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| 1 | Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China:a decision analysis and implications for practice显示文摘Background: Mortality outcomes in trials of low-dose computed tomography(CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect.Methods: A decision tree model with three scenarios(low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort(100,000 smokers aged45-80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality(primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables.Results: Among the 100,000 subjects, there were 448,541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively(17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, lowdose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths(relative numbers) with low-dose CT screening in the worst and optimal cases were16(5.4%) and 288(40.2%) over no screening, respectively.Conclusions: In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China.However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed. | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2017 | Chinese Journal of Cancer2017，36，8： | 9 |
| 2 | Analysis and simulation of high strain compression of anisotropic open-cell elastic foams显示文摘By elongating the regular Kelvin model in one direction and keeping unchanged in the other two directions,the anisotropic model was constructed.Then,the simplified periodic structural cell was obtained according to the periodicity and symmetry of the model in the whole space.Using the half-strut element and elastic deflection theory to analyze the mechanical behavior as were adopted in the previous studies,this paper obtained the theoretical expressions for the compressive stress and strain as well as the corresponding curves in the rise and transverse directions.In addition,the theoretical results were examined by the finite element simulation.Results indicated that the theoretical analysis was very close to the finite element simulation when the strain was not too high,which confirmed the validity of theoretical analysis.At the same time,the anisotropy was shown to have a significant effect on the mechanical properties of open-cell foams.As the anisotropy ratio increased,the compressive stress was improved in the rise direction but dropped in the transverse direction under the same strain. | LU ZiXing,HUANG JiXiang&CHEN Xin School of Aeronautic Science and Engineering,Beijing University of Aeronautics and Astronautics,Beijing 100191,China | 2010 | Science China(Technological Sciences)2010，53，3： | 4 |
| 3 | 中国城市人群低剂量计算机断层扫描筛查肺癌的死亡率结果:决策分析和实践意义显示文摘背景与目的不同低剂量计算机断层扫描(computed tomography,CT)筛查肺癌试验得出的死亡率结果不一致。本研究旨在评价中国城市CT筛查是否能够降低肺癌死亡率,并探讨影响筛查效果的因素。方法建立了3种场景(低剂量CT筛查、胸部X线筛查和无筛查)的决策树模型来比较模拟的中国城市人群(100,000例年龄45–80岁的吸烟者)的筛查结果。从国家登记和流行病学调查中获得了参与者特征数据并估算了肺癌患病比例。根据文献调研选择了低剂量CT和胸部X线筛查的灵敏度和特异度等其他树变量。计算了3种筛查方法间肺癌死亡率(主要结局)、误诊和误诊导致死亡的差异。通过敏感性分析找出了与筛查结果相关的因素,并确定了在变量可能范围内的最差和最优筛查效果。结果 100,000例研究对象中,低剂量CT、胸部X线和无筛查场景分别有448例、541例和591例肺癌死亡(低剂量CT筛查比胸部X线筛查死亡人数减少17.2%,比无筛查减少24.2%)。100,000例研究对象中,2种筛查场景的代价分别为9387例和2497例误诊及7例和2例误诊导致的死亡。低剂量CT筛查比无筛查的死亡数降低,影响最大的因素是筛查人群的肺癌患病比例、低剂量CT的灵敏度和低剂量CT检出肺癌中早期癌的比例。综合了所有可能性,低剂量CT筛查肺癌的死亡人数(相对数)在最坏和最好情况下分别比无筛查降低了16例(5.4%)和288例(40.2%)。结论就死亡率结局而言,我们的研究结果支持在中国城市人群中进行低剂量CT筛查。然而,急需策略来减少误诊和优化纳入标准等重要筛查条件。 | Zixing Wang Wei Han Weiwei Zhang Fang Xue Yuyan Wang Yaoda Hu Lei Wang Chunwu Zhou Yao Huang Shijun Zhao Wei Song Xin Sui Ruihong Shi Jingmei Jiang | 2018 | 癌症2018，37，8： | 3 |
| 4 | Challenges and research opportunities for lung cancer screening in China显示文摘Following publication of the results of the National Lung Screening Trial in the United States,a randomized controlled trial in Italy(ITALUNG)and two simulation studies in China reported similar findings in 2017 favoring lung cancer screening with low-dose computed tomography among smokers.With such advances in lung cancer screening,worldwide interest has gradually shifted from evaluating whether refining lung cancer screening protocols is effective in preventing deaths.However,there are several practical problems to be resolved,including the balance of enroll-ment criteria and cost effectiveness,precise measurements to reduce false positive findings,risk-based optimization of screening frequency,challenges associated with cancer heterogeneity,strategies to combine image screening with novel biomarkers,dynamic monitoring of the natural history of cancer,accurate identification and diagnosis of cases among huge populations,and the impact of tobacco control policy and environment protection.As one in three individuals with lung cancer worldwide resides in China,these questions pose great challenges as well as research opportunities for population screening programs in China. | Zixing Wang Yuyan Wang Yao Huang Fang Xue Wei Han Yaoda Hu Lei Wang Wei Song Jingmei Jiang | 2018 | Cancer Communications2018，38，1： | 3 |
