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| 1 | Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China显示文摘 | TAO Li-li HU Bi-jie HE Li-xian WEI Li XIE Hong-mei WANG Bao-qing LI Hua-ying CHEN Xue-hua ZHOU Chun-mei DENG Wei-wu | 2012 | Chinese Medical Journal2012，，17： | 91 |
| 2 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 3 | Peat record reflecting Holo-cene climatic change in the Zoige Plateau and AMS radiocarbon dating显示文摘Through the use of reliable AMS dating of high resolution (15-30 years) peat and the establishment of monsoon climate proxies sequence, we have been able to recognize several cold, dry events in the Tibetan Plateau during the Holocene. The more obvious ones occurred around 12800, 11300, 10200, 9580, 8900, 6400, 4400, 3700, 2800 and 1500 cal. aBP. These events correlate well with both ice rafting events recorded in high latitude North Atlantic Ocean sediment cores and cooling events in the low latitude SST. Spectral analysis indicates high frequency climate variation on centennial-millennial time scale during the Holocene. This further reflects Holocene climate instability and the existence of centennial-millenium scale rhythm in mid latitude areas as well. | ZHOU Weijian LU Xuefeng WU Zhengkun DENG Lin A.J.T.Jull D.Donahue W.Beck | 2002 | Chinese Science Bulletin2002，47，1： | 68 |
| 4 | Research advances in the Mesozoic tectonic regimes during the formation of Jiaodong ore cluster area显示文摘在诺思中国的东方区域在中生代时代在 Jiaodong 矿石簇区域和相关构造政体转变把构造政体的进展基于研究,在这篇论文,我们首先总结要求后面被学习的一些关键问题。然后,我们建议一条途径到处理这些问题。在 Jiaodong 矿石的金存款聚类区域,这被知道,它具有不同矿化作用式样,空间 istributions 和地质的背景,可能作为从在中生代的至少一个地质的事件的结果。到现在为止,特别在上述事件的 geodynamic 机制上,关于时间的进化和空间迁居顺序的这种研究是远非足够的。而且,描述行动模式和构造动态政体的时间空间的框架并且提出每构造动态政体的相对贡献因为 metallogensis 是静止的质问到地质学家在 Jiaodong 的形成上学习的份量上矿石簇区域。根据地区性的构造分析,结构的动力学,观察和矿化作用网络的探索的解释,我们建议有一些的一个 geological-physical-chemical 模型抑制从全面分析发源。我们然后使用这个模型模仿结构的变丑,热运输,液体流动和化学反应的联合过程。获得的结果显示模型在进一步在 Jiaodong 矿石簇区域并且在进一步理解集体 metallogensis 的性质分析构造政体的时间空间的进化小道是有效的。 | DENG Jun YANG Liqiang GE Liangsheng WANG Qingfei ZHANG Jing GAO Bangfei ZHOU Yinghua JIANG Shaoqing | 2006 | Progress in Natural Science:Materials International2006，16，8： | 51 |
| 5 | MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2显示文摘新兴的证据与肿瘤开发和前进显示出异常地表示的 microRNAs (miRNAs ) 的协会。然而,很少在胃的 carcinogenesis 对 miRNAs 的潜在的角色被知道。这里,我们执行了 miRNA microarray 屏蔽在配对的胃的癌症和他们的邻近的 nontumor 纸巾表示并且发现 miR-375 是的 miRNAs 差别极大地在胃的癌症纸巾的 downregulated。量的即时 PCR 分析证实那 miR-375 表情显著地从经历胃的切除术的病人与他们的 nontumor 对应物相比在超过 90% 主要胃的癌症被减少。miR-375 的 Overexpression 显著地在 vitro 并且在 vivo 禁止了胃的癌症房间增长。在胃的癌症房间的 miR-375 的强迫的表示显著地减少了 Janus kinase 的蛋白质水平 2 ( JAK2 )并且镇压带 JAK2 的 3 鈥? untranslated 区域的一个酶记者的活动,被预言的 miR-375-binding 地点的变化废除,显示那 JAK2 可以是 miR-375 目标基因。由由 RNAi 的 JAK2 的 AG490 或 silencing 的 JAK2 活动的任何一个抑制压制了类似于 miR-375 overexpression 的胃的癌症房间增长。而且, JAK2 的宫外的表示能部分颠倒 miR-375 引起的房间增长的抑制。最后,我们在胃的癌症发现了在 miR-375 表示和 JAK2 蛋白质水平之间的重要反的关联。因此,这些数据建议 miR-375 可以作为肿瘤 suppressor 工作由指向 JAK2 oncogene 潜在地调整胃的癌症房间增长,含有在胃的癌症的致病的 miR-375 的一个角色。 | Ling Ding Yanjun Xu Wei Zhang Yujie Deng Misi Si Ying Du Haomi Yao Xuyan Liu Yuehai Ke Jianmin Si Tianhua Zhou | 2010 | Cell Research2010，20，7： | 59 |
