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| 1 | Gastroesophageal reflux: the features in elderlypatients显示文摘AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients. | Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F | 1999 | World Journal of Gastroenterology1999，5，5： | 12 |
| 2 | Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis显示文摘Pathogeneticfactorsafectinggastroesophagealrefluxinpatientswithesophagitisandconcomitantduodenalulcer:amultivariateanalysisZH... | Zhu, HM Huang, X Deng, CZ Porro, GP Pace, F Sangaletti, O | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 3 | Antioxidant and free radical-scavenging activities of wheat germ protein hydrolysates (WGPH) prepared with alcalase显示文摘 | Zhu KX Zhou HM Qian HF | 2006 | Process Biochemistry2006，41，： | 1 |
| 4 | Effect of flow rate,negative pressure,and duration of modified ultrafiltration on hemodynamics and inflammatory mediators显示文摘 | Wang W Zhu DM Huang HM | 2007 | ASAIO J2007，53，1： | 1 |
| 5 | Proteins extracted from defattedwheat germ: Nutritional and structural properties 显示文摘 | KX Zhu HM Zhou HF Qian | 2006 | CerealChemistry2006，83，1： | 1 |
| 6 | The Chinese diagnostic criteriafor osteoporosis suggested(second draft)显示文摘 | LIU ZH YANG D ZH ZHU HM | 2000 | Chinese Journal of Osteo-porosis2000，6，1： | 1 |
| 7 | Characteristic of immobilized cephalosporin C acylase and its application in one-step enzymatic conversion of cephalosporin C to 7-aminocephalosporanic acid 显示文摘 | Zhu XW Luo H Chang YH Su HB Li QA Yu HM Shen ZY | 2011 | World J Microb Biotechnol2011，27，4： | 1 |
| 8 | Nasal septal perforation combined with chronic invasive fungal rhinosinusitis:three cases report显示文摘 | Zhu HM Zhang WT Zhang YJ | 2012 | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi2012，47，8： | 1 |
| 9 | Effect of flow rate, negative pressure, and duration of modified ultrafiltration on hemodynamics and inflammatory mediators显示文摘 | Wang W Zhu DM Huang HM | 2007 | ASAIO J2007，53，1： | 1 |
| 10 | Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP- 9 expression 显示文摘 | Wagsaeter D Zhu CY Bjoerck HM | 2009 | Atherosclerosis2009，202，2： | 1 |
| 11 | Numerical study of the behaviour of wall shear stress in pulsatile stenotic flows 显示文摘 | Ooi A Blackburn HM Zhu S | 2007 | Australasian Fluid Mechanics Conference2007，12，： | 1 |
| 12 | Respiratory rate and sings in roentgenographically confirmed pneumonia among children in china显示文摘 | Dai Y Foy HM Zhu Z et al | 1995 | Pediatr Infect Dis J1995，14，1： | 1 |
| 13 | SNP Cutter: a comprehensive tool for SNPPCR-RFLP assay design 显示文摘 | Zhang RF Zhu ZH Zhu HM | 2005 | Nucleic Acids Research2005，33，： | 1 |
| 14 | Studies of poly( ethylene glycol) modification of HM-3 polypeptides显示文摘 | Zhou K Zhu BL Xu HM | 2010 | Bioconjugate chemistry2010，20，5： | 1 |
| 15 | Site-specific modification of antiangiogenesis peptide HM-3 by polyethylene glycol molecular weight of 20 kDa显示文摘 | Zhu BL Xu HM Zhao LM | 2010 | Journal of Biochemistry2010，148，3： | 1 |
| 16 | Modified ultrafiltration in paediatric cardiopulmonary bypass 显示文摘 | Wang W Huang HM Zhu DM | 1998 | Perfusion1998，5，5： | 1 |
| 17 | Three Gorges Dam and its impact on the potential transmission of schistosomiasis in regions along the Yangtze River 显示文摘 | Zhu HM Xiang S Yang K | 2008 | Ecohealth2008，5，2： | 1 |
| 18 | Anatomic and sexual out- comes after vaginoplasty using tissue-engineered biomaterial graft in patients with mayer-rokitansky-kuster-hauser syn- drome : a new minimally invasive and effective surgery 显示文摘 | Zhu L Zhou HM Sun ZX | 2013 | J Sex Med2013，10，6： | 1 |
| 19 | Effect of sinus Membrane perforation on the survival of implants placed in combination with osteotome sinus floor elevation显示文摘 | Ding X Zhu XH Wang HM | | 0，，02： | 1 |
| 20 | Regulation of embryo implantation by nitric oxide in mouse显示文摘Intrauterine injection and zymography were used to investigate the effect of nitric oxide (NO) on embryo implantation in mice. On day 3, one uterine horn of female pregnant mice was injected intraluminally with various doses of nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine methyl ester (L-NAME), while the contralateral horn served as control. Animals were sacrificed by cervical dislocation on day 7 of gestation, and the number of implanted embryos in each horn was calculated. The results showed that lower doses (0.05mg L-NAME) did not inhibit implantation significantly (P > 0.05), but high doses (0.2 mg L- NAME) resulted in a significant reduction in the number of implanted embryos (P < 0.05). Co-administration of SNP, a generator of NO, with L-NAME would reverse the anti-implantation effect of L-NAME. To further understand the precise mechanism of NO in implantation, matrix metallo-proteinase (MMPs) activities were detected by gelatin zymography. The reduction in the number of implanted | Zhang, X Wang, HM Lin, HY Li, QL Liu, DL Qian, D Liu, GY Zhu, C | 2002 | Chinese Science Bulletin2002，47，17： | 1 |
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