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| 1 | Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients显示文摘AIM:To investigate prevalence,type and time of onset of extraintestinal manifestations(EIMs)in a series of Italian inflammatory bowel disease(IBD)patients.METHODS:Data of 811 IBD consecutive patients,first referred to our Centre from 2000 to 2011,were retrospectively evaluated.RESULTS:Eight hundred and eleven IBD patients(437M,374 F)were studied:595 ulcerative colitis(UC)(73.4%)and 216 Crohn’s disease(CD)(26.6%).Among these,329(40.6%)showed EIMs:210 UC(35.3%)and119 CD(55.1%)(P<0.0001).Considering the time of the diagnosis of IBD,37 EIMs(11.2%)were developed before,229(69.6%)after and 63(19.2%)were simultaneous.The type of EIM were as follows:240 musculoskeletal(29.6%),in 72 CD patients and in 168 UC(P<0.0001);47 mucocutaneous(5.8%),in 26 CD and in21 UC(P=0.0049);26 ocular(3.2%),in 16 CD and in10 UC(CD 7.4%vs UC 1.7%,P=0.0093);6 hepatobiliary(0.8%);10 endocrinological(1.2%).In particular,with regards to the involvement of the musculoskeletal system,arthritis Type 1 was found in 41 CD(19%)and in 61 UC(10.2%)(P=0.0012)and Type 2 in 25 CD(11.6%)and in 100 UC(16.8%)(P=0.0012).CONCLUSION:Mucocutaneous manifestations,arthritis Type 1 and uveitis were significantly more frequent in CD than UC.The complications of the musculoskeletal system were the mostly observed ones,often with symptoms more severe than intestinal ones,confirming the need for close cooperation with rheumatologists. | Maddalena Zippi Claudia Corrado Roberta Pica Eleonora Veronica Avallone Claudio Cassieri Daniela De Nitto Paolo Paoluzi Piero Vernia | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 2 | Biological therapy for dermatological manifestations of inflammatory bowel disease显示文摘Ulcerative colitis and Crohn's disease are the two forms of inflammatory bowel disease(IBD). The advent of biological drugs has significantly changed the management of these conditions. Skin manifestations are not uncommon in IBD. Among the reactive lesions(immunemediated extraintestinal manifestations), erythema nodosum(EN) and pyoderma gangrenosum(PG) are the two major cutaneous ills associated with IBD, while psoriasis is the dermatological comorbidity disease observed more often. In particular, in the last few years, anti-tumor necrosis factor(TNF)-α agents have been successfully used to treat psoriasis, especially these kinds of lesions that may occur during the treatment with biological therapies. The entity of the paradoxical manifestations has been relatively under reported as most lesions are limited and a causal relationship with the treatment is often poorly understood. The reason for this apparent side-effect of the therapy still remains unclear. Although side effects may occur, their clinical benefits are undoubted. This article reviews the therapeutic effects of the two most widely used anti-TNF-α molecules, infliximab(a fusion protein dimer of the human TNF-α receptor) and adalimumab(a fully human monoclonal antibody to TNF-α), for the treatment of the major cutaneous manifestations associated with IBD(EN, PG and psoriasis). | Maddalena Zippi Roberta Pica Daniela De Nitto Paolo Paoluzi | 2013 | World Journal of Clinical Cases2013，1，2： | 5 |
| 3 | Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum显示文摘尽管在煽动性的肠疾病和胃肠的感染之间的协会被建议了,涉及 Crohn 的疾病(CD ) 的致病的机制仍然是未经决定的。我们报导以后与 Crohn 的疾病被诊断的一个人,开始由于 Yersinia pseudotubercolosis 感染与 mes 伤寒淋巴腺炎介绍了,的案例。这个案例遵守在建议那 CD 是在遗传上易受影响的个人连接到对伤寒细菌的反常有免疫力的回答的疾病的文学的最近的证据。 | Maddalena Zippi Maria Chiara Colaiacomo Adriana Marcheggiano Roberta Pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli Francesca Maccioni | 2006 | World Journal of Gastroenterology2006，12，24： | 5 |
| 4 | Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis显示文摘In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical manifestations.These patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course.In a few cases,these symptoms may also present before the appearance of respiratory symptoms.To penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver cholangiocytes.In several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial origin.About 2%-11%of patients with COVID-19 have known underlying hepatic pathologies.In 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization. | Maddalena Zippi Sirio Fiorino Giuseppe Occhigrossi Wandong Hong | 2020 | World Journal of Clinical Cases2020，8，8： | 4 |
