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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | Parallel activationof mitochondrial oxidative metabolism with increasedcardiac energy expenditure is not dependent on fatty acidoxidation in pigs显示文摘 | Zhou L Cabrera ME Huang H | 2007 | J Physiol2007，579，3： | 1 |
| 3 | Coexpression of TIM-3 and PD-1 identifies a CD8 T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia 显示文摘 | Zhou Q Munger ME Veenstra RG | 2011 | Blood2011，117，17： | 1 |
| 4 | Primary amyloidosis of the breast presenting as a solitary nodule:case report and review of the literature显示文摘 | Huerter ME Hammadeh R Zhou Q | 2014 | Ochsner J2014，14，2： | 1 |
| 5 | Cypher a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C 显示文摘 | Zhou Q Ruiz-Lozano P Martone ME | 1999 | J Biol Chem1999，274，19： | 1 |
| 6 | Co-expression of TIM-3 and PD-1 identifies a CD8+ T cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia显示文摘 | Zhou Q Munger ME Veenstra RG | 2011 | {H}Blood2011，，17： | 1 |
| 7 | DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity 显示文摘 | Yuan BZ Zhou X Durkin ME | 2003 | Oncogene2003，22，3： | 1 |
| 8 | Association screening of common and rare genetic variants by penalized regression 显示文摘 | Zhou H Sehl ME Sinsheimer JS | 2010 | Bioinformatics2010，26，19： | 1 |
| 9 | DLC-lgene inhibits human breast cancer cell growth and in vivo tumorigenicity 显示文摘 | Yuan BZ Zhou X Durkin ME | 2003 | Oncogene2003，22，3： | 1 |
| 10 | DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity显示文摘 | Yuan BZ Zhou X Durkin ME | 2003 | Oncogene2003，22，： | 1 |
| 11 | Functional consequences of IGFβP excess-lessons from tranggenic mice pediatric显示文摘 | Wolf E Schneider ME Zhou E | 2005 | Nephrology2005，20，5： | 1 |
| 12 | Routine Os Analysis by Isotope Dilution-inductively Coupled Plasma Source Mass Spectrometry: OsO4 in Water Solution Gives High Sensitivity 显示文摘 | Sun YL Zhou ME Sun M | 2001 | JAAS2001，16，： | 1 |
| 13 | Sulphur byproduct: The relationship volatile sulphur compounds and dental plaqueinduced gingivitis 显示文摘 | Zhou H Me Combs GS Darby ML | 2004 | J Contemp Dent Pract2004，5，2： | 1 |
| 14 | Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia 显示文摘 | Zhou Q Bucher C Munger ME Highfill SL Tolar J Munn DH | 2009 | Blood2009，114，18： | 1 |
| 15 | Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate protein kinase A-dependent mechanism 显示文摘 | Wang X Zhou J Doyle ME | 2001 | Endocrinology2001，142，5： | 1 |
| 16 | Abdominal obesity and peripheral vascular disease in men and women : a comparison of waist-to-thigh ratio and waist circ- umference as measures of abdominal obesity 显示文摘 | Lu B Zhou J Waring ME | 2010 | Atheresclerosis2010，208，1： | 1 |
| 17 | DLC-1 : A Rho GTPase-acti- rating protein and tumour suppressor 显示文摘 | Durkin ME Yuan BZ Zhou X | 2007 | J Cell Mol Med2007，11，5： | 1 |
| 18 | DLC - 1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity 显示文摘 | Yuan BZ Zhou X Durkin ME | 2003 | Oncogene2003，22，： | 1 |
| 19 | Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors显示文摘 | Almasieh M Zhou Y Kelly ME Casanova C Di Polo A | 2010 | CeU Death Dis2010，，： | 1 |
| 20 | Recurrent angiomatoid fibrous histiocytoma a ease report and review of the literature 显示文摘 | Huerter ME Hammadeh R Zhou Q et ul | 2014 | Ochsner J2014，14，3： | 1 |
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