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| 1 | Investigation on the Thermal Conductivity of 3-Dimensional and 4-Directional Braided Composites显示文摘It is vital to choose a factual and reasonable micro-structural model of braided composites for improving the calculating precision of thermal property of 3-D braided composites by finite element method (FEM). On the basis of new microstructure model of braided composites proposed recently, the model of FEM calculation for thermal conductivity of 3-dimennsional and 4-directional braided composites is set up in this paper. The curves of coefficient of effective thermal conductivity versus fiber volume ratio and interior braiding angle are obtained. Furthermore, comparing the results of FEM with the available experimental data,the reasonability and veracity of calculation are confirmed at the same time. | Liu Zhenguo Zhang Haiguo Lu Zixing Li Diansen | 2007 | Chinese Journal of Aeronautics2007，20，4： | 23 |
| 2 | ROP11 GTPase is a Negative Regulator of Multiple ABA Responses in Arabidopsis显示文摘The phytohormone abscisic acid (ABA) plays crucial roles in plant development and plant responses to environmental stresses. Although ABA receptors and a minimal set of core molecular components have recently been discovered, understanding of the ABA signaling pathway is still far from complete. In this work, we characterized the function of ROP11, a member of the plant-specific ROP small GTPases family, in the ABA signaling process. ROP11 is preferentially expressed in guard cells in all plant organs with stomata. Expression of a constitutively active ROP11 (CA-ROP11) suppresses ABA-mediated responses, whereas reduced expression of ROP11 or expression of its dominant-negative form (DN-ROP11) causes the opposite phenotypes. The affected ABA-mediated responses by ROP11 include seed germination, seedling growth, stomatal closure, induction of ABA-responsive genes, as well as plant response to drought stress. Furthermore, we showed that ROP11 and its closest-related family member, ROP10, act in parallel in mediating these responses. ABA treatment does not affect ROP11 transcription and protein abundance; however, it causes the accumulation of CA-ROP11 in the nucleus. These results demonstrated that ROP11 is a negative regulator of multiple ABA responses in Arabidopsis. | Zixing Li Jun Kang Ning Sui Dong Liu | 2012 | Journal of Integrative Plant Biology2012，54，3： | 14 |
| 3 | ROP11 GTPase Negatively Regulates ABA Signaling by Protecting ABI1 Phosphatase Activity from Inhibition by the ABA Receptor RCAR1/PYL9 in Arabidopsis显示文摘The phytohormone abscisic acid (ABA) regulates many key processes in plants, such as seed germina- tion, seedling growth, and abiotic stress tolerance. In recent years, a minimal set of core components of a major ABA signaling pathway has been discovered. These components include a RCAR/PYR/PYL family of ABA receptors, a group of PP2C phosphatases, and three SnRK2 kinases. However, how the interactions between the receptors and their targets are regulated by other proteins remains largely unknown. In a companion paper published in this issue, we showed that ROP11, a member of the plant- specific Rho-like small GTPase family, negatively regulates multiple ABA responses in Arabidopsis. The current work demonstrated that the constitutively active ROP11 (CA-ROP11) can modulate the RCAR1/PYL9-mediated ABA signaling pathway based on reconstitution assays in Arabidopsis thaliana protoplasts. Furthermore, using luciferase complementation imaging, yeast two-hybrid assays, co- immunoprecipitation assays in Nicotiana benthamiana and bimolecular fluorescence complementation assays, we demonstrated that CA-ROP11 directly interacts with ABI1, a signaling component downstream of RCAR1/PYL9. Finally, we provided biochemical evidence that CA-ROP11 protects ABI1 phosphatase activity from inhibition by RCAR1/PYL9 and thus negatively regulates ABA signaling in plant cells. A model of how ROP11 acts to negatively regulate ABA signaling is presented. | Zixing Li Zheng Li Xiang Gao Viswanathan ChinnusamyI Ray Bressant Zhi-Xin Wang Jian-Kang Zhu Jia-Wei Wu Dong Liu | 2012 | Journal of Integrative Plant Biology2012，54，3： | 11 |
