| 6 | Toxicological study of lufironil in rats and dogs显示文摘The aim of this study is to verify the toxicity of lufironil(LF),a competitive inhibitor of prolyl hydroxylase by long term administration in animals.SD rats and Beagle dogs were administered orally with LF for 6 months.The daily dose were 0.05,0.35,2.5mg·kg^-1 and 0.05,0.15,0.45mg·kg^-1,respectively.The recovery after stopping treatments were observed for 1 month.Hydroxyproline(Hyp) assay in serum and tissues,such as liver,kidney,lung and skin were made besides routine examinations of growth rates,food consumption,hematology,clinical chemistry and histology.The results showed that LF reduced total protein and Alb in serum,increased BUN and the weight indexes of liver,kidney and lung in the rats at the highest dose.Hykp decreased only in serum and liver.No other significant changes were seen.All the tested parameters remained normal in the dogs.It is concluded that LF is a safe drug with high selectivity on prolyl hydroxylase and its toxicity occurs only at extremely high dosage and is reversible. | ZhouYP ChenSY | 2002 | 中国药理学与毒理学杂志2002，16，6： | 0 |
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