|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B/pyrin domain-containing protein 3 pathway显示文摘OBJECTIVE: To evaluate the effectiveness of Sini powder for the treatment of non-alcoholic fatty liver disease(NAFLD) in rats and the molecular mechanisms involved.METHODS: A rat model of stress-induced NAFLD was established by a combination of long-term tethering and feeding of a high-fat, high-calorie diet. These rats were then intragastrically administered with either simvastatin, Sini powder, or vehicle for 1 week. The body mass and field test scores for each group were recorded weekly. Serum aspartate aminotransferase and alanine aminotransferase activities, and triglyceride, total cholesterol,and free fatty acid concentrations were measured.Liver tissue histopathology was examined on hematoxylin and eosin-stained paraffin sections and oil red O-stained frozen sections. The hepatic m RNA expression of nuclear factor kappa-B(NF-κB),NOD-, LRR-, and pyrin domain-containing protein 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC), and caspase-1 were measured by reverse transcription-polymerase chain reaction(RT-PCR). The hepatic protein concentrations of NF-κB and NLRP3, ASC, caspase-1, interleukin-1β(IL-1β), interleukin-6(IL-6), and the serum concentrations of IL-1β and IL-6 were measured by enzyme-linked immunosorbent assay.RESULTS: Compared with the Blank group, rats in the Compound model group showed significant pathologic manifestations of NAFLD, and the expression of NF-κB, NLRP3, ASC, caspase-1, IL-1βand IL-6 were significantly higher(all P < 0.01). Both simvastatin and Sini powder significantly ameliorated the NAFLD pathology and the abnormal expression of NF-κB, NLRP3, ASC, caspase-1, IL-1β, and IL-6(all P < 0.01).CONCLUSION: Sini powder inhibits the inflamma-tory response in rats with NAFLD, which is mediated by NF-κB/NLRP3, IL-1β, and IL-6, reduces the effects of psychological stress, and improves lipid metabolism. Therefore, Sini powder may be effective for the treatment of stress-related NAFLD through multiple mechanisms. | Mu Jie Cheng Fafeng Wang Qingguo Wang Xueqian Zhu Wenxiang Ma Chongyang Yin Xiangjun Ren Beida Lian Yajun Du Xin Zhang Haixia Liu Shuling Zhang Shuang | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 2 | Design Bistatic Interferometric DEM Generation Algorithm and Its Theoretical Accuracy Analysis for LuTan-1 Satellites显示文摘LuTan-1(LT-1)is a constellation with two full-polarization L-band radar satellites designed by China,and the first satellite was scheduled to be launched in December 2021 and the second one in January 2022.The LT-1 will be operated for deformation monitoring in repeat-pass mode,and for DEM generation in bistatic mode,improving self-sufficiency of SAR data for the field of geology,earthquake,disaster reduction,geomatics,forestry and so on.In this paper,we focused on designing an algorithm for interferometric DEM generation using LT-1 bistatic satellites.The basic principle,main error sources and errors control of the DEM generation algorithm of LT-1 were systematically analyzed.The experiment results demonstrated that:①The implemented algorithm had rigorous resolution with a theoretic accuracy better than 0.03 m for DEM generation.②The errors in satellite velocity and Doppler centroid had no obvious effect on DEM accuracy and they could be neglected.While the errors in position,baseline,slant range and interferometric phase had a significant effect on DEM accuracy.And the DEM error caused by baseline error was dominated,followed by the slant range error,interferometric phase error and satellite position error.③To obtain an expected DEM accuracy of 2 m,the baseline error must be strictly controlled and its accuracy shall be 1.0 mm or better for Cross-Track and Normal-Direction component,respectively.And the slant range error and interferometric phase error shall be reasonably controlled.The research results were of great significance for accurately grasping the accuracy of LT-1 data products and their errors control,and could provide a scientific auxiliary basis for LT-1 in promoting global SAR technology progress and the generation of high-precision basic geographic data. | Bing XU Liqun LIU Zhiwei LI Yan ZHU Jingxin HOU Wenxiang MAO | 2022 | Journal of Geodesy and Geoinformation Science2022，5，1： | 6 |
| 3 | Sleeve Design of Permanent-magnet Machine for Low Rotor Losses显示文摘In this study,a novel rotor sleeve for permanent-magnet(PM)machines equipped with fractional-slot concentrated-windings(FSCW)is proposed.With the newly designed rotor sleeve,the rotor eddy-current(EC)losses are significantly reduced,and the torque density of the machine is improved.First,the rotor EC losses of a surface-mounted PM machine with the sleeve are analyzed.Meanwhile,the sleeve EC barriers and PM segmentation technologies for the suppression of the rotor EC losses are evaluated.Subsequently,an FSCW PM machine with the newly designed sleeve is proposed and optimized for a given set of specifications.Its electromagnetic and mechanical performances are evaluated by the finite element method(FEM).Finally,three assembling methods are presented and assessed comprehensively in terms of their merits and drawbacks. | Junqiang Zheng Wenxiang Zhao Jinghua Ji Jihong Zhu Christopher H.T.Lee | 2020 | Chinese Journal of Electrical Engineering2020，6，4： | 5 |
| 4 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 5 | A review of the techniques for the mold manufacturing of micro/nanostructures for precision glass molding显示文摘Micro/nanostructured components play an important role in micro-optics and optical engineering,tribology and surface engineering,and biological and biomedical engineering,among other fields.Precision glass molding technology is the most efficient method of manufacturing micro/nanostructured glass components,the premise of which is meld manufacturing with complementary micro/nanostructures.Numerous mold manufacturing methods have been developed to fabricate extremely small and high-quality micro/nanostructures to satisfy the demands of functional micro/nanostructured glass components for various applications.Moreover,the service performance of the mold should also be carefully considered.This paper reviews a variety of technologies for manufacturing micro/nanostructured molds.The authors begin with an introduction of the extreme requirements of mold materials.The following section provides a detailed survey of the existing micro/nanostructured mold manufacturing techniques and their corresponding mold materials,including nonmechanical and mechanical methods.This paper concludes with a detailed discussion of the authors recent research on nickel-phosphorus(Ni-P)mold manufacturing and its service performance. | Tianfeng Zhou Yupeng He Tianxing Wang Zhanchen Zhu Ruzhen Xu Qian Yu Bin Zhao Wenxiang Zhao Peng Liu Xibin Wang | 2021 | International Journal of Extreme Manufacturing2021，3，4： | 3 |
| 6 | Molecular mechanism of non-alcoholic fatty liver disease induced and aggravated by chronic stress through HSL/ATGL-FFA which promotes fat mobilization显示文摘Objective:To study the effects of social stress(CS)and social stress combined with high-fat diet on fat mobilization as a candidate mechanism for the induction or aggravation of non-alcoholic fatty liver disease(NAFLD).Methods:Thirty-two male Wistar rats(250±10 g)were randomly allocated to a blank control group(BC),a high-fat diet group(HFD),a CS group,and a combined CS and high-fat diet group(CS t HFD).Rats were sacrificed and tissues were collected after 8 weeks.Liver and body mass were measured and used to calculate the liver index.Serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),and free fatty acids(FFAs)were measured.Liver sections were examined microscopically after oil red O and hematoxylin and eosin staining.The relative mRNA expression of acetyl-CoA carboxylase(ACCase),hydroxymethylglutaryl coenzyme A(HMG-CoA)reductase in liver,and hormone-sensitive lipase(HSL),and adipose triglyceride lipase(ATGL)in subcutaneous adipose tissue,were measured by real-time PCR.The liver concentrations of triglyceride,reactive oxygen species,and ACCase were measured by ELISA and HSL activity was determined using turbidimetry.Results:NAFLD developed in the CS,HFD,and CS t HFD groups,with the most severe NAFLD being in the CS t HFD group.Serum AST,ALT,and FFA,liver index,and hepatic triglyceride,FFA,and tumor necrosis factor-a were significantly higher in both the CS and CS t HFD groups.However,food intake and ACCase mRNA expression were lower.The mRNA expression of HSL and ATGL in adipose tissue was much higher,and HSL activity was higher in the CS group than in the BC group,and in the CS t HFD group than in the HFD group.Conclusion:We have successfully established two models of stress-induced NAFLD,suggesting stress can induce and aggravate NAFLD by promoting fat mobilization through upregulation of HSL and ATGL. | Jie Mu Xueqian Wang Qingguo Wang Fafeng Cheng Wenxiang Zhu Changxiang Li Chongyang Ma Changming Zhai Yajun Lian Xin Du | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，4： | 2 |
| 7 | Direct thrust control for multivariable turbofan approach显示文摘A novel turbofan Direct Thrust Control(DTC)architecture based on Linear ParameterVarying(LPV)approach for a two-spool turbofan engine thrust control is proposed in this paper.Instead of transforming thrust command to shaft speed command and pressure ratio command,the thrust will be directly controlled by an optimal controller with two control variables.LPV model of the engine is established for the designing of thrust estimator and controller.A robust LPV H∞filter is introduced to estimate the unmeasurable thrust according to measurable engine states.The thrust estimation error system is proved to be Affinely Quadratically Stable(AQS)in the whole parameter box with a prescribed H∞performance indexγ.Due to the existence of overdetermined equations,the solving of controller parameters is a multi-solution problem.Therefore,Particle Swarm Optimization(PSO)algorithm is used to optimize the controller parameters to obtain satisfactory control performance based on the engine’s LPV model.Numerical simulations show that the thrust estimator can acquire smooth and accurate estimating results when sensor noise exists.The optimal controller can receive desired control performance both in steady and transition control tasks within the engine working states above the idle,verifying the effectiveness of the proposed DTC architecture’s application in thrust direct control problem. | Yiyang ZHU Jinquan HUANG Muxuan PAN Wenxiang ZHOU | 2022 | Chinese Journal of Aeronautics2022，35，6： | 2 |
| 8 | A transient cosimulation approach to performance analysis of hybrid excited doubly salient machine considering indirect field-circuit coupling显示文摘 | Zhu Xiaoyong Cheng Ming Zhao Wenxiang | 2007 | IEEE Transactions on Magnetics2007，43，6： | 1 |
| 9 | T-DNA transfer and integration as a tool for insertional mutagenesis in the taxol-producing fungus显示文摘Agrobacterium tumefaciens-mediated DNA transformation method was applied to transformNodulisporium sylviforme fusant HDF-68,a taxol-producing fungus.We constructed a binary vectorpBI121-43 carrying a hygromycin-resistant gene cassette between the right and left borders of T-DNA.Optimal co-cultivation of N.sylviforme with A.turnefaciens containing pBI121-43 led to 110~130 hy-gromycin-resistant transformants per million conidia.Putative transformants were found to be mitoticallystable.The molecular analysis of transformants demonstrated the random integration of single copy of theT-DNA into the host genome.This transformation system serves as a basic tool for insertional mutagenesisin N.sylviforme fusant HDF-68,and the development of such system lays a solid foundation for con-structing high-yied gene engineering strain and clarifying taxol biosynthesis pathway in this fungus. | 迟彦 Ping Wenxiang Li Shanshan Zhu Jing Ma Xi Gao Fengshan Zhou Dongpo | 2008 | High Technology Letters2008，14，1： | 1 |
| 10 | A transient co-simulation approach to performance analysis of a hybrid excited doubly salient motor considering indirect field-circuit coupling 显示文摘 | Zhu Xiaoyong Cheng Ming Zhao Wenxiang | 2007 | IEEE Transactions on Magnetics2007，43，6： | 1 |
| 11 | Stability analysis and application of the exponential time differencing scheme显示文摘 | Du Qiang Zhu Wenxiang | 2004 | Journal of Computation Mathematicsm2004，22，2： | 1 |
| 12 | Analysis of fault-tolerant performance of a doubly salient permanent-magnet motor drive using transient cosimulation method显示文摘 | Zhao Wenxiang Cheng Ming Zhu Xiaoyong | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 13 | Energy-efficient cell-association bias adjustment algorithm for ultra-dense networks显示文摘In recent years, energy efficiency has become an important topic, especially in the field of ultradense networks(UDNs). In this area, cell-association bias adjustment and small cell on/off are proposed to enhance the performance of energy efficiency in UDNs. This is done by changing the cell association relationship and turning off the extra small cells that have no users. However, the variety of cell association relationships and the switching on/off of the small cells may deteriorate some users' data rates, leading to nonconformance to the users' data rate requirement. Considering the discreteness and non-convexity of the energy efficiency optimization problem and the coupled relationship between cell association and scheduling during the optimization process, it is difficult to achieve an optimal cell-association bias. In this study, we optimize the network energy efficiency by adjusting the cell-association bias of small cells while satisfying the users' data rate requirement. We propose an energy-efficient centralized Gibbs sampling based cell-association bias adjustment(CGSCA) algorithm. In CGSCA, global information such as channel state information, cell association information, and network load information need to be collected. Then, considering the overhead of the messages that are exchanged and the implementation complexity of CGSCA to obtain the global information in UDNs, we propose an energy-efficient distributed Gibbs sampling based cell-association bias adjustment(DGSCA) algorithm with a lower message-exchange overhead and implementation complexity.Using DGSCA, we derive the updated formulas for calculating the number of users in a cell and the users' SINR. We analyze the implementation complexities(e.g., computation complexity and communication complexity) of the proposed two algorithms and other existing algorithms. We perform simulations, and the results show that CGSCA and DGSCA have faster convergence speed, as well as a higher performance gain of the energy efficiency and throughput compared to other existing algorithms. In addition, we analyze the importance of the users' data rate constraint in optimizing the energy efficiency, and we compare the energy efficiency performance of different algorithms with different number of small cells. Then, we present the number of sleeping small cells as the number of small cells increases. | Wenxiang ZHU Pingping XU Thi Oanh BUI Guilu WU Yan YANG | 2018 | Science China(Information Sciences)2018，61，2： | 1 |
| 14 | Ultraviolet-induced crosslinking of poly(butylene succinate) and its thermal property,dynamic mechanical property, and biodegradability显示文摘 | Huang Xi Li Chuncheng Zhu Wenxiang | 2011 | Polymers for Advanced Technologies2011，22，64： | 1 |
| 15 | High Mo- lectdar Weight Aliphatic Polycarbonates by Melt Polyca- ondensation of Dimethyl Carbonate and Aliphatic Diols- Synthesis and Characterization 显示文摘 | Wenxiang Zhu Xi Huang Chuncheng Li | 2011 | Society of Chemical Industry2011，60，： | 1 |
| 16 | Analysis of fault tolerant performance of a doubly salient permanent magnet motor drive using transient co-simulation method 显示文摘 | ZHAO Wenxiang CHENG Ming ZHU Xiaoyong | 2008 | IEEE Transactions on Industrial Electronics2008，55，4： | 1 |
| 17 | Analysis of fault tolerant performance of a doublysalient permanent magnet motor drive using transientcosimulation method显示文摘 | Zhao Wenxiang Cheng Ming Zhu Xiaoyong | 2008 | IEEE Transactions onIndustry Electronics2008，55，4： | 1 |
| 18 | A novel one-dimensional copper( Ⅱ ) complex of a carboxymethylated tricyclic azacrown ether derivative linked by hydrogen bonding显示文摘 | Ma Shulan Zhu Wenxiang Yuan Daqiang | 2003 | J Coord Chem2003，56，5： | 1 |
| 19 | Synthesis, structure and magnetic properties of aμcarboxylate bridged ferromagnetic trinuclear copper( Ⅱ ) complex显示文摘 | Ma Shulan Zhu Wenxiang Gao Song | 2004 | Eur J Inorg Chem2004，，： | 1 |
| 20 | High-Mole- cular-Weight Aliphatic Polycarbonates by Melt Polycondensation of Dirnethyl Carbonate and Aliphatic Diols: Synthesis and Characterization显示文摘 | Zhu Wenxiang Huang Xi Li Chuncheng | 2011 | Polymlnt2011，60，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员