| 4 | Predictions of mortality related to four major cancers in China,2020 to 2030显示文摘Background:Cancer has become a global health problem,and assessments of cancer mortality are important for effective public health policy-making and adequate resource allocation.In this study,we aimed to predict the mortality rates and numbers of deaths related to four common cancers(lung,liver,stomach,and esophagus)in China from 2020 to 2030 and to estimate the corresponding cancer burden caused by population aging and tobacco smoking.Methods:Cancer mortality data(2004-2017)were extracted from China’s death surveillance datasets,and China’s population figures(2020-2030)were obtained from the United Nations population projections.Smoking prevalence data were retrieved from a World Health Organization global report,and relative risks of smoking and cancers were derived from large-scale Asian studies.We predicted the deaths related to the four major cancers and age-standardized mortality rates using joinpoint regression and linear regression models.The tobacco smoking related burden of these four major cancers was estimated using the population attributable fraction.Results:Unlike lung cancer mortality which was predicted to continue to increase,the age-standardized mortality rates for digestive cancers(liver,stomach,and esophageal cancers)are predicted to decline over the next decade.The number of deaths caused by the four major cancers is predicted to increase from 1,490,304 in 2020 to 1,823,960 in 2030.The age-specific mortality rates of the four major cancers are predicted to increase with age after 40-45 years,peaking in the age groups of 80-84 and ≥85 years.In 2030,the combined number of deaths from the four examined cancers among adults aged ≥65 years is predicted to be 1,167,153,accounting for 64% of all deaths from these cancers.Tobacco smoking is predicted to contribute to nearly 29% of deaths fromthese cancers,corresponding to 527,577 deaths.Conclusions:The overall trend in the combined total mortality from four major cancers is predicted to decline over the next decade;however,the corresponding death toll is expected to surge,in the context of China’s population aging and high smoking prevalence.These estimates provide data-driven evidence for China to implement effective cancer control measures in the future. | Ning Li Peng Wu Yubing Shen Cuihong Yang Luwen Zhang Yali Chen Zixing Wang Jingmei Jiang | 2021 | Cancer Communications2021，41，5： | 4 |
| 5 | A precision medicine approach to managing 2019 novel coronavirus pneumonia显示文摘In December 2019,several patients with pneumonia of an unknown cause were detected in Wuhan,China.On 7 January 2020,the causal organism was identified as a new coronavirus,later named as the 2019 novel coronavirus(2019-nCoV).Genome sequencing found the genetic sequence of 2019-nCoV homologous to that of severe acute respiratory syndrome-associated coronavirus.As of 29 January 2020,the virus had been diagnosed in more than 7000 patients in China and 77 patients in other countries.It is reported that both symptomatic and asymptomatic patients with 2019-nCoV can play a role in disease transmission via airborne and contact.This finding has caused a great concern about the prevention of illness spread.The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections,making it difficult to diagnose.Given that the virus has a strong ability to spread between individuals,it is of top priority to identify potential or suspected patients as soon as possible—or the virus may cause a serious pandemic.Therefore,a precision medicine approach to managing this disease is urgently needed for detecting and controlling the spread of the virus.In this article,we present such an approach to managing 2019-nCoV-related pneumonia based on the unique traits of the virus recently revealed and on our experience with coronaviruses at West China Hospital in Chengdu,China. | Minjin Wang Yanbing Zhou Zhiyong Zong Zongan Liang Yu Cao Hong Tang Bin Song Zixing Huang Yan Kang Ping Feng Binwu Ying Weimin Li | 2020 | Precision Clinical Medicine2020，3，1： | 3 |