| 6 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 7 | Coupling Effects on Gold Mineralization of Deep and Shallow Structures in the Northwestern Jiaodong Peninsula, Eastern China显示文摘为在金矿化作用上理解可能的深层的过程和 geodynamicconstrains,全面物理化学并且金矿化作用的 geochemical 研究在这篇论文从 Jiaodong 半岛的西北的部分在 metallogenicepoch 期间在 paleo 岩石圈框架以内被承担了。尽管它被 post-metallogenictectonic 运动附加了并且改过, thepaleo 外壳的一幅一般图象被仍然是。金矿存款通常在本地人发生高举,坡度系上带子展示拐弯从对陡峭在花岗石变形的接触变质带轻轻,亲戚 Curler 等温的接口的坡度地区高举,等深线被等温线垂直地切的莫霍断绝和区域的消沉。金矿化作用和石版印刷开始被高温度,低压力和热流动的高力量描绘。从 0.8 ~ 4.5 km 的矿化作用范围的深度。在 metallogenic 时代的花岗石的建筑群的最高的接口的深度是大约 3 km。在有到 19.5 km 的深度结束的上地壳的底部有低速度的层(LVL ) ,它可以是在外壳中的一条分开带。LVL 的外观显示 paleo 过高热的液体的存在或熔融的岩浆储源的遗物,它反映在 diagenetic 和 metallogenic 时代和 Tanlu 断层带砍的走向滑倒的重叠效果期间的在外壳以内的部分融化。莫霍的沉淀可能被归因于在 NorthChina 和扬采·布洛克之间的 NW-SE 大陆碰撞的联合过程, Tanlu 差错的走向滑倒运动在 Jiaodong 半岛的西北的部分伴随了披风岩浆的 withunderplating。在披风的 plating 下面,岩浆可以导致部分融化并且向上做花岗石岩浆转移。这为 metallogenic 材料从的迁居是有利的对深对浅被充实形成存款。联合在 Tanlu 差错的走向滑倒之间的相互作用,在披风岩浆的 plating 下面,在外壳,和过高热的液体以内的部分融化,等等可以是在 metallogenic 系统控制金矿化作用和空间结构的重要因素。 | YANG Liqiang DENG Jun WANG Qingfei ZHOU Yinghua | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 42 |
| 8 | The Structure of Ore-controlling Strain and Stress Fields in the Shangzhuang Gold Deposit in Shandong Province,China显示文摘Shangzhuang 改变岩石的类型金牌矿石存款位于中间的片断并且在 Jiaodong 金省的西北的部分由 Wang'ershan 差错地区控制了,中国。在 Shangzhuang 存款的变丑进化,紧张的结构和压力地和它的控制矿石的效果在这份报纸被讨论。变丑进化主要经历了四个阶段,这被揭示:早可锻的变丑,第二 NE 惹人注目水平简单砍,第三 NE 惹人注目的压缩砍和最后的 NW 惹人注目的压缩。矿化作用发生在在的第三个阶段期间最大的主要压力逐渐地从 NE 的 transited 到 NW。 3-D 压力地的数字模拟证明在最大的主要压力是NE惹人注目的条件上,在差错地区的破裂发展被赞成,当时当最大的主要压力是NW惹人注目的时,差错地区是相对 extensional 和它对形成矿石的液体的流入和炮兵阵地合适。压缩砍紧张地被类型结构在矿化作用期间描绘,积极的花结构,等等。Orebodies 等距离地主要位于 dilatational 空格,它在不可分的有压缩性的情形是分布式的。并且在差错态度变化的地方, dilatational 空格被开发或砍联合系统发展。在全面压缩砍应力地里,紧张地在多重规模忍受自我类似,包括 orebody,矿石存款和 orefield。结构的自我类似在各种各样的规模在一样的规模和破裂的类似的形状包括破裂的 subequidistant 分发。由于特殊地质的结构,然而, orebodies 主要在 Shangzhuang 存款位于挂的墙它与在 Jiaodong 金省的大多数存款不同。在存款的控制矿石的压力和紧张地的分析为寻求的沉积物提供一个重要基础。 | DENG Jun WANG Qingfei YANG Liqiang ZHOU Lei GONG Qingjie YUAN Wanming XU Hao GUO Chunying LIU Xiangwei | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 41 |
| 9 | Major causes of fever of unknown origin at Peking Union Medical College Hospital in the past 26 years显示文摘 | SHI Xiao-chun LIU Xiao-qing ZHOU Bao-tong ZHANG Li-fan MA Xiao-jun DENG Guo-hua LI Tai-sheng SHENG Rui-yuan WANG Ai-xia | 2013 | Chinese Medical Journal2013，，5： | 47 |
| 10 | Studies on Temporal and Spatial Variations of Phytoplankton in Lake Chaohu显示文摘这研究的目的是在乔胡湖,描述浮游植物集合的时间、空间的变化,并且讨论位于这些变化下面的可能的机制在中国的一个大浅发育营养正常促进剂湖,与 cyanobacteria 上的强调。191 浮游植物种类的一个总数被识别,在哪个评价的绿色植物(101 ) 之中第一,由 Cyanophytes (46 ) 和 Bacillariophytes (28 ) 列在后面。平均在全部湖上,最大的全部的海藻的生物资源在 11 月与最小(5.05 mg/l ) 出现在 6 月(19.70 mg/l ) 。以累年平均生物资源, cyanobacteria 贡献了 45.43% 总计海藻的生物资源,跟随的 byChlorophytes (27.14%) ,和 Bacillariophytes (20.6%) 。当硝酸盐(NO3-N ) 和集中顺便坐坐的铵(NH4-N ) 跳时,修理氮的 cyanobacterium (淡水藻类的一种) 快速开发了 dranked 第一以在夏天的生物资源。zooplanktivorous 鱼和小甲壳纲的动物浮游动物的那优势赞成了发展,是可能的不可食细丝状或殖民地形成 cyanobacteria。在整个所有季节的 cyanobacteria 的坚持的优势可以在乔胡湖显示对超营养作用的浮游植物的反应的一个新趋势…… | Dao-Gui Deng Ping Xie Qiong Zhou Hua Yang Long-Gen Guo | 2007 | Journal of Integrative Plant Biology2007，49，4： | 36 |
