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| 1 | Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘 | Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao | 2017 | Frontiers of Medicine2017，11，4： | 37 |
| 2 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 3 | Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants显示文摘Fabricating a desired porous structure on the surface of biomedical polyetheretherketone(PEEK)implants for enhancing biological functions is crucial and difficult due to its inherent chemical inertness.In this study,a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide(SO3)for different time(5,15,30,60 and 90 min).Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical properties.The protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of sulfonation.In combination of the appropriate micromorphology and bioactive sulfonate components,the cell adhesion,migration,proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 min.Finding from this study revealed that controllable sulfonation by gaseous SO3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties. | Teng Wan Zixue Jiao Min Guo Zongliang Wang Yizao Wan Kaili Lin Qinyi Liu Peibiao Zhang | 2020 | Bioactive Materials2020，5，4： | 5 |
| 4 | Rambutan-like hollow carbon spheres decorated with vacancy-rich nickel oxide for energy conversion and storage显示文摘Transition metal oxides hold great promise for lithium-ion batteries(LIBs)and electrocatalytic water splitting because of their high abundance and high energy density.However,designing and fabrication of efficient,stable,high power density electrode materials are challenging.Herein,we report rambutan-like hollow carbon spheres formed by carbon nanosheet decorated with nickel oxide(NiO)rich inmetal vacancies(denoted as h-NiO/C)as a bifunctional electrode material for LIBs and electrocatalytic oxygen evolution reaction(OER).When being used as the anode of LIBs,the h-NiO/C electrode shows a large initial capacity of 885mAh g−1,a robust stability with a high capacity of 817mAh g−1 after 400 cycles,and great rate capability with a high reversible capacity of 523mAh g−1 at 10Ag−1 after 600 cycles.Moreover,working as an OER electrocatalyst,the h-NiO/C electrode shows a small overpotential of 260mV at 10mAcm−2,a Tafel slope of 37.6mVdec−1 along with good stability.Our work offers a cost-effective method for the fabrication of efficient electrode for LIBs and OER. | Zixu Sun Xinghui Wang Hu Zhao See W.Koh Junyu Ge Yunxing Zhao Pingqi Gao Guangjin Wang Hong Li | 2020 | Carbon Energy2020，2，1： | 4 |
| 5 | Genome editing in plants with MAD7 nuclease显示文摘MAD7 is an engineered nuclease of the Class 2 type V-A CRISPR-Cas(Cas12 a/Cpf1)family with a low level of homology to canonical Cas12 a nucleases.It has been publicly released as a royalty-free nuclease for both academic and commercial use.Here,we demonstrate that the CRISPR-MAD7 system can be used for genome editing and recognizes T-rich PAM sequences(YTTN)in plants.Its editing efficiency in rice and wheat is comparable to that of the widely used CRISPR-Lb Cas12 a system.We develop two variants,MAD7-RR and MAD7-RVR that increase the target range of MAD7,as well as an M-AFID(a MAD7-APOBEC fusion-induced deletion)system that creates predictable deletions from 50-deaminated Cs to the MAD7-cleavage site.Moreover,we show that MAD7 can be used for multiplex gene editing and that it is effective in generating indels when combined with other CRISPR RNA orthologs.Using the CRISPR-MAD7 system,we have obtained regenerated mutant rice and wheat plants with up to 65.6%efficiency. | Qiupeng Lin Zixu Zhu Guanwen Liu Chao Sun Dexing Lin Chenxiao Xue Shengnan Li Dandan Zhang Caixia Gao Yanpeng Wang Jin-Long Qiu | 2021 | Journal of Genetics and Genomics2021，48，6： | 4 |
| 6 | Chaperone-mediated autophagy and neurodegeneration:connections,mechanisms,and therapeutic implications显示文摘Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy(CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA activity declines with age and is altered in neurodegenerative diseases. Its impairment leads to the accumulation of aggregated proteins, some of which may be directly tied to the pathogenic processes of neurodegenerative diseases. Its induction may accelerate the clearance of pathogenic proteins and promote cell survival, representing a potential therapeutic approach for the treatment of neurodegenerative diseases. In this review, we summarize the current findings on how CMA is involved in neurodegenerative diseases, especially in Parkinson's disease. | Xiaolei Liu Sihua Huang Xingqin Wang Beisha Tang Wenming Li Zixu Mao | 2015 | Neuroscience Bulletin2015，31，4： | 4 |