| 6 | The role of watermelon caffeic acid O-methyltransferase (ClCOMT1) in melatonin biosynthesis and abiotic stress tolerance显示文摘Melatonin is a pleiotropic signaling molecule that regulates plant growth and responses to various abiotic stresses.The last step of melatonin synthesis in plants can be catalyzed by caffeic acid O-methyltransferase(COMT),a multifunctional enzyme reported to have N-acetylserotonin O-methyltransferase(ASMT)activity;however,the ASMT activity of COMT has not yet been characterized in nonmodel plants such as watermelon(Citrullus lanatus).Here,a total of 16 putative O-methyltransferase(ClOMT)genes were identified in watermelon.Among them,ClOMT03(Cla97C07G144540)was considered a potential COMT gene(renamed ClCOMT1)based on its high identities(60.00–74.93%)to known COMT genes involved in melatonin biosynthesis,expression in almost all tissues,and upregulation under abiotic stresses.The ClCOMT1 protein was localized in the cytoplasm.Overexpression of ClCOMT1 significantly increased melatonin contents,while ClCOMT1 knockout using the CRISPR/Cas-9 system decreased melatonin contents in watermelon calli.These results suggest that ClCOMT1 plays an essential role in melatonin biosynthesis in watermelon.In addition,ClCOMT1 expression in watermelon was upregulated by cold,drought,and salt stress,accompanied by increases in melatonin contents.Overexpression of ClCOMT1 enhanced transgenic Arabidopsis tolerance against such abiotic stresses,indicating that ClCOMT1 is a positive regulator of plant tolerance to abiotic stresses. | Jingjing Chang Yanliang Guo Jingyi Yan Zixing Zhang Li Yuan Chunhua Wei Yong Zhang Jianxiang Ma Jianqiang Yang Xian Zhang Hao Li | 2021 | Horticulture Research2021，8，1： | 2 |
| 7 | Egg-like magnetically immobilized nanospheres: A long- lived catalyst model for the hydrogen transfer reaction in a continuous-flow reactor显示文摘新奇像鸡蛋的 nanosphere 作为长寿催化剂被设计并且被描述为 Fe 3 O 4@nSiO2-NH2-Fe2 O 3 xBi 2 O 3@mSiO2 。催化剂用修改的圣被准备 ? 有没有模板的保护表面的蚀刻的 ber 方法。催化剂粒子由磁性的 Fe 3 是的 O 4 核心蛋黄,忍受活跃 Fe 2 O 3 xBi 2 卵白人,和外部 mesoporous 硅石作为卵轰炸的 O 3 种类。它在一张改正床在 nitro aromatics 的催化减小展出优秀表演到相应苯胺连续流动的反应堆。反应能在学习被做的 80 onal 被执行。题目是怀疑有 TB 感染的病人。在怀疑的区域的整个身体和 SPECT-CT 成像被做 1 和 4 ? 在 370-555 的注射以后的 h ? MBq 99m Tc-ethambu 吗?? | Yongjian Ai Zenan Hu Zixing Shao Li Qi Lei Liu Junjie Zhou Hongbin Sun Qionglin Liang | 2018 | Nano Research2018，11，1： | 2 |
| 8 | Preparation and char-acterization of sulfonated graphene- enhanced poly (vinyl alco-hol) composite hydrogel and its application as dye absorbent显示文摘 | Li Hong Fan Jinchen Shi Zixing | 2015 | Polymer2015，，60： | 1 |
| 9 | Single‐Doped White Organic Light‐Emitting Device with an External Quantum Efficiency Over 20%显示文摘 | Tyler Fleetham Jeremy Ecton Zixing Wang Nathan Bakken Jian Li | 2013 | Adv Mater2013，，18： | 1 |
| 10 | A Novel Intelligent Control Method Evolutionary Control显示文摘 | Cai Zixing Zhou Xiang Li Meiyi | 2000 | Proceedings of the 3''d World Congress on Intelligent Control and Automation2000，，： | 1 |
| 11 | Improvement of Stress-rupture Life for Modified-HR6W Austenitic Stainless Steel显示文摘Stress-rupture life of HR6W austenitic stainless steel modified with B and Mg additions was measured, and the microstructures were analyzed by optical microscopy, X-ray diffraction, scanning electron microscopy and transmission electron microscopy equipped with energy dispersive spectroscopy. The results indicated that the enhancement of the stress-rupture life was mainly due to the precipitation with B in the elemental form at the grain boundaries, and the improvement of the form of carbides at grain boundaries and the removal of O and S elements by addition of Mg. The micro-alloying elements have a beneficial effect on stress-rupture life of the modified-HR6W austenitic stainless steel at high temperature. | Shiyun Cui Zixing Zhang Yulai Xu Jun Li Xueshan Xiao Changchun Zhu | 2011 | Journal of Materials Science & Technology2011，27，11： | 1 |
