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| 1 | Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells显示文摘 | Lin Jiang Zhuoan Cheng Shaobo Qiu Zujun Que Wenjing Bao Chao Jiang Fangyuan Zou Ping Liu Jianwen Liu | 2012 | International Immunopharmacology2012，，2： | 1 |
| 2 | NK cell depletion promotes liver metastasis of lung cancer cells显示文摘Lung cancer is the malignant tumor with the highest morbidity and mortality in the world[1].Metastasis is the main cause of death in lung cancer patients[2].Cancer cells that are shed from the primary tumor tissue and enter the peripheral circulation are called circulating tumor cells(CTCs)[3].Among them,tumor cells that reach and colonize distant target organs are named disseminated tumor cells(DTCs)[4].Influenced by the microenvironment,immune surveillance,angiogenesis and other factors,DTCs have a weak ability to proliferate or even enter a dormant state[5].Therefore,reducing proliferative activity or maintaining the dormancy of DTCs has emerged as a novel strategy to prevent lung cancer metastasis. | Pan Yu Long Zhang Jianhui Tian Jiajun Liu Zujun Que Ge Li Yiyang Zhou | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 3 | Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatment of lung cancer显示文摘Targeted delivery and smart response of nanomedicine hold great promise for improving the therapeutic efficacy and alleviating the side effects of chemotherapy agents in cancer treatment.However,availability of only a few studies that discuss organic nanomedicines with these properties limits the development prospects of nanomedicines.In the present study,folic acid(FA)-targeted delivery and glutathione(GSH)smart responsive nanomedicine were rationally designed for pacli-taxel(PTX)delivery for the treatment of lung cancer.Compared with other stimuli-responsive nanomedicines,this nanocarrier was not only sensitive to biologically relevant GSH for on-demand drug release but also biodegradable into biocompatible products after fulfilling its delivery task.The nanomedicine first entered tumor cells via FA and its receptor-mediated endocytosis.After the lysosomal escape,poly(lactic-co-glycolic acid)(PLGA)nanomedicine was triggered by a higher level of GSH and released its cargo into the tumor microenvironment.In vitro and in vivo results revealed that the PLGA nanomedicine not only inhibited the proliferation and promoted the apoptosis of lung cancer cells significantly but also possessed less toxic side effects when compared with free PTX.Therefore,the proposed drug delivery system demonstrates the potential of a multifunctional nano-platform to enhance bioavailability and reduce the side effects of chemotherapy agents. | Wang Yao Jialiang Yao Fangfang Qian Zujun Que Pan Yu Tianle Luo Dan Zheng Zhanxia Zhang Jianhui Tian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 4 | Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway显示文摘Lung cancer is the leading cause of cancer-related death in China and worldwide[1].Although the popularization and application of PET-CT have improved the detection rate of patients with early lung cancer,there is still a lack of effective drugs to prevent and treat lung cancer metastasis and prolong the survival of patients[2,3].Circulating tumor cells(CTCs),as seeds of tumor metastasis,play an important role in the metastasis of lung cancer. | Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
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