than 10 years.These events were clustered and had relatively shallow focal depths.The impoundment of the Jiayan Reservoir had not officially begun during this study period,but earthquake location results suggested a high seismicity level in this reservoir area.Therefore,any seismicity in this reservoir area after the official impoundment deserves special attention. | Longfei Duan Cuiping Zhao Xingzhong Du Lianqing Zhou | 2023 | Earthquake Science2023，36，2： | 1 |
| 16 | Expression of hippo pathway in colorectal cancer显示文摘 | Kun Liang Guangxi Zhou Qi Zhang Jing Li Cuiping Zhang | 2014 | Saudi Journal of Gastroenterology2014，，3： | 1 |
| 17 | Three-dimensional V-P and V-P/V-S structure in the Longtan Reservoir Area by local earthquake tomography 显示文摘 | ZHOU Lianqing ZHAO Cuiping CHEN Zhangli | 2012 | Pure and Applied Geophysics2012，169，1： | 1 |
| 18 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
| 19 | Current progress and prospects of enzyme technologies in future foods显示文摘Enzyme technologies are widely used in the food industry due to their advantages of high efficiency,specificity,and safety.Recently,“future foods”is emerging as a new research hotspot with healthier foods that are more nutritious,delicious,and sustainable;however,these foods still have problems with texture,nutrition,and flavor.Advances in enzyme technology have enabled the development of new tools and approaches to better manipulate food textures and nutritional aspects.In this review,we summarize enzyme technology applications in future food production,focusing on food texture,safety,and flavors.Furthermore,we discuss the prospects of enzyme-based technologies for future food production,including the modification of enzyme activities,the development of suitable food-grade hosts for enzyme production,and the optimiza-tion synergistic multi-enzyme systems. | Cuiping Pang Xinxin Yin Guoqiang Zhang Song Liu Jingwen Zhou Jianghua Li Guocheng Du | 2021 | Systems Microbiology and Biomanufacturing2021，1，1： | 1 |
| 20 | Mechanism of seeded infiltration growth process analysed by magnetic susceptibility measurements and in situ observation显示文摘 | Haitao Cao X. Chaud J.G. Noudem Cuiping Zhang Rui Hu Jinshan Li Lian Zhou | 2010 | Ceramics International2010，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员