| 5 | Endoscopic papillary balloon dilation for diffi cult common bile duct stones:Our experience显示文摘AIM: To evaluate the eff icacy and safety of endoscopic balloon dilation(EBD) performed for common bile duct(CBD) stones.METHODS: From a computer database, we retrospectively analyzed the data relating to EBD performed in patients at the gastrointestinal unit of the Sandro Pertini Hospital of Rome(small center with low case volume) who underwent endoscopic retrograde cholangiopancreatography(ERCP) for CBD from January 1, 2010 to February 29, 2012. All patients had a proven diagnosis of CBD stones studied with echography, RMN cholangiography and, when necessary, with computed tomography of the abdomen(for example, in cases with pace-makers). Prophylactic therapies, with gabexate mesilate 24 h before the procedure and with an antibiotic(ceftriaxone 2 g) 1 h before, were administered in all patients. The duodenum was intubated with a side-viewing endoscope under deep sedation with intravenous midazolam and propofol. The patients were placed in the supine position in almost all cases. EBDof the ampulla was performed under endoscopic and f luoroscopic guidance with a balloon through the scope(Hercules, wireguided balloon, Cook Ireland Ltd. and CRE, Microvasive, Boston Scientific Co., Natick, MA, United States). RESULTS: A total of 14 patients(9 female, 5 male; mean age of 73 years; range 57-82 years) were enrolled in the study, in whom a total of 15 EBDs were performed. All patients underwent minor endoscopic sphincterotomy(ES) prior to the EBD. The size of balloon insuff lation depended on stone size and CBD dilation and this was performed until it reached 16 mm in diameter. EBD was performed under endoscopic and f luoroscopic guidance. The balloon was gradually f illed with diluted contrast agent and was maintained inf lated in position for 45 to 60 s before def lation and removal. The need for precutting the major papilla was 21.4%. In one patient(an 81-year-old), EBD was performed in a Billroth Ⅱ. Periampullary diverticula were found only in a 74-year-old female. The adverse event related to the procedures(ERCP + ES) was only an intra procedural bleeding(6.6%) that occurred after ES and was treated immediately with adrenaline sclerotherapy. No postoperative complications were reported.CONCLUSION: With the current endoscopic techniques, very few patients with choledocholithiasis require surgery. EBD is an eff icacious and safe procedure. | Maddalena Zippi Isabella De Felici Roberta Pica Giampiero Traversa Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 4 |
| 6 | Schwannoma of the rectum:A case report and literature review显示文摘Schwannoma is a tumor originating from the Schwann cells. Gastrointestinal schwannomas are uncommon stromal tumors of the intestinal tract and, in particular, rectal schwannomas are extremely rare. In fact, it is well established that schwannomas appear more frequently in the stomach and in the small intestine, while location in the colon or in the rectum is uncommon. Reading the literature, only few cases of rectal schwannoma have been reported. Their diagnosis is confirmed by the immunohisto chemical panel(S-100 protein). When these tumors are located in the colon and in the rectum, radical excision with wide margins is mandatory, due to their tendency to recur locally or become malignant, if left untreated. In the present study, we describe a case of a rectal schwannoma occured in a 72-year-old man, presented as a small polypoid lesion, which was successfully removed in toto by hot-biopsy, during the same endoscopy, due to the dimensons. No recurrence of the lesion was observed after 6 mo of follow-up. | Maddalena Zippi Roberta Pica Renzo Scialpi Claudio Cassieri Eleonora Veronica Avallone Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 7 | Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis显示文摘BACKGROUND The proton pump inhibitors(PPIs),used to reduce gastric acid secretion,represent one of the most widely used pharmaceutical classes in the world.Their consumption as a risk factor for the evolution of severe forms of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been investigated as well as the mortality of these patients.These risks also appear to be linked to the duration and the dosage.On the other hand,several studies have emerged with regard to the protective or therapeutic effects of these drugs.More and more evidence underlines the immunomodulatory and anti-fibrotic role of PPIs.In addition,their ability to alkalize the contents of endosomes and lysosomes serves as an obstacle to the entry of the virus into the host cells.AIM To identify studies on the relationship between the intake of PPIs and coronavirus disease 2019(COVID-19)in patients affected by SARS-CoV-2 infection,with the main objective