| 7 | Long noncoding RNA UC.98 stabilizes atherosclerotic plaques by promoting the proliferation and adhesive capacity in murine aortic endothelial cells显示文摘Pathological studies have shown that the vulnerability of plaques affects outcomes in patients with atherosclerosis(AS),a chronic inflammatory disease and common cause of morbidity and mortality worldwide.Although emerging technologies have enabled early diagnosis of AS with high-risk vulnerable plaques,more accurate and noninvasive diagnostic methods are urgently required.To this end,molecules involved in genetic or epigenetic regulation of the vulnerability of atherosclerotic plaques have been extensively studied.Here,we evaluated long noncoding RNA(IncRNA)variability by microarray assay in murine aortic endothelial cells(MAECs)bearing wulnerable plaques and identified the novel functional IncRNA UC.98,whose expression pattern was associated with the vulnerability of atherosclerotic plaques.Consisient with this,clinical statistics comparing the peripheral blood specimens from sets of patients with AS with or without vulnerable plaques confirmed the linear relationship between the expression pattern of UC.98 and plaque instabilty.Moreover,MTT assays and western blot analysis showed that silencing of intrinsic UC 98 in MAECs not only suppressed cell proliferation but also decreased the expressions of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1,thereby inactivating the nuclear factorkB pathway.In conclusion,our results highlighted the pivotal role of UC.98 in regulating the vulnerability of plaques during AS progression and suggested that UC.98 may be a biomarker of the early diagnosis and prognosis of AS with vulnerable plaques and a potential therapeutic target for slowing AS progression. | Zixu Fan Ying Zhang Danrui Xiao Jianwei Ma Hua Liu Linghong Shen Min Zhang Ben He | 2020 | Acta Biochimica et Biophysica Sinica2020，52，2： | 3 |
| 8 | Improved hemostatic effects by Fe^(3+)modified biomimetic PLLA cotton-like mat via sodium alginate grafted with dopamine显示文摘The development of an excellent,bioabsorbable hemostatic material for deep wound remains a challenge.In this work,a biodegradable cotton-like biomimetic fibrous mat of poly(L-lactic acid)(PLLA)was made by melt spinning.Subsequently,SD composite was prepared by cross-linking sodium alginate(SA)with dopamine(DA).It was immobilized on the fibre surface,which inspired by mussel byssus.Finally,Fe^(3+)was loaded onto the 0.5SD/PLLA composite by chelation with the carboxyl of alginate and phenolic hydroxy of dopamine.The haemostasis experiment found that the hemostatic time 47 s in vitro.However,the bleeding volume was 0.097 g and hemostatic time was 23 s when 20Fe^(3+)-0.5SD/PLLA was applied in the haemostasis of the rat liver.As a result of its robust hydrophilicity and bouffant cotton-like structure,it could absorb a large water from blood,which could concentrate the component of blood and reduce the clotting time.Furthermore,the addition of Fe^(3+)in the 0.5SD/PLLA had a significant effect on improve hemostatic property.It also displayed excellent antibacterial property for Escherichia coli and Staphylococcus aureus.Notably,it possesses superior hemocompatibility,cytocompatibility and histocompatibility.Hence,20Fe^(3+)-0.5SD/PLLA has high potential application in haemostasis for clinical settings due to its outstanding properties. | Caili Lv Linlong Li Zixue Jiao Huanhuan Yan Zongliang Wang Zhenxu Wu Min Guo Yu Wang Peibiao Zhang | 2021 | Bioactive Materials2021，6，8： | 3 |