| 12 | Effects of population aging on the mortality burden of related cancers in urban and rural areas of China, 2004–2017: a population-based study显示文摘Objective:China is a developing country with urban–rural disparities and accelerating population aging.Therefore,quantifying the effects of population aging on the cancer mortality burden is urgently needed.Methods:Using data from China’s death surveillance datasets(2004–2017),we decomposed and quantified the effects of population aging and factor variations on cancer mortality rates in urban and rural China during 2004–2017 through a decomposition method.R ratios were used to assess the extent of the mortality decreases attributable to factor variations offsetting the increases attributable to population aging for 4 aging-related cancers(lung,colorectal,esophageal,and stomach cancer).Results:Overall,population aging has led to continued increases in cancer mortality rates in China during 2004–2017(mortality rates attributable to population aging:8.63/100,000 for urban men,4.21/100,000 for urban women,11.95/100,000 for rural men,and 5.66/100,000 for rural women).The 4 cancers displayed 3 patterns.The mortality rates from lung cancer in rural China and from colorectal cancer nationwide increased because of both population aging and factor variations.Population aging was primarily responsible for the growing mortality due to lung cancer in urban areas.However,for esophageal and stomach cancer,the effect of population aging was not dominant,thus resulting in decreases in mortality rates.Conclusions:Health resource allocation should prioritize areas or cancers more adversely affected by population aging.The burden of cancer will continue to increase in the future,because of rapid population aging,but can still be offset or even reversed with enhanced cancer control and prevention. | Yali Chen Cuihong Yang Ning Li Zixing Wang Peng Wu Jin Du Jingmei Jiang | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 13 | Up-regulation of TIMP-2 expression promotes SHI-1 leukemic cells proliferation and infiltration in immunodeficiency mice显示文摘 | Li Zhenjiang Chen Zixing Cen Jiannong He Jun Qiu Qiaocheng Xue Yongquan | 2014 | Chinese Medical Journal2014，，24： | 1 |
| 14 | A Novel Intelligent Control Method Evolutionary Control 显示文摘 | Cai Zixing Zhou Xiang Li Meiyi | 2000 | Proceedings of the 3''d World Congress on Intelligent Control and Automation2000，，： | 1 |
| 15 | Immune Evolutionary Computations for Concurrent Mapping And Location显示文摘 | Li Meiyi Cai Zixing | 2005 | Fuzzy Sys-tems and Knowledge Discovery2005，，3： | 1 |
| 16 | Microstructure and mechanical properties of three-dimensional five-directional braided composites显示文摘 | Li Diansen Lu Zixing Chen Li Li Jialu | 2009 | International Journal of Solids and Structures2009，46，1819： | 1 |
| 17 | Synthesis and evaluation of peptide-fentanyl analogue conjugates as dualμ/δ-opioid receptor agonists for the treatment of pain显示文摘Novel peptide-fentanyl analogue conjugates were synthesized by the covalent coupling of carfentanyl derivatives to the C-terminus or N-terminus of the conformationally constrained dermorphin tetrapeptide BVD03 via a chemical linker.The carfentanyl-related analogues displayed distinct binding and functional activities atμ/δopioid receptors(MOR/DOR)and antinociceptive effects when conjugated to the peptide.The most potent compound,SW-LJ-11,displayed mixed MOR/DOR agonist properties in the low nanomolar range and significant analgesic efficacy in vivo in four classic mouse models of pain.Interestingly,SW-LJ-11 did not exhibit any physical dependence or respiratory depression,in contrast to an equipotent analgesic dose of morphine or BVD03,indicating that the use of opioid peptide-fentanyl analogue conjugates as dual MOR/DOR agonists may be a promising strategy for obtaining safer opioids. | Jing Li Tao Zhang Jialin Sun Fengxia Ren Hongxin Jia Zixing Yu Jingchao Cheng Weiguo Shi | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