| 11 | Colorectal cancer lymph node staining by activated carbon nanoparticles suspension in vivo or methylene blue in vitro显示文摘AIM:To investigate whether activated carbon nanoparticles suspension(ACNS) or methylene blue(MB) can increase the detected number of lymph nodes in colorectal cancer.METHODS:Sixty-seven of 72 colorectal cancer patients treated at our hospital fulfilled the inclusion criteria of the study which was conducted from December 2010 to February 2012.Seven patients refused to participate.Eventually,60 patients were included,and randomly assigned to three groups(20 in each group):ACNS group(group A),MB group(group B) and non-stained conventional surgical group(group C).In group A,patients received subserosal injection of 1 mL ACNS in a 4-quadrant region around the mass.In group B,the main artery of specimen was identified and isolated after the specimen was removed,and 2 mL MB was slowly injected into the isolated,stretched and fixed vessel.In group C,no ACNS and MB were injected.All the mesentery lymph nodes were isolated and removed systematically by visually inspecting and palpating the adipose tissue.RESULTS:No difference was observed among the three groups in age,gender,tumor location,tumor diameter,T-stage,degree of differentiation,postoperative complications and peritoneal drainage retention time.The total number of detected lymph nodes was 535,476 and 223 in the three groups,respectively.The mean number of detected lymph nodes per patient was significantly higher in group A than in group C(26.8 ± 8.4 vs 12.2 ± 3.2,P < 0.001).Similarly,there were significantly more lymph nodes detected in group B than in group C(23.8 ± 6.9 vs 12.2 ± 3.2,P < 0.001).However,there was no significant difference between group A and group B.There were 50,46 and 32 metastatic lymph nodes dissected in 13 patients of group A,10 patients of group B and 11 patients of group C,without significant differences among the three groups.Eleven of the 60 patients had insufficient number of detected lymph nodes(< 12).Only one patient with T 4a rectal cancer had 10 lymph nodes detected in group B,the other 10 patients were all from group C.Based on the different diameter categories,the number of detected lymph nodes in groups A and B was significantly higher than in group C.However,there was no statistically significant difference between group A and group B.The metastatic lymph nodes were not significant different among the three groups.Similarly,tumor location,T stage and tumor differentiation did not affect the staining results.Body mass index was a minor influencing factor in the two different staining methods.The stained lymph nodes can easily be identified from the mesenteric adipose tissues,and the staining time for lymph nodes was not significantly different compared with unstained group.None of the patients in groups A and B had drug-related complications.CONCLUSION:Both activated carbon nanoparticles suspension in vivo and methylene blue in vitro can be used as tracers to increase the detected number of lymph nodes in colorectal cancer. | Hong-Ke Cai Hai-Fei He Wei Tian Mei-Qi Zhou Yue Hu Yong-Chuan Deng | 2012 | World Journal of Gastroenterology2012，18，42： | 39 |