| 9 | Biomimetic polyetheretherketone microcarriers with specific surface topography and self-secreted extracellular matrix for large-scale cell expansion显示文摘Reusable microcarriers with appropriate surface topography,mechanical properties,as well as biological modification through decellularization facilitating repeated cell culture are crucial for tissue engineering applications.Herein,we report the preparation of topological polyetheretherketone(PEEK)microcarriers via gas-driven and solvent exchange method followed by hydrothermal treatment at high temperature and pressure.After hydrothermal treated for 8 h,the resulting topological PEEK microcarriers exhibit walnut-like surface topography and good sphericity as well as uniform size distribution of 350.24619.44 mm.And the average width between ravine-patterned surface of PEEK microcarriers is 7806290 nm.After repeated steam sterilization by autoclaving for three times,topological PEEK microcarriers show nearly identical results compared with previous ones indicating strong tolerance to high temperature and pressure.This is a unique advantage for large-scale cell expansion and clinical applications.Moreover,PEEK microcarriers with special topography possess higher protein adsorption efficiency.In addition,the reutilization and biofunctionalization with repeated decellularization of topological PEEK microcarriers show highly beneficial for cell adhesion and proliferation.Therefore,our study is of great importance for new generation microcarriers with micro-and nano-scale surface feature for a broad application prospect in tissue engineering. | Qingming Ji ZongliangWang Zixue Jiao Yu Wang Zhenxu Wu Peng Wang Yuhang Zhu Shuo Sun Yi Liu Peibiao Zhang | 2020 | Regenerative Biomaterials2020，7，1： | 3 |
| 10 | A potential-driven switch of activity promotion mode for the oxygen evolution reaction at Co_(3)O_(4)/NiO_(x)H_(y) interface显示文摘Co_(3)O_(4)spinel oxides have manifested promising activity toward the oxygen evolution reaction(OER)through effective modifications.For them to become top electrocatalysts,however,accurate accounts of the catalytic kinetics are essential to gain a deep understanding of the activity promotion mechanisms.Herein,we use a newly proposed kinetic model based on energetic span as the rate-determining term for the electrocatalytic reaction to throw light on the promotion mechanism of Co_(3)O_(4)interfaced with nickel hydroxides(NiO_(x)H_(y))for the OER.We find that depending on the electrode potential,the OER kinetics at the designed interface between Co_(3)O_(4)and NiO_(x)H_(y)are boosted in entirely different ways.As a result,the OER can occur at a lower onset potential as well as a low Tafel slope.This work emphasizes the benefit of using rational theoretical models for electrocatalyst design. | Wang Wang Zixu Wang Youcheng Hu Yucheng Liu Shengli Chen | 2022 | eScience2022，2，4： | 2 |
| 11 | Taurine-upregulated gene 1 contributes to cancers through sponging microRNA显示文摘Long non-coding RNAs(lncRNAs)are a class of RNAs whose transcripts are more than 200 nucleotides in length and lack protein-coding ability.Taurine-upregulated gene 1(TUG1),a novel cancer-related lncRNA,has been documented to be abnormally expressed in various types of cancers and act as an oncogene or anti-oncogene.It has been considered previously that TUG1 is closely related to the cell proliferation,invasion,metastasis,and apoptosis of cancer.In recent years,it has been found that TUG1 acts as a microRNA(miRNA)sponge to indirectly regulate the expression of the miRNA target gene and dominates cancer progression in several types of cancers.However,TUG1 also binds to different miRNAs to produce diverse regulatory mechanisms in the same cancer.TUG1 is expected to be a biomarker and a new therapeutic target for the diagnosis and prognosis of certain cancers.In this review,we highlight the up-to-date original studies that focus on the role of TUG1 sponging miRNA in cancers and summarize the function of TUG1 in cancer progression.The novel TUG1–miRNA regulatory network is comprehensively and minutely included in this review.We hope that this review will help readers obtain a more detailed knowledge of the molecular mechanism by which TUG1 sponging miRNA plays its role in cancers,and provide some insights and directions for future cancer research. | Hui Zhou Zixu Gao Fusheng Wan | 2019 | Acta Biochimica et Biophysica Sinica2019，51，2： | 2 |