| 18 | Network prediction of surgical complication clusters:a prospective multicenter cohort study显示文摘Complicated relationships exist in both occurrence and progression of surgical complications,which are difficult to account for using a separate quantitative method such as prediction or grading.Data of 51,030 surgical inpatients were collected from four academic/teaching hospitals in a prospective cohort study in China.The relationship between preoperative factors,22 common complications,and death was analyzed.With input from 54 senior clinicians and following a Bayesian network approach,a complication grading,cluster-visualization,and prediction(GCP)system was designed to model pathways between grades of complication and preoperative risk factor clusters.In the GCP system,there were 11 nodes representing six grades of complication and five preoperative risk factor clusters,and 32 arcs representing a direct association.Several critical targets were pinpointed on the pathway.Malnourished status was a fundamental cause widely associated(7/32 arcs)with other risk factor clusters and complications.American Society of Anesthesiologists(ASA)score≥3 was directly dependent on all other risk factor clusters and influenced all severe complications.Grade III complications(mainly pneumonia)were directly dependent on4/5 risk factor clusters and affected all other grades of complication.Irrespective of grade,complication occurrence was more likely to increase the risk of other grades of complication than risk factor clusters. | Xiaochu Yu Peng Wu Zixing Wang Wei Han Yuguang Huang Shijie Xin Qiang Zhang Shengxiu Zhao Hong Sun Guanghua Lei Taiping Zhang Luwen Zhang Yubing Shen Wentao Gu Hongwei Li Jingmei Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 19 | Facile anodization approach derived low-crystalline NiCoeOH/NiCoOOH composite films for ultra-high areal capacity and mass loading supercapacitors显示文摘The design of supercapacitor materials with both high areal capacity(C)and high mass loading is vitally important for enhancing energy density(E).Herein,we prepared a NiCosingle bondOH/NiCoOOH composite film consisting of NiCosingle bondOH/NiCoOOH nanosheets on an expanded graphite paper(EGP)by using a facial anodization method.The as-prepared NiCosingle bondOH/NiCoOOH film exhibits ultra-high C of 11 mA·h·cm^(-2)at a mass loading of 165 mg·cm^(-2),high rate capability of 71%and excellent cycling stability of 95%after 12000 cycles.The outstanding performance is ascribed to the low-crystalline feature of the NiCosingle bondOH/NiCoOOH nanosheets,and the synergistic effect of the NiCosingle bondOH and NiCoOOH phases and high conductive porous EGP.An aqueous asymmetric supercapacitor,assembled with the NiCosingle bondOH/NiCoOOH on EGP and Fe_(2)O_(3)on EGP as positive-and negative-electrode,respectively,shows a highest E of 3.8 mW·h·cm^(-2)at a power density(P)of 4 mW·cm^(-2)and a maximum P of 107 mW·cm^(-2)at an E of 2.7 mW·h·cm^(-2). | Mingyuan Gao Yuexin Liu Xiaoyu Li Ying Liu Zixing Wang Kefeng Cai | 2023 | Journal of Materiomics2023，9，1： | 0 |
| 20 | Ruins of the Bronze Age Inscribed on the World Heritage List显示文摘On July 13, Yin Xu, ruins of ancient Shang Dynasty capital in Anyang City was inscribed on the World Heritage List and became China’s 33rd World Heritage site. | Zhou Wei & Li Zixing | 2006 | China & The World Cultural Exchange2006，72，9： | 0 |
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