| 12 | A High-Density SNP Genotyping Array for Rice Biology and Molecular Breeding显示文摘一个高密度的单个核苷酸多型性(SNP ) 数组为遗传学者和分子的 breeders.With 是极其重要的 genomic 的巨大的数量的累积重新定序为精确 SNP 察觉的数据和可得到的技术,设计高密度、高质量的米饭 SNP 数组是可能的。这里,我们报导一个高密度的 riceSNP 数组和它的实用程序的开发。SNP 探针被屏蔽超过 10 设计从变化和一个数组说出 RiceSNP50 的 801 米饭的 re-sequencingdata 提取的 000 000 SNP loci 在 Illumina Infinium 站台上被生产。数组 contained51 478 个均匀地分布式的标记,其 68% 个在遗传因子的区域以内。有 parent/F1 relationshipswere 的几百米饭植物过去常为精确 SNP 打电话产生一个高质量的簇文件。应用程序测试证明这穿有的 highgenotyping 精确性,并且能被用于不同目的。例如,有好分辨率的精英米饭变化 wasclustered 的一个核心集合。染色体宽的协会研究(GWAS ) 分析正确地识别了描绘的 QTL.Further,这个数组成功地为变化确认和特点基因渗入被使用。作为一个精确 high-throughputgenotyping 工具, RiceSNP50 将在两功能的 genomics 学习和分子的 breeding.Key 词起一个重要作用: | Haodong Chen Weibo Xie Hang He Huihui Yu Wei Chen Jing Li Renbo Yu Yue Yao Wenhui Zhang Yuqing He Xiaoyan Tang Fasong Zhou Xing Wang Deng Qifa Zhang | 2014 | Molecular Plant2014，7，3： | 38 |
| 13 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 14 | The hydrological effect between Jingjiang River and Dongting Lake during the initial period of Three Gorges Project operation显示文摘从 1951 ~ 2008 基于测量水文学数据,在 Jingjiang 河和东廷·莱克之间的链水文学效果被比较方法在三峡工程操作以后分析。结果显示那 1 ) 用 Yichang 在 78.9% 总数上面做到 Chenglingji 的 Jingjiang 河里的搜索数量,和它搜索紧张的一般水准比后者高;2 ) 在 Jingjiang 河的三个插头的水和沙转向率被 2.33% 和 2.78% 独立减少;3 ) 通过总共进东廷·莱克的三个插头的多年一般水准流量和沉积的比例分别地在 7.7% 和 24.4% 减少了;4 ) 在东廷·莱克,,沉积累积的速度被 26.7% 降低在洪水季节,流量数量是 20.2% 不到多年一般水准价值,逐年导致水的季节的缺乏。当后者在连续的年,喝的缺乏和工业水里在夏天和秋天导致了干旱时,前者延长了湖生活,装运象鸟的减少和 Microtus 的快增加那样的紧张,以及生态的问题强音;5 ) 在湖插头的沉积和洪水搬运能力的多年一般水准价值被 26.6% 和 3.7% 分别地增加,堤有效地被保护。然后,适应河湖关系的新变化,一些建议被提出例如优化三座峡水库的进一步的操作节目,再考河的想法和湖规定,和河和湖的维持的连接。 | CHANG Jiang LI Jingbao LU Dianqing ZHU Xiang LU Chengzhi ZHOU Yueyun DENG Chuxiong | 2010 | Journal of Geographical Sciences2010，20，5： | 33 |
| 15 | Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes显示文摘瞄准: 调查 RhoA/Rho kinase (岩石) 的激活是否在糖尿病的心涉及心肌的纤维变性。 | Hong ZHOU Yong-jun LI Mian WANG Li-hui ZHANG Zhan-sheng ZHAO Feng-ling MENG Yong-gui DENG Rui-ying WANG | 2011 | Acta Pharmacologica Sinica2011，32，8： | 32 |
| 16 | Structural characteristics of the Tan-Lu fault zone in Cenozoic basins offshore the Bohai Sea显示文摘The Tan-Lu fault zone across the eastern margin of the Cenozoic basins offshore the Bohai Sea is a NNE-trending right-lateral strike-slip fault system developed in the Cenozoic basin cover. It cuts through NE-to NNE-striking major extensional faults that controlled the formation of Paleogene basins. Recent petroleum exploration indicates that Cenozoic structural activities of the Tan-Lu fault system have directly or indirectly affected oil and gas distribution offshore the Bohai Sea. As part of a deep fault zone the Tan-Lu fault zone has been activated since the Oligocene,and obviously affected the tectonic evolution of offshore Bohai basins since then. The formation of Paleogene rift basins offshore the Bohai Sea has utilized the pre-existing