| 12 | Public-transcriptome-database-assisted selection and validation of reliable reference genes for qRT-PCR in rice显示文摘Accurate quantitative reverse transcription PCR(q RT-PCR)requires reliable reference genes whose expression does not vary in different tissues and developmental stages.However,few reliable reference genes are available for q RT-PCR in rice(Oryza sativa).Here,we established an effective strategy for identifying novel reference genes(NRGs)for reliable normalization of q RT-PCR data in various rice organs and developmental stages.We selected candidate NRGs using the Information Commons for Rice Database and confirmed their expression in Rice Expression Profile Database(Rice XPro)data.Genes with low variation(<2.5 cycle quantification)across tissues and developmental stages,and little fluctuation in expression in heatmaps from Rice XPro data were considered stable NRGs.To validate this strategy,we selected 11 candidate NRGs and calculated their expression stability in different spatio-temporal conditions using five programs,and compared these genes with five established reference genes(ERGs).Only one of the ERGs(UBQ5)was reliable and 10 of the candidate NRGs were more stable than the four remaining ERGs.Therefore,public transcriptomic databases are useful for identifying NRGs.We selected two NRGs,UFC1(Homolog of UFM1-Conjugating Enzyme 1)and Fha B(Homolog of Adhesin Fha B)for q RT-PCR analysis in rice;their homologs might be suitable for other monocot plants. | Zhe Zhao Zixu Zhang Zhi Ding Hengjun Meng Rongxin Shen Huiwu Tang Yao-Guang Liu Letian Chen | 2020 | Science China(Life Sciences)2020，63，1： | 2 |
| 13 | One-step anti-superbug finishing of cotton textiles with dopamine-menthol显示文摘In this work,the one-step stereochemical antimicrobial finishing of cotton textiles(CT)was achieved by the oxidative copolymerization of a dopamine-menthol derivative(DAM)and dopamine(DA).The obtained DAM-modified CT(P(DAM-co-DA)-CT)exhibited broad-spectrum microbial anti-adhesion properties against bacteria(E.coli and P.aeruginosa),including superbugs(MRSA and VREF),and fungi(A.niger,A.flavus,M.racemosus and P.chrysogenum).Because of its unique stereochemical antimicrobial mechanism,the obtained P(DAM-co-DA)-CT is a non-releasing antimicrobial material that causes no skin sensitization and exhibits good biocompatibility.The coating was also found to enhance the UVresistant and mechanical properties of the CT.Furthermore,it displayed durable washing fastness and antimicrobial properties after the endurance of 30 laundering cycles.The observed achievements provide a broader understanding of stereochemical antimicrobial surfaces and endow this method with wider applications. | Jiangqi Xu Zixu Xie Fanglin Du Xing Wang | 2021 | Journal of Materials Science & Technology2021，，10： | 2 |
| 14 | Ni3S2 nanorods growing directly on Ni foam for all-solid-state asymmetric supercapacitor and efficient overall water splitting显示文摘Transition metal compounds are attractive for their significant applications in supercapacitors and as non-noble metal catalysts for electrochemical water splitting.Herein,we develop Ni3 S2 nanorods growing directly on Ni foam,which act as multifunctional additive-free Ni3 S2@Ni electrode for supercapacitor and overall water splitting.Based on PVA-KOH gel electrolyte,the assembled all-solid-state Ni3 S2@Ni//AC asymmetric supercapacitor delivers a high areal energy density of 0.52 mWh cm^-2 at an areal power density of 9.02 MW cm^-2,and exhibits an excellent cycling stability with a capacitance retention ratio of 89%after 10000 GCD cycles at a current density of 30 mA cm^-2.For hydrogen evolution reaction and oxygen evolution reaction in 1 M KOH,Ni3 S2@Ni electrode achieves a benchmark of 10 mA cm^-2at overpotentials of 82 mV and 310 mV,respectively.Furthermore,the assembled Ni3 S2@Ni‖Ni3 S2@Ni electrolyzer for overall water splitting attains a current density of 10 mA cm^-2 at 1.61 V.The in-situ synthesis of Ni3 S2@Ni electrode enriches the applications of additive-free transition metal compounds in high-performance energy storage devices and efficient electrocatalysis. | Baoxin Wu Hao Qian Zhongwu Nie Zhongping Luo Zixu Wu Peng Liu Hao He Jianghong Wu Shuguang Chen Feifei Zhang | 2020 | Journal of Energy Chemistry2020，29，7： | 2 |
