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| 1 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 2 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 3 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 4 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 5 | Three-dimensional flexibility and stiffness properties of the human thoracic spine 显示文摘 | Panjabi M M Brand R A Jr White A A 3rd | | J Biomech0，1976，： | 1 |
| 6 | Effect of col- ored shade nets on pepper powdery mildew 显示文摘 | ELAD Y MESSIKA Y BRAND M | 2007 | Phyto- parasitica2007，35，3： | 1 |
| 7 | Kinetic modelling of reactions in heated disaccharide-casein systems显示文摘 | BRANDS C M J VAN BOEKEL M A J S | 2003 | Food Chemistry2003，83，： | 1 |
| 8 | Topiramatefor mi graine prevention: a randomizedcontrolled trial 显示文摘 | Brandes JL Saper JR Diamond M | 2004 | JAMA2004，291，8： | 1 |
| 9 | Surface pressure measurements on a body subject to vortex wake interaction显示文摘 | Brand A Komerath N M McMahon H M | 1989 | AIAA Journal1989，27，5： | 1 |
| 10 | Division size and shade density influence growth and container production of Hakonechloa macra Makion 'Aureola'显示文摘 | Harvey M P Brand M H | 2002 | Hortscience2002，37，1： | 1 |
| 11 | Insights into neural stem cell biology in flies显示文摘 | Egger B Chell J M Brand A | 2008 | Phil Trans R Soe B2008，363，1489： | 1 |
| 12 | Photoreactor analysis and design: fundamentals and applications 显示文摘 | Cassano A E Martin C A Brand R J Alfamo O M | 1995 | Ind Eng Chem Res1995，34，： | 1 |
| 13 | Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes 显示文摘 | Koyanagi M Brandes RP Haendeler J | 2005 | Circ Res2005，96，： | 1 |
| 14 | Dihydropyrimidinones-a new class of anti-Staphylococcal antibiotics显示文摘 | Brands M Endermann R Gahlmann R | 2003 | Bioorg Med Chem Lett2003，13，2： | 1 |
| 15 | A dynamic wind farm aggregate model for the simulation of power fluctuations due to wind turbulence显示文摘 | Tommasi L D Gibescu M Brand A J | 2010 | Journal of Computational Science2010，1，2： | 1 |
| 16 | Reactions of mono- saccharides during heating of sugar-casein systems: Build- ing of a reaction network model显示文摘 | Brands C M J Van-Boekel M A J S | 2001 | Journal of Agriculturaland Food Chemistry2001，49，10： | 1 |
| 17 | Association between mitochondrial dysfunction and severity and outcome of septic shock 显示文摘 | Brealey D Brand M Hargreaves I | 2002 | Lancet2002，360，9328： | 1 |
| 18 | Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis显示文摘 | Kain R Exner M Brandes R | 2008 | Nat Med2008，14，10： | 1 |
| 19 | Structural analysis and evaluation of the aldo sterone synthase gene in hypertension 显示文摘 | Brand E Chatelain N M ulatero P | 1998 | Hypertension1998，32，1： | 1 |
| 20 | 60 20 emission the unequal distribution of greenhouse gas emissions from personal, non business travel in the UK显示文摘 | Brand C Preston J M | 2010 | Transport Policy2010，17，1： | 1 |
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