structural elements of the Tan-Lu fault zone that developed in the late Mesozoic. | QI JiaFu1,2,ZHOU XinHuai3,DENG RongJing4 & ZHANG KeXin2 1 State Key Laboratory of Petroleum Resource and Prospecting,China Petroleum University,Beijing 102249,China 2 Department of Earth Sciences,China Petroleum University,Beijing 102200,China 3 Tianjin Branch of CNOOC China Limited,Tianjin 300451,China 4 Beijing Research Center of CNOOC China Limited,Beijing100027,China | 2008 | Science China Earth Sciences2008，51，S2： | 33 |
| 17 | Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease显示文摘Background Since early December 2019,the 2019 novel coronavirus disease(COVID-19)has caused pneumonia epidemic in Wuhan,Hubei province of China.This study aimed to investigate the factors affecting the progression of pneumonia in COVID-19 patients.Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia.Methods Patients tested positive for the COVID-19 based on nucleic acid detection were included in this study.Patients were admitted to 3 tertiary hospitals in Wuhan between December 30,2019,and January 15,2020.Individual data,laboratory indices,imaging characteristics,and clinical data were collected,and statistical analysis was performed.Based on clinical typing results,the patients were divided into a progression group or an improvement/stabilization group.Continuous variables were analyzed using independent samples t-test or Mann-Whitney U test.Categorical variables were analyzed using Chi-squared test or Fisher’s exact test.Logistic regression analysis was performed to explore the risk factors for disease progression.Results Seventy-eight patients with COVID-19-induced pneumonia met the inclusion criteria and were included in this study.Efficacy evaluation at 2 weeks after hospitalization indicated that 11 patients(14.1%)had deteriorated,and 67 patients(85.9%)had improved/stabilized.The patients in the progression group were significantly older than those in the disease improvement/stabilization group(66[51,70]vs.37[32,41]years,U=4.932,P=0.001).The progression group had a significantly higher proportion of patients with a history of smoking than the improvement/stabilization group(27.3%vs.3.0%,χ^2=9.291,P=0.018).For all the 78 patients,fever was the most common initial symptom,and the maximum body temperature at admission was significantly higher in the progression group than in the improvement/stabilization group(38.2[37.8,38.6]vs.37.5[37.0,38.4]°C,U=2.057,P=0.027).Moreover,the proportion of patients with respiratory failure(54.5%vs.20.9%,χ^2=5.611,P=0.028)and respiratory rate(34[18,48]vs.24[16,60]breaths/min,U=4.030,P=0.004)were significantly higher in the progression group than in the improvement/stabilization group.C-reactive protein was significantly elevated in the progression group compared to the improvement/stabilization group(38.9[14.3,64.8]vs.10.6[1.9,33.1]mg/L,U=1.315,P=0.024).Albumin was significantly lower in the progression group than in the improvement/stabilization group(36.62±6.60 vs.41.27±4.55 g/L,U=2.843,P=0.006).Patients in the progression group were more likely