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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 3 | Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria 显示文摘 | Zoetendal E G Akkermans A D L De Vos W M | 1998 | Applied and Environmental Microbiology1998，64，10： | 1 |
| 4 | Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria显示文摘 | Zoetendal EG Akkermans ADL de Vos WM | | 0，，10： | 1 |
| 5 | A microbial world within us显示文摘 | Zoetendal EG Vaughan EE de Vos WM | 2006 | Mol Microbiol2006，59，6： | 1 |
| 6 | Temperature gradient gel electrophoresis analysis from human fecal samples reveals stable and host-specific communities of active bacteria显示文摘 | ZOETENDAL E G AKKERMANS A D L | 1998 | Appl Envir Microbiol1998，64，： | 1 |
| 7 | Molecular ecological analysis of the gastrointestinal microbiota:A review显示文摘 | Zoetendal E G Collier C T Koike S | 2004 | Journal of Nutrition2004，134，： | 1 |
| 8 | The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates显示文摘 | Zoetendal EG Raes J van den Bogert B | 2012 | ISME J2012，6，7： | 1 |
| 9 | Molecular ecological analysis of the gastrointestinal microbiota: a review 显示文摘 | ZOETENDAL E G COLLIER C T KOIKE S | 2004 | The Journal of Nutrition2004，134，2： | 1 |
| 10 | Molecular eco- logical analysis of the gastrointestinal microbiota: a review显示文摘 | ZOETENDAL E G COLLIER C T KOIKE S | 2004 | J Nu- tr2004，134，2： | 1 |
| 11 | Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria 显示文摘 | ZOETENDAL E G AKKERMANS A D De VOSW M | 1998 | Appl Environ Microbiol1998，64，38： | 1 |
| 12 | Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria显示文摘 | Zoetendal E G Akkermans A D De Vos W M | 1998 | Appl Environ Microbiol1998，64，10： | 1 |
| 13 | Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria显示文摘 | Akkermans A L Devos W M | 1998 | Appl Environ Microbiol1998，64，： | 1 |
| 14 | Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces显示文摘 | Zoetendal EG yon Wright A Vilpponen-Salmela T | 2002 | Appl Environ Microbiol2002，68，7： | 1 |
| 15 | Molecular microbial ecology of the gastrointestinal tract:from phylogeny to function显示文摘 | Zoetendal E G Cheng Biao Koike S | 2004 | Current Issues in Intestinal Microbiology2004，5，2： | 1 |
| 16 | Temperature gra- dient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacte- ria 显示文摘 | Zoetendal E G Akkermans A D L de Vos W M | 1998 | Appl Environ Microbiol1998，64，10： | 1 |
| 17 | The host genotype affects the bacterial community in the human gastronintestinal tract 显示文摘 | ZOETENDAL EG AKKERMANS ADL AKKERMANS- VAN VLIET WM | 2001 | Microbial Ecology in Health and Disease2001，13，： | 1 |
| 18 | Quantification of uncultured Ruminococcus obeum-like bacteria in human fecal samples by fluorescent in situ hybridization and flow cytometry using 16S rRNA-targeted probes显示文摘 | Zoetendal EG Ben-Amor K Harmsen HYM | | 0，，9： | 1 |
| 19 | Molecular ecological analysis of the gastrointestinal microbiota显示文摘 | Collier C T Koike S | 2004 | A review J Nutr2004，134，： | 1 |
| 20 | Molecular ecological analysis of the gastrointestinal microbiota:A review显示文摘 | Zoetendal E G Collier C T Koike S | 2004 | J Nutrit2004，134，： | 1 |
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