|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE. | Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 4 | Determination of nitrate and nitrite by high-performance liquid chromatography in human plasma 显示文摘 | VERA J ZOLTAN P STEFAN A | 2002 | Analytica Che-mica Acta2002，780，： | 1 |
| 5 | Angiogene- sis in rheumatoid arthritis 显示文摘 | ZOLTAN S TIMEA B GYORGY P | 2009 | Autoimmunity2009，42，7： | 1 |
| 6 | Determination of selenoamino acids by high-performance liquid chomatography-hydranlia high pressure nebulization -a tomic fluorescence spectrometry显示文摘 | ERZSEBET P ZOLTAN M PETER F | 1999 | J Anal at Spectrom1999，14，6： | 1 |
| 7 | Determination of nitrate and nirie by high performance liquid chromatography in human plasma 显示文摘 | VERA J ZOLTAN P STEFAN A | 2002 | Analytica Chemiea Acta2002，78，6： | 1 |
| 8 | A concise synthetic pathway towards 5-substituted indolizidines显示文摘 | Tamás R Varga Péter Nemes Zoltan Mucsi | | 0，，07： | 1 |
| 9 | Comparative investigation of the adhesion of Ce conversion layers and silane layers to a AA 2024-T3 substrate through mechanical and electrochemical test 显示文摘 | Luis E P Zoltan P | 2007 | Materials Research2007，10，4： | 1 |
| 10 | Ionchannels and lymphocyte activation显示文摘 | Gyorgy P Zoltan V Rezs'o G | 2004 | Immunol Lett2004，92，1： | 1 |
| 11 | Thermal degradation of segmented polyurethanes显示文摘 | Zoran S P Zoltan Z Joseph H | 1994 | Applied Polymer Science1994，51，6： | 1 |
| 12 | A Ccmparison of the ECMWF,MSC,and NCEP global ensemble prediction systems显示文摘 | Buizza R P L Houtekamer Zoltan Toth | 2005 | Mon Wea Rev2005，133，5： | 1 |
| 13 | Post-transcriptional regulation of the Bacillus subtilis pst operon encoding a phosphate-specific ABC transporter显示文摘 | Nicholas E E Nicola O C Zoltan P | 2004 | Microbiology2004，150，： | 1 |
| 14 | Lycopene content and colour of ripening tomatoes as affected by environmental conditions 显示文摘 | Sara B Zoltan P Eva B | 2006 | Journal of the Science of Food and Agriculture2006，86，4： | 1 |
| 15 | Ionizing radiation promotes the acquisition of a senescence-associated secreto- ry phenotype and impairs angiogenic capacity in cerebromi- crovascular endothelial cells : role of increased DNA damage and decreased DNA repair capacity in microvascular radio- sensitivity显示文摘 | Zoltan U Andrej P Danuta S | 2013 | Gerontol A Biol Sci Med Sci2013，68，： | 1 |
| 16 | Management of severe idiopathic oligohydramnios: is antepartum transabdominal amnioinfusion really a treatment option?显示文摘 | Zoltan Kozinszky Norbert Pá sztor Melinda Vanya Já nos Sikovanyecz Attila Pá l | 2013 | Journal of Maternal-Fetal and Neonatal Medicine2013，，4： | 1 |
| 17 | Laparoscopic splenec- tomy:outcome and efficacy for massive and supramassive spleens显示文摘 | Vadim P Koshenkov MD Zoltan H | 2012 | The American Journal of Surgery2012，203，5： | 1 |
| 18 | Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster显示文摘 | Zoltan P Jose M Gonzalez | 2001 | Virus Genes2001，23，1： | 1 |
| 19 | Ionchannels and lymphocyte activation 显示文摘 | Gyorgy P Zoltan V Rezso G | 2004 | Immunol Lett2004，92，1： | 1 |
| 20 | SZTAKI Desktop Grid (SZDG): A Flexible and Scalable Desktop Grid System显示文摘 | Kacsuk P Jozsef K Zoltan F | 2009 | Journal of Grid Computing2009，7，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员