to receive high-level respiratory support than in the improvement/stabilization group(χ^2=16.01,P=0.001).Multivariate logistic analysis indicated that age(odds ratio[OR],8.546;95%confidence interval[CI]:1.628-44.864;P=0.011),history of smoking(OR,14.285;95%CI:1.577-25.000;P=0.018),maximum body temperature at admission(OR,8.999;95%CI:1.036-78.147,P=0.046),respiratory failure(OR,8.772,95%CI:1.942-40.000;P=0.016),albumin(OR,7.353,95%CI:1.098-50.000;P=0.003),and C-reactive protein(OR,10.530;95%CI:1.224-34.701,P=0.028)were risk factors for disease progression.Conclusions Several factors that led to the progression of COVID-19 pneumonia were identified,including age,history of smoking,maximum body temperature at admission,respiratory failure,albumin,and C-reactive protein.These results can be used to further enhance the ability of management of COVID-19 pneumonia. | Wei Liu Zhao-Wu Tao Lei Wang Ming-Li Yuan Kui Liu Ling Zhou Shuang Wei Yan Deng Jing Liu Hui-Guo Liu Ming Yang Yi Hu | 2020 | Chinese Medical Journal2020，，9： | 31 |
| 18 | Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma显示文摘Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited survival.It is imperative to find a combination strategy to increase sorafenib efficacy.Artesunate is such a preferred candidate,because artesunate is clinically well-tolerated and more importantly both drugs can induce ferroptosis through different mechanisms.In this study we investigated the combined effect of sorafenib and artesunate in inducing ferroptosis of HCC and elucidated the involved molecular mechanisms.We showed that artesunate greatly enhanced the anticancer effects of low dose of sorafenib against Huh7,SNU-449,and SNU-182 HCC cell lines in vitro and against Huh7 cell xenograft model in Balb/c nude mice.The combination index method confirmed that the combined effect of sorafenib and artesunate was synergistic.Compared with the treatment with artesunate or sorafenib alone,combined treatment induced significantly exacerbated lipid peroxidation and ferroptosis,which was blocked by N-acetyl cysteine and ferroptosis inhibitors liproxstatin-1 and deferoxamine mesylate,but not by inhibitors of other types of cell death(z-VAD,necrostatin-1 and belnacasan).In Huh7 cells,we demonstrated that the combined treatment induced oxidative stress and lysosome-mediated ferritinophagy,two essential aspects of ferroptosis.Sorafenib at low dose mainly caused oxidative stress through mitochondrial impairments and SLC7A11-invovled glutathione depletion.Artesunate-induced lysosome activation synergized with sorafenib-mediated pro-oxidative effects by promoting sequential reactions including lysosomal cathepsin B/L activation,ferritin degradation,lipid peroxidation,and consequent ferroptosis.Taken together,artesunate could be repurposed to sensitize sorafenib in HCC treatment.The combined treatment can be easily translated into clinical applications. | Zhong-jie Li Hui-qi Dai Xiao-wei Huang Ji Feng Jing-huan Deng Zi-xuan Wang Xiao-mei Yang Yu-jia Liu Yong Wu Pan-hong Chen Huan Shi Ji-gang Wang Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，2： | 31 |