| 5 | A precision medicine approach to managing 2019 novel coronavirus pneumonia显示文摘In December 2019,several patients with pneumonia of an unknown cause were detected in Wuhan,China.On 7 January 2020,the causal organism was identified as a new coronavirus,later named as the 2019 novel coronavirus(2019-nCoV).Genome sequencing found the genetic sequence of 2019-nCoV homologous to that of severe acute respiratory syndrome-associated coronavirus.As of 29 January 2020,the virus had been diagnosed in more than 7000 patients in China and 77 patients in other countries.It is reported that both symptomatic and asymptomatic patients with 2019-nCoV can play a role in disease transmission via airborne and contact.This finding has caused a great concern about the prevention of illness spread.The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections,making it difficult to diagnose.Given that the virus has a strong ability to spread between individuals,it is of top priority to identify potential or suspected patients as soon as possible—or the virus may cause a serious pandemic.Therefore,a precision medicine approach to managing this disease is urgently needed for detecting and controlling the spread of the virus.In this article,we present such an approach to managing 2019-nCoV-related pneumonia based on the unique traits of the virus recently revealed and on our experience with coronaviruses at West China Hospital in Chengdu,China. | Minjin Wang Yanbing Zhou Zhiyong Zong Zongan Liang Yu Cao Hong Tang Bin Song Zixing Huang Yan Kang Ping Feng Binwu Ying Weimin Li | 2020 | Precision Clinical Medicine2020，3，1： | 3 |
| 6 | Halogenated Thermally Activated Delayed Fluorescence Materials for Efficient Scintillation显示文摘Organic scintillators,materials with the ability to exhibit luminescence when exposed to X-rays,have aroused increasing interest in recent years.However,the enhancement of radioluminescence and improving X-ray absorption of organic scintillators lie in the inherent dilemma,due to the waste of triplet excitons and weak X-ray absorption during scintillation.Here,we employ halogenated thermally activated delayed fluorescence materials to improve the triplet exciton utilization and X-ray absorption simultaneously,generating efficient scintillation with a low detection limit,which is one order of magnitude lower than the dosage for X-ray medical diagnostics.Through experimental study and theoretical calculation,we reveal the positive role of X-ray absorption,quantum yields of prompt fluorescence,and intersystem crossing in promoting the radioluminescence intensity.This finding offers an opportunity to design diverse types of organic scintillators and expands the applications of thermally activated delayed fluorescence. | Xiao Wang Guowei Niu Zixing Zhou Zhicheng Song Ke Qin Xiaokang Yao Zhijian Yang Xiaoze Wang He Wang Zhuang Liu Chengzhu Yin Huili Ma Kang Shen Huifang Shi Jun Yin Qiushui Chen Zhongfu An Wei Huang | 2023 | Research2023，，4： | 1 |
| 7 | Analysis of defectson the compressive behaviors of open-cell metal foamsthrough models using the FEM 显示文摘 | Lu Zixing Liu Qiang Huang Jixiang | 2011 | Materials Science andEngineering A (S0921-5093)2011，530，： | 1 |
| 8 | Preparation of Enantiomerically Pure 1,1'-Bi-2-naphthols from 85% Cinchonine and 1,1'-Bi-2-naphtholboric Anhydride显示文摘Enantiomericalypure1,1'-bi-2-naphthols(1A,1BSchemeⅠ)haveprovedtobeveryusefulchiralauxiliariesinstoichiometricandcatalyticasym... | Xiong, Ying Shan, Zixing Cheng, Fuyong Huang, Shiwen Zhao, Dejie | 1998 | Wuhan University Journal of Natural Sciences1998，3，3： | 0 |