| 15 | Porous polyetheretherketone microcarriers fabricated via hydroxylation together with cellderived mineralized extracellular matrix coatings promote cell expansion and bone regeneration显示文摘Porous microcarriers have aroused increasing attention recently by facilitating oxygen and nutrient transfer,supporting cell attachment and growth with sufficient cell seeding density.In this study,porous polyetheretherketone(PEEK)microcarriers coated with mineralized extracellular matrix(mECM),known for their chemical,mechanical and biological superiority,were developed for orthopedic applications.Porous PEEK microcarriers were derived from smooth microcarriers using a simple wet-chemistry strategy involving the reduction of carbonyl groups.This treatment simultaneously modified surface topology and chemical composition.Furthermore,the microstructure,protein absorption,cytotoxicity and bioactivity of the obtained porous microcarriers were investigated.The deposition of mECM through repeated recellularization and decellularization on the surface of porous MCs further promoted cell proliferation and osteogenic activity.Additionally,the mECM coated porous microcarriers exhibited excellent bone regeneration in a rat calvarial defect repair model in vivo,suggesting huge potential applications in bone tissue engineering. | Shuo Sun Zixue Jiao Yu Wang Zhenxu Wu Haowei Wang Qingming Ji Yi Liu Zongliang Wang Peibiao Zhang | 2021 | Regenerative Biomaterials2021，8，2： | 2 |
| 16 | Integrated microdevice with a windmill-like hole array for the clog-free,efficient,and self-mixing enrichment of circulating tumor cells显示文摘Circulating tumor cells(CTCs)have tremendous potential to indicate disease progression and monitor therapeutic response using minimally invasive approaches.Considering the limitations of affinity strategies based on their cost,effectiveness,and simplicity,size-based enrichment methods that involve low-cost,label-free,and relatively simple protocols have been further promoted.Nevertheless,the key challenges of these methods are clogging issues and cell aggregation,which reduce the recovery rates and purity.Inspired by the natural phenomenon that the airflow around a windmill is disturbed,in this study,a windmill-like hole array on the SU-8 membrane was designed to perturb the fluid such that cells in a fluid would be able to self-mix and that the pressure acting on cells or the membrane would be dispersed to allow a greater velocity.In addition,based on the advantages of fluid coatings,a lipid coating was used to modify the membrane surface to prevent cell aggregation and clogging of the holes.Under the optimal conditions,recovery rates of 93%and 90%were found for A549 and HeLa cells in a clinical simulation test of our platform with a CTC concentration of 20-100 cells per milliliter of blood.The white blood cell(WBC)depletion rate was 98.7%(n=15),and the CTC detection limit was less than 10 cells per milliliter of blood(n=6).Moreover,compared with conventional membrane filtration,the advantages of the proposed device for the rapid(2 mL/min)and efficient enrichment of CTCs without clogging were shown both experimentally and theoretically.Due to its advantages in the efficient,rapid,uniform,and clog-free enrichment of CTCs,our platform offers great potential for metastatic detection and therapy analyses. | Hao Li Jinze Li Zhiqi Zhang Zhen Guo Changsong Zhang Zixu Wang Qiuquan Guo Chao Li Chuanyu Li Jia Yao Anran Zheng Jingyi Xu Qingxue Gao Wei Zhang Lianqun Zhou | 2022 | Microsystems & Nanoengineering2022，8，1： | 1 |
| 17 | Combustion behaviours of tobacco stem in a thermogravimetric analyser and a pilot-scale fluidized bed reactor显示文摘 | YANG Zixu ZHANG Shihong LIU Lei | 2012 | Bioresource Technology2012，110，： | 1 |
| 18 | In vitro inhibition of CSFV replication by retroviral vector-mediated RNA interference显示文摘 | Jiangnan Li Huancheng Guo Zixue Shi Changchun Tu | 2010 | Journal of Virological Methods2010，，2： | 1 |
| 19 | Effect of monochromatic light on the egg quality of laying hens显示文摘 | Er Dunmutu Wang Zixu Cao Jing | 2007 | J Appl Poul Res2007，16，4： | 1 |
| 20 | Preparation of modified carbon black with nano-scale size and enhanced stability in organic solvent by solid state method显示文摘 | Qiuying Li Na Yu Zixue Qiu Xiaojun Zhou Chi Fei Wu | 2007 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2007，，1： | 1 |
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