| 19 | Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14显示文摘Previous studies have shown that baicalin,an active ingredient of the Chinese traditional medicine Huangqin,attenuates LPS-induced inflammation by inhibiting the activation of TLR4/NF-κBp65 pathway,but how it affects this pathway is unknown.It has been shown that CD14 binds directly to LPS and plays an important role in sensitizing the cells to minute quantities of LPS via chaperoning LPS molecules to the TLR4/MD-2 signaling complex.In the present study we investigated the role of CD14 in the anti-inflammatory effects of baicalin in vitro and in vivo.Exposure to LPS(1μg/mL)induced inflammatory responses in RAW264.7 cells,evidenced by marked increases in the expression of MHC II molecules and the secretion of NO and IL-6,and by activation of MyD88/NF-κB p65 signaling pathway,as well as the expression of CD14 and TLR4.These changes were dose-dependently attenuated by pretreatment baicalin(12.5–50μM),but not by baicalin post-treatment.In RAW264.7 cells without LPS stimulation,baicalin dose-dependently inhibit the protein and mRNA expression of CD14,but not TLR4.In RAW264.7 cells with CD14 knockdown,baicalin pretreatment did not prevent inflammatory responses and activation of MyD88/NF-κB p65 pathway induced by high concentrations(1000μg/mL)of LPS.Furthermore,baicalin pretreatment also inhibited the expression of CD14 and activation of MyD88/NF-κB p65 pathway in LPS-induced hepatocyte-derived HepG2 cells and intestinal epithelial-derived HT-29 cells.In mice with intraperitoneal injection of LPS and in DSS-induced UC mice,oral administration of baicalin exerted protective effects by inhibition of CD14 expression and inflammation.Taken together,we demonstrate that baicalin pretreatment prevents LPS-induced inflammation in RAW264.7 cells in CD14-dependent manner.This study supports the therapeutic use of baicalin in preventing the progression of LPS-induced inflammatory diseases. | Ya-jun Fu Bo Xu Shao-wei Huang Xia Luo Xiang-liang Deng Shuang Luo Chang Liu Qing Wang Jin-yan Chen Lian Zhou | 2021 | Acta Pharmacologica Sinica2021，42，1： | 31 |
| 20 | Altered Disease Development in the eui Mutants and Eui Overexpressors Indicates that Gibberellins Negatively Regulate Rice Basal Disease Resistance显示文摘赤霉素(气体) 形成涉及植物生长和开发的许多方面的一组重要植物 tetracyclic diterpenoid 荷尔蒙。新兴的证据含有那气体也在压力回答起作用。然而,在关於生命的应力的气体的角色大部分是未知的。这里,我们报导那个大美人或 overexpression 伸长最高编码撤销的 GA 的 internode (Eui ) 基因分别地,酶损害或增加疾病抵抗到细菌的老家(Xanthomonas oryzae pv。oyrzae ) 并且米饭强风(Magnaporthe oryzae ) 。分别地, GA3 和 GA 合成(uniconazol ) 的禁止者的外长的申请能增加疾病危险性和抵抗到细菌的老家。同样, uniconazol 恢复了 eui 异种的疾病抵抗, GA3 减少了到细菌的老家的 Eui overexpressors 的疾病抵抗。因此,抵抗的变化把层次归因于 GA。在有这的一致性, GA 新陈代谢基因 OsGA20ox2 和 OsGA2ox1 在病原体挑战期间是下面调整的。我们也发现那 PR1a 正式就职被提高,但是 SA 水平在 Eui overexpressor 被减少,当 JA 水平在 eui 异种被减少时。一起,我们的当前的学习显示气体在米饭起一个否定作用基础疾病电阻,与是的 EUI 通过调整 bioactive 气体的水平的一个积极调节的人。 | Dong-Lei Yang Qun Li Yi-Wen Deng Yong-Gen Lou Mu-Yang Wang Guo-Xing Zhou Ying-Ying Zhang Zu-Hua He | 2008 | Molecular Plant2008，1，3： | 29 |
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