| 9 | Imaging evaluation of sorafenib for treatment of advanced hepatocellular carcinoma显示文摘Sorafenib,which is a novel targeted agent,plays an important role in treating advanced hepatocellular carcinoma(HCC)through its antiangiogenic and antiproliferative effects.However,conventional morphology-based radiographic evaluation systems may underestimate the efficacy of sorafenib in HCC due to a lack of apparent tumor shrinkage or altered tumor morphology in many cases.This calls for the development of more accurate imaging methods for evaluating sorafenib.The introduction of tumor burden measurements based on viability and other evolving imaging approaches for assessing therapeutic effects are promising for overcoming some of the limitations of the morphology-based criteria.In this review,we summarize various imaging methods that are used to assess treatment responses of advanced HCC to sorafenib.Imaging markers predictive of prognosis in advanced HCC after treatment with sorafenib are also included and discussed. | Tianying Zheng Hanyu Jiang Yi Wei Zixing Huang Jie Chen Ting Duan Bin Song | 2018 | Chinese Journal of Cancer Research2018，30，3： | 0 |
| 10 | Bridging bronchus complicated with a left pulmonary artery sling a rare entity显示文摘To the editor:The bridging bronchus (BB) is a rarely reported congenital anomaly in which right middle and lower lobes are supplied by an accessory bronchus arising from the left main bronchus.1 A sling left pulmonary artery (SLPA) is also a rare congenital cardiac malformation,in which the left pulmonary artery arises from the right pulmonary artery and passes between the trachea and esophagus,causing tracheal stenosis by the pulsating pulmonary artery.2 Here we present a rare pediatric case of BB complicated with a SLPA. A three-year-old boy was admitted with complaints of recurrent respiratory distress and cough,with no signs of cyanosis and clubbing fingers. | Lin Jing Shen Yongchun Huang Zixing Wen Fuqiang | 2014 | Chinese Medical Journal2014，，19： | 0 |
| 11 | Network prediction of surgical complication clusters:a prospective multicenter cohort study显示文摘Complicated relationships exist in both occurrence and progression of surgical complications,which are difficult to account for using a separate quantitative method such as prediction or grading.Data of 51,030 surgical inpatients were collected from four academic/teaching hospitals in a prospective cohort study in China.The relationship between preoperative factors,22 common complications,and death was analyzed.With input from 54 senior clinicians and following a Bayesian network approach,a complication grading,cluster-visualization,and prediction(GCP)system was designed to model pathways between grades of complication and preoperative risk factor clusters.In the GCP system,there were 11 nodes representing six grades of complication and five preoperative risk factor clusters,and 32 arcs representing a direct association.Several critical targets were pinpointed on the pathway.Malnourished status was a fundamental cause widely associated(7/32 arcs)with other risk factor clusters and complications.American Society of Anesthesiologists(ASA)score≥3 was directly dependent on all other risk factor clusters and influenced all severe complications.Grade III complications(mainly pneumonia)were directly dependent on4/5 risk factor clusters and affected all other grades of complication.Irrespective of grade,complication occurrence was more likely to increase the risk of other grades of complication than risk factor clusters. | Xiaochu Yu Peng Wu Zixing Wang Wei Han Yuguang Huang Shijie Xin Qiang Zhang Shengxiu Zhao Hong Sun Guanghua Lei Taiping Zhang Luwen Zhang Yubing Shen Wentao Gu Hongwei Li Jingmei Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 12 | Variation of Effective Mass and Level Density Parameter with Nuclear Temperature in Semi-infinite Nuclear Matter显示文摘The temperature dependence of the self-energy of a particle is studied in semi-infinite nuclear matter.Based on the finite temperature Green’s function Mat-subara formalism and applying it to the single particle-states in ^(208)Pb,the calculated results show that the characteristic enhancement of the effective mass at near the Fermi energy disappears at temperature T=3 MeV,and correspondingly,as a consequence the level-density parameter should decrease in agreement with recent empirical data. | HUANG Weizhi WANG Zixing PFBortignon RABroglia | 1992 | Chinese Physics Letters1992，9，8： | 0 |
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