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| 1 | Late Mesozoic-Cenozoic dcollement structure and its deep geological background in western Shandong,China显示文摘Data from seismic reflection profiles, drilling, stratigraphy, structural deformation studies and physical rock properties reveal the existence of dcol1ement structures in both shallow and deep levels in western Shandong, China. The most outstanding shallow dcol1ement structures occur along the regional unconformity surface between the Cambrian and Archean, and the disconformity surface between the Carboniferous and Ordovician. The dcollement structure surface manifests as a fault zone with cataclastic rocks and asymmetrical folds. Some of the cataclastic rocks underwent dynamic metamorphism and hydrothermal alteration, including silicification, marbleization and specularite mineralization. Above the dcol1ement structure, the bottom of the Cambrian might be missing or overprinted because of dcollement. The striations, asymmetrical folds and boudinage structures indicate the direction of the main dcollement to the NNW and NNE. A deep level dcollement structure occurs at a depth of 12-22 km and up to 30 km distance to the south. The early Cretaceous and Eocene are two main periods of activity, with the Cretaceous dcollement probably initiated by mantle upwelling derived from subduction and collision of the Yangtze Plate with the North China Plate along the Tancheng-Lujiang Fault in the late Triassi-early Jurassic. This circumstance implies a multidirection of subduction and collision of these two plates in the early late Mesozoic. | Li, Li Zhong, Dalai Shi, Xiupeng Tang, Zibo Hu, Qiuyuan Xu, Yi Li, Zhiwei | 2009 | Progress in Natural Science:Materials International2009，19，5： | 12 |
| 2 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 3 | Effects of cyclic extrusion and compression parameters on microstructure and mechanical properties of Mg–1.50Zn–0.25Gd alloy显示文摘 | Hua Huang Zibo Tang Yuan Tian Gaozhi Jia Jialin Niu Hua Zhang Jia Pei Guangyin Yuan Wenjiang Ding | 2015 | Materials & Design2015，，： | 1 |
| 4 | NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5显示文摘Colon cancer is a common malignant tumor.However,its pathogenesis still needs further study.In this study,we explored the role of nucleosome assembly protein 1-like 1(NAP1L1)in colon cancer and its underlying mechanism.Based on analysis of The Cancer Genome Atlas data,we found that NAP1L1 is augmented in colorectal cancer,and the elevated NAP1L1 expression is associated with a poor prognosis in patients with colon cancer.Immunohistochemistry staining results showed that upregulated NAP1L1 protein level is an unfavorable factor that stimulates colon cancer progression.To further investigate the role of NAP1L1 in colon cancer,we established a colon cancer cell line with NAP1L1 knockdown,and found that repressing NAP1L1 expression in colon cancer cells markedly reduces cell proliferation in vivo and in vitro by MTT assay,colony formation,EdU incorporation,and subcutaneous tumorigenesis in nude mice.Furthermore,we found that NAP1L1 binds to HDGF,recruits DDX5,and inducesβ-catenin/CCND1 signaling,which promotes colon cancer cell proliferation.Finally,transfection with HDGF or DDX5 restores cell growth in NAP1L1-knockdown colon cancer cells by upregulating DDX5/β-catenin/CCND1 signaling.Our study demonstrates that NAP1L1 functions as a potential oncogene that promotes colon cancer tumorigenesis by binding to HDGF,which stimulates DDX5/β-catenin/CCND1 signaling. | Xuemin Liang Zibo Tang Yewei Zhang Yihan Sun Jiang Wang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 5 | Self-oxygenated co-assembled biomimetic nanoplatform for enhanced photodynamic therapy in hypoxic tumor显示文摘Photodynamic therapy(PDT)has shown great application potential in cancer treatment and the important manifestation of PDT in the inhibition of tumors is the activation of immunogenic cell death(ICD)effects.However,the strategy is limited in the innate hypoxic tumor microenvironment.There are two key elements for the realization of enhanced PDT:specific cellular uptake and release of the photosensitizer in the tumor,and a sufficient amount of oxygen to ensure photodynamic efficiency.Herein,self-oxygenated biomimetic nanoparticles(CS@M NPs)co-assembled by photosensitizer prodrug(Ce6-S-S-LA)and squalene(SQ)were engineered.In the treatment of triple negative breast cancer(TNBC),the oxygen carried by SQ can be converted to reactive oxygen species(ROS).Meanwhile,glutathione(GSH)consumption during transformation from Ce6-S-S-LA to chlorin e6(Ce6)avoided the depletion of ROS.The co-assembled(CS NPs)were encapsulated by homologous tumor cell membrane to improve the tumor targeting.The results showed that the ICD effect of CS@M NPs was confirmed by the significant release of calreticulin(CRT)and high mobility group protein B1(HMGB1),and it significantly activated the immune system by inhibiting the hypoxia inducible factor-1alpha(HIF-1α)-CD39-CD73-adenosine a2a receptor(A2AR)pathway,which not only promoted the maturation of dendritic cells(DC)and the presentation of tumor specific antigens,but also induced effective immune infiltration of tumors.Overall,the integrated nanoplatform implements the concept of multiple advantages of tumor targeting,reactive drug release,and synergistic photodynamic therapy-immunotherapy,which can achieve nearly 90%tumor suppression rate in orthotopic TNBC models. | Bingchen Zhang Ling Lin Jizong Mao Weisheng Mo Zibo Li Shengtao Wang Yan Tang Chunhui Cui Yifen Wu Zhiqiang Yu | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
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