of evaluating the outcomes related to severity and mortality.METHODS A literature review was performed in November 2020.The MEDLINE/PubMed,Cochrane Library,EMBASE and Google Scholar databases were searched for all relevant articles published in English on this topic.The search terms were identified by means of controlled vocabularies,such as the National Library of Medicine’s MESH(Medical Subject Headings)and keywords.The MESH terms and keywords used were as follows:“COVID-19”,“proton pump inhibitors”,“PPIs”,“SARS-CoV-2”,“outcomes”,“severity”and“mortality”.The inclusion criteria regarding the studies considered in our analysis were:meta-analysis,casecontrol,hospital-based case-control,population-based case-control,retrospective studies,online survey,as well as cohort-studies,while articles not published as full reports,such as conference abstracts,case reports and editorials were excluded.We tried to summarize and pool all the data if available.RESULTS A total of 9 studies were found that described the use of PPIs,of which only 5 clearly reported the severity and mortality data in SARS-CoV-2 patients.Our pooled incidence analysis of severe events did not differ between patients with and without PPIs(odds ratio 1.65,95%confidence interval:0.62-4.35)(P=0.314),or for mortality(odds ratio 1.77,95%confidence interval:0.62-5.03)(P=0.286).CONCLUSION Detailed and larger case studies are needed to accurately understand the role of PPIs in this viral infection. | Maddalena Zippi Sirio Fiorino Roberta Budriesi Matteo Micucci Ivan Corazza Roberta Pica Dario de Biase Claudio Giuseppe Gallo Wandong Hong | 2021 | World Journal of Clinical Cases2021，9，12： | 2 |
| 8 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 9 | Network Analysis of Knowledge Construction in Asynchronous Learning Networks 显示文摘 | Aviv Reuven Erlich Zippy | 2003 | Journal of Asynchronous Learning Networks2003，3，： | 1 |
| 10 | Amebic liver abscess,Mirizzi syndrome,and acute hepatic failure显示文摘 | Severi C Zippi M Baccini F | 2004 | Dig Dis Sci2004，49，2： | 1 |
| 11 | Amebic liver abscess,Mirizzi syndrore,and acute hepatic failure显示文摘 | Severi C Zippi M Baccini F | 2004 | Dig Dis Sci2004，49，2： | 1 |
| 12 | Rifaximin improves symptoms of acquired uncomplicated diverticular disease of the colon显示文摘 | Giovanni Latella Maria Pimpo Sandra Sottili Maddalena Zippi Angelo Viscido Maria Chiaramonte Giuseppe Frieri | 2003 | International Journal of Colorectal Disease2003，，1： | 1 |
| 13 | CASE REPORT: Amebic Liver Abscess, Mirizzi Syndrome, and Acute Hepatic Failure显示文摘 | C. Severi M. Zippi F. Baccini G. Gentile M. Bezzi F. Fiocca R. Caprilli | 2004 | Digestive Diseases and Sciences2004，，： | 1 |
| 14 | Amebic liver abscess,Mi-rizzi syndrome,and acute hepatic failure显示文摘 | Severi C Zippi M Baccini F | 2004 | Dig Dis Sci2004，49，2： | 1 |
| 15 | Diagnosis and treatment of bleeding peptic ulcer: our experience显示文摘 | Zippi M Febbraro I De Felici I | 2008 | Clin Terl2008，159，4： | 1 |
| 16 | Use of argon plasma coagulation in digestive endoscopy:a concise review显示文摘 | Zippi M Traversa G Cocco A | 2012 | Clin Ter2012，163，6： | 1 |
| 17 | Rectal cancer or rectal chancre?显示文摘 | I. Febbraro G. Manetti P. Balestrieri M. Zippi | 2008 | Digestive and Liver Disease2008，，： | 1 |
| 18 | Data Mining by Means of Binary Representation: A Model for Similarity and Clustering显示文摘 | Zippy Erlich Roy Gelbard Israel Spiegler | 2002 | Information Systems Frontiers2002，2，： | 1 |
| 19 | Amebic liver abscess, Mirizzi syndrome, and acute hepatic failure 显示文摘 | Severi C Zippi M Baccini F | 2004 | Dig Dis Sei2004，49，2： | 1 |
| 20 | Infliximab for the treatment of pouchitis显示文摘Pouchitis is not a rare complication that develops after an ileal-pouch anastomosis, performed after colectomy in patients refractory to treatment or with complicated ulcerative colitis. This condition may become chronic and unresponsive to medical therapies, including corticosteroids, antibiotics and probiotics. The advent of biological therapies(tumor necrosis factor-α inhibitors) has changed the course of these complications. In particular, in these cases, infliximab(IFX) may represent a safe and effective therapy in order to avoid the subsequent operation for a permanent ileostomy. This article reviews the therapeutic effects of one of the most widely used anti-tumor necrosis factor-α molecules, IFX, for the treatment of complicated pouchitis(refractory to conventional treatment and/or fistulizing). | Maddalena Zippi Claudio Cassieri Eleonora Veronica Avallone Roberta Pica | 2013 | World Journal of Clinical Cases2013，1